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What is a clinical trial?

Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. We have both interventional & observational types of studies. Interventional studies are those in which the research subjects are assigned by the investigator to a treatment or other intervention, and their outcomes are measured. Observational studies are those in which individuals are observed and their outcomes are measured by the investigators.

Current & upcoming clinical trials - Updated 7/20/2014
Enrolling by invitation
Phase 1/Phase 2

Breast Cancer



Homeopathic Protocol for Advanced Breast Cancer

August 2014 - August 2017
The objective of this study is to conduct a feasibility study at Meir Oncology Institute examining whether patients with advanced breast cancer would follow a homeopathic protocol for three to six months. The primary aim of the study is to establish if patients with advanced breast cancer in Meir Oncology Institute would follow a regimen of treatment as used by Dr Banerji in India, for six months. The secondary aim is to observe the quality of life and wellbeing of patients undergoing this protocol
Sponsor: Meir Medical Center
Study type: Interventional
July 2014 - June 2018
This multicenter study in patients with HER2-positive eBC will investigate patie nts' pain and discomfort of subcutaneous (SC) trastuzumab (Herceptin) administer ed either via a single-use injection device (SID) or via vial for manual adminis tration using a hand-held syringe (SC vial). In total, patients wil obtain at le ast 18 cycles/1 year of trastuzumab (4 cycles of IV and 14 cycles of SC trastuzu mab).
Sponsor: Hoffmann-La Roche
Study type: Interventional
July 2014 - July 2015
Postsurgical pain is a relevant side effect following surgery which increases the risk of various complications and delays postoperative patient recovery. Among the many types of surgeries, mastectomy causes not only acute but also chronic pain in many patients. Therefore, it is important to control pain and increase patients' recovery satisfaction following many kinds of operations by using as small an opioid analgesic dose as possible and adding a nonopioid analgesic to reduce the side effects of narcotic analgesics. Among nonopioid analgesics, lidocaine and magnesium are drawing attention, having been shown to be helpful in controlling postoperative pain by lowering pain hypersensitivity to surgical stimuli. An intraoperative intravenous injection of lidocaine has been reported to improve postoperative pain control by reducing postoperative pain and opioid consumption. Another report showed that an intraoperative intravenous injection of lidocaine improved the quality of postoperative functional recovery after general anesthesia in a laparoscopic cholecystectomy patient. In addition, a review article on the effect of intraoperative intravenous injection of magnesium found it to be an effective analgesic that may be added to conventional opioid-based therapy because it generally reduces opioid consumption, decreases pain assessment for 24 hours after surgery, and lacks severe side effects in relation to magnesium administration. However, there has been insufficient research comparing the intraoperative intravenous injection of lidocaine or magnesium in terms of which is more helpful for general functional recovery and decreased postoperative pain. Recently, the scope of research on anesthesia has come to embrace postanesthetic recovery; to help patients return to daily life, the research trend is now shifting from the improvement or resolution of a specific symptom to the measurement of general recovery. A widely used method to measure postoperative recovery is the Quality of Recovery 40 (QoR-40) survey. Therefore, in this study, the researchers investigated the intraoperative intravenous injection of lidocaine and the intravenous injection of magnesium to compare these drugs' helpfulness in the functional recovery of mastectomy patients after general anesthesia.
Sponsor: Yonsei University
Study type: Interventional
July 2014 -
The goal of this clinical research study is to compare the level of effectiveness for 2 acupuncture treatment schedules for chronic CIPN in breast cancer survivors. Researchers also want to study how patients may respond to acupuncture treatments, and how the treatments may affect quality of life, hand function, balance, and the use of drugs for neuropathy pain.
Sponsor: M.D. Anderson Cancer Center
Study type: Interventional
Enrolling by invitation

HIV



Planning for SUCCESS

July 2014 -
Planning for SUCCESS (Sustained, Unbroken Connections to Care, Entry Services, and Suppression) is a project to improve the connection to community care for HIV infected persons leaving Fulton County Jail or Atlanta City Detention Center in Atlanta. Hypothesis: Participants who receive the intervention will be more likely to link to medical care after jail release than similar participants who do not receive the intervention. Rationale and objective: This project aims to make sure HIV positive persons leaving jail maintain medical care. Case managers will use strength based case management and phone texting technology to improve release's connections to care in the community. This study will have extensive tracking of outcomes. The key outcome will be whether HIV infected participants receiving an intervention experience suppression of their viral load after release from jail . The investigators wish to demonstrate the ability to recruit participants into the SUCCESS intervention and repeatedly check community medical records to see how well their infection is being controlled after they linked to care. Investigators also want to conduct a survey at baseline, 3 months and 12 months. Investigators will compare the viral load of participants receiving the intervention to participants passing through the jail who do not receive the outcome.
Sponsor: Emory University
Study type: Interventional
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