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Ischemic Stroke clinical trials

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NCT ID: NCT05044507 Not yet recruiting - Ischemic Stroke Clinical Trials

The Efficacy of a Frequency-tuned Electromagnetic Field Treatment in Facilitating the Recovery of Subacute Ischemic Stroke Patients - a Pivotal Study

Start date: September 2021
Phase: N/A
Study type: Interventional

This is a multicenter study that will be conducted at up to 20 inpatient rehabilitation facilities (IRFs) in the United States. BQ 2.0 is a wearable medical device that produces and delivers non-invasive, extremely-low-intensity and low-frequency, frequency-tuned electromagnetic fields in order to stimulate neuronal networks with the aim of reducing disability and promoting neurorecovery. In this study, BQ 2.0 is intended to reduce disability in adult patients with subacute ischemic stroke, with a moderate to severe disability which includes an upper extremity motor impairment. BQ 2.0 will be used for 9 weeks in conjunction with physical and occupational therapy (PT/OT), with treatment initiated in inpatient rehabilitation facilities (IRF) and then continued post-discharge in subjects' homes under periodic remote supervision of a trained site study team member. The study will enroll up to 150 subjects who will be randomly assigned (1:1 allocation ratio) to either active or sham study intervention using BQ 2.0.

NCT ID: NCT05041010 Not yet recruiting - Ischemic Stroke Clinical Trials

Rescues On Reperfusion Damage In Cerebral Infarction by Nelonemdaz

RODIN
Start date: September 2021
Phase: Phase 3
Study type: Interventional

Efficacy and safety of Neu2000, a multi-target drug designed to prevent both NMDA receptor-mediated excitotoxicity and free radical toxicity, will be investigated in acute ischemic stroke patients receiving endovascular treatment to remove clot within 12 hours following stroke onset. Neu2000KWL will be administered before endovascular treatment.

NCT ID: NCT05032053 Not yet recruiting - Ischemic Stroke Clinical Trials

Antithrombotic Drug Use in Patients With Ischemic Stroke and Microbleeds

AIM-2
Start date: October 1, 2021
Phase:
Study type: Observational [Patient Registry]

To observe the effect of different antithrombotic drugs on the prognosis of ischemic stroke patients with cerebral microbleeds. And further combined with proteomic methods to explore serological markers that can be used to accurately predict the prognosis of such patients.

NCT ID: NCT05028868 Recruiting - Ischemic Stroke Clinical Trials

Clinical Research of Intravenous Thrombolysis for Ischemic Stroke in Northeast of China

CRISTINA
Start date: June 1, 2015
Phase:
Study type: Observational [Patient Registry]

This research is based on clinic treatment of intravenous thrombolysis for patients with acute ischemic stroke.By building up a database of these patients, the investigators aim to find some significance between groups by analyzing population information, clinical status and such for better evaluation and optimal treatment decision.

NCT ID: NCT05024292 Enrolling by invitation - Ischemic Stroke Clinical Trials

Oriental Research AlliaNce of Acute Ischemic Stroke Given Endovascular Treatment

ORANGE
Start date: September 2021
Phase:
Study type: Observational [Patient Registry]

For patients with acute ischemic stroke (AIS) with anterior circulation proximal large vessel occlusion (LVO), mechanical thrombectomy (MT) reduces disability in patients when it is performed within 6 h of the time the patients with a stroke were last known to be healthy and up to 24 h after stroke onset in patients selected using brain perfusion imaging. For patients with acute ischemic stroke (AIS) with posterior circulation large vessel occlusion, MT could be benefit the patients when performed within 24 hours since onset. This is a multicenter registration study of the AIS-LVO treated with endovascular intervention under the guideline. This study will record the patients' demographic and clinical data, image data, procedure of neurointervention and outcomes in 3 months. Samples of thrombus and serum will be collected and stored for later analysis.

NCT ID: NCT05022069 Recruiting - Ischemic Stroke Clinical Trials

Delphi Early Feasibility Study

DELPHI EFS
Start date: June 8, 2021
Phase: N/A
Study type: Interventional

An early feasibility study to evaluate the safety and first pass effect technical assessment of Delphi Revascularization Device for clot retrieval in Anterior circulation ischemic stroke in the intracranial ICA, MCA M1 and proximal dominant MCA M2, up to 8hrs of symptom onset or Last Known Well (LKW).

NCT ID: NCT05008588 Not yet recruiting - Ischemic Stroke Clinical Trials

Combination of Conditioned Medium and Umbilical Cord-Mesenchymal Stem Cells Therapy for Sub-Acute Stroke Infarct

Start date: September 2021
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study was to determine the effectiveness of a combination of intranasal conditioned medium (CM) with intraparenchymal umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in sub-acute stroke patients to induce neurogenesis. This study has 3 arms namely CM and UC-MSCs treatment, UC-MSCs treatment only, and control. The investigator hypothesized that group of CM and UC-MSCs combination is the optimal treatment to induce neurogenesis in stroke patients.

NCT ID: NCT05004233 Not yet recruiting - Ischemic Stroke Clinical Trials

Transmission Electron Microscopy Images for Platelet Ultrastructural Criteria Before and After the Onset of an Antiplatelet Agent

ELECTROSTROKE
Start date: September 2021
Phase: N/A
Study type: Interventional

The aim of the pilot study is to collect all the ultrastructural platelet characteristics by transmission electron microscopy before and after the onset of an antiplatelet treatment in patients hospitalized for an ischemic stroke ; and to assess recurrence of Ischemic Cerebral Accident (ICA) at 6 months in patients hospitalized for Ischemic stroke.

NCT ID: NCT05002348 Recruiting - Ischemic Stroke Clinical Trials

Laser Acupuncture Improves Constipation in Patients Hospitalized for Stroke During the COVID-19 Pandemic

Start date: December 1, 2020
Phase: N/A
Study type: Interventional

With the aging of today's population, stroke is the top three causes of disability and death among people over the age of 60 in the world. About 5.5 million people die each year from strokes in Taiwan, and Taiwan's top ten causes of death in cerebrovascular disease rank fourth in the world. Constipation is the most common complication of stroke patients and increases the risk of brain damage and re-stroke. Although the clinical use of drugs can relieve intestinal symptoms, there is also a risk of potential side effects. The systematic literature points out that the use of acupoint stimulation can improve spontaneous bowel movements and promote bowel motility, but there is no conclusion on effective acupuncture points. Therefore, the purpose of this study is to improve the constipation of patients with stroke by non-invasive and precise acupoint care. This study used a single-blind randomized control trial. The neurosurgery ward of a medical center in the north was used as the research site, and patients with ischemic stroke were used as the research objects. The experimental group received precision acupoint care, and the control group received routine care. The questionnaire was used to collect basic patient information (basic attributes, disease care and TCM constitution), and gut-related assessments. Data analysis was performed using IBM SPSS 22.0 software for descriptive statistical analysis and inferential statistical analysis, and p <.05 was considered to have statistical significance.

NCT ID: NCT04987710 Not yet recruiting - Ischemic Stroke Clinical Trials

Intracranial Rescue Stenting for Acute Ischemic Stroke, Predictors of Outcomes

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The use of rescue intracranial stenting is thought to be associated with better outcomes than with patients received medical treatment only after failed thrombectomy as Reperfusion technique. This raised the questions about the factors that affect outcomes of rescue intracranial stenting angioplasty, so the best outcomes can be achieved.