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Acute Ischemic Stroke clinical trials

View clinical trials related to Acute Ischemic Stroke.

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NCT ID: NCT05073159 Recruiting - Clinical trials for Acute Ischemic Stroke

Head-of-Bed Positioning in Large Artery Acute Ischemic Stroke

Start date: February 11, 2020
Phase: Phase 3
Study type: Interventional

Positioning of the patient with hyperacute large artery ischemic stroke (IS) is an important, yet understudied aspect of care that could impact the course of treatment and ultimately clinical outcome. Positioning with the head of bed (HOB) at 0-degree has been shown in small studies to increase cerebral blood flow across arterial occlusion in hyperacute large artery IS, leading to clinical improvement in stroke symptoms. However, this position is believed to increase the risk of aspiration pneumonia. In this randomised clinical trial, the investigators aim to evaluate whether use of 0-degree HOB positioning is associated with clinical stability in hyperacute IS. Investigators hypothesise that patients with large artery occlusions placed in a 0-degree HOB position will experience less early neurologic deterioration within the first 24 hours, than those in the 30-degree or more HOB elevation group. The study aims to confirm the safety of 0-degree-HOB positioning in a large, generalizable sample of hyperacute large artery IS patients. In this randomised trial, patients presenting to the study centers and eligible for intravenous thrombolysis, with (if presenting within 4.5 hours of symptom-onset) or without (presenting between 4.5 to 16 hours of symptom-onset) mechanical thrombectomy. Eligible patients would be randomised to either a zero-degree HOB or an HOB of 30-degree or more. Impact of HOB position on neurological status would be evaluated with serial NIHSS scores. Cerebral hemodynamics would be monitored by transcranial Doppler ultrasonography. Validated criteria would be used to diagnose pneumonia. Functional outcome would be measured by modified Rankin scale (mRS) where the score of 0-2 describe good functional recovery. SPSS version 20 would be used to analyse the data. The trial would provide clinical and hemodynamic data to determine the optimal HOB position in patients with large artery acute ischemic stroke.

NCT ID: NCT05070260 Recruiting - Clinical trials for Acute Ischemic Stroke

Adaptive Efficacy and Safety Study of Glenzocimab Used as an add-on Therapy on Top of Standard of Care un the 4.5 Hours Following an Acute Ischemic Stroke

ACTISAVE
Start date: September 23, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

A randomized, double blind, multicenter, multinational, placebo controlled, parallel group, single dose, adaptive phase II/III study (respectively Part 1 and 2). The study evaluates the efficacy and safety of a fixed dose of glenzocimab (1000 mg IV over 6 hrs including initial bolus of 15 minutes) on top of the best standard of care.

NCT ID: NCT05029414 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke

DISTAL
Start date: January 2022
Phase: N/A
Study type: Interventional

Acute ischemic stroke (AIS) is one of the main causes of disability and loss of quality adjusted life years. This study is to analyze whether endovascular therapy (EVT) in addition to best medical treatment (BMT) reduces the degree of disability and dependency in daily activities after a Medium Vessel Occlusion (MeVO) stroke compared to BMT alone.

NCT ID: NCT05024526 Recruiting - Clinical trials for Acute Ischemic Stroke

Protective Effects of Edaravone Dexborneol

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

The patients of acute ischemic stroke were divided into two groups, edaravone dexborneol treatment group and edaravone treatment group. The purpose of this study was to observe the changes of imaging and the improvement of NIHSS and mRS in different groups.

NCT ID: NCT05005962 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

Prospective Registry for Assessment of Acute Ischemic Stroke Patients Treated With Neurothrombectomy Devices in India

PRAAN
Start date: September 2021
Phase:
Study type: Observational [Patient Registry]

PRAAN is a post-market registry designed to collect real-world data associated with the use of Medtronic market release neurothrombectomy devices in acute ischemic stroke (AIS) patients from India.

NCT ID: NCT05001984 Recruiting - Clinical trials for Acute Ischemic Stroke

Trial of PCSK9 Inhibition in Patients With Acute Stroke and Symptomatic Intracranial Atherosclerosis

TOPICAL-MRI
Start date: August 1, 2021
Phase: Phase 2
Study type: Interventional

This study will evaluate whether low-density lipoprotein (LDL-C) lowering with alirocumab results in greater change from baseline in intracranial atherosclerotic plaque at week 26 than control in adults with acute ischemic stroke from intracranial atherosclerosis taking lipid lowering therapy.

NCT ID: NCT04995757 Completed - Clinical trials for Acute Ischemic Stroke

CAPTURE Registration Trial of the Thrombectomy System for the Treatment of Acute Ischemic Stroke.

Start date: March 21, 2018
Phase: N/A
Study type: Interventional

As this will be a pre-market registration trial, in which devices will be used in accordance with appropriately labeled indications, pre-study notifications and approval requests will be addressed with CFDA. All trial results will be shared with CFDA.

NCT ID: NCT04984577 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke

Start date: September 2021
Phase: Phase 2
Study type: Interventional

The primary objective of the study is to confirm the efficacy of compound Edaravone Injection via intravenous infusion every 12 hours in the patients with Acute Ischemic Stroke(AIS) in a double-blind, active-controlled manner. The study is also to examine the safety of compound Edaravone Injection for the AIS patients.

NCT ID: NCT04980651 Recruiting - Clinical trials for Acute Ischemic Stroke

Safety and Efficacy of Remote Ischemic Conditioning for Acute Ischemic Stroke

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of remote ischemic conditioning for acute ischemic stroke.

NCT ID: NCT04980625 Recruiting - Clinical trials for Acute Ischemic Stroke

Safety and Efficacy of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis for Acute Ischemic Stroke

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of remote ischemic conditioning combined with intravenous thrombolysis in treating acute ischemic stroke.