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Stroke clinical trials

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NCT ID: NCT03195907 Completed - Rehabilitation Clinical Trials

Pulmonary Physiotherapy for Ischemic Stroke

Start date: February 1, 2015
Phase: N/A
Study type: Observational

This study evaluates the predictors of intensive care unit admission and mortality among stroke patients and the effects of pulmonary physiotherapy on these stroke patients. One-hundred patients participated in the pulmonary rehabilitation program and 81 patients served as a control group.

NCT ID: NCT03194464 Recruiting - Stroke Clinical Trials

Interlimb Transfer Post-stroke

Start date: October 1, 2015
Phase: N/A
Study type: Observational

This study investigates the effects of sub-maximal exercise to task-failure (e.g., fatigue) with the less involved, or so-called non-paretic hand, in people who have experienced a stroke. In previous work the investigators found that non-paretic hand exercise to task-failure increased excitability of the motor cortex in the more involved hemisphere and produced behavioral improvements in the unexercised paretic hand. Importantly, the magnitude of increased brain excitability is greater than what has been observed following brain stimulation with either repetitive transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) and lasts longer. This approach could be implemented in the clinical setting and could be accessible to a greater number of people than brain stimulation. The investigators' goals in the current study are to: repeat previous findings in a different group of participants and investigate the neural mechanisms that produce brain and behavioral facilitation in order to inform development of this approach for clinical implementation.

NCT ID: NCT03194282 Not yet recruiting - Clinical trials for Stroke, Cardiovascular

Effects of the Insole on Balance Capacity in Chronic Stroke

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

Poor balance capacity is one of clinical symptoms of stroke patient. The reason of loss balance capacity is motor impairment, as well as a diminished capacity to voluntarily shift body weight or to with stand external pertubations. An important determinant of activities of daily living performance is standing balance. Therefore, poor balance, or postural stability, is significant predictors the risk of fall. After a fall, the patient can experience psychological, physical, social, economic, and sometimes fatal effects. The injuries can reduce the patient's mobility as well as independence and influence quality of life. Postural movement patterns include three discrete control strategies: hip, knee, and ankle strategy. The ankle rocker is an important factor to maintain balance during standing and the ankle strategy restores the center of mass (CoM) to a position of stability through body movement. As a result, effective control of foot motion and ankle stability may decrease postural sway and the risk of fall in chronic stroke. The purpose of this study is to investigate the effects of the insole on balance capacity in chronic stroke.

NCT ID: NCT03192332 Not yet recruiting - Ischemic Stroke Clinical Trials

Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke

Start date: August 31, 2017
Phase: N/A
Study type: Interventional

Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA) has been the only proven therapy for acute ischemic stroke (AIS) for almost 20 years. Whether IV t-PA prior to endovascular clot retrieval is beneficial for AIS patients with a proximal vessel occlusion in the anterior circulation has currently become a matter of debate and is a relevant unanswered question in clinical practice. The main objective is to determine whether subjects experiencing an AIS due to large intracranial vessel occlusion in the anterior circulation will have non-inferior functional outcome at 90 days when treated with direct mechanical thrombectomy (MT) compared to subjects treated with combined IV t-PA and MT. The secondary objectives are to study causes of mortality, dependency and quality of life in these AIS patients.

NCT ID: NCT03192215 Not yet recruiting - Stroke Clinical Trials

AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

Start date: September 1, 2017
Phase: Phase 3
Study type: Interventional

Objectives - Primary: To test the hypothesis that apixaban is superior to aspirin for the prevention of recurrent stroke in patients with cryptogenic ischemic stroke and atrial cardiopathy. - Secondary: To test the hypothesis that the relative efficacy of apixaban over aspirin increases with the severity of atrial cardiopathy.

NCT ID: NCT03191422 Completed - Chronic Stroke Clinical Trials

LSVT BIG for Chronic Stroke Rehabilitation

Start date: July 4, 2016
Phase: N/A
Study type: Interventional

This study aims to explore if the LSVT BIG™ - a motor learning based treatment program designed for rehabilitation of people with Parkinson's disease could be beneficial for chronic stroke rehabilitation. A single-case experimental design with two adult participants, will be monitored for performance on self-selected goals before, during and after participating in the treatment program.

NCT ID: NCT03186157 Recruiting - Stroke Clinical Trials

Prevalence of Trephined Syndrome After Decompressive Craniectomy

Start date: February 1, 2012
Phase: N/A
Study type: Observational

Decompressive craniectomy is frequently used to treat increased intracranial pressure or an intracranial mass effect. Trephined Syndrome describes a neurological deterioration, which is attributed to a large craniectomy. The symptomatology is varied but includes headache, aggravation of a hemisyndrome or cognitive disorders, often has an orthostatic component and improves or disappears with cranioplasty. The incidence of Trephined Syndrome has been reported between 7% and 26%. However, it might be underestimated if the course of cognitive functions before and after cranioplasty were insufficiently documented.

NCT ID: NCT03185858 Not yet recruiting - Stroke Clinical Trials

SINEMA Model of Care to Improve the Health of Stroke Patients in Rural China

Start date: June 2017
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the effectiveness the SINEMA model via a one-year cluster randomized controlled trial in a resource-poor rural area in China. The hypothesis is that trained village doctors (VDs) and family caregivers, equipped with digital health technology, can provide essential evidence-based care to stroke survivors in rural China.

NCT ID: NCT03185520 Recruiting - Clinical trials for Embolic Stroke of Undetermined Source

Young ESUS Patient Registry

Start date: February 15, 2017
Phase: N/A
Study type: Observational [Patient Registry]

This study seeks to determine the clinical characteristics of young ESUS patients using diagnostic criteria of the Cryptogenic Stroke / ESUS International Working Group, and to determine the rates of stroke recurrence, death, and hospital readmission in a contemporary cohort of young ESUS patients during follow-up of up to 18 months.

NCT ID: NCT03185234 Not yet recruiting - Stroke Clinical Trials

Rehabilitating (Stroke-induced) Apraxia With Direct Current Stimulation

Start date: June 2017
Phase: N/A
Study type: Interventional

The objective of the clinical trial is to investigate whether weak transcranial direct current stimulation (tDCS) can ameliorate the motor cognitive deficit apraxia during stroke rehabilitation. Stroke patients with apraxia will either receive a real stimulation or a sham stimulation (placebo) for 10 minutes at a time on 5 consecutive days during their in-patient stay in a rehabilitation center. Additionally, motor tasks are performed before and after the stimulation. The effect of the weak current stimulation on motor function is assessed 3-4 days after the last stimulation and 3 months after enrollment.