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NCT ID: NCT06460246 Not yet recruiting - Healthy Clinical Trials

Pulse Oximeter Accuracy During Stable Hypoxia Plateaus

Start date: June 25, 2024
Phase: N/A
Study type: Interventional

This project aims to test the accuracy of pulse oximeters in the range of arterial HbO2 saturations from 100% down to 70%.

NCT ID: NCT06457204 Not yet recruiting - Healthy Clinical Trials

A Study in Healthy People to Compare Two Different Sifrol® Tablets

Start date: June 27, 2024
Phase: Phase 1
Study type: Interventional

The main objective of this trial is to establish the bioequivalence of Sifrol® tablets manufactured at two different sites.

NCT ID: NCT06453356 Not yet recruiting - Healthy Clinical Trials

A Study to Learn How the Study Medicine Called Zavegepant is Taken Up Into Blood and Breast Milk of Healthy Breast-Feeding Women

Start date: June 11, 2024
Phase: Phase 1
Study type: Interventional

The purpose of the study is to look at the amount of zavegepant that is present in breast milk after single dose of zavegepant is sprayed through the nose in healthy breast-feeding women. This would allow to see if there are any possible risk to infants from medicines during breast-feeding. The study is seeking for about 12 healthy breast-feeding females who are: - 18 to 55 years of age. - actively breast-feeding or producing breast milk. - at least 2 weeks post-partum and not pregnant at present. Participants will not be allowed to breast-feed their infant from the evening of the day before to the first dose till 48 hours (2 days) after the dose. Eligible participants will check into the clinical research unit (CRU) on Day -1. Participants will receive the zavegepant dose sprayed into the nose at the CRU on Day 1. The participants will stay at the CRU until the morning of Day 2. There will be collections of breast milk and plasma over 24 hours. Participants will be sent from the CRU on Day 2 and may begin to breastfeed their infant 48 hours (2 days) after the dose. A safety follow-up call will be done at about 28 to 35 days from the day the first dose of study medicine was given.

NCT ID: NCT06452745 Recruiting - Healthy Clinical Trials

Early Diagnosis of Colorectal Cancer Based on a Non-invasive Metabolomics Profile

EarlyCRC
Start date: July 20, 2019
Phase:
Study type: Observational

Colorectal cancer is the most frequent tumor in our environment if both sexes are considered together. Every year almost 800 cases are diagnosed in the districts of Tarragona. A little more than half of colorectal cancers are cured with surgery, with or without the addition of complementary treatments with chemotherapy and/or radiation therapy. Those who are not cured is because at the time of diagnosis the disease has already spread or they spread after having been treated surgically with curative intent. The purpose of the EarlyCRC project is to determine whether metabolites (substances of low molecular weight) can be found in the urine and stool of patients with colorectal cancer or polyps that can be easily and cheaply differentiated (urine or stool analysis) between the patients affected by colorectal cancer or polyps, from healthy individuals. For the identification of these possible metabolites, the urine analysis will be performed using the usual techniques in metabolomics, which studies the existing metabolites in biological processes.

NCT ID: NCT06452199 Not yet recruiting - Healthy Clinical Trials

The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial

BEGIN
Start date: June 2024
Phase: N/A
Study type: Interventional

The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B. infantis), given to healthy newborns can affect various health outcomes and to explore impacts of the infant gastrointestinal microbiome. The main questions it aims to answer are: - Does B. infantis probiotics impact immune function and does it lower the number of bacterial infections and use of antibiotics? - Does B. infantis probiotics impact overall health, development, growth and wellbeing? - Does B. infantis probiotics impact inflammatory diseases, allergies and autoimmune diseases Researchers will compare B. infantis probiotics to a placebo (a look-alike substance that contains no probiotic) to see if B. infantis colonization impact the human immunesystem and various clinical and biochemical health markers. Participants (parents) will - Orally administrate the B. infantis probiotic to their newborn child daily in three weeks from 7 days of age. - Answer baseline and follow up questionnaires in a study app - Take five stool samples from the child and one stool sample from the mother - Collect a 4 week of passive dust sample at home (Electrostatic Dust fall Collector) - Donate one dried bloodspot and one blood sample from their child

NCT ID: NCT06450743 Completed - Healthy Clinical Trials

Age-matched Reference Values for Circulating Natural Killer T-like Cells

NKT
Start date: May 3, 2024
Phase: N/A
Study type: Interventional

Few data are so far available regarding the adult normal values of circulating NKT-like cell concentration, and none for the pediatric population. The primary objective of this study is to determine the reference values for NKT-like cells in pediatric and adult patients (derivation cohort). The secondary objective is to validate the results obtained from the adult derivation cohort with those obtained from an adult validation cohort, consisting of a group of healthy adult volunteers.

NCT ID: NCT06449703 Recruiting - Healthy Clinical Trials

A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide in Healthy Chinese Subjects

Start date: May 6, 2024
Phase: Phase 1
Study type: Interventional

The main purpose of the trial is to compare the pharmacokinetics of insulin degludec and liraglutide as part of a combination product insulin degludec/liraglutide compared with Xultophy®. During the trial period, serials of blood samples will be collected from the participants at two dosing periods, in order to determine the concentration of insulin degludec and liraglutide. The total volume of blood taken throughout the whole trial period will be less than 400 mL. Participants will be asked to stay on daytime and overnight in the trial sites on some predefined days. For other outpatient days, participants need to attend the trial site as required for drug administration or required assessments.

NCT ID: NCT06449300 Completed - Healthy Clinical Trials

Effects of Different Volumes of Resistance Training

Start date: November 11, 2021
Phase: N/A
Study type: Interventional

This study explores the effects of varying volumes of resistance training on body composition, strength, peak power, and muscle thickness in untrained women over eight weeks. A randomized controlled trial involving 45 female college students assessed the outcomes across three groups: low-volume training (LVT) with three weekly sessions, moderate-volume training (MVT) with four weekly sessions, and high-volume training (HVT) with five weekly sessions. Participants were untrained, aged 18-65, and free from cardiovascular diseases or performance-enhancing drugs. The hypothesis suggested that moderate volume training would yield optimal muscle development, considering the potential non-linear dose-response relationship where excessive training might be detrimental. Measurements included body composition, muscle thickness, and peak power through a force platform during vertical jumps. Data analysis focused on changes in muscle thickness, strength, and body composition, with statistical significance set at p < 0.05. The study aimed to provide insights into how different training volumes affect physiological adaptations in untrained women, potentially guiding fitness regimen optimizations for similar populations.

NCT ID: NCT06448247 Recruiting - Healthy Clinical Trials

A Study of SPY001-001 in Healthy Volunteers

Start date: June 6, 2024
Phase: Phase 1
Study type: Interventional

This is a Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose, first in human safety, tolerability, and pharmacokinetic study of SPY001-001 in healthy participants.

NCT ID: NCT06448000 Completed - Healthy Clinical Trials

Effect of Long-time Human Sperm Storage in Liquid Nitrogen on Semen Parameters

CRYOFERT
Start date: January 2010
Phase:
Study type: Observational

Sperm cryopreservation is an essential tool for men fertility preservation in the context of gonadotoxic treatments or/and pathologies such as cancers, gamete donation and ART. Nevertheless, it is validated that the freezing and thawing procedures affect sperm parameters and in particular motility. It is therefore essential to determine the impact of storage time on motility and particularly the number of progressive motile spermatozoa which will determine the choice of ART technique. However, few studies have analyzed the impact of storage time in liquid nitrogen and no study over a long period on human spermatozoa and their use in ART. The aim of this study is to assess the impact of long-time storage, from 2 to 12 years, in liquid nitrogen on standard semen parameters, notably motility.