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NCT ID: NCT04978506 Suspended - Healthy Clinical Trials

A Study in Healthy Men to Test How Well Different Doses of BI 1569912 Are Tolerated

Start date: August 11, 2021
Phase: Phase 1
Study type: Interventional

The main objectives of this trial are to investigate (1) safety, tolerability, pharmacokinetics and pharmacodynamics following multiple rising doses of BI 1569912; (2) tolerability of BI 1569912 in an up-titrating dosing scheme.

NCT ID: NCT04920578 Suspended - Healthy Clinical Trials

A Study of JNJ-69095897 in Healthy Participants

Start date: June 16, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the safety and tolerability of JNJ-69095897 versus placebo and to characterize the pharmacokinetic (PK) of JNJ-69095897 in blood, plasma, cerebrospinal fluid (CSF) and urine after single oral dose administration (ascending dose levels) in healthy participants.

NCT ID: NCT04730804 Suspended - Healthy Clinical Trials

A Study of ALXN1830 in Healthy Adult Participants

Start date: March 17, 2021
Phase: Phase 1
Study type: Interventional

This trial will study the effects of single and multiple doses of ALXN1830 in healthy adult participants.

NCT ID: NCT04586920 Suspended - Healthy Clinical Trials

A Study of LY3509754 in Healthy Non-Japanese and Japanese Participants

Start date: October 20, 2020
Phase: Phase 1
Study type: Interventional

The main purpose of this study in healthy participants is to learn more about the safety of LY3509754 and any side effects that might be associated with it. Blood tests will be performed to check how much LY3509754 gets into the bloodstream and how long it takes the body to eliminate it.

NCT ID: NCT04543383 Suspended - Healthy Clinical Trials

A Study to Assess the Reversal of the Anticoagulant Effects of JNJ-70033093 by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants

Start date: July 27, 2020
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to evaluate the reversal of the anticoagulant effects of JNJ-70033093 by 4-Factor Prothrombin Complex Concentrate (4F-PCC) and Recombinant Human Factor VIIa (rFVIIa) in healthy participants as measured by changes from baseline of the coagulation testing parameters (activated partial thromboplastin time [aPTT] and thrombin generation assay [TGA]).

NCT ID: NCT04330248 Suspended - Healthy Clinical Trials

A Study of Steady-state Rifampin on the Single-dose of Erdafitinib Tablets in Healthy Adult Participants

Start date: April 3, 2020
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to evaluate the effect of multiple doses of rifampin (a strong inducer of CYP3A4 and a moderate inducer of CYP2C9) on the pharmacokinetics of a single oral dose of erdafitinib in healthy adult participants.

NCT ID: NCT04307628 Suspended - Healthy Clinical Trials

Response of Gut Microbiota and Cardiometabolic Biomarkers to Consumption of Walnuts

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The researchers will investigate blood and fecal responses in qualified study participants after eating walnuts for 4 weeks compared to not eating walnuts for 4 weeks. The two dietary interventions will be separated by a 4 week washout period. The order of diets will be random; study participants will complete both interventions. Dietary modifications will be part of the study protocol.

NCT ID: NCT03983070 Suspended - Healthy Clinical Trials

The Effects of Lower Extremity Blood Flow Restriction Training on Power, and Muscle Size.

Start date: June 1, 2019
Phase: N/A
Study type: Interventional

Blood-flow restriction training (BFR) is a technique utilized to provide the benefits of high intensity exercise (strength, power, hypertrophy) when applied to exercise intensities that are insufficient to produce these benefits without BFR. The technique involves the application of an occlusive cuff (similar in design to a blood pressure cuff) over the limb of an individual that is set to occlude arterial blood flow at a given percentage during exercise. BFR has demonstrated increased strength and muscle hypertrophy compared to control interventions in various populations including: healthy subjects, athletes, post-surgery, clinical rehabilitation, and older adults. Most research on BFR has been conducted on single joint exercises and not exercises that exhibit more complex movements typically associated with daily activities. The early evidence of complex exercises combined with BFR suggests that strength and hypertrophy both improve, however more research needs to be conducted. The purpose of this project is to determine if four weeks of BFR training combined with approach rowing and deadlifts increases strength, power, aerobic capacity, and muscle size. These results will be compared to an isovolumetric control.

NCT ID: NCT03722953 Suspended - Healthy Clinical Trials

Cerebrovascular Response to Acute Exercise

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

NCT ID: NCT03165968 Suspended - Healthy Clinical Trials

Test and Evaluation of Non-Invasive Neuro-Assessment Devices (NINAD): NeuroKinetics, Inc, iPAS

NINADiPAS
Start date: February 22, 2018
Phase:
Study type: Observational

The long term goal for the Traumatic Injury Research Program (TIRP) is testing of novel devices for the identification and longitudinal assessment of traumatic brain injury (TBI). The Department of Defense (DoD) has now tasked TIRP with the test and evaluation of these devices to assess reliability and validity. The objective of this effort is to test the reliability of the NeuroKinetics Inc (NKI), i-PAS (portable assessment system) device using a test/re-test protocol with healthy controls. The basic research design adopted here is the test/re-test paradigm with three assessments obtained on three separate visits. This will allow the assessment of reliability of both the device and the measure(s) that are computed from the input signals. Participants will be Healthy Controls (HC) as defined in the inclusion exclusion section. In this initial study we will be administering standardized self-report instruments ( Short Form - 36 (SF-36) and the Symptom Checklist-90 (SCL-90r)), standard three-lead electrocardiogram. In addition we will administer the NKI i-PAS specific protocol as delineated by NKI.