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NCT ID: NCT06050889 Not yet recruiting - Healthy Clinical Trials

Mechanisms of Exercise-Induced Hypoalgesia

Start date: October 20, 2023
Phase: N/A
Study type: Interventional

Exercise-Induced Hypoalgesia (EIH) is a lessening of pain sensitivity in response to an acute bout of exercise. Limited research has examined the effects of expectations on EIH during a dynamic resistance training during different intensities. Therefore, the purpose of this study is to examine the effects of positive and negative expectations on EIH.

NCT ID: NCT06050356 Not yet recruiting - Healthy Clinical Trials

First-in-Human Trial of the Novel Tuberculosis Vaccine Candidate, H107/CAF®10b

nTB-01
Start date: October 2023
Phase: Phase 1
Study type: Interventional

Tuberculosis (TB) is an infection caused by bacteria passed from one person to another through the air when an infected person for instance coughs, speaks, or sneezes. This study tests the safety and vaccine-induced immune response of a new preventive TB vaccine called H107e/CAF®10b. H107e is a copy of protein parts from the bacterium causing tuberculosis, Mycobacterium tuberculosis, which are also called antigens. CAF®10b is an adjuvant which helps the body discover the antigen. The adjuvant and antigen are mixed together to formulate the final vaccine. The final formulated vaccine enhances the immune system's response against the antigen. This is a first-in-human study, meaning this vaccine is being given to people for the first time. The primary objective is to evaluate the safety of the vaccine and its components; however, the study will also evaluate the specific immune responses generated by the new vaccine. The study is divided into two parts, phase 1a and phase 1b. Phase 1a investigates unadjuvanted H107e, CAF®10b adjuvant, H107e/CAF®10b vaccine (low adjuvant dose), and H107e/CAF®10b vaccine (full adjuvant dose). The trial products are administered twice intramuscularly. H107e is also administered intranasally in one of the groups on Day 85. Phase 1b investigates H107e/CAF®10b, H107e/CAF®10b+Bacillus Calmette-Guérin (BCG), BCG, and placebo. A placebo is a look-alike substance that contains no active drug. All groups in phase 1b receive H107e intranasally on Day 211. A preventive TB vaccine such as H107e/CAF®10b should be able to introduce the body's immune system to antigens from Mycobacterium tuberculosis. This will result in memory in the immune system, meaning that when a person gets infected with Mycobacterium tuberculosis, the immune system will recognise and target the bacteria to prevent disease, thereby avoiding the need for antibiotic treatment and/or other treatments and their side effects.

NCT ID: NCT06049108 Not yet recruiting - Healthy Clinical Trials

A Study of Carbon-14-Labelled [14C] LY3871801 in Healthy Male Participants

Start date: September 15, 2023
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to evaluate how much of the study drug (LY3871801), administered as a single dose that has the radioactive substance 14C incorporated into it, passes from blood into urine, feces and expired air in healthy male participants. The study will also measure how much of the study drug gets into the bloodstream, how its broken down, and how long it takes the body to get rid of it. The study will last up to approximately 9 weeks including the screening period.

NCT ID: NCT06049095 Not yet recruiting - Healthy Clinical Trials

A Phase 1 Single and Multiple Ascending Dose Study of LTG-001 Administered Orally to Evaluate the Safety, Tolerability, and Pharmacokinetics in Healthy Participants

Start date: October 2023
Phase: Phase 1
Study type: Interventional

This is a sequential, randomized, double-blind, placebo-controlled Phase 1 single (SAD) and multiple (MAD) ascending dose study to evaluate the safety, tolerability, and pharmacokinetics (PK) of orally administered LTG-001 in healthy male and female participants

NCT ID: NCT06048302 Not yet recruiting - Healthy Clinical Trials

PK and Safety in Participants Taking Obicetrapib With Moderate Hepatic Impairment Relative to Normal Hepatic Function

Start date: September 18, 2023
Phase: Phase 1
Study type: Interventional

To investigate the safety and pharmacokinetics in patients with moderate hepatic impairment compared to healthy participants after a single oral dose of obicetrapib (10 mg).

NCT ID: NCT06048016 Recruiting - Healthy Clinical Trials

Effect Of Scaling and Root Planning on ALP in Saliva and GCF In Periodontitis Patients Compared With Healthy Individuals

Start date: June 15, 2023
Phase: N/A
Study type: Interventional

The goal of this [interventional clinical trial] is to test effect of scaling and root plaining on Alkaline phosphatase in Saliva and Gingival crevicular fluid in periodontitis patients compared with healthy subjects The population from periodontitis patients compared with healthy individuals It aims to answer are: • 1_Alkaline phosphatase level in saliva and GCF. 2_Scaling and root plaining effect on Alkaline Phosphatase level. 0 participants will be asked to maintain their oral hygiene instructions. Researchers will compare [periodontitispatientsto healthyindividuals] to see if [AlkalinePhosphatase level].

NCT ID: NCT06045611 Not yet recruiting - Healthy Clinical Trials

The Effect of Oral Intake of Animal and Plant Proteins on the Metabolism in Healthy Women

PAN-Promet
Start date: October 2023
Phase: N/A
Study type: Interventional

The goal of this interventional study is to learn about the effects of different proteins (from animals or plants) on the metabolism in healthy, normal weight women between 18-45 year who are not on hormonal birth-control. The main questions the study aims to answer are: 1. How do different proteins affect biological markers of the metabolism and which protein has the strongest effect? 2. How are the different proteins digested and taken up from our body? Participants will drink four different shakes on four different study days in a random order. Three of them contain each a different protein and one does not contain protein. Right before drinking the shake and on 11 timepoints after drinking the shake blood samples will be drawn.

NCT ID: NCT06043089 Recruiting - Healthy Clinical Trials

Impact of Beetroot Supplementation in Athletes

Start date: August 23, 2023
Phase: N/A
Study type: Interventional

Several previous studies observed a positive effect of beetroot supplementation on sports performance in athletes, mainly in endurance performance. However, less attention has been paid to its effects on short-duration performance, especially in youth athletes. Moreover, only a few previous investigations performed biochemical analyses, including pro-oxidant balance assessments. It is especially important because chronic nitrate intake might directly cause the production of reactive nitrogen species and reactive oxygen species in other subcellular compartments, leading to more oxidative stress. Additionally, no previous study verified the impact of beetroot intake on sleep.

NCT ID: NCT06042959 Completed - Healthy Clinical Trials

Effects of Laughter Yoga Practiced by Nursing Students Before Clinical Practice

Start date: May 8, 2023
Phase: N/A
Study type: Interventional

Aim: We conducted this randomized controlled study to determine the effect of laughter yoga practiced by first year nursing students before clinical practice on their perceptions of stress and meaning of life. Background: Laughter yoga has a positive effect on the person's mental/general health, life satisfaction and psychological well-being and enables the person to cope with stress. Design: In this experimental randomized and controlled study including a control group, we administered a pre-test, post-test one and post-test two to the participating students. Methods: We conducted the study with 45 first year nursing students in the intervention group, and 45 first year nursing students in the control group. The students in the intervention group took part in eight sessions of laughter yoga for four weeks, twice a week. We used the Descriptive Information Form, Perceived Stress Scale, and Meaning and Purpose of Life Scale to collect the study data.

NCT ID: NCT06042387 Recruiting - Healthy Clinical Trials

Diverse Ancestry Study in IBD

Start date: May 1, 2022
Phase:
Study type: Observational

Objective: To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD in diverse ancestries: African, African American, Black, Afro-Caribbean, Afro-Latino/a/x, Latino/a/x, Hispanic, or any other Black or Latin or indigenous ancestry.