Clinical Trials Logo

Depression clinical trials

View clinical trials related to Depression.

Filter by:

NCT ID: NCT03852082 Not yet recruiting - Depression Clinical Trials

Predictors and Clinical Outcomes of Patients With Coronary Heart Disease Co-morbid Depression Post Percutaneous Coronary Intervention

PCI CODE
Start date: March 2, 2019
Phase:
Study type: Observational [Patient Registry]

A prospective, multicenter, registered cohort study to observe the incidence of 1-year major adverse cardiac events in patients with coronary heart disease co-morbid depression treated with percutaneous coronary intervention and to clarify the predictors of 1-year major adverse cardiac events post PCI among these patients.

NCT ID: NCT03851380 Not yet recruiting - Depression Clinical Trials

Improving Brain Stimulation Through Imaging

IBSI
Start date: May 1, 2019
Phase:
Study type: Observational

Repetitive pulse transcranial magnetic stimulation (rTMS) is a noninvasive treatment that involves stimulating the brain; however, treatment benefit depends on placing a TMS coil in the correct place on the head to reach critical brain regions below. Clinicians typically use scalp-based targeting, a process in which rather than using MRI guidance to target brain regions for stimulation, they use landmarks on the scalp. Several researchers, including the investigators' lab, showed that the current scalp-based targeting techniques do not position stimulation above the correct brain region, and patients fail to respond. The investigators propose to improve clinical scalp-based targeting by comparing it to MRI guided targeting. The most common clinical population receiving rTMS therapy is depressed patients. The investigators' plan is to study the accuracy of certain scalp-based rules in patients with depression. Accurate brain stimulation targeting is critical for effective rTMS therapy.

NCT ID: NCT03851016 Not yet recruiting - Quality of Life Clinical Trials

Life Story Book With Mentally Alert Residents of Nursing Homes

Start date: February 25, 2019
Phase: N/A
Study type: Interventional

This study evaluates the effects of the Life Story Book intervention on depressive symptoms and meaning in life for mentally alert residents of nursing homes. Half of the participants will receive the intervention while the other half receive care-as-usual. The intervention will then be switched, and the participants who received care-as-usual will receive the intervention while the home that received the intervention will then receive care-as-usual.

NCT ID: NCT03850834 Not yet recruiting - Depression Clinical Trials

Study of Ammoxetine Hydrochloride Enteric-coated Tablets in Healthy Subject

Start date: March 10, 2019
Phase: Phase 1
Study type: Interventional

This study evaluates the safety, tolerability and pharmacokinetics of Ammoxetine Hydrochloride Enteric-coated Tablets in Chinese healthy subjects

NCT ID: NCT03849417 Not yet recruiting - Depression Clinical Trials

Brain Imaging Biomarkers of Pathological Brain Aging in Late-life Depression

Start date: March 2019
Phase:
Study type: Observational

This study investigates the relationships and differences in PET-MRI brain imaging biomarkers of abnormal aging and behavioral measures in late life depression compared to healthy controls, and evaluates relationships and differences in the same imaging and behavioral measures following electroconvulsive therapy. The study tests the hypotheses that late-life depression will be associated with higher levels of accelerated aging and brain disease biomarkers, and that electroconvulsive therapy works by stimulating the reorganization of brain tissue.The data collected with contribute to improved knowledge about the neurobiology of late-life psychopathology and its treatment.

NCT ID: NCT03848715 Not yet recruiting - Depression Clinical Trials

Effects of Inflammation on Affect and Behavior

Start date: February 2019
Phase: Phase 1
Study type: Interventional

Compelling evidence indicates inflammation plays a role in depression, but potential mechanisms linking inflammation to depression, such as dysregulated reward processing, are poorly understood. This study comprehensively evaluates effects of inflammation on reward across dimensions (e.g., anticipating versus receiving a reward) and types (e.g., money vs. smiling faces) in younger and older women. Characterizing how inflammation shapes the dynamic and multidimensional reward system, and how this may differ by age, may give insight into risk factors for depression and help identify critical points for intervention.

NCT ID: NCT03846674 Recruiting - Depressive Symptoms Clinical Trials

Depression Symptoms Among Ever Married Females Attending Primary Health Care Units in Dairut City

Start date: December 22, 2018
Phase:
Study type: Observational

Depression is defined as a cluster of specific symptoms with associated impairment. The clinical and diagnostic features of the disorder are broadly similar in adolescents and adults. Nevertheless, depression in adolescents is more often missed than it is in adults, possibly because of the prominence of irritability, mood reactivity, and fluctuating symptoms in adolescents. While depression is the leading cause of disability for both males and females, the burden of depression is 50% higher for females than males. In fact, depression is the leading cause of disease burden for women in both high-income and low- and middle-income countries.

NCT ID: NCT03845504 Recruiting - Depression Clinical Trials

iTBS in Refractory Pediatric Depression

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

This work will mark the first step in understanding the neural targets for rTMS in youth with difficult to treat depressive symptoms, creating benchmarks for optimizing the safety and efficacy of rTMS for pediatric populations through precision targeting, and encourage funding applications for larger sham- controlled randomized clinical studies.

NCT ID: NCT03843333 Not yet recruiting - Clinical trials for Cognitive Impairment

A Community Health Worker Program to Support Rural Older Adults

Start date: February 2019
Phase: N/A
Study type: Interventional

This study will investigate an intervention delivered by community health workers for older adults with signs of cognitive impairment, mobility loss, and depression in the rural primary care setting.

NCT ID: NCT03842345 Not yet recruiting - Healthy Clinical Trials

DELPhI Evaluation of Psychiatric Conditions

Start date: February 2019
Phase:
Study type: Observational

DELPhI acquisition and analysis software, a QuantalX Neuroscience development, which is designed to measure, analyze, and display brain electrical activity of human electroencephalogram (EEG), to transcranial magnetic stimulation (TMS), will be used to evaluate different psychiatric conditions.