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Stroke clinical trials

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NCT ID: NCT06061887 Completed - Stroke Clinical Trials

Factors Associated With Recurrent Falls in Stroke Patients

Start date: March 31, 2021
Study type: Observational

The goal of this observational study is to learn about the recurrent falls in patients with acute stroke. The main question[s] it aims to answer are: - what is the frequency of recurrent falls - which factors are associated with recurrent falls in patients with acute stroke. Participants will be evaluated in terms of - frequency of recurrent falls within the six months after stroke - fear of falling - the stroke severity (Canadian Neurological Scale), - ambulation level (Functional Ambulation Classification), - functional disability (Functional Independence Scale) - Postural control and balance - functional status (Modified Rankin Scale)

NCT ID: NCT06061770 Not yet recruiting - Stroke Clinical Trials

Comparison of the Effectiveness of an Adapted Physical Activity Program in a Dedicated Structure to a Self-program in Patients in Chronic Phase of a Stroke

Start date: December 2023
Phase: N/A
Study type: Interventional

This is a prospective, randomized, controlled, two parallel arms, single-blind pilot study. In this design, all included patients in the chronic phase of a stroke will receive both modes of physical activity. This study includes patients over 18 years of age with spastic hemiparesis sequelae of a first unilateral hemispheric stroke older than 6 months and able to walk for 6 minutes. The non-inclusion criteria were the inability to walk without human assistance (with or without technical aids), the existence of cognitive disorders compromising informed consent, in particular the inability to understand the objective and the modalities of the protocol, the inability to communicate with the examiners, and the presence of an additional neurological disorder or a pathology contraindicating the practice of physical activity. The primary endpoint is based on daily activity measurement by measuring the number of steps per day, collected over the duration of the study, via a Stepwatchâ„¢ device. Secondary end points involve a written physical activity report, assessment of walking ability (via walking-test 6, heart rate, and blood pressure), a measure of perceived exertion, stroke-specific quality of life, balance, and motivation to perform physical activity.

NCT ID: NCT06061757 Recruiting - Stroke Clinical Trials

Use of 4D-ICE in Conjunction With TEE for Left Atrial Appendage Closure

Start date: May 10, 2023
Phase: N/A
Study type: Interventional

This is a prospective, single center, non-randomized study with two parallel arms intended to study if 4D Intracardiac echocardiography (4D-ICE) (Nuvision, Nuvera TM) will provide better visualization of the anatomical landmarks from the larger imaging volume and provide optimal intra procedural guidance similar to Transesophageal echocardiography (TEE) (GE 6VT-D ULTRASOUND TRANSDUCER) for Left atrial appendage closure (LAAC). The study will enroll approximately 52 subjects and will be followed through 12 months.

NCT ID: NCT06061601 Recruiting - Stroke Sequelae Clinical Trials

ACTive Exoskeleton for Unilaterally-Assisted Locomotion (ACTUAL)

Start date: April 12, 2021
Phase: N/A
Study type: Interventional

Walking difficulties are common symptoms after stroke, significantly reducing quality of life. Walking recovery is therefore one of the main priorities of rehabilitation. Wearable powered exoskeletons have been developed to provide lower limb assistance and enable training for persons with gait impairments by using typical physiological movement patterns. Exoskeleton were originally designed for individuals without any walking capacities, such as subjects with a complete spinal cord injury. Recent systematic reviews suggested that lower limb exoskeletons could be valid tools to restore independent walking in subjects with residual motor function, such as persons post-stroke.The aim of the study was to identify the end-users needs and to develop a user-centered-based control system for the TWIN lower limb exoskeleton to provide an efficient post-stroke rehabilitation of gait. The investigators thus carried out the development and validation through evaluation sessions performed on healthy clinical experts and persons with stroke to evaluate TWIN-Acta usability, acceptability, and barriers of usage. A phase two includes a pilot study of efficacy of using the TWINActa for gait rehabilitation for persons with stroke.

NCT ID: NCT06060912 Not yet recruiting - Clinical trials for Left Atrial Appendage Occlusion

LAmbre Versus AMPLATZER Amulet Left AtrIal Appendage Occluder for StRoke ProphylaxIs

Start date: October 15, 2023
Phase: N/A
Study type: Interventional

The objective of this trial is to compare two different commercially available left atrial appendage occlusion (LAAO) devices in patients with non-valvular Atrial fibrillation/ atrial flutter (AF) at increased risk for stroke with regard to safety and efficacy. The investigators hypothesize that LAAO using the LAmbre occlusion device (Lifetech Scientific, Shenzhen, China) is non-inferior to LAAO using the AMPLATZER Amulet occlusion device (Abbott Medical, Chicago, ILL, USA) with regards to the primary endpoint, which is peri-device leak (PDL) size 3 months after LAAO, as assessed with transesophageal echocardiography (TOE) in patients with non-valvular AF.

NCT ID: NCT06060470 Not yet recruiting - Chronic Stroke Clinical Trials

Active Balance and Cardio Care Intervention on Physical and Cardiovascular Health in People With Chronic Stroke

ABC care
Start date: October 1, 2023
Phase: N/A
Study type: Interventional

Neurological impairment such as stroke is a leading cause of adult disability. Traditional rehabilitative therapies can help regain motor function and ameliorate disability. There are increasing community and other facilities offering rehabilitation in the form of conventional, recreational and alternative therapy. However, the implementation of these conventional therapy techniques in individuals with a neurological disorder like stroke is tedious, resource-intensive, and costly, often requiring transportation of patients to specialized facilities. Based on recent evidence suggesting significant benefits of repetitive, task-orientated training, investigators propose to evaluate the feasibility of an alternative therapies such as exergaming-based therapy to improve overall physical function of community-dwelling individuals with neurological impairments, compared to conventional therapeutic rehabilitation. This pilot study aims to systematically obtain data on compliance and efficacy of a randomized controlled trial. The objective of the study is to determine the safety, feasibility, compliance and efficacy of exergaming therapy to improve overall physical function of community-dwelling chronic stroke individuals.

NCT ID: NCT06059872 Not yet recruiting - Stroke Clinical Trials

Biomarkers of Reaction To HIIT Exercise

Start date: January 2024
Phase: N/A
Study type: Interventional

Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.

NCT ID: NCT06059742 Recruiting - Stroke Clinical Trials

Action Observation Therapy With and Without Acoustic Stimulation in Post Stroke Gait and Balance

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

Stroke causes the interruption of blood flow towards the brain cells which results in cell death and lead to variety of disorders including deficits in balance and gait. It is well known that it is causing death and disability .The incidence of stroke is increasing in low-income countries because of not using evidence-based practice in health-related conditions in these countries. Action observation training is one of the new developing rehabilitation technique that targets motor learning by the activation of mirror neurons and is the most important approach that targets the motor and functional recovery in stroke patients. A new treatment approach i .e action observation therapy, in which the movements are observed by the patient to provide visual stimulus, then patients are asked to perform those movements. A new approach acoustic stimulation is introduced for improving gait and balance in post stroke patients in which individual patient cadence is used to adjust the beats of sound so that auditory stimulation causes recovery.

NCT ID: NCT06059482 Recruiting - Stroke Clinical Trials

The Effect of Trunk Control on Sitting Balance and Upper Extremity Functions in Patients With Subacute Stroke

Start date: July 5, 2023
Study type: Observational

The study aims to examine whether trunk control affects sitting balance and upper extremity functions in patients with subacute stroke.

NCT ID: NCT06059144 Not yet recruiting - Stroke, Acute Clinical Trials

Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine

Start date: January 1, 2024
Phase: Phase 3
Study type: Interventional

PRESSURE is a multicenter, prospective, randomized, open, blinded end-point assessed (PROBE) trial, that aims to evaluate the efficacy and safety of drug-induced hypertension using peripheral dilute norepinephrine, in patients with acute ischemic stroke in a perforating artery territory and experiencing early neurological deterioration.