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NCT ID: NCT04330248 Suspended - Healthy Clinical Trials

A Study of Steady-state Rifampin on the Single-dose of Erdafitinib Tablets in Healthy Adult Participants

Start date: April 3, 2020
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to evaluate the effect of multiple doses of rifampin (a strong inducer of CYP3A4 and a moderate inducer of CYP2C9) on the pharmacokinetics of a single oral dose of erdafitinib in healthy adult participants.

NCT ID: NCT04307628 Suspended - Healthy Clinical Trials

Response of Gut Microbiota and Cardiometabolic Biomarkers to Consumption of Walnuts

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The researchers will investigate blood and fecal responses in qualified study participants after eating walnuts for 4 weeks compared to not eating walnuts for 4 weeks. The two dietary interventions will be separated by a 4 week washout period. The order of diets will be random; study participants will complete both interventions. Dietary modifications will be part of the study protocol.

NCT ID: NCT03983070 Suspended - Healthy Clinical Trials

The Effects of Lower Extremity Blood Flow Restriction Training on Power, and Muscle Size.

Start date: June 1, 2019
Phase: N/A
Study type: Interventional

Blood-flow restriction training (BFR) is a technique utilized to provide the benefits of high intensity exercise (strength, power, hypertrophy) when applied to exercise intensities that are insufficient to produce these benefits without BFR. The technique involves the application of an occlusive cuff (similar in design to a blood pressure cuff) over the limb of an individual that is set to occlude arterial blood flow at a given percentage during exercise. BFR has demonstrated increased strength and muscle hypertrophy compared to control interventions in various populations including: healthy subjects, athletes, post-surgery, clinical rehabilitation, and older adults. Most research on BFR has been conducted on single joint exercises and not exercises that exhibit more complex movements typically associated with daily activities. The early evidence of complex exercises combined with BFR suggests that strength and hypertrophy both improve, however more research needs to be conducted. The purpose of this project is to determine if four weeks of BFR training combined with approach rowing and deadlifts increases strength, power, aerobic capacity, and muscle size. These results will be compared to an isovolumetric control.

NCT ID: NCT03722953 Suspended - Healthy Clinical Trials

Cerebrovascular Response to Acute Exercise

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

NCT ID: NCT03165968 Suspended - Healthy Clinical Trials

Test and Evaluation of Non-Invasive Neuro-Assessment Devices (NINAD): NeuroKinetics, Inc, iPAS

NINADiPAS
Start date: February 22, 2018
Phase:
Study type: Observational

The long term goal for the Traumatic Injury Research Program (TIRP) is testing of novel devices for the identification and longitudinal assessment of traumatic brain injury (TBI). The Department of Defense (DoD) has now tasked TIRP with the test and evaluation of these devices to assess reliability and validity. The objective of this effort is to test the reliability of the NeuroKinetics Inc (NKI), i-PAS (portable assessment system) device using a test/re-test protocol with healthy controls. The basic research design adopted here is the test/re-test paradigm with three assessments obtained on three separate visits. This will allow the assessment of reliability of both the device and the measure(s) that are computed from the input signals. Participants will be Healthy Controls (HC) as defined in the inclusion exclusion section. In this initial study we will be administering standardized self-report instruments ( Short Form - 36 (SF-36) and the Symptom Checklist-90 (SCL-90r)), standard three-lead electrocardiogram. In addition we will administer the NKI i-PAS specific protocol as delineated by NKI.

NCT ID: NCT03133559 Suspended - Healthy Clinical Trials

Mapping the Human HIV Chronobiome

Start date: April 19, 2017
Phase:
Study type: Observational

Individuals infected with HIV have a high risk of developing metabolic comorbidities not traditionally associated with the immune dysregulation and deficiency associated with HIV infection and AIDS. Many of these comorbidities in HIV uninfected individuals have been linked to a disordered circadian clock function. The study investigators will further evaluate the circadian clock in HIV infection as a mechanism underlying the metabolic dysregulation in this population.

NCT ID: NCT02502435 Suspended - Healthy Clinical Trials

Human Plasma Fatty Acid Oscillations

Start date: July 2015
Phase:
Study type: Observational

This study wishes to look at the 24-hour rhythm of certain fats in the blood stream. Recent studies in animals and healthy participants suggest that unusual eating habits may be connected to a change in the 24-hour rhythm of the blood fats the investigators wish to measure. The investigators will ask persons suffering from night eating syndrome, a condition where people eat additional meals throughout the night, to participate in this study. Healthy volunteers who are of the same age and gender, and have a comparable body-mass-index, a number calculated from a person's weight and height, will also be asked to participate. The aim is to learn how the 24-hour rhythm of the blood fats the investigators measure differs between the persons experiencing the night eating episodes and persons who do not.

NCT ID: NCT02091817 Suspended - Healthy Clinical Trials

The Effect of Oxytocin on Face Perception

Start date: November 2013
Phase: Phase 0
Study type: Interventional

The purpose of this study is to determine whether oxytocin affect face perception

NCT ID: NCT01340183 Suspended - Healthy Clinical Trials

Clinical Study Assessing the Safety, Tolerability, and Pharmacokinetics of Intravenous AZD5099 in Healthy Subjects

Start date: May 2011
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of the drug AZD5099 after intravenous administration of single doses in healthy volunteers. The results from this study will form the basis for decisions regarding the future development of AZD5099 as a novel antibiotic for the treatment of serious infections in humans.

NCT ID: NCT00684333 Suspended - Healthy Clinical Trials

Safety and Efficacy of EZ-Ject Injector a Pain-Free Subcutaneous Automatic Injection in Healthy Volunteers

Start date: June 2009
Phase: N/A
Study type: Interventional

Subcutaneous injections are a widely used method for drug delivery. One of its major drawbacks is the pain inflicted during the process. Sindolor has developed the chemical-free EZ-Ject Injector device, based on employing cutaneous local anesthesia on the injection site by an electronic anesthetic system. The purpose of this study is to determine the safety and efficacy of the EZ-Ject for subcutaneous injections.