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NCT ID: NCT04978506 Suspended - Healthy Clinical Trials

A Study in Healthy Men to Test How Well Different Doses of BI 1569912 Are Tolerated

Start date: August 11, 2021
Phase: Phase 1
Study type: Interventional

The main objectives of this trial are to investigate (1) safety, tolerability, pharmacokinetics and pharmacodynamics following multiple rising doses of BI 1569912; (2) tolerability of BI 1569912 in an up-titrating dosing scheme.

NCT ID: NCT04894656 Suspended - Healthy Clinical Trials

Intestinal Permeability and Gastroparesis

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate potential mechanisms that could lead to the development of a condition known as gastroparesis.

NCT ID: NCT04586920 Suspended - Healthy Clinical Trials

A Study of LY3509754 in Healthy Non-Japanese and Japanese Participants

Start date: October 20, 2020
Phase: Phase 1
Study type: Interventional

The main purpose of this study in healthy participants is to learn more about the safety of LY3509754 and any side effects that might be associated with it. Blood tests will be performed to check how much LY3509754 gets into the bloodstream and how long it takes the body to eliminate it.

NCT ID: NCT04543383 Suspended - Healthy Clinical Trials

A Study to Assess the Reversal of the Anticoagulant Effects of JNJ-70033093 by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants

Start date: July 27, 2020
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to evaluate the reversal of the anticoagulant effects of JNJ-70033093 by 4-Factor Prothrombin Complex Concentrate (4F-PCC) and Recombinant Human Factor VIIa (rFVIIa) in healthy participants as measured by changes from baseline of the coagulation testing parameters (activated partial thromboplastin time [aPTT] and thrombin generation assay [TGA]).

NCT ID: NCT04480736 Suspended - Healthy Clinical Trials

A Study of JNJ-64281802 Against Dengue Serotype 1 Infection in a Dengue Human Challenge Model in Healthy Adult Participants

Start date: July 28, 2020
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the antiviral activity of JNJ-64281802 versus placebo in terms of reduction of dengue virus 1 (DENV-1) ribonucleic acid (RNA) viral load (VL).

NCT ID: NCT03998709 Suspended - Healthy Clinical Trials

Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion

Start date: February 1, 2020
Phase: Phase 4
Study type: Interventional

Researchers are trying to determine how changes in fasting glucose and free fatty acids (products released from fat) affect insulin secretion.

NCT ID: NCT03165968 Suspended - Healthy Clinical Trials

Test and Evaluation of Non-Invasive Neuro-Assessment Devices (NINAD): NeuroKinetics, Inc, iPAS

Start date: February 22, 2018
Study type: Observational

The long term goal for the Traumatic Injury Research Program (TIRP) is testing of novel devices for the identification and longitudinal assessment of traumatic brain injury (TBI). The Department of Defense (DoD) has now tasked TIRP with the test and evaluation of these devices to assess reliability and validity. The objective of this effort is to test the reliability of the NeuroKinetics Inc (NKI), i-PAS (portable assessment system) device using a test/re-test protocol with healthy controls. The basic research design adopted here is the test/re-test paradigm with three assessments obtained on three separate visits. This will allow the assessment of reliability of both the device and the measure(s) that are computed from the input signals. Participants will be Healthy Controls (HC) as defined in the inclusion exclusion section. In this initial study we will be administering standardized self-report instruments ( Short Form - 36 (SF-36) and the Symptom Checklist-90 (SCL-90r)), standard three-lead electrocardiogram. In addition we will administer the NKI i-PAS specific protocol as delineated by NKI.

NCT ID: NCT03133559 Suspended - Healthy Clinical Trials

Mapping the Human HIV Chronobiome

Start date: April 19, 2017
Study type: Observational

Individuals infected with HIV have a high risk of developing metabolic comorbidities not traditionally associated with the immune dysregulation and deficiency associated with HIV infection and AIDS. Many of these comorbidities in HIV uninfected individuals have been linked to a disordered circadian clock function. The study investigators will further evaluate the circadian clock in HIV infection as a mechanism underlying the metabolic dysregulation in this population.

NCT ID: NCT02502435 Suspended - Healthy Clinical Trials

Human Plasma Fatty Acid Oscillations

Start date: July 2015
Study type: Observational

This study wishes to look at the 24-hour rhythm of certain fats in the blood stream. Recent studies in animals and healthy participants suggest that unusual eating habits may be connected to a change in the 24-hour rhythm of the blood fats the investigators wish to measure. The investigators will ask persons suffering from night eating syndrome, a condition where people eat additional meals throughout the night, to participate in this study. Healthy volunteers who are of the same age and gender, and have a comparable body-mass-index, a number calculated from a person's weight and height, will also be asked to participate. The aim is to learn how the 24-hour rhythm of the blood fats the investigators measure differs between the persons experiencing the night eating episodes and persons who do not.

NCT ID: NCT02091817 Suspended - Healthy Clinical Trials

The Effect of Oxytocin on Face Perception

Start date: November 2013
Phase: Phase 0
Study type: Interventional

The purpose of this study is to determine whether oxytocin affect face perception