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Depression clinical trials

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NCT ID: NCT04732169 Withdrawn - Clinical trials for Treatment Resistant Depression

Cannabidiol for Treatment Resistant Depression

CBD
Start date: July 1, 2021
Phase: Phase 4
Study type: Interventional

With this study, the investigators will address the following scientific aims: 1. Demonstrate the antidepressant effects of CBD in human adults with treatment refractory MDD as measured by standard rating scales. 2. Confirm CBD's safety profile in human adult patients with MDD.

NCT ID: NCT04586309 Withdrawn - Depression Clinical Trials

Improving the Mental Health of Resident Physicians and Fellows Through Transcendental Meditation

Start date: June 2021
Phase: N/A
Study type: Interventional

This proposal aims to optimize resident physician and fellow wellness and performance at Banner University Medical Center through an evidence-based stress reduction program, Transcendental Meditation (TM). It is particularly timely due to the enormous pressure and stress that residents face as front-line workers during the current 2019 novel coronavirus (COVID-19) pandemic. Participants will be randomly assigned to the TM training (group 1), or delayed TM training (group 2). Study outcomes will be assessed at baseline and at 1 and 3 months post-training. Participants who are assigned to group 2 , will receive the TM training following the three month assessment, and then complete assessments at 1 and 3 months post-training. These assessment tools look at anxiety (Generalized Anxiety Disorder Scale-GAD-7), depression (Patient Health Questionnaire (PHQ-9), insomnia (Pittsburgh Sleep Quality Index PSQI), psychological distress (Brief Symptom Inventory BSI18), burnout (Maslach Burnout Inventory-MBI), resilience (Conner-Davidson Resilience Scale- RISC), and alcohol use (Alcohol Use Disorder Identification Test - AUDIT).

NCT ID: NCT04496505 Withdrawn - Clinical Depression Clinical Trials

Neuromodulation Device Use in Patients With Major Depressive Disorder

Start date: August 17, 2020
Phase: N/A
Study type: Interventional

Study the neuromodulation device in the treatment of Major Depressive Disorder and associated symptoms. In this study we use the Hamilton Depression Rating Scale (HAM-D), the Quality of Life Scale (QQLS), the Rumination Response Scale (RRS), the Brief Irritability Test (BIT), the Generalized Anxiety Disorder 7 Item Scale (GAD 7), and the Future Orientation Scale (FOS). This study was designed to mirror real life situations, and thus patients are not asked to stop their pharmaceutical treatments. Primary hypothesis for this study is: o Daily use of the device will decrease depressive symptoms as measured by HAM-D. Secondary hypotheses for these study are: - Daily use of the device will increase quality of life as measured by the QQLS. - Daily use of the device will decrease rumination as measured by the RRS. - Daily use of the device will decrease irritability as measured by the BIT. - Daily use of the device will increase future orientation as measured by the FOS. - Daily use of the device will decrease anxiety as measured by the GAD-7.

NCT ID: NCT04388202 Withdrawn - Clinical trials for Major Depressive Disorder

Leveraging EEG for Antidepressant Prediction With Sertraline and Escitalopram

LEAP-SE
Start date: October 15, 2020
Phase: Phase 4
Study type: Interventional

The LEAP-SE study will be conducted to validate the utility of EEG biomarkers as an aid to antidepressant treatment selection in adults with MDD.

NCT ID: NCT04388189 Withdrawn - Clinical trials for Major Depressive Disorder

Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion

LEAP-DB
Start date: October 15, 2020
Phase: Phase 4
Study type: Interventional

The LEAP-DB study will be conducted to validate the utility of EEG biomarkers as an aid to antidepressant treatment selection in adults with MDD.

NCT ID: NCT04369001 Withdrawn - Depression Clinical Trials

Program ACTIVE: Phase 2

Start date: December 2020
Phase: N/A
Study type: Interventional

The present study seeks to tailor the original Program ACTIVE (Adults Coming Together to Increase Vital Exercise) to meet the cultural norms and needs of adult Black men with comorbid Type 2 diabetes and depression by using focus groups comprised of Black men with Type 2 diabetes. The use of peer perspectives allows for an improved strategy to reach, retain, and improve outcomes in this population. Following the tailoring of program materials, the intervention (Program ACTIVE) will be facilitated with Black men with comorbid Type 2 diabetes and depression using evidence-based cognitive behavioral therapy and community-based exercise interventions.

NCT ID: NCT04327362 Withdrawn - Depression Clinical Trials

tDCS-Augmented Prolonged Exposure Therapy

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the effects of a brain stimulation technique known as transcranial direct current stimulation, or tDCS, on the benefits of Prolonged Exposure therapy, or PE, which is an effective treatment for posttraumatic stress disorder, or PTSD. tDCS has been demonstrated to be safe and effective for influencing brain activity by passing a weak electrical current through the scalp. In this study, tDCS is provided in addition to PE treatment, through the National Crime Victim's Research and Treatment Center at MUSC, or the PTSD Clinical Team Clinic within the Ralph H. Johnson VA Medical Center.

NCT ID: NCT04317001 Withdrawn - Clinical trials for Major Depressive Disorder

Treatment for Cognitive Impairment in Depression

T-CID
Start date: December 1, 2018
Phase: Phase 3
Study type: Interventional

The proposed study seeks to investigate the effects of modafinil on cognitive function in depression, which holds promise for better treating cognitive impairment in depression, as well as better understand cognitive dysfunction in MDD from a neural rather than diagnostic point of view to better classify and treat these disabling symptoms.

NCT ID: NCT04283058 Withdrawn - Depression Clinical Trials

Low Dose Ketamine Infusion for the Treatment of Resistant Depression

Start date: June 29, 2020
Phase:
Study type: Observational

The purpose of this investigator-initiated observational study is to examine how low Ketamine infusion treatments impact antidepressant and anti-suicidal effects for refractory and non-refractory depression.

NCT ID: NCT04273191 Withdrawn - Clinical trials for Postpartum Depression

A Study to Evaluate Multimodal Neuroimaging Parameters in Women With Postpartum Depression Who Are Receiving ZULRESSO™ (Brexanolone)

Start date: February 2020
Phase: Phase 4
Study type: Interventional

In this Phase 4 study, women who have been prescribed commercial ZULRESSO™ (brexanolone) by a physician as standard of care for postpartum depression (PPD) and who are planning to receive the infusion per United States Prescribing Information (USPI) at a Risk Evaluation and Mitigation Strategy (REMS)-certified healthcare center are being asked to participate to collect data on multimodal neuroimaging parameters in order to evaluate the relationship between changes in depressive symptoms and changes in neuroimaging parameters.