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NCT ID: NCT04853524 Withdrawn - Healthy Clinical Trials

A Study of JNJ-56136379 in Healthy Participants

Start date: May 6, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the effect of multiple-dose JNJ-56136379 on the single-dose pharmacokinetics (PK) of the combination of bictegravir (BIC), emtricitabine (FTC), tenofovir alafenamide (TAF) in healthy adult participants.

NCT ID: NCT04712006 Withdrawn - Healthy Clinical Trials

A Study of JNJ-64304500 Following Subcutaneous Injection in Healthy Chinese Adult Participants

Start date: May 30, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the pharmacokinetic following single subcutaneous administration of Dose 1 or Dose 2 of JNJ-64304500 in healthy Chinese adult participants.

NCT ID: NCT04393597 Withdrawn - Healthy Clinical Trials

Effects of Food on the Pharmacokinetics of DWJ1458 in Healthy Adults

Start date: May 28, 2020
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the food effect on the pharmacokinetics of DWJ1458 after oral administration in healthy volunteers.

NCT ID: NCT04391868 Withdrawn - Healthy Clinical Trials

A Bioequivalence Study of Sildenafil Citrate Orally-Disintegrating Film Dosage Form

Start date: January 30, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the bioequivalence of Sildenafil ODF 50 mg to Viagra® tablet 50 mg under fasted conditions.

NCT ID: NCT04183153 Withdrawn - Healthy Clinical Trials

Neuroendocrine Mapping of the Cerebral Cortex

Start date: August 2020
Phase: N/A
Study type: Interventional

This study is investigating brain regions that share functional connectivity with the hypothalamus and the stimulation of those regions using repetitive transcranial magnetic stimulation (rTMS) to activate the hypothalamus indirectly. The goal of this study is to determine the effectiveness of rTMS in influencing the hypothalamus to better understand the mechanisms between it and the neuroendocrine processes it controls.

NCT ID: NCT04155268 Withdrawn - Healthy Clinical Trials

Flotation-REST for Chronic Pain, Stress, and Sleep

Start date: March 9, 2020
Phase: N/A
Study type: Interventional

This randomized crossover trial aims to examine the effects of Flotation-REST (Reduced, Environmental, Stimulation, Technique/Therapy) compared to laying in a dark room (with reduced environmental stimulation) for those with chronic musculoskeletal pain. This design will allow for comparisons between the two interventions on daily diary assessments of pain, stress, and sleep, both between groups and within individuals.

NCT ID: NCT04056000 Withdrawn - Healthy Clinical Trials

Lipodystrophy and Fat Metabolism During Exercise

FAT
Start date: September 1, 2019
Phase: N/A
Study type: Interventional

Mandibular dysplasia with deafness and progeroid features (MDP) syndrome is a rare genetic metabolic disorder that causes lipodystrophy: the inability of the body to store subcutaneous adipose tissue (fat under the skin). This creates a unique scenario where any ingested fat is diverted to the abdomen and liver, often leading to diabetes. The investigators have an opportunity to study an individual with MDP who has competed in and won national para-cycling championships and is able to prevent/control his diabetes by regular bicycle training. He has approached us for advice on nutritional strategies to improve his cycling performance, and insight into how he uses fat during exercise. The investigators also wish to study a moderately-trained cyclist with Familial partial lipodystrophy (FPL). Those with FPL show a different pattern of lipodystrophy than those with MDP, allowing us to further increase the investigator's understanding of fat utilisation in those with lipodystrophy during exercise. The investigators know how subcutaneous fat is used during exercise, and how duration, nutrition, carbohydrate availability, and exercise intensity can affect this. The investigators aim to investigate these processes during exercise in MDP and FPL. This will potentially provide nutrition and performance advice to the individuals, and insight on fat use in lipodystrophy and diabetes.

NCT ID: NCT03995550 Withdrawn - Healthy Clinical Trials

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics After Single and Multiple Doses of LEO 142397 in Healthy People, Including Japanese

Start date: August 1, 2019
Phase: Phase 1
Study type: Interventional

This is the first clinical trial with LEO 142397. The purpose of the trial is to assess the safety and tolerability of LEO 142397, along with the pharmacokinetics (what the body does to the drug) and the pharmacodynamics (what the drug does to the body) in healthy people. The trial consists of 2 parts: - In Part 1, participants will receive a single dose of LEO 142397. There will be up to 8 different dose groups. - In Part 2, participants will receive a daily dose of LEO 142397 for 14 days. There will be up to 6 different dose groups. Each participant will be enrolled into 1 dose group in either Part 1 or Part 2.

NCT ID: NCT03939780 Withdrawn - Healthy Clinical Trials

Tau Tracer Comparison in Healthy Controls and Alzheimer's Disease Patients

Start date: January 2020
Phase: N/A
Study type: Interventional

The primary objective of this study is to identify a new radioligand for imaging of tauopathy in Alzheimer's disease through direct comparisons of two potential candidates, [18F]RO-948 (formerly known as [18F]6958948) and [18F]MK-6240, and demonstration of the candidates' absence of off-target binding.

NCT ID: NCT03890341 Withdrawn - Healthy Clinical Trials

Study in Women on the Effect of JNJ-64530440 on Oral Contraceptive and Midazolam, and the Effect of a High-fat Meal on JNJ-64530440

Start date: June 1, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the effect of JNJ-64530440 single- and multiple-dose administration on the single-dose pharmacokinetics of drospirenone and ethinylestradiol (oral contraceptive) in healthy female participants.