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Stroke clinical trials

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NCT ID: NCT06317194 Enrolling by invitation - Stroke Clinical Trials

A Novel Method of Non-Invasive Brain Stimulation (kTMP) to Enhance Motor Function in Chronic Stroke Patients

Start date: March 15, 2024
Phase: N/A
Study type: Interventional

Stroke is a leading cause of disability with many patients suffering chronic motor function impairments that affect their day-to-day activities. The goal of this proposal is to provide a first assessment of the efficacy of an innovative non-invasive brain stimulation system, kTMP, in the treatment of motor impairment following stroke.

NCT ID: NCT06234618 Enrolling by invitation - Stroke Clinical Trials

The Effect of Covered Eye Walking on Electroencephalogram in Stroke Patients Compared With Open Eye Walking

Start date: December 15, 2023
Phase:
Study type: Observational

Post-stroke walking abnormalities present significant rehabilitation challenges. Visual deprivation training has been shown to be more effective than open-eye training. The investigators intend to examine the changes in electroencephalography patterns in stroke patients during visually deprived walking tasks. The stroke participants will be fitted with a brain cap. The participants will walk with their eyes open for 60 seconds, and then their eyes will be blindfolded as they continue walking for another 60 seconds. Electroencephalography will monitor the signals in real-time during both walks.

NCT ID: NCT06214494 Enrolling by invitation - Stroke, Ischemic Clinical Trials

Blood Flow Restricted High-Intensity Treadmill Training on Independently Ambulating Chronic Ischemic CVA Survivors

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

Individuals surviving Chronic Ischemic Stroke have lingering walking deficits long after their infarct. The main goal of this study is to compare two high intensity treadmill walking programs to see which improves walking more. The main question we aim to answer is: How does blood flow restricted high-intensity treadmill training impact walking function? Participants will be randomly separated into two groups. One group will perform the high intensity treadmill training with blood flow restriction on their Stroke affected leg, while the second group performs high intensity treadmill training only. Every week participants will be asked to walk on the treadmill for a total of 75 minutes during 2x 1-hour sessions. On visit 1, participants will undergo strength, balance, and walking testing. They will then be treated 2x weekly for 4 weeks (visit 2-9) and be re-tested to track progress on visit 10. Participants will again be treated 2x weekly for 4 more weeks (visit 11-18) and be tested to see the end results on visit 19. Researchers will then compare both groups to see if blood flow restriction training changes walking function, strength, and balance.

NCT ID: NCT06213376 Enrolling by invitation - Stroke Clinical Trials

MIT Intensive Treatment Study

MITTXS
Start date: December 28, 2023
Phase: N/A
Study type: Interventional

This study is examining the use of intensive melodic intonation therapy and video feedback as a means of aiding individuals with nonfluent aphasia and co-occurring motor speech impairments. Individuals with nonfluent aphasia have difficulty with language, particularly with word retrieval.

NCT ID: NCT06192485 Enrolling by invitation - Stroke Clinical Trials

Proactive and Reactive Balance Training Effects on Balance and Functional Performance Among Chronic Stroke Survivors

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

The study is an RCT study, comparing the proactive and reactive balance training among stroke survivors, the participants will be chronic stroke patients aged between 50- 75 years old, and the participants will receive a balance training program for 8 weeks 3 sessions in the week, the participants will randomly be allocated in two groups proactive group and the reactive group, at the end of the study will compare the different effects between proactive and reactive balance training

NCT ID: NCT06168942 Enrolling by invitation - Stroke Clinical Trials

Laminar LAAX Pivotal IDE Study

Start date: February 22, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare the Laminar Left Atrial Appendage Closure System to commercially available left atrial appendage closure devices. This procedure is for patients with non-valvular atrial fibrillation who are at increased risk for stroke, but have a reason to seek an alternative to blood thinning medications. This clinical trial will compare the safety and efficacy of the Laminar Left Atrial Appendage Closure System to commercially available left atrial appendage closure devices. Participants in this trial will be randomly assigned one-to-one (like flipping a coin) for treatment with either the Laminar Left Atrial Appendage Closure System or a commercially available device (WATCHMAN™ left atrial appendage closure device / Amulet™ left atrial appendage occluder).

NCT ID: NCT06152328 Enrolling by invitation - Stroke Clinical Trials

Virtual Reality Based Mirror Therapy

Start date: November 15, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to examine the effectiveness of 3D virtual reality assisted mirror therapy based rehabilitation applications compared to classical methods used in stroke rehabilitation.

NCT ID: NCT06126523 Enrolling by invitation - Stroke Clinical Trials

Effect of ESWT Applied After Botulinum Toxin Injection on Ankle Spasticity in Stroke Patients.

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

Stroke is the second most common cause of death and the third most important cause of disability worldwide, with an annual death rate of 5.5 million. Spasticity is a common condition in stroke patients and has a negative impact on daily living activities. BTX-A has been successfully used in the treatment of spasticity in patients with stroke. ESWT is a physical therapy method applying high intensity pressure waves. ESWT has been increasingly used in the management of spasticity as a safe and effective method, but the literature about ESWT in spasticity is heterogeneous and the treatment protocols are not very clear about the number of applications. The aim of this study is to determine the effects of rESWT treatment on ankle plantar flexors spasticity applied after BTX-A injection.

NCT ID: NCT06108102 Enrolling by invitation - Stroke Clinical Trials

International Post-Stroke Epilepsy Research Repository

IPSERR
Start date: March 2024
Phase:
Study type: Observational [Patient Registry]

The International Post-Stroke Epilepsy Research Repository (IPSERR): The study aims to collate and categorize data reported by post-stroke epilepsy (PSE) researchers and lodge it within the IPSERR. Using the IPSERR database, we will conduct two individual patient data (IPD) analyses: (1) determine epilepsy, functional, and cognitive outcomes in stroke patients who develop post-stroke seizure and (2) build and validate post-stroke epilepsy prediction model and compare performance against existing models.

NCT ID: NCT06099444 Enrolling by invitation - Stroke Clinical Trials

Muscle Coordination-Based Feedback for Stroke Rehabilitation

Start date: March 19, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to compare two interventions currently used to improve gait and lower limb function in individuals with chronic stroke (i.e., high-intensity gait training and high-intensity gait training with functional electrical stimulation (FES)) with novel interventions based on the coordinated activity of multiple muscles, known as muscle synergies. To this end, the researchers will recruit chronic stroke patients to participate in training protocols according to the currently used rehabilitation programs as well as novel rehabilitation programs that provide real time feedback of muscle synergies using multichannel FES and visual feedback.