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NCT ID: NCT04926961 Recruiting - Healthy Clinical Trials

Testing the Contribution of Orbitofrontal Cortex Networks to Reward Identity Learning

Start date: June 2021
Phase: N/A
Study type: Interventional

This research study examines the contribution of orbitofrontal cortex (OFC) networks to learn reward identity expectations.

NCT ID: NCT04926246 Not yet recruiting - Healthy Clinical Trials

A Study in Healthy Men to Find the Best Formulation of BI 685509 and to Test How it is Taken up in the Body

Start date: June 28, 2021
Phase: Phase 1
Study type: Interventional

The main objective of this trial is to select a formulation and to optimize the identified formulation of BI 685509, if needed.

NCT ID: NCT04926116 Not yet recruiting - Healthy Clinical Trials

A Study of AK3280 in Chinese Healthy Volunteers

Start date: June 2021
Phase: Phase 1
Study type: Interventional

This study is a randomized, double-blind, placebo-controlled, single-center, phase I study to evaluate the safety, tolerability, and pharmacokinetics of AK3280 in healthy Chinese subjects.

NCT ID: NCT04925336 Recruiting - Healthy Clinical Trials

Cerebral and Autonomic Responses to Pain in Healthy Humans

ALGOBLOC-1
Start date: April 6, 2021
Phase: N/A
Study type: Interventional

Evaluating the intraoperative pain is a major challenge for the anesthesia team. During anesthesia, changes in heart rate and blood pressure are interpreted qualitatively to evaluate the sympathetic response to nociceptive stimulation or the adaptation of analgesia during surgery. The new nociception monitors under development quantitatively explore other variables dependent on sympathetic activity or sympathetic / parasympathetic balance, such as the pulse wave amplitude measurement (Surgical Pleth Index (SPI index)), the pupil dilation reflex, respiratory sinus arrhythmia (ANI, Analgesia Nociception Index), or skin conductance index. Taken independently, these tools provide an assessment of nociception based on variations in the autonomic system, more robust than simply observing heart rate or blood pressure raw values. However, the relationship between variations in the neurovegetative system and pain can be compromised by various factors or intraoperative events such as hypovolemia, bleeding, certain sympathomimetic or sympatholytic treatments, the hypnosis depth, ventilation variation, fast filling, or body temperature. Moreover, investigators do not know the delay between the application of the painful stimulus and the observation of the variation of the different neurovegetative variables. This constitutes a limit of the practitioners' confidence in these monitoring tools. The nociception transmission pathways of to the vegetative centers and cortical areas are complex. Investigators hypothesis is that neurovegetative variations in response to nociceptive stimulation are not always associated with a cortical somatosensory response. In this project investigators investigate the relation between cortical (EEG) and vegetative reactions to acute and tonic nociceptive stimuli, as a preliminary step to apply these procedures to assess intraoperative reactions to nociceptive procedures in anesthetized patients.

NCT ID: NCT04923282 Recruiting - Healthy Clinical Trials

Recombinant Human Alkaline Phosphatase in Healthy Japanese Subjects

Start date: May 7, 2021
Phase: Phase 1
Study type: Interventional

Clinical Phase 1 study to investigate the pharmacokinetics and to assess the safety and tolerability of recAP after single and multiple intravenous doses in healthy Japanese subjects.

NCT ID: NCT04923269 Not yet recruiting - Healthy Clinical Trials

A Study of LY3532226 in Healthy Participants

Start date: June 10, 2021
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY3532226 in healthy participants. Blood tests will be performed to check how much LY3532226 gets into the bloodstream and how long it takes the body to eliminate it. This study will last approximately 8 weeks including screening period.

NCT ID: NCT04922684 Recruiting - Healthy Clinical Trials

Can Mimic Emotional Expression Training Help Improve Emotion Processing

Start date: March 30, 2020
Phase: N/A
Study type: Interventional

The main aim of the present study is to investigate whether mimicking emotional expressions training via FaceReader software can improve emotional processing and recognition in healthy subjects, especially individuals with hityer autistic traits.

NCT ID: NCT04920578 Not yet recruiting - Healthy Clinical Trials

A Study of JNJ-69095897 in Healthy Participants

Start date: June 6, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the safety and tolerability of JNJ-69095897 versus placebo and to characterize the pharmacokinetic (PK) of JNJ-69095897 in blood, plasma, cerebrospinal fluid (CSF) and urine after single oral dose administration (ascending dose levels) in healthy participants.

NCT ID: NCT04920539 Not yet recruiting - Healthy Clinical Trials

In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans

Start date: July 1, 2021
Phase: Phase 1
Study type: Interventional

In this study, the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes.

NCT ID: NCT04920370 Recruiting - Healthy Clinical Trials

Study of Subcutaneous and Intravenous ALXN1720 With and Without rHuPH20 in Healthy Subjects

Start date: September 4, 2019
Phase: Phase 1
Study type: Interventional

This study is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of ALXN1720 administered subcutaneously (SC) or intravenously (IV).