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Stroke clinical trials

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NCT ID: NCT06234618 Suspended - Stroke Clinical Trials

The Effect of Covered Eye Walking on Electroencephalogram in Stroke Patients Compared With Open Eye Walking

Start date: February 28, 2024
Study type: Observational

Post-stroke walking abnormalities present significant rehabilitation challenges. Visual deprivation training has been shown to be more effective than open-eye training. The investigators intend to examine the changes in electroencephalography patterns in stroke patients during visually deprived walking tasks. The stroke participants will be fitted with a brain cap. The participants will walk with their eyes open for 60 seconds, and then their eyes will be blindfolded as they continue walking for another 60 seconds. Electroencephalography will monitor the signals in real-time during both walks.

NCT ID: NCT06198946 Suspended - Stroke Clinical Trials

External Diaphragm Pacing Therapy and Correlation Analysis of Trunk Balance and Respiratory Function in Stroke Patients

Start date: February 13, 2023
Phase: N/A
Study type: Interventional

The goal of this study is to observe the enhancement of trunk balance ability, pulmonary function, and diaphragm function in stroke patients after treatment of external diaphragm pacing(EDP), and analyze the potential correlation between trunk balance ability and respiratory function metrics. The main questions it aims to answer are: - What is the effect of EDP treatment on trunk balance and respiratory function in stroke patients? - Is there a correlation between trunk balance ability and respiratory function? Participants admitted to the Department of Rehabilitation Medicine at the First Affiliated Hospital of Anhui Medical University were randomly divided into an observation group and a control group: - The control group received conventional rehabilitation therapy for 4 weeks. - The observation group received EDP treatment in addition to conventional rehabilitation therapy for 4 weeks.

NCT ID: NCT05671874 Suspended - Clinical trials for Traumatic Brain Injury

Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI

Start date: March 28, 2023
Phase: N/A
Study type: Interventional

The goal is to pilot test a highly accessible, web-based, pragmatic, scalable intervention to overcome ongoing problems with high stakes decision-making by surrogate decision-makers of patients in ICUs with severe acute brain injury (SABI), including those with moderate-severe traumatic brain injury, large hemispheric acute ischemic stroke and intracerebral hemorrhage.

NCT ID: NCT05262699 Suspended - Stroke Clinical Trials

Crossmodal Learning in Therapeutic Processes (Task 2-1)

Start date: April 14, 2021
Phase: N/A
Study type: Interventional

Interventional study of the effects of vibro-tactile feedback on behavioral deficits and learning during motor training in patients with stroke.

NCT ID: NCT05207345 Suspended - Hemorrhagic Stroke Clinical Trials

Effectiveness of Core Stability Training on Trunk Control in Patients With Post-hemorrhagic Stroke

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

Stroke is responsible for about 7% of disabilities in the European population. Intracerebral hemorrhage (ICH) represents 15% of stroke cases in Europe. In order to avoid disabling sequelae, an essential role is played by early rehabilitation, which has also proved effective for ICH. In addition to its role in physical recovery, it plays a fundamental role in the psychological well-being of patients with ICH. Impairments in trunk function are a common sequela and are related to reduced mobility, balance and functional independence. Trunk exercises could improve trunk control, postural control, and functional recovery. The hypothesis is that a specific exercise program, based on core stability, will induce clinically significant and long-term improvements from the point of view of trunk control, and secondly in postural control, disability and quality of life in subjects with hemorrhagic stroke outcomes, versus general physiotherapy, and that these improvements will be maintained at least one year after the intervention.

NCT ID: NCT05128513 Suspended - Hemorrhagic Stroke Clinical Trials

Delipid Extracorporeal Lipoprotein Filter From Plasma (DELP) for Acute Hemorrhagic Stroke

Start date: January 14, 2022
Phase: N/A
Study type: Interventional

Delipid Extracorporeal Lipoprotein filter from Plasma (DELP) has been found to improve neurological function and life ability of AIS patients and approved for the treatment of AIS by China Food and Drug Administration (CFDA). A recent study imply that the neuroprotective effect of DELP involved multiple neuroprotective mechanism such as anti-inflammation, free radical scavenging, and decreasing MMP-9. Based on the multiple mechanisms, the investigator argues that DELP may exert neuroprotective effect on acute cerebral hemorrhage (ACH). In this context, the prospective, random, open-label, blind-endpoint, multi-centre study is designed.

NCT ID: NCT05006248 Suspended - Stroke Clinical Trials

Robotic Interventions for Spasticity Treatment

Start date: March 27, 2022
Phase: N/A
Study type: Interventional

The researchers have developed games controlled by electromyographic (EMG) and inertial measurement unit (IMU) activity recorded by a sensor. These will provide biofeedback to participants post-stroke about the activity of their paretic muscles. The researchers anticipate that providing visual biofeedback will allow subjects to observe the level of co-activation in an agonist-antagonist muscle pair, and therefore initiate interventions to reduce their level of co-activation. Similarly, the researchers will provide additional haptic feedback using an assistive robot at the ankle joint (i.e., M1) and compare the results with the pure visual feedback condition. At the end, the main objective is to compare 1) conventional robotic continuous passive movement (CPM) training to 2) training with visual biofeedback and 3) training with both visual and haptic biofeedback.

NCT ID: NCT04984577 Suspended - Clinical trials for Acute Ischemic Stroke

Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke

Start date: November 15, 2021
Phase: Phase 2
Study type: Interventional

The primary objective of the study is to confirm the efficacy of compound Edaravone Injection via intravenous infusion every 12 hours in the patients with Acute Ischemic Stroke(AIS) in a double-blind, active-controlled manner. The study is also to examine the safety of compound Edaravone Injection for the AIS patients.

NCT ID: NCT04891913 Suspended - Clinical trials for Acute Ischemic Stroke

SY007 in Patients With Acute Ischemic Stroke

Start date: July 1, 2023
Phase: Phase 1
Study type: Interventional

This Phase 1b multiple center, randomized, double-blind, placebo-controlled study is a dose escalation trial evaluating the safety, tolerability, PK characteristics and efficacy of SY-007 after injection in acute ischemicstroke patients. The immunogenicity of SY-007 will be evaluated and this study will provide the recommended dosage for subsequent clinical trials.

NCT ID: NCT04743076 Suspended - Clinical trials for Vertebrobasilar Stroke

A Randomized Trial Of Endovascular Treatment For Acute Posterior Large Vessel Occlusion

Start date: March 16, 2021
Phase: N/A
Study type: Interventional

The aim of this trial is to investigate whether endovascular treatment can improve the 90-day functional outcome of acute large vessel occlusion in the posterior circulation.