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Depression clinical trials

View clinical trials related to Depression.

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NCT ID: NCT05488782 Not yet recruiting - Depression Clinical Trials

A Pilot RCT of a Remotely Delivered Self-management Program for Depressed Young African American Women at Risk for Hypertension

TEAM-Red
Start date: October 1, 2022
Phase: N/A
Study type: Interventional

The proposed project is a 24-week prospective randomized controlled trial (RCT) evaluating the effects of TargEted MAnageMent Intervention (TEAM, N=25) vs. enhanced wait-list (eWL, N=25) control in depressed young (≤50 years) AA women at risk for hypertension.

NCT ID: NCT05486676 Not yet recruiting - Clinical trials for Major Depressive Disorder

VR-Moodboost; an Innovative Virtual Reality Treatment for Adolescents With Depression

VR-Moodboost
Start date: July 25, 2022
Phase: N/A
Study type: Interventional

Major depressive disorder (MDD) is a prevalent and disabling mental health condition. A recent meta-analysis shows that across all forms of psychotherapy, only 43% of all depressive patients fully recover from MDD and relapse rates are high. Therefore, there is a strong need for innovative interventions with better treatment outcomes. Most traditional psychotherapies for depression focus on reducing negative affect. However, in patients suffering from depression, anhedonia, or loss of positive affect, is associated with poor prognosis and increased chance of suicide. Recent studies show promising results for novel psychotherapies with a focus on enhancing positive affect. Experimental studies indicate that non-verbal stimuli have a stronger impact on activation of positive affect than verbal stimuli, which makes Virtual reality (VR) a promising tool to enhance positive affect. For the current study the investigators developed an innovative VR treatment protocol to enhance positive affect and reduce depressive symptoms in patients with MDD. This study will include 10 adolescents aged 15 to 23 years old, who have a diagnosis of unipolar mild to severe depression. A trained psychologist will perform the VR-Moodboost intervention in twelve weekly sessions. The overall aim of this explorative proof-of-concept study is to provide first evidence that treatment with VR-Moodboost will lead to symptom improvement in adolescents with depression. The investigators hypothesize that VR-Moodboost will lead to an increase in positive affect, daily positive mood and a decrease in negative affect and daily negative mood in adolescents with mild to severe depression. Secondary, the investigators hypothesize that the VR-moodboost will lead to a decrease of depressive symptoms, an increase in daily activation, an increase in quality of life and an increase of self-efficacy for the participating patients. Moreover, the investigators hypothesize that VR-Moodboost leads to high patient acceptability and high usability for both patient and therapist.

NCT ID: NCT05486611 Not yet recruiting - Depression Clinical Trials

A RCT of a Digital Therapeutic and Educational App for Depression Among Adolescents

Start date: August 2022
Phase: N/A
Study type: Interventional

The primary aim of this study is to investigate the difference in depression symptoms at 4-weeks across two types of programs for addressing depressive symptoms, including Woebot (WB002) and Digital Education (ED002). The secondary aim of this study is to investigate the difference in anxiety symptoms at 4-weeks across the two programs. The tertiary aim of this study is to evaluate the feasibility, acceptability, and satisfaction of each program.

NCT ID: NCT05485701 Not yet recruiting - Depression Clinical Trials

Perinatal Mental Health in India: A Cohort and Validation Study

PMHI
Start date: September 2022
Phase:
Study type: Observational

The purpose of this observational study is to improve understanding of mental disorders among perinatal women in India.

NCT ID: NCT05482672 Not yet recruiting - Depression Clinical Trials

GetHealthy-OA: A Program to Improve Pain and Function for Patients With Knee Osteoarthritis, Obesity, and Depression

Start date: July 1, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The investigators have previously identified knee osteoarthritis patients with the combination of depression and an unhealthy weight may be an increased risk of more rapid joint degeneration and worsening pain. The GetHealthy-OA program combines a mind-body program with the oral supplement fisetin to potentially reduce the risk for this population by treating psychosocial, mechanical, and inflammatory mechanisms of knee osteoarthritis. This randomized clinical trial will compare the GetHealthy-OA program to minimally-enhanced usual care plus an oral placebo.

NCT ID: NCT05477758 Not yet recruiting - Depression Clinical Trials

The Impact of Pain on Depression Outcomes

Start date: July 2022
Phase:
Study type: Observational

This study is a secondary data analysis of three of largest Randomised Controlled Trials (RCTs) of behavioural activation (BA) for older people with depression in the United Kingdom (UK) primary care. The analysis will aim to explore the impact of pain on depression outcomes of older people receiving BA and potentially identify sub-groups of people who may not respond as well to treatment.

NCT ID: NCT05476237 Not yet recruiting - Depression Clinical Trials

Adolescent Depression Screening and Treatment in Mozambican Primary Care

Start date: November 2022
Phase: N/A
Study type: Interventional

This is a cluster-randomized pilot trial of depression screening and treatment implementation at four Youth-friendly Health Services (YFHS) in primary care clinics, two in Maputo City and two in Maputo Province. YFHS will be stratified by urbanicity, such that one YFHS in Maputo City and one YFHS in Maputo Province will be randomized to interpersonal psychotherapy (IPT)-A and the other YFHS in each location with be randomized to treatment as usual (TAU).

NCT ID: NCT05475535 Not yet recruiting - Stress Clinical Trials

Can a Self-guided Mobile Phone Application Program Improve Wellbeing in University Students

Start date: August 1, 2022
Phase: N/A
Study type: Interventional

This study seeks to evaluate and compare the effectiveness of a mobile phone application-based intervention in improving wellbeing in young adults. 400 University students are randomized into 1 of 4 intervention types. Pre, mid and post-intervention outcome measures are compared to determine effectiveness of the various intervention types.

NCT ID: NCT05474846 Not yet recruiting - Depression Clinical Trials

Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

Start date: December 1, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

To learn if Cognitive Behavior Therapy (called CBT), combined with either Bright Light Therapy (called BLT), methylphenidate, and/or melatonin, can help improve sleep and other related symptoms such as fatigue, anxiety, and depression in cancer patients. This is an investigational study. In this study, BLT, Methylphenidate and Melatonin will be compared to their placebos.

NCT ID: NCT05466851 Not yet recruiting - Depression Clinical Trials

An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression

BPS
Start date: August 1, 2022
Phase:
Study type: Observational

This research study is studying how thoughts, feelings, surroundings, and individual biology may contribute to why and how people experience anxiety or depression. We are trying to find out the wide variety of reasons that people may experience anxiety or depression, and why different people are helped by different forms of treatment. We are trying to determine why people stay in treatment, and what factors contribute to a positive or negative response to treatment. These reasons may be due to thoughts, feelings, beliefs, personality, biology, social support network, life events, and barriers to treatment. A wide range of information about factors that impact anxiety and depression will be included. These include, among others, measures of inflammation, hormone levels, behavior, spoken language, personality, medical history, social determinants of health, and attitudes toward mental health and its treatment. The study involves psychological and psychiatric treatments in the form of psychotherapy and medication management. The participant will be asked to set specific goals for study treatment, and to provide videos between sessions about relevant medication, emotional, and sleep factors in their life. In summary, this study will collect biological, psychological, and social factors that may play a role in anxiety and depression. This will inform both individual's diagnosis and treatment and will be used in a later set of analyses that can inform diagnosis and treatment for other individuals who share similar characteristics.