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Stroke clinical trials

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NCT ID: NCT03924765 Not yet recruiting - Stroke Clinical Trials

Assistive Hip Exoskeleton Study for Stroke

Start date: May 20, 2019
Phase: N/A
Study type: Interventional

The increased metabolic and biomechanical demands of ambulation limit community mobility in persons with lower limb disability due to neurological damage. There is a critical need for improving the locomotion capabilities of individuals with stroke to increase their community mobility, independence, and health. Robotic exoskeletons have the potential to assist these individuals by increasing community mobility to improve quality of life. While these devices have incredible potential, current technology does not support dynamic movements common with locomotion such as transitioning between different gaits and supporting a wide variety of walking speeds. One significant challenge in achieving community ambulation with exoskeletons is providing an adaptive control system to accomplish a wide variety of locomotor tasks. Many exoskeletons today are developed without a detailed understanding of the effect of the device on the human musculoskeletal system. This research is interested in studying the question of how the control system affects stroke biomechanics including kinematic, kinetics and muscle activation patterns. By optimizing exoskeleton controllers based on human biomechanics and adapting control based on task, the biggest benefit to patient populations will be achieved to help advance the state-of-the-art with assistive hip exoskeletons.

NCT ID: NCT03923946 Not yet recruiting - Stroke Clinical Trials

STRICTLy CFT: A Feasibility Randomised Control Trial of a Compassion Focussed Therapy Intervention to Aid Recovery Post-stroke

Start date: May 2019
Phase: N/A
Study type: Interventional

Individuals who have had a stroke are at greater risk of developing distress (e.g. depression and anxiety). These individuals are also likely to be highly critical of themselves as they are no longer able to do the things they used to be able to do. Compassion Focused Therapy is a form of psychotherapy aimed at reducing an individual's self-criticism and increasing their self-compassion. CFT has been found to be effective at reducing distress in the general population and there is emerging evidence in the brain injury population. However, to date, there has not been a rigorous study to establish the effectiveness of CFT. Therefore, this feasibility randomised control trial aims to: Establish the feasibility of recruitment, randomisation, and retention of participants; determine the acceptability and feasibility of a CFT intervention within a stroke population; determine the suitability of pre and post measures for assessing the impact of the intervention; Analyse the cost-effectiveness of the study; Establish effect sizes to enable an accurate estimation of the number of participants needed in a full scale RCT to find a treatment effect. Individuals will be randomised into either a CFT intervention group, an active control arm (akin to a befriending type service) or a treatment as usual arm. Participants will receive up to three one hour sessions of CFT (intervention group) or befriending (active control group) or will not receive any additional support (treatment as usual group). A total of 36 participants will be recruited, 12 in each arm of the study. Participants will be recruited from the Early Supported Stroke Discharge Teams within Derbyshire. Participants will complete well-being, distress and self-criticism measures, pre, post and at 4 months follow-up. A semi-structured interview will also be conducted with a selection of participants from each arm.

NCT ID: NCT03923790 Enrolling by invitation - Blood Pressure Clinical Trials

Stroke Telemedicine Outpatient Prevention Program for Blood Pressure Reduction

STOP-Stroke
Start date: March 4, 2019
Phase: N/A
Study type: Interventional

The purpose of this pilot trial is to compare post-stroke care blood pressure (BP) treatment using an interdisciplinary telehealth model [called the Stroke Telemedicine Outpatient Program (STOP) for Blood Pressure Reduction] to usual care in stroke patients at risk for uncontrolled BP. The intervention will address general and stroke-related factors associated with racial disparities in BP control. We will assess feasibility of implementation of the trial and will use the measures and outcomes assessed in the pilot to examine knowledge gaps.

NCT ID: NCT03923439 Not yet recruiting - Stroke Clinical Trials

High B Value Diffusion and Stroke

HBS
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

This study will include 100 stroke patients with significant penumbra at the acute stage and successfully recanalized thanks to thrombectomy. Patients will be explored with the multi-b diffusion sequence on a new 3T research magnet equipped with high gradient system. In this project the investigators hypothesize that diffusion MRI at high and ultra-high b-values could be sensitive enough to quantify selective neuronal loss in the rescued penumbra and to study its relationship with the initial hypoperfusion and its impact in terms of clinical recovery.

NCT ID: NCT03917511 Recruiting - Chronic Stroke Clinical Trials

Effects of Combined Robot-assisted Therapy With Mirror Priming in Stroke Patients

Start date: December 17, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the effects of combining robotic-assisted training and mirror therapy on upper extremity motor and physiological function, daily functions, quality of life and self-efficacy in stroke patients.

NCT ID: NCT03916562 Recruiting - Stroke Clinical Trials

Optimization Principles in Hemiparetic Gait

Start date: November 13, 2018
Phase: N/A
Study type: Interventional

This project seeks to identify the how walking impairments in stroke survivors contribute to mobility deficits through the use of behavioral observations and computational models. The chosen approach integrates biomechanical analyses, physiological assessments and machine learning algorithms to explain how asymmetries during walking influence balance and the effort required to walk. Ultimately, the results of this work may lead to more personalized rehabilitation strategies to improve walking capacity and efficiency, and ultimately reduce fall risk in stroke survivors.

NCT ID: NCT03915782 Not yet recruiting - Stroke, Ischemic Clinical Trials

Neuroprotective Effect of Remote Ischemic Conditioning in Ischemic Stroke Treated With Mechanical Thrombectomy

PROTECT I
Start date: July 1, 2019
Phase: N/A
Study type: Interventional

The benefit of mechanical thrombectomy in the treatment of ischemic stroke has been demonstrated in several multicenter randomized trials. However, it leads to a sudden reperfusion of the brain parenchyma associated to an extension of the infarct volume. Evidence has indicated that remote ischemic conditioning (RIC) reduces final infarct size in animal stroke models. The main objective of the present study is to determine whether remote ischemic conditioning can limit the final infarct volume after recanalization of the occluded cerebral artery.

NCT ID: NCT03915431 Not yet recruiting - Ischemic Stroke Clinical Trials

A Study of NCS-01 in Patients With Acute Ischemic Stroke

Start date: August 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This is an initial Phase1/2 dose-finding, double-blind, placebo-controlled, multi-center study to evaluate the safety and tolerability of NCS-01 in patients with acute ischemic stroke. All patients will be randomized within 24 hours of stroke onset. This study will be conducted in 2 stages.

NCT ID: NCT03913624 Completed - Stroke Clinical Trials

Effectiveness of Neuromuscular Electrical Stimulation After Stroke

Start date: July 2009
Phase: N/A
Study type: Interventional

A Randomized Clinical Trial (RCT) was conducted to determine the effects of two neuromuscular electrical stimulation protocols with different stimulation frequencies on motor recovery in older adults with spastic hemiparesis after a stroke.

NCT ID: NCT03913286 Recruiting - Stroke Clinical Trials

Neuromotor Prosthetic to Treat Stroke-Related Paresis

Cortimo
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

The purpose of the research is to develop a new medical device prototype to restore functional movement of an arm made weak due to a chronic stroke