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NCT ID: NCT05693961 Completed - Healthy Clinical Trials

An Invasive Controlled Desaturation Study to Determine the Accuracy of the CART-I Pulse Oximeter

Start date: June 12, 2021
Phase: N/A
Study type: Interventional

A pulse oximeter is used for continuous monitoring of peripheral oxygen saturation (SpO2) and plays an important role in the early detection of hypoxia, guiding the titration of supplemental oxygen, and reducing the need for blood gas analysis. Therefore, the SpO2 accuracy of a pulse oximeter should be validated for patient safety. The objective of this study is to evaluate whether the CART-I pulse oximeter with a ring-type wearable PPG sensor (Sky Labs Inc., Seoul, Korea) provides clinically reliable SpO2 readings over the range of 70-100% SaO2, during steady-state, non-motion conditions.

NCT ID: NCT05691777 Completed - Healthy Clinical Trials

Study of Cortical Activation During Hand and Shoulder Movements in Healthy Subjects

Start date: June 25, 2020
Study type: Observational

Characterization of cortical activation patterns during movements in healthy adults may help our understanding of how the injured brain works. Upper limb motor tasks are commonly used to assess impaired motor function and to predict recovery in individuals with neurological disorders such as stroke. This study aimed to explore cortical activation patterns associated with movements of the hand and shoulder using functional near-infrared spectroscopy (fNIRS). The investigators hypothesized that the activation pattern observed with fNIRS would differ for shoulder and hand movements. More specifically, the investigators hypothesized that the cerebral activation during hand movements would mainly involve the contralateral hemisphere, particularly the lateral part of primary motor cortex; whereas activation during shoulder movements would be more medial and more extensive than that of the hand.

NCT ID: NCT05684640 Completed - Healthy Clinical Trials

A Single and Multiple Dose of Rodatristat Ethyl in Healthy Adult Subjects to Evaluate the Effect of Food and Safety

Start date: September 29, 2022
Phase: Phase 1
Study type: Interventional

This is a single and multiple dose food effect study of rodatristat ethyl in healthy subjects

NCT ID: NCT05674669 Completed - Healthy Clinical Trials

A Dose-Ranging Study of 50 µg to 100 µg LSD in Healthy Volunteers

Start date: October 20, 2015
Phase: Phase 1
Study type: Interventional

This study with low-dose LSD comprised 2 substudies in healthy subjects. Subjects who met all inclusion and no exclusion criteria provided written informed consent. Part 1 was an open-label dose-escalation study in hallucinogen non-naïve subjects with significant prior experience with hallucinogens, during which each subject received a single dose of LSD: 50, 75, or 100 µg. Part 2 was a double blind, placebo controlled, randomised, crossover study in hallucinogen naïve subjects with no prior experience with hallucinogens in the last 7 years, during which each subject was assigned to 1 of 8 cohorts and then randomly assigned to receive single doses of LSD 50 µg followed by 75 µg, or placebo followed by 75 µg, with dosing separated by at least 7 days. Subjects were followed up on the day after each dosing, and 1 week and 1 month after the last dose of study treatment. A total of 32 subjects were enrolled.

NCT ID: NCT05673174 Completed - Healthy Clinical Trials

Avicena LVDP Validation Study in Healthy Volunteers

Start date: June 16, 2022
Study type: Observational

The purpose of this study is to document the utility of the Vivio System in quantifying LVDP in healthy volunteers.

NCT ID: NCT05645705 Completed - Healthy Clinical Trials

A Two-Week Study of Clinical Safety and Saliva Flow Quantification

Start date: November 28, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the oral tissue tolerance (tissues within the mouth) for irritation caused by added ingredients in mouthwashes. This will be assessed based on oral tissue exams and adverse reactions.

NCT ID: NCT05642689 Completed - Healthy Clinical Trials

Evaluation of Fe Absorption From Iron Salt in Milk

Start date: November 2009
Phase: N/A
Study type: Interventional

The primary objective was: - to compare iron absorption in apparently healthy children aged 3-6y from an instant full cream milk drink fortified with ferric pyrophosphate or ferric ammonium phosphate relative to ferrous sulfate as the reference fortificant. - To compare iron absorption from ferric pyrophosphate to ferric ammonium phosphate from the milk drink

NCT ID: NCT05642546 Completed - Healthy Clinical Trials

First-in-Human (FIH) Clinical Study of NM8074 in Healthy Adult Volunteers

Start date: August 12, 2020
Phase: Phase 1
Study type: Interventional

This is a Phase 1 randomized, double-blind, placebo-controlled, single administration, sequential cohort with sentinel dosing, dose escalation study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of NM8074 in healthy subjects. This study will include 5 cohorts, with each cohort consisting of a total of 8 healthy subjects, including both males and females, randomized in a 3:1 ratio of NM8074 to placebo (6 subjects assigned to NM8074 and 2 subjects assigned to placebo).

NCT ID: NCT05630287 Completed - Healthy Clinical Trials

A Study of Absorption, Metabolism, Excretion, and Absolute Bioavailability of Carbon-14-Labelled [14C] Selpercatinib (LY3527723) in Healthy Male Participants

Start date: August 1, 2018
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to compare the amount of selpercatinib that gets into the blood stream and how long it takes the body to get rid of it and also to assess the pharmacokinetics (PK), metabolism, and routes and extent of elimination of selpercatinib in healthy male participants. The study will last up to 59 days (Part 1) or 46 days (Part 2) including screening and 7-day safety follow-up.

NCT ID: NCT05630274 Completed - Healthy Clinical Trials

A Study of Effect of Selpercatinib (LY3527723) on Corrected QT (QTc) Interval in Healthy Participants

Start date: April 16, 2019
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to assess the effect of Selpercatinib (LY3527723) on the heart rate-corrected QT (QTc) interval. The study will last up to 41 days.