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Stroke clinical trials

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NCT ID: NCT05029284 Suspended - Stroke Clinical Trials

Behavioral Activation for Post-Stroke Sedentary Behavior Using Telehealth

Start date: December 20, 2021
Phase: N/A
Study type: Interventional

Adults with stroke-related disability spend more time sedentary than adults without stroke-related disability, which places them at risk for poor cardiovascular health outcomes. Few interventions are designed to reduce post-stroke sedentary time. The purpose of this research is to test whether the teleABLE (Activating Behavior for Lasting Engagement) Intervention is feasible and acceptable to adults within the first 12 months post-stroke. The hypothesis is that teleABLE can be feasibly delivered using videoconferencing within the first 12 months post-stroke. 10 participants will complete assessments and activity monitoring (activPAL micro3) at 0 (baseline) and 8 (post-intervention)-weeks. Participants will complete 12 sessions of the teleABLE intervention. Findings from this study will be used to guide the intervention protocol in the planned next phase of this research.

NCT ID: NCT04891913 Suspended - Clinical trials for Acute Ischemic Stroke

SY007 in Patients With Acute Ischemic Stroke

Start date: July 1, 2023
Phase: Phase 1
Study type: Interventional

This Phase 1b multiple center, randomized, double-blind, placebo-controlled study is a dose escalation trial evaluating the safety, tolerability, PK characteristics and efficacy of SY-007 after injection in acute ischemicstroke patients. The immunogenicity of SY-007 will be evaluated and this study will provide the recommended dosage for subsequent clinical trials.

NCT ID: NCT04743076 Suspended - Clinical trials for Vertebrobasilar Stroke

A Randomized Trial Of Endovascular Treatment For Acute Posterior Large Vessel Occlusion

Start date: March 16, 2021
Phase: N/A
Study type: Interventional

The aim of this trial is to investigate whether endovascular treatment can improve the 90-day functional outcome of acute large vessel occlusion in the posterior circulation.

NCT ID: NCT04436770 Suspended - Stroke Sequelae Clinical Trials

Medical Recovery and Social Reintegration for Post-stroke Patients Using Virtual Reality

Start date: July 18, 2019
Phase: N/A
Study type: Interventional

Application of Virtual Reality therapy and occupational therapy versus and standard physiotherapy and occupational therapy to patients with post-stroke sequelae, using specifical assessment tools, standard physiotherapy and occupational therapy programs.

NCT ID: NCT04417231 Suspended - Stroke, Ischemic Clinical Trials

CASTRO1 - Study on CRP Apheresis After Ischemic Stroke

Start date: January 28, 2021
Phase: N/A
Study type: Interventional

CASTRO1 is a study to investigate the reduction of C-reactive protein (CRP) by therapeutic apheresis (CRP-apheresis) in patients after primary treatment of ischemic stroke. The term therapeutic apheresis commonly refers to medical procedures, where pathogenic constituents are being removed from the circulating blood. Elimination is performed by adsorbers outside the body in an extracorporeal circulation. For removal of the pathogenic substances the plasma is separated from the blood (circulation) to pass the adsorber. The purified plasma is merged with the solid blood components thereafter and returned to the patient. The adsorber "PentraSorb® CRP" used for CRP apheresis is CE-certified. It is designated to the selective depletion of C-reactive protein from human blood.

NCT ID: NCT04290988 Suspended - Stroke Clinical Trials

Circuitry Assessment and Reinforcement Training Effects on Recovery

Start date: September 23, 2020
Phase: N/A
Study type: Interventional

This study investigates if electroencephalography (EEG) neurofeedback training is more beneficial than sham feedback training for the improvement of communication, anxiety, and sleep quality in individuals with aphasia. Half of the participants will receive active EEG neurofeedback sessions first, followed by sham feedback sessions in a crossover design. The other half of participants will undergo sham feedback sessions first, followed by active neurofeedback.

NCT ID: NCT04288960 Suspended - Stroke Clinical Trials

Validity of a Belt Mounted Accelerometer to Assess Walking Measures in Patients With Chronic Stroke

Start date: September 1, 2022
Study type: Observational

The aim of this study is to validate the G-walk for several gait parameters, tested against a gold standard three dimensional camera system. This research will inform researchers and practitioners as to whether the G-Walk is a suitable and valid tool to easily assess walking ability in people with chronic stroke.

NCT ID: NCT04140110 Suspended - Clinical trials for Acute Ischemic Stroke

Second Enhanced Control of Hypertension and Thrombectomy Stroke Study (ENCHANTED2)

Start date: July 20, 2020
Phase: N/A
Study type: Interventional

ENCHANTED2 is an international, multicenter, prospective, randomised, open, blinded end-point assessed (PROBE) trial, to assess different approaches to manage blood pressure (BP) in acute ischemic stroke (AIS) patients who have undergone mechanical thrombectomy (MT). There are two nested substudies evaluating different approaches to secondary prevention in this high-risk stroke population.

NCT ID: NCT04062539 Suspended - Stroke Clinical Trials

Total Cerebral Protection With Embolic Protection Devices Thoracic Aortic Stenting

Start date: October 4, 2018
Study type: Observational

Stroke and silent cerebral infarction are a real risk with thoracic enodvascular aortic repair (TEVAR). The investigator propose to prospectively observational study with enrolment of all patients undergoing TEVAR for thoracic and thoracoabdominal conditions including aneurysmal degeneration, Type B dissection and acute aortic syndromes over a 24 month period, equating to a minimum of 20-30 patients per year. Patients undergoing juxtra-renal and infra-renal aortic stenting will form a control group.

NCT ID: NCT04048668 Suspended - Stroke, Acute Clinical Trials

tDCS to Treat Subacute Aphasia

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

This study proposes to use transcranial direct current stimulation (tDCS), a technique by which a very small electrical current (2 mA) is applied to the scalp, along side speech therapy in patients with subacute stroke and aphasia in order to enhance language recovery. Aphasic patients in an inpatient neurorehabilitation facility who have experienced a stroke between one week and three months prior to enrollment will be invited to participate. Participants will receive either real or sham tDCS to the left hemisphere of the brain for a minimum of 5 consecutive sessions to up-to a max of 10 sessions depending on the length of their rehab stay . Stimulation will be paired with with the patient's normal speech therapy schedule. Participant's language skills will be assessed at baseline and immediately after the last session of therapy in order to determine whether tDCS is associated with either transient or persistent improvement in language.