Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. We have both interventional & observational types of clinical trials found on this site.
Teriparatide (PTH) is the only bone formation therapy that has been approved for the
treatment of postmenopausal osteoporosis in Canada. Osteoporosis is currently diagnosed
using a bone mineral density (BMD) scan, which measures the amount of mineral (calcium etc)
in bones (the higher the amount of mineral, the lower the fracture risk). Although BMD is
linked to bone strength and is used to measure fracture risk, it does not give information
on bone structure (called bone geometry) which can also tell us a great deal about fracture
risks. Clinical trials have shown that teriparatide increases BMD at the lumbar spine and
total hip, while BMD at the forearm may decrease after 20 months of therapy. However, bone
biopsies of the pelvis done on people taking teriparatide show improvement of bone geometry
(ie bone thickness and increased trabeculae (small interconnecting rods of bone), suggesting
that a change in bone geometry at the wrist may be occurring as well. Currently, there is a
new technology, high resolution pQCT (HR-pQCT) that can assess bone geometry without a
biopsy. Since bone strength is affected both by BMD and bone structure (as well as other
material properties), our group is interested in examining changes in bone geometry at the
radius and tibia in men and women with osteoporosis who receives 24 months of teriparatide
The investigators believe that this new approach of measuring bone strength will help us better understand the mechanisms of therapeutic efficacy of teriparatide. In addition, measuring indices of bone strength such as the material composition (bone mineral content or BMD) and structural properties of bone (size and shape, and microarchitecture) may provide more data about the mechanisms of how teriparatide treatment can decrease fracture risk. In the end, this data will benefit and improve patient care by allowing us to show patients and their providers that whether BMD increases, decreases or stay the same, there are changes in their bone geometric structure with teriparatide therapy that increases bone strength.
The purpose of this study will be to evaluate, in a multi-center setting, the ability of radiofrequency ablation (RFA) of breast cancer lumpectomy sites to extend the "final" negative margin and consequently decrease the rates of re-operation. During the initial breast conservation procedure (lumpectomy), immediately following routine surgical resection of the tumor, radiofrequency energy (RFA) is applied to the wall (bed) of the fresh lumpectomy cavity, thus extending tumor free margin radially beyond the volume of the resected specimen.
The objective of this study is to test and determine whether a high protein diet is efficacious, safe and beneficial to curtail food intake and body weight in obese adult human patients and to establish whether neurohormonal mechanisms of a high protein diet induce an early signal of fullness or satiety in a relevant experimental model, focusing on activation of gastric vagal afferents.