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Depression clinical trials

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NCT ID: NCT04846504 Not yet recruiting - Clinical trials for Perinatal Depression

Accelerating Implementation of Mindful Mood Balance for Moms

MMB4Moms
Start date: June 1, 2021
Phase: N/A
Study type: Interventional

The Mindful Mood Balance for Moms (MMBFM) study examines whether using an internet program called Mindful Mood Balance for Moms to deliver Mindfulness Based Cognitive Therapy (MBCT) over an 8-week time period, is effective for reducing depression symptoms among pregnant women with a history of prior depression, and studies the effects of implementation strategies on the reach of the MMBFM program. This study will enroll 470 women from Kaiser Permanente Colorado, Southern California, Georgia. The investigators will compare clinical outcomes between those that receive mental health clinician coaching and those that receive peer coaching throughout the 8-week program. Survey data will be collected at 4 time points throughout the study (baseline, 12 weeks, 3rd trimester, and 3 months postpartum). The cost-effectiveness of both the clinical and peer coaching models at each health care system will be evaluated. For the implementation portion of the study, 30 OB clinics across the 4 health systems will be randomized in equal numbers to provide clinician facing implementation strategies (e.g., recruitment flyers, script pads, electronic medical record prompts) to encourage engagement in the MMBFM program or to usual care where women are only recruited by the study team with no clinician involvement. The primary outcome for testing clinician facing implementation strategies is reach, the percentage of women outreached who initially engage in the MMBFM program.

NCT ID: NCT04845347 Not yet recruiting - Clinical trials for Post Partum Depression

A Wearable Morning Light Treatment for Postpartum Depression

Start date: May 2021
Phase: N/A
Study type: Interventional

This study will test a consumer health light therapy device (Re-Timer) for women with postpartum depression to better understand how it affects mood and the body clock (also called the circadian clock). Eligible participants will be enrolled and randomized after baseline assessments. In addition to using the Re-Timer light for 5 weeks participants will complete questionnaires at various timepoints, record sleep information, wear an actigraph watch, and provide saliva samples. Additionally, the sleep of the participants' infants will also be monitored using an ankle-worn device (actigraph) and sleep diary at certain time-points as this may influence the mother's mood/sleep, and in turn affect the results. The hypotheses regarding the bright light versus the placebo dim light of the study are: - morning bright light therapy will produce greater improvement from pre- to post-treatment on the Hamilton Rating Scale for Depression - morning bright light therapy will lengthen the Phase angle difference (PAD) and this will mediate change in depression symptoms. - morning bright light therapy will produce greater improvements on self-reported depression symptoms, excessive daytime sleepiness, maternal-infant bonding, social functioning, and sleep-related impairment from pre- to post-treatment.

NCT ID: NCT04844034 Not yet recruiting - Depression Clinical Trials

Effects of a High EPA Multinutrient Supplement on Negative Affect in Young Adults.

NutriMOOD
Start date: September 2021
Phase: N/A
Study type: Interventional

This is a 24-week-long, randomised, double-blind, placebo-controlled trial exploring the efficacy of a high-EPA multinutrient supplement in the management of high, non-clinical anxiety and depression. The investigators focus on young and healthy, adult university students, who may otherwise not be eligible for pharmacological or cognitive behavioural therapy interventions.

NCT ID: NCT04843462 Not yet recruiting - Clinical trials for Major Depressive Disorder

Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine Spray

Esketamin+
Start date: April 12, 2021
Phase: N/A
Study type: Interventional

Pragmatic clinical trial of an addon-therapy regarding the use of edupression.com® - a licensed computer-based selfhelp programm - on patients with therapy-resistant depression receiving esketamine nasal spray

NCT ID: NCT04841603 Not yet recruiting - Anxiety Clinical Trials

Brief Digital CBT for Mood and Anxiety Symptoms in Acute Psychiatric Inpatients

Start date: April 2021
Phase: N/A
Study type: Interventional

A randomized control trial examining the feasibility, acceptability, and preliminary efficacy of providing access to the MindShift CBT mobile app via tablet for acute psychiatric inpatients.

NCT ID: NCT04839822 Not yet recruiting - Clinical trials for Recurrent Depressive Disorder, Current Episode Mild

Efficacy of Edupression.Com® in Depressive Patients

eFICASY
Start date: April 12, 2021
Phase: N/A
Study type: Interventional

The aim of the study is to investigate the efficacy and adherence of the digital self-help programme edupression.com®.

NCT ID: NCT04838210 Not yet recruiting - Pregnancy Related Clinical Trials

Elevating Voices, Addressing Depression, Toxic Stress and Equity in Group Prenatal Care

EleVATE GC
Start date: May 2021
Phase: N/A
Study type: Interventional

This study will provide high-quality, representative data on the capacity of Elevating Voices, Addressing Depression, Toxic Stress and Equity in Group Prenatal Care (EleVATE GC) to reduce perinatal depression, preterm birth, and low birthweight in African-American women. If findings from this study indicate that EleVATE GC is feasible and effective, this model could be implemented nationwide to help achieve mental and obstetric health parity for low-income women of color in the United States.

NCT ID: NCT04837573 Not yet recruiting - Depression Clinical Trials

Feasibility & Acceptability of a Virtual Sister Circle Intervention for Black Women With Depressive Symptoms

Start date: July 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the feasibility and acceptability of a protocol for middle- and older-aged Black women with depressive symptoms.

NCT ID: NCT04837521 Not yet recruiting - Depression Clinical Trials

UP for Older Adults

Start date: July 2021
Phase: N/A
Study type: Interventional

Research suggests older adults report wide-ranging emotional distress (e.g., symptoms of anxiety, depression) that negatively impacts their physical and mental health, and is associated with a reduction in daily activity. The overarching goal of this proposal is to adapt an existing evidence-based intervention, the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), to increase activity in older adults by reducing emotional distress. The primary aim of the proposed study is to adapt a 5-session version of the UP for use with older adults reporting emotional distress and reduced engagement in daily activities, and to also develop a self-guided version of this intervention. This aim will be accomplished in two phases. In Phase 1, patient will receive the UP as written via telehealth. At the end of treatment they will provide feedback on the treatment, including any suggested changes as well as provide suggestions for changing the treatment that might allow an individual to successfully complete it on their own. This information will be used to iteratively change the treatment and develop a self-guided version of the treatment. In Phase 2, we will compare the therapist-delivered and self-guided version of treatment to see if patients find them acceptable. In this phase, patients will be randomized to receive one of these two treatments.

NCT ID: NCT04836585 Not yet recruiting - Anxiety Clinical Trials

eMBC for Perinatal Depression and Anxiety

eMBC
Start date: April 15, 2021
Phase: N/A
Study type: Interventional

Depression and anxiety that occur around the time of pregnancy can adversely impact a person's health and well-being, and their child's health and development. Fewer than 20% of affected people are adequately treated, often because of under-use of medications. Measurement based care (MBC) is a model of care where psychiatric symptoms are routinely tracked and reviewed together by a patient and their doctor to better manage symptoms. It has not been systematically evaluated for perinatal depression and anxiety. The overall objective of this study is to test the feasibility of MBC in this population to inform a future large randomized controlled trial for definitive evaluation. In order to avoid known barriers to MBC, electronic MBC (eMBC) will be used. With eMBC, patients can enter their symptoms into their electronic medical records before their appointment so that they can be evaluated by their doctor during the appointment. In this pilot study, the feasibility of recruitment for a future efficacy trial, including feasibility of recruitment, and retention, acceptability and adherence to a trial protocol will be evaluated.