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Stroke clinical trials

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NCT ID: NCT04845542 Not yet recruiting - Stroke Clinical Trials

Promoting Resilience in Stroke Survivor-carepartner Dyads (ReStoreD)

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

Affecting nearly 800,000 people in the US every year, stroke is a leading cause of long-term disability, and has serious consequences for stroke survivors and their carepartners. Our project uses a scientifically rigorous efficacy study to evaluate a remotely delivered 8-week dyadic (couples-based) positive psychology intervention to reduce emotional distress in stroke survivors and their carepartners. If successful, couples may be better emotionally equipped to cope with the sequelae of stroke, and have better rehabilitation outcomes and quality of life.

NCT ID: NCT04845529 Not yet recruiting - Stroke Clinical Trials

Improving Awareness for Spatial Neglect With tDCS

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

Brain-damaged patients can show severe neurological and cognitive deficits, and yet often remain strikingly unaware of these symptoms: this condition is called anosognosia. The aim of this study is to improve awareness in right-brain-damaged patients with Unilateral Spatial Neglect (USN) following stroke using transcranial direct current stimulation (tDCS). tDCS is a neuromodulatory technique that delivers low-intensity current to the brain facilitating (anodal tDCS) or inhibiting (cathodal tDCS) spontaneous neuronal activity. tDCS does not induce activity in resting neuronal networks, but modulates spontaneous neuronal activity: consequently, the amount and direction of effects critically depend on the previous state of the neural structures. We will test USN patients showing anosognosia for neglect symptoms. Different brain areas will be stimulated, to target explicit and implicit components of anosognosia, including parietal and frontal brain regions.

NCT ID: NCT04835363 Not yet recruiting - Stroke Clinical Trials

Early Occupational Therapy Intervention in the Hospital Discharge After Stroke

Start date: May 1, 2021
Phase: N/A
Study type: Interventional

The general objective of this study is to determine if an early occupational therapy intervention together with the usual care at hospital discharge after suffering a stroke has a positive effect on the functional independence of the patient, compared with the control group that will have the usual care and rehabilitation. We designed a four-week OT intervention program with the support of the main caregiver in patients who have suffered a stroke with the aim of improving the functional result and facilitating the return home by providing knowledge to the caregiver about specific care and neurorehabilitation.

NCT ID: NCT04833400 Not yet recruiting - Stroke Clinical Trials

Intelligent Cardiopulmonary Rehabilitation System for Patients With Chronic Stroke

Start date: April 15, 2021
Phase: N/A
Study type: Interventional

By comparing with traditional aerobic exercise training (TAET), we investigate the effects of an intelligent cardiopulmonary rehabilitative system (ICRS) on cardiopulmonary fitness and patient satification among patients with chronic stroke.

NCT ID: NCT04833088 Not yet recruiting - Stroke Clinical Trials

Exploratory Study About the Implementation of Technology in the Rehabilitation

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

This qualitative study aims to identify the needs and recommendations of both patients and healthcare professionals in terms of rehabilitation technology, more specific three pre-defined user scenarios. These scenario were developed based on brainstorm sessions with healthcare professionals from the rehabilitation ward of UZ Brussel and AZ Sint-Maria Halle. The purpose of this study is to create an overview of recommendations that will be used to develop the smart devices in a later stage of the SAIRE project.

NCT ID: NCT04830436 Not yet recruiting - Stroke Clinical Trials

Impact of Undernutrition in Patients Over 70 Years of Age Thrombolysed and/or Thrombectomized for Stroke

Start date: April 12, 2021
Study type: Observational

Undernutrition is a frequent problem in hospitals (at least 30% of patients, SENECA-NHANES studies). Its impact on morbidity and mortality is well known in gerontology, oncology and intensive care. There are very few neurovascular studies dealing with the consequences of undernutrition present before the stroke. Indeed, most of the medical literature concerns only undernutrition acquired after a stroke. We propose to analyze medical data from a cohort of patients over 70 years of age thrombolysed and/or thrombectomized in the neurovascular department between the years 2014 and 2019.

NCT ID: NCT04830163 Not yet recruiting - Stroke Clinical Trials

Phase-dependent PCMS in Chronic Stroke

Start date: July 2021
Phase: Phase 1/Phase 2
Study type: Interventional

After stroke, people often have difficulty using their hands. Combined brain and nerve stimulation can strengthen the neural pathways that control hand function. In this study, we will deliver combined brain and nerve stimulation during specific time windows that increase activation of neural pathways underlying hand function. We will compare the effects of combined brain and nerve stimulation during these optimal time windows to the effects of combined brain and nerve stimulation applied during random time windows on post-stroke hand function.

NCT ID: NCT04829071 Not yet recruiting - Stroke Clinical Trials

Cognition and Motor Learning Post-stroke

Start date: August 15, 2021
Phase: Early Phase 1
Study type: Interventional

This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

NCT ID: NCT04824768 Not yet recruiting - Spasticity, Muscle Clinical Trials

Effect of CRet in Addition of Functional Massage in Post-stroke Spasticity

Start date: April 29, 2021
Phase: N/A
Study type: Interventional

Spasticity is due to an abnormal processing of a normal input from muscle spindles in the spinal cord.

NCT ID: NCT04818944 Not yet recruiting - Ischemic Stroke Clinical Trials

Clinical Trial to Evaluate the Safety of Continuous IV Tirofiban in Acute Ischemic Stroke

Start date: May 1, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

We will recruit men and non-pregnant women of any ethnic background between the age ≥ 18 and ≤ 90 years that have acute ischemic stroke and underwent Mechanical Thrombectomy (MT) with TICI 2b or 2b following MT. These subject's will be will be randomized to placebo vs. Tirofiban after consent is obtained. This will be administered via continuous IV starting within 60 minutes of MT procedure completion. At the end of the 24 hour continuous IV dosing period a CT angiography and CT perfusion (CTA/CTP) will be obtained. The rest of the subjects inpatient hospital stay will be done per standard of care. The subject's NIHSS and modified Rankin Score (mRS) will be assessed at 90 days.