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Stroke clinical trials

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NCT ID: NCT03637270 Not yet recruiting - Chronic Stroke Clinical Trials

Protein Supplement for Chronic Stroke Treatment

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Stroke patients usually have difficulties with moving and are venerable to secondary problems such as sarcopenia and strength loss. These problems may accelerate the disability process during aging. It is well known that exercise helps to maintain or promote human fitness. This study is conducted to explore the beneficial effects of exercise and protein supplement on fitness and body composition among patients with chronic stroke.

NCT ID: NCT03635749 Not yet recruiting - Clinical trials for Transient Ischemic Attack

Intensive Medical Therapy for High-risk Intracranial or Extracranial Arterial Stenosis

Start date: August 30, 2018
Phase: Phase 3
Study type: Interventional

Large-artery stenosis plays an important role in the occurrence of ischemic stroke. The primary purpose of this study is to evaluate the efficacy and safety of intensive antiplatelet therapy versus standard antiplatelet therapy and early intensive statin therapy (80mg atorvastatin) versus delayed intensive statin therapy (40mg atorvastatin) and intensive antiplatelet combined with early intensive statin therapy (80mg atorvastatin) versus standard antiplatelet combined with delayed intensive statin therapy (40mg atorvastatin) in reducing the risk of stroke at 90 days in patients with acute and high-risk symptomatic extracranial or intracranial arterial stenosis.

NCT ID: NCT03635502 Not yet recruiting - Healthy Clinical Trials


Start date: August 2018
Study type: Observational

Motor imagery (MI) might be described as a dynamic process in which an individual mentally stimulates an action without any overt movement. After stroke, motor imagery ability is impaired and also due to structure of MI, not every stroke patients is able to perform MI. Therefore, the aim of the study is a) to compare the motor imagery ability of stroke patients and healthy participants, b) to define motor imagery ability of stroke patients in accordance with their demographical and clinical features.

NCT ID: NCT03635476 Enrolling by invitation - Stroke Clinical Trials

Focus Group Study of Lifelong Food and Nutrition Assistance (LIFANA) in Stroke Patients and Caregivers

Start date: August 2018
Study type: Observational

Many elderly suffer from nutritional problems that can cause (or can be caused by) a number of complications such as weakened immune systems and chronic health conditions (diabetes type 2, high blood pressure, cardiovascular diseases or even osteoporosis). Through appropriate adjustments in the diets, on the basis of nutritional advice, the burden of established diseases as well as the risks of developing further conditions can be diminished. The goal of our proposed project LIFANA is to develop and evaluate the LIFANA Nutrition Solution to support healthy nutrition.. This may include general preferences, such as culture, taste, and budget, but more importantly automated and personalised nutritional recommendations based on advice provided by professional nutritionists and allergists. This is a national project co-funded by the European Union. One of the activities of the project is to collect information through focus group discussions with patients. These discussions will contribute to creating solutions that can explore the perspectives of patients.

NCT ID: NCT03635177 Not yet recruiting - Stroke, Lacunar Clinical Trials

Effect of Remote Ischemic Conditioning on Vascular Health in Stroke Patients

Start date: August 20, 2018
Phase: N/A
Study type: Interventional

The main aim of the current study is to assess cardiovascular effects of remote ischemic conditioning in patients who have suffered from stroke. A group of stroke patients will be subjected to four weeks of daily remote ischemic conditioning and four weeks of placebo and vascular function is assessed as a primary outcome.

NCT ID: NCT03635151 Recruiting - Stroke Clinical Trials

Caregiver Self-Management Needs Through Skill-Building

Start date: April 9, 2018
Phase: N/A
Study type: Interventional

Caring for a family member after a stroke can be very difficult and worsen the physical and mental health of untrained caregivers. The Telephone Assessment and Skill-Building Kit (TASK III) intervention is a unique, comprehensive caregiver intervention program that enables caregivers to develop the necessary skills to manage care for the survivor, while also taking care of themselves. The long-term goal of this study is to offer training and support for family caregivers through an efficacious, cost-effective program.

NCT ID: NCT03635008 Not yet recruiting - Stroke Clinical Trials

Anodal tDCS Over the Contralesional Hemisphere With Robotic Arm Training in Subacute Stroke Patients With Severe Upper Limb Hemiparesis

Start date: September 15, 2018
Phase: N/A
Study type: Interventional

Upper limb recovery is not predicted by the initial severity of paralysis and the parameters reflecting the integrity of the corticospinal tract (e.g. motor evoked potential, fractional anisotropy in diffusion tensor imaging). Although the inhibition of the contralesional hemisphere is known to be beneficial for the upper limb recovery after stroke in previous studies, this is not proven in the severely paralyzed upper limb. And the studies using the noninvasive stimulation in subacute stroke is lack. In addition, the role of contralesional (unaffected) hemisphere is known to be playing the important role in severe stroke. In this randomized, double-blind, sham-controlled studies, the patients with subacute stroke (<3 months after stroke onset), severe paralysis of the upper limb with poor prognosis (poor motor score and no response of motor evoked potential recorded in the extensor carpi radialis muscle) will be recruited. Interventional group will receive the 30mins of anodal transcranial direct current stimulation (tDCS) over the contralesional premotor area plus 30 mins of robotic arm training per session for 10 sessions in 2 weeks. Control group will receive the same treatment except for sham tDCS instead of anodal tDCS over the contralesional premotor area. Functional outcome will be measured before and after the intervention (baseline, immediately after the intervention and 1 month after the intervention). Cortical activation pattern will be measured by the electroencephalography (EEG) at baseline and immediately after the intervention.

NCT ID: NCT03634748 Recruiting - Stroke, Acute Clinical Trials

Thrombolysis in stRoke With Unknown onSet Based on noncontrasT CT

Start date: September 1, 2017
Study type: Observational

Multicentric, observational, registry-based study of 0.9 mg/kg i.v. thrombolysis in wake-up stroke or stroke with unknown onset based on non-contrast CT appearance only

NCT ID: NCT03634397 Not yet recruiting - Stroke Clinical Trials

Virtual Reality and Manipulation Training of the Non-paretic Arm in Chronic Stroke Survivors

Start date: November 2018
Phase: N/A
Study type: Interventional

This study will test the hypothesis that the combination of low-moderate to severe motor deficits in the paretic arm and persistent motor deficits in the non-paretic arm limits functional independence in chronic stroke survivors. We, therefore, predict that intense remediation, focused on improving the speed, coordination, and accuracy of the non-paretic arm should improve functional independence.

NCT ID: NCT03633422 Recruiting - Stroke, Acute Clinical Trials

Evaluation of Stroke Patient Screening

Start date: September 25, 2017
Study type: Observational [Patient Registry]

Background and Rationale: Traditionally, stroke rehabilitation studies have been performed in stroke patients beyond the first one to three months poststroke [Stinear et al. 2013; Veerbeek et al. 2014]. Acknowledging that early stroke rehabilitation should be initiated soon after stroke onset to optimize stroke outcomes, it is has been stressed that stroke rehabilitation trials should be initiated within the first month [Stinear 2013]. Early stroke rehabilitation trials face difficulties regarding patient recruitment with corresponding low enrollment rates [AVERT 2015; Winters 2015]. Explanations are for example priority given to (sub)acute medical interventions, highly dynamic situation at a stroke unit, and a more rapid change in patients' abilities when compared to patients in later stages poststroke. With the low enrollment rates (~7%), the generalizability of study results is questionable. Participant screening methods and procedures for research eligibility are part of the patient selection and recruitment process in clinical trials. However, no information is available regarding screening procedures and methods for these early initiated stroke rehabilitation trials, including reasons for not enrolling patients. This knowledge is essential to improve screening procedures and methods, in order to optimize patient enrollment and with that, increase the generalizability of study results. Objective: The objective of this project is to evaluate screening methods and procedures for stroke rehabilitation research. Study Design: Observational study