Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. We have both interventional & observational types of clinical trials found on this site.
Subject of the proposed study is the non-invasive in vivo imaging of bone, bone marrow and
localized microcirculation in test animals with osteoporosis, fractures and after placement
of bone substitute material with volume computed tomography (VCT) (animals only) and
functional magnetic resonance imaging (MRI). Furthermore patients with multiple myeloma (MM)
will be examined before and after placement of a commercially available bone substitute
material. Osseous structures before intervention and structural changes of the bone
especially at the junction of substitute material and residual bone will be documented. At
this, the proposed techniques allow imaging of the dynamic healing processes in the living
As next step patients with asymptomatic MM will be investigated with functional Imaging longitudinally to predict the occurence of osteolyses at time of Progression.
Hypothesis: Affection of microcirculation at the junction of bone and bone substitute material can be displayed by VCT and functional MRI
RATIONALE: Androgens can cause the growth of prostate cancer cells. Androgen deprivation
therapy may stop the adrenal glands from making androgens. Radiation therapy uses high-energy
x-rays to kill tumor cells.
PURPOSE: This randomized phase III trial studies androgen-deprivation therapy and radiation therapy in treating patients with prostate cancer.
About 15,000 patients with FFR (Fractional Flow Reserve) will be enrolled and evaluated for the natural history of coronary lesions at 2 years clinical and imaging follow-up.