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Healthy clinical trials

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NCT ID: NCT04872231 Completed - Healthy Clinical Trials

Single Ascending Dose and Multiple Ascending Dose Study of Voriconazole Inhalation Powder in Healthy Adult Subjects

Start date: November 22, 2019
Phase: Phase 1
Study type: Interventional

This is a Phase 1 (heathy adult volunteers), 2-part, double-blind, randomized, placebo controlled trial to evaluate the safety and PK profiles of escalating single doses of Voriconazole Inhalation Powder versus placebo (SAD part) and escalating multiple doses of Voriconazole Inhalation Powder versus placebo (MAD part). SAD part will be initiated first and includes a sentinel design. MAD part will not utilize a sentinel design and will be initiated once the lowest doses from SAD part are deemed safe.

NCT ID: NCT04871971 Not yet recruiting - Healthy Clinical Trials

Glycaemic Response and Insulinaemic Response for Nutralys S85 Plus and Whey Protein

Start date: June 2021
Phase: N/A
Study type: Interventional

A comparison of the glycaemic response and insulinaemic response to glucose, Nutralys S85 Plus pea protein and whey protein using a single-blind, randomised, repeat measure, crossover design trial.

NCT ID: NCT04869865 Not yet recruiting - Healthy Clinical Trials

The Effects of a Springtime Home Cleanse on Skin, Gut, Metabolic and Mental Health

Start date: April 29, 2021
Phase: N/A
Study type: Interventional

This pilot study will evaluate the effects of a Springtime Home Cleanse on skin, gut, metabolic, and mental health. The study will also assess changes in overall quality of life. The results will be used to design a larger cleanse-based study in the future.

NCT ID: NCT04869696 Recruiting - Healthy Clinical Trials

Medical Adhesive Repeat Application Study

Start date: March 8, 2021
Phase:
Study type: Observational

This study is to determine the relative effects imparted by different medical tapes to skin when comparing normal skin to skin after ten repeated tape applications and removals.

NCT ID: NCT04869111 Recruiting - Healthy Clinical Trials

The BrainHealth Project

Start date: August 1, 2020
Phase: N/A
Study type: Interventional

The BrainHealth Project is a ten-year, longitudinal study focused on identifying determinants of brain health and performance. Participants will have the opportunity to complete semi-annual (twice a year) online assessments to track their performance over time. In between semi-annual assessments, participants will have access to online trainings and ongoing supplemental content regarding ways to optimize brain health and performance. Additionally, quarterly online one-on-one coaching sessions will be offered to participants to answer questions and provide support in applying the information to their daily lives. A small portion of participants will be invited to participate in the brain imaging portion of this study. The main objectives are: (i) to characterize lifestyle, cognitive, and behavioral markers related to an individual's cognitive function from adolescent to elderly ages, (ii) to assess the neural/biological determinants predictive of maintenance of brain health, and (iii) to evaluate the impact of available cognitive and lifestyle interventions on improving and maintaining brain health and performance.

NCT ID: NCT04867733 Recruiting - Healthy Clinical Trials

Visualizing Dermal Micropores With OCT

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

The study to be performed will allow visualization of skin micropores following microneedle treatment in healthy subjects in differing racial/ethnic backgrounds.

NCT ID: NCT04867655 Active, not recruiting - Healthy Clinical Trials

Acute Effect of Orange Juice Mixed With Oat β-Glucan on Bioavailability of Polyphenols in Healthy Individuals

Start date: July 10, 2019
Phase: N/A
Study type: Interventional

Brief summary Orange juice is the most widely consumed fruit juice, accounting for around a third of the total fruit juice market and is a rich source of vitamin C and bioactive compounds, predominantly flavonoids. Current research into the health effects of fruit juice consumption has presented some conflicting conclusions. Although potential health benefits have been attributed to the anti-inflammatory and anti-oxidant properties of the bioactive components in juice, other studies have suggested that the benefits of consuming orange are outweighed by the negative implications of the high sugar content leading to increases in blood glucose and insulin. At the same time it is well established that supplementation with a mean dose of 5g of β-Glucan, a soluble fibre derived from cereals such as oats or barley, significantly reduces insulin and glucose in healthy subjects and metabolic compromised individuals. Thus, the formulation of an OJ beverage with an added β-Glucan supplement may be a useful strategy to attenuate the detrimental impact of high sugar content. However, while delaying the absorption of glucose brings about favourable effects on post-prandial glycemia, dietary fibre may also reduce the bioavailability of some beneficial compounds, including polyphenols. So far, it remains unclear how addition of β-Glucan impacts bioavailability of orange juice flavanones. Thus, this study aims to determine how the bioavailability of orange juice polyphenols of healthy adults is affected mixing orange juice with 3 g and 6 g of oat β-Glucan.

NCT ID: NCT04866160 Not yet recruiting - Healthy Clinical Trials

A Trial in Healthy Men and Women to Find Out How Well Different Doses of BI 1291583 Are Tolerated

Start date: May 17, 2021
Phase: Phase 1
Study type: Interventional

The main objectives of this trial are to investigate safety, tolerability and pharmacokinetics (PK) of BI 1291583 in healthy male and female subjects following administration of multiple rising doses over 4 weeks and to explore the pharmacokinetics (PK) and pharmacodynamics (PD) of BI 1291583 after multiple dosing and assess the PK/PD relationship.

NCT ID: NCT04865744 Not yet recruiting - Healthy Clinical Trials

The Effect of Semaglutide on Pituitary Function

Start date: May 10, 2021
Phase: Phase 4
Study type: Interventional

The primary aim of the study is to describe the effect of a single oral dose of semaglutide 7 mg on growth hormone secretion.

NCT ID: NCT04865666 Completed - Healthy Clinical Trials

Examining the Real-World Effectiveness of the Movr App

Start date: September 25, 2019
Phase: N/A
Study type: Interventional

The objective of this 8-week pilot pragmatic randomized controlled trial was to examine the real-world impact of movr on functional movement, flexibility, strength, and cardiovascular fitness.