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Major Depressive Disorder clinical trials

View clinical trials related to Major Depressive Disorder.

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NCT ID: NCT05707299 Not yet recruiting - Clinical trials for Major Depressive Disorder

The Effect of Intradermal Acupuncture on Gallbladder Meridian Points on Cerebral Hemodynamics in Relevant Brain Regions for Major Depressive Disorder Based on fNIRS Technology

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

Gallbladder meridian(GB) acupoints may play an important role in the treatment of major depressive disorder (MDD). Therefore, this study is designed to focus on the traditional Chinese medicine (TCM) theory of " gallbladder dominating decision ", take the GB as the entry point, and use functional Near-Infrared Spectroscopy(fNIRS) technology to observe the effect of intradermal acupuncture on the cerebral hemodynamic indexes of the prefrontal cortex and bilateral temporal cortex of patients with MDD.

NCT ID: NCT05703256 Not yet recruiting - Clinical trials for Major Depressive Disorder

Amygdala Neurofeedback for Depression - Large Scale Clinical Trial

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as a stand-alone intervention for major depressive disorder

NCT ID: NCT05701345 Not yet recruiting - Clinical trials for Major Depressive Disorder

Study of Virtual Reality-based Medical Device for Patients With Depressive Disorder

Start date: January 30, 2023
Phase: Phase 3
Study type: Interventional

This study apply a wearable visual device (HMD)-VR-based software medical device for patients with depressive disorder for 8 weeks. The investigator would like to confirm evaluate the safety and efficacy of the wearable visual device(HMD)-VR-based software medical device effect of improving depressive disorder in patients.

NCT ID: NCT05697172 Recruiting - Clinical trials for Major Depressive Disorder

Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression

Start date: December 15, 2022
Phase: N/A
Study type: Interventional

The investigators propose to use low-intensity transcranial focused ultrasound (LIFU), a novel neuromodulation method, to probe the causal involvement of individually defined components of an anteromedial brain circuit in the processing of self-referential thoughts, and the production of repetitive negative thinking (RNT), a prominent transdiagnostic manifestation with adverse clinical consequences. The investigators hypothesize that real vs. sham low-intensity sonication of individually-defined anteromedial structures connecting medial orbitofrontal and anterior cingulate cortices with ventral striatum and anterior thalamus will show reduced initiation or maintenance of RNT as measured by (1) Brief State Rumination Inventory (BSRI) scores and distress associated to repetitive negative thoughts, and (2) improvement of the affective valence associated to self-referential adjectives, and that these changes will be associated with decreased connectivity between structures mentioned above. The present early feasibility study is an initial step that aims to determine its feasibility and help with the planning of a larger study addressed at actual hypothesis testing.

NCT ID: NCT05695365 Active, not recruiting - Clinical trials for Major Depressive Disorder

Feasibility of Resistance Exercise to Treat Major Depression Via Cerebrovascular Mechanisms

Start date: April 4, 2022
Phase: N/A
Study type: Interventional

This project is a single-arm pilot trial to investigate the feasibility, acceptability, and plausible efficacy of a 16-week resistance exercise training (RET) program for treatment of major depressive disorder.

NCT ID: NCT05694754 Recruiting - Clinical trials for Major Depressive Disorder

Transcranial Magnetic Stimulation Theta Burst (TMS), Depression and Smoking.

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

This study evaluates de efficacy of Theta Burst Transcranial Magnetic Stimulation (TMS) applied on the left dorsolateral prefrontal cortex in patients with Major Depressive disorder and tobacco consumption.

NCT ID: NCT05694156 Not yet recruiting - Clinical trials for Major Depressive Disorder

Musical Attention Control and Executive Function Training for Adults With MDD

Start date: April 2023
Phase: N/A
Study type: Interventional

The investigators have developed music-based cognitive training sessions derived from Neurologic Music Therapy (NMT) techniques. The music-based cognitive training sessions will address areas of attention and executive function, which appear to progress over time and worsen as an individual experiences more episodes of depression. The aim of this pilot is to test 8-weeks of music-based cognitive training to improve cognitive function among adults with major depressive disorder.

NCT ID: NCT05693922 Not yet recruiting - Clinical trials for Major Depressive Disorder

Augmenting Single-session Behavioral Activation (BA) With Delta-beta Transcranial Alternating Current Stimulation (tACS) for the Treatment of Depression

ABBA
Start date: January 2023
Phase: N/A
Study type: Interventional

Investigating whether delta-beta cross-frequency transcranial alternating current stimulation can augment the effects of a single session of behavioral activation in participants with major depressive disorder.

NCT ID: NCT05686668 Enrolling by invitation - Clinical trials for Major Depressive Disorder

Evolution of the Sensory Profile in Depression

DEPSENS
Start date: January 10, 2022
Phase:
Study type: Observational

The perception of the environment through the study of sensory awareness is important to understand the adaptive or symptomatological behaviors (e.g., withdrawal, increased activity level, stimulation seeking, etc.). Sensory processing disorders, such as hypersensitivities or hyposensitivities, have been described in people with depression using the Adolescent Adult Sensory Profile scale. In a recent study, similar results consistent with extreme sensory profiles (hypersensitivity, hyposensitivity, sensation avoidance) in adults with a major depressive disorder were observed. The evolution over time of the sensory profile in people with a depressive disorder is not known. It is currently unknown whether these extreme sensory processing profiles are stable over time or whether they may evolve with the depressive symptomatology to normalize with clinical improvement. This knowledge could have an important impact both on the symptomatological expression of the disorder, its recognition, and also on the management of the patient. The investigators aim to study the evolution over time of the sensory profile of depressed subjects hospitalized using the ASSP. The behavioral responses of individuals with sensory processing disorder may be related to the coping strategies of these individuals with their living environment. In a second step, the investigators will study the second step the sensory profile of subjects with depression according to their coping strategies, their living environment and their clinical characteristics (anxiety (anxiety, psychomotor slowing, self-esteem, anhedonia).

NCT ID: NCT05685758 Recruiting - Depression Clinical Trials

A Treatment for Depression Via a Gamified Mobile Phone Application Based on a New Cognitive Model

FTP
Start date: November 3, 2022
Phase: N/A
Study type: Interventional

The study is a randomized controlled treatment study comparing changes in depressive symptoms over 8 weeks between individuals with Major Depressive Disorder (MDD) who have access to an FTP-based mobile phone application and a control group not engaging with the app. FTP, the process of Facilitating Thought Progression, trains the brain's cognitive thought process to expand, accelerate, and be more creative, to alleviate depressive symptoms.