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Depression clinical trials

View clinical trials related to Depression.

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NCT ID: NCT06267846 Not yet recruiting - Clinical trials for Major Depressive Disorder

A Study to Evaluate the Efficacy and Safety of NBI-1070770 in Adults With Major Depressive Disorder

Start date: March 2024
Phase: Phase 2
Study type: Interventional

To evaluate the efficacy, safety, and tolerability of NBI-1070770 compared to placebo on improving symptoms of depression in participants with major depressive disorder (MDD).

NCT ID: NCT06266715 Not yet recruiting - Depression Clinical Trials

Improvement of Depression With Use of ATP

Start date: February 20, 2024
Phase: N/A
Study type: Interventional

This clinical study is a randomized, double-blind, placebo-controlled trial with an intervention period of 4 weeks. Participants will be patients with moderate to severe depression who meet the inclusion criteria during the screening period. After recruitment written informed consent form will be signed and the baseline evaluation will be done then the treatment period follows. The subjects will be randomly assigned to a control group (escitalopram plus NA) and an ATP group (escitalopram plus adenosine disodium triphosphate(ATP)) in a 1:1 ratio for treatment, with a total number of 120 recruited patients. Assessment will be carried out as an analysis of changes in Hamilton Depression Rating Scale, cognitive function test, brain functional network, inflammatory markers, and other indicators in the first, second, and fourth week of intervention which will evaluate the effectiveness of ATP in improving moderate to severe depression preliminarily.

NCT ID: NCT06266611 Not yet recruiting - Depression Clinical Trials

Cannabis for Palliative Care in Cancer

ARCTiC
Start date: March 1, 2024
Phase: Phase 2
Study type: Interventional

Many cancer patients suffer from pain, sleep, and mood problems and are using cannabis to relieve these symptoms. Cannabis may provide such relief but may also produce negative side effects including cognitive impairment, an especially problematic issue for cancer patients, indicating more research on cannabis use in the cancer context is required. In this endeavor, the present study seeks to compare the use of hemp-derived CBD (Cannabidiol) with and without THC (Delta-9-tetrahydrocannabinol) versus placebo on measures of sleep, pain, mood, subjective and objective cognitive functioning, and quality of life within 185 cancer patients.

NCT ID: NCT06266390 Not yet recruiting - Depression Clinical Trials

Engaging sgACC With TMS for Depression

Start date: March 30, 2024
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the responses of the brain region known as the subgenual anterior cingulate cortex (sgACC) during transcranial magnetic stimulation (TMS) in individuals with depression. Specifically, investigators aim to determine whether the sgACC is engaged when TMS is delivered to specific targets and if the engagement of sgACC changes throughout a full TMS treatment intervention. To achieve this goal, the investigators will employ a combination of TMS and Magnetic Resonance Imaging (MRI) procedures. Study participation will include completing various questionnaires, clinical assessments, receiving a full transcranial magnetic stimulation (TMS) treatment intervention (every weekday for 4-6 weeks), and undergoing MRI scans, both with and without concurrent TMS.

NCT ID: NCT06265701 Not yet recruiting - Depression Clinical Trials

Does a Novel Intervention Targeting Derailment Decrease Depressive Symptoms?

Start date: February 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to understand if a reflective journaling intervention-"Me Through Time"- which is intended to decrease derailment (defined as the inability to meaningfully connect one's past self to their current self) may have downstream impacts on depressive symptoms.

NCT ID: NCT06263738 Not yet recruiting - Depression Clinical Trials

Cold and Heat Investigation to Lower Levels of Depression

CHILL'D
Start date: April 1, 2024
Phase: N/A
Study type: Interventional

This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water plunge. Participants will complete a baseline assessment of their depressive symptoms as well as 1-week and 2-week post-treatment followup assessments.

NCT ID: NCT06263660 Recruiting - Depression Clinical Trials

Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression

Start date: January 9, 2024
Phase: Phase 2
Study type: Interventional

This study aims to determine whether a keto-like supplement relative to placebo results in functional brain changes during fMRI tasks evaluating positive and negative valence in individuals with moderate to severe depression. In this double-blind randomized placebo-controlled trial, 75 individuals with a Patient Health Questionnaire (PHQ-9) scale score ≥ 10 (MDD) will be enrolled to participate in an 8-week treatment study to obtain 60 completers. Participants will be randomized with a 1-1 ratio to receive the keto-like supplement (n= 30 completers) or placebo (n=30 completers) taken orally three times per day for 8 weeks. Participants will undergo a 10.5-hour screening/baseline evaluation visit split over 2 days at week 0 including questionnaires, neuroimaging before and after supplement or placebo administration and blood draws, office visits at week 2 (1.5 hours), week 4 (3 hours), week 6 (0.5 hours), week 8 (6 hours), a follow-up visit at week 10 (1.5 hours) and two phone calls between visits (weeks 1 and 3) during which a brief clinical assessment will be obtained (10 minutes each). The total time involved in the study is approximately 23.5 hours.

NCT ID: NCT06263400 Recruiting - Psychoeducation Clinical Trials

Recovery Levels of Depression Patients and Caregiver Psychoeducation

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

To determine the effect of psychoeducation given to patients and caregivers on patients' depression and recovery levels, caregivers' emotional expression and family burden levels.

NCT ID: NCT06262178 Not yet recruiting - Depression Clinical Trials

Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children

Start date: April 2024
Phase: N/A
Study type: Interventional

The purpose of this study, which includes a clinical trial, is to adapt and assess the efficacy of Parenting-STAIR (PSTAIR), an intervention which combines existing evidence-based treatments Skills Training in Affective and Interpersonal Regulation (STAIR) and Parent-Child Care (PC-Care) to reduce symptoms of Post-traumatic Stress Disorder (PTSD) and improve parenting among military-connected mothers. Participants in the clinical trial will receive PSTAIR or trauma-focused treatment as usual (either prolonged exposure or cognitive processing therapy).

NCT ID: NCT06261463 Not yet recruiting - Depression Clinical Trials

Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

Start date: March 2024
Phase: N/A
Study type: Interventional

The proposed study draws on prior research to evaluate the feasibility, acceptability and explore preliminary effectiveness of Coffee and Family Education and Support, Version (CAFES2) using a pilot randomized type 1 hybrid effectiveness-implementation design. CAFES2 is a peer-led family and social strengthening multiple family group intervention that is designed to respond to multi-level needs of refugee families. Results of the trial will contribute to the emerging evidence base on family-based mental health interventions for refugee and newcomer communities. The trial will also generate new insights regarding implementation strategies needed to promote successful delivery of services by peer providers and the unique role of human-centered design practices for adaptation of mental health and psychosocial interventions.