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What is a clinical trial?

Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. We have both interventional & observational types of studies. Interventional studies are those in which the research subjects are assigned by the investigator to a treatment or other intervention, and their outcomes are measured. Observational studies are those in which individuals are observed and their outcomes are measured by the investigators.

Current & upcoming clinical trials - Updated 5/19/2013
May 2013 -
The goal of this clinical research study is to learn if erlotinib can help to control AML. The safety of this drug will also be studied.
Sponsor: M.D. Anderson Cancer Center
Study type: Interventional
May 2013 - August 2014
The purpose of this study is to investigate potential metabolic effects of resveratrol in morbidly obese women undergoing gastric bypass surgery. The investigators hypothesize that resveratrol will: - Decrease hepatic very-low-density-lipoprotein-triglyceride (VLDL-TG) secretion - Decrease hepatic and adipose tissue VLDL-TG uptake - Increase insulin sensitivity The investigators will look at changes in: - Lipid turnover (VLDL-TG kinetics, palmitate kinetics,calorimetry) - VLDL-TG uptake in different tissues (subcutaneous femoral adipose tissue, subcutaneous abdominal adipose tissue, visceral adipose tissue and liver tissue) - Insulin sensitivity (glucose kinetics during hyperinsulinaemic euglycaemic clamp) - Regulation of liver fat handling - Lipoprotein lipase activity and fat cell size (abdominal and femoral adipose tissue)
Sponsor: University of Aarhus
Study type: Interventional
May 2013 - September 2015
This is a study of overweight men and women. Everybody will receive a very low calorie diet to eat in place of meals for 10 weeks. During the last two weeks of the diet, half of the patients will receive an intervention to activate parts of their brain that can help them eat less. The other half of the patient will receive a placebo or sham intervention. The intervention will involve a small electric current given every day for 10 days. Everybody will be monitored for 16 more weeks (total of 26 weeks) while on a weight maintenance diet to see if the intervention helps people keep the weight off.
Sponsor: Massachusetts General Hospital
Study type: Interventional
May 2013 -
The goal of this clinical research study is to learn if giving cells called natural killer (NK) cells after receiving fludarabine, melphalan, lenalidomide, and a UCB transplant can improve response in patients with CLL. The safety of this treatment and whether NK cells can lessen the risk of graft vs. host disease (GVHD) will also be studied. The first 3 patients enrolled on this study will not receive NK cells but will receive a cord blood transplant. UCB and NK cells may be able to kill leukemia cells that remain in your body after chemotherapy treatment. The UCB cells are also designed to increase blood production and strengthen your immune system. Fludarabine and melphalan are designed to interfere with the DNA (genetic material) of cancer cells, which may cause the cancer cells to die. Lenalidomide is being used in this study because it may increase the NK cell activity.
Sponsor: M.D. Anderson Cancer Center
Study type: Interventional
May 2013 - January 2018
This study tries to evaluate the role of chemoradiation with capecitabine and bevacizumab in oligometastatic patients neither being progressive nor resectable after chemotherapy.
Sponsor: Universitätsklinikum Hamburg-Eppendorf
Study type: Interventional
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