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NCT ID: NCT04853524 Withdrawn - Healthy Clinical Trials

A Study of JNJ-56136379 in Healthy Participants

Start date: May 6, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the effect of multiple-dose JNJ-56136379 on the single-dose pharmacokinetics (PK) of the combination of bictegravir (BIC), emtricitabine (FTC), tenofovir alafenamide (TAF) in healthy adult participants.

NCT ID: NCT04712006 Withdrawn - Healthy Clinical Trials

A Study of JNJ-64304500 Following Subcutaneous Injection in Healthy Chinese Adult Participants

Start date: March 1, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the pharmacokinetic following single subcutaneous administration of Dose 1 or Dose 2 of JNJ-64304500 in healthy Chinese adult participants.

NCT ID: NCT04393597 Withdrawn - Healthy Clinical Trials

Effects of Food on the Pharmacokinetics of DWJ1458 in Healthy Adults

Start date: May 28, 2020
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the food effect on the pharmacokinetics of DWJ1458 after oral administration in healthy volunteers.

NCT ID: NCT04391868 Withdrawn - Healthy Clinical Trials

A Bioequivalence Study of Sildenafil Citrate Orally-Disintegrating Film Dosage Form

Start date: January 30, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the bioequivalence of Sildenafil ODF 50 mg to Viagra® tablet 50 mg under fasted conditions.

NCT ID: NCT04155268 Withdrawn - Healthy Clinical Trials

Flotation-REST for Chronic Pain, Stress, and Sleep

Start date: March 9, 2020
Phase: N/A
Study type: Interventional

This randomized crossover trial aims to examine the effects of Flotation-REST (Reduced, Environmental, Stimulation, Technique/Therapy) compared to laying in a dark room (with reduced environmental stimulation) for those with chronic musculoskeletal pain. This design will allow for comparisons between the two interventions on daily diary assessments of pain, stress, and sleep, both between groups and within individuals.

NCT ID: NCT03995550 Withdrawn - Healthy Clinical Trials

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics After Single and Multiple Doses of LEO 142397 in Healthy People, Including Japanese

Start date: August 1, 2019
Phase: Phase 1
Study type: Interventional

This is the first clinical trial with LEO 142397. The purpose of the trial is to assess the safety and tolerability of LEO 142397, along with the pharmacokinetics (what the body does to the drug) and the pharmacodynamics (what the drug does to the body) in healthy people. The trial consists of 2 parts: - In Part 1, participants will receive a single dose of LEO 142397. There will be up to 8 different dose groups. - In Part 2, participants will receive a daily dose of LEO 142397 for 14 days. There will be up to 6 different dose groups. Each participant will be enrolled into 1 dose group in either Part 1 or Part 2.

NCT ID: NCT03939780 Withdrawn - Healthy Clinical Trials

Tau Tracer Comparison in Healthy Controls and Alzheimer's Disease Patients

Start date: January 2020
Phase: N/A
Study type: Interventional

The primary objective of this study is to identify a new radioligand for imaging of tauopathy in Alzheimer's disease through direct comparisons of two potential candidates, [18F]RO-948 (formerly known as [18F]6958948) and [18F]MK-6240, and demonstration of the candidates' absence of off-target binding.

NCT ID: NCT03890341 Withdrawn - Healthy Clinical Trials

Study in Women on the Effect of JNJ-64530440 on Oral Contraceptive and Midazolam, and the Effect of a High-fat Meal on JNJ-64530440

Start date: June 1, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the effect of JNJ-64530440 single- and multiple-dose administration on the single-dose pharmacokinetics of drospirenone and ethinylestradiol (oral contraceptive) in healthy female participants.

NCT ID: NCT03794154 Withdrawn - Healthy Clinical Trials

A Study Of Duloxetine Hydrochloride Hard Gelatinous Capsule Compared To Cymbalta Under Fed Conditions

Start date: March 30, 2020
Phase: Phase 4
Study type: Interventional

In Brazil, duloxetine is currently available as hard gelatinous capsule with delayed release microgranules for oral administration containing enteric-coated pellets of 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 30 mg or 60 mg of duloxetine (Cymbalta®), respectively. The Sponsor has developed a hard gelatinous capsule with delayed release microgranules formulation containing enteric-coated pellets of 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 30, or 60 mg of duloxetine, respectively. The purpose of this study is to verify through a single dose study, if the test formulation of duloxetine is bioequivalent to the reference formulation (Cymbalta®) when administered with the same dosage and under fed conditions in healthy male research subjects.

NCT ID: NCT03747926 Withdrawn - Healthy Clinical Trials

This Study is Done in Healthy Japanese Volunteers. It Looks at How Different Doses of BI 705564 Are Taken up in the Body and How Well They Are Tolerated

Start date: April 5, 2019
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to investigate the safety and tolerability of BI 705564 in healthy male subjects following oral administration of single rising doses. A secondary objective is the exploration of the PK including dose proportionality of BI 705564 after single dosing.