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NCT ID: NCT05436912 Completed - Healthy Clinical Trials

A Study of Effects of Selpercatinib in Hepatically Impaired Participants and Healthy Participants

Start date: December 10, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The main purpose of this study is to assess how selpercatinib gets into the blood stream and how long it takes the body to remove it when administered to participants with impaired hepatic function compared to healthy participants. Information about safety and tolerability will be collected. The study will last up to about 7 weeks, inclusive of screening period.

NCT ID: NCT05428306 Completed - Healthy Clinical Trials

Pharmacokinetic Interaction Between Ibuprofen and Acetaminophen, Tablets Administered Individually or in Combination

Start date: October 23, 2018
Phase: Phase 1
Study type: Interventional

This study was carried out in the Clinical and Analytical Unit of the Pharmacology and Toxicology Department of the Faculty of Medicine of the Autonomous University of Nuevo León, with the aim of comparing the bioavailability (Cmax, AUC) of an oral formulation containing ibuprofen 400 mg/ Acetaminophen 1000 mg in combination with the two oral formulations ibuprofen 400 mg or Acetaminophen 1000 mg administered as a single dose, in healthy subjects under fasting conditions

NCT ID: NCT05428293 Completed - Healthy Clinical Trials

Pharmacokinetic Interaction Between Ibuprofen and Acetaminophen Oral Suspension

Start date: February 22, 2019
Phase: Phase 1
Study type: Interventional

This study was carried out in the Clinical and Analytical Unit of the Pharmacology and Toxicology Department of the Faculty of Medicine of the Autonomous University of Nuevo León, in order to compare the bioavailability (Cmax, AUC) of an oral formulation containing Ibuprofen 100 mg/Acetaminophen 125 mg in combination with the two oral formulations Ibuprofen 100 mg or Acetaminophen 125 mg administered as a single dose, in healthy subjects under fasting conditions.

NCT ID: NCT05427604 Completed - Healthy Clinical Trials

To Evaluate the Effects of Omega 3 Fatty Acids in the Context of Cancer Prevention

Start date: February 23, 2021
Phase: N/A
Study type: Interventional

Previous studies have demonstrated, in an in vitro micro-tumour model (the spheroid) and in a mouse model, that long-chain omega-3 fatty acids, in particular docosahexaenoic acid (DHA), can inhibit tumour development. Therefore, the aim of this study was to collect DHA-enriched human serum, following ingestion of a DHA-enriched oil, in order to assess its effect on tumour development in vitro. Blood enriched in fatty acids not containing DHA will be used as a control condition, obtained after ingestion of olive oil. This study is an important step to determine the interest of DHA supplementation as a new approach to prevent tumour development, and/or as an adjuvant to cancer treatments.

NCT ID: NCT05425017 Completed - Healthy Clinical Trials

Analysis of Crepitus in Human Subjects

SoC
Start date: June 12, 2021
Phase:
Study type: Observational

Chiropractic adjustment has been shown to gap certain joints in the spine, thereby improving mobility in individuals with decreased movement capabilities. During normal motion, joints in the spine produce sounds and vibrations called crepitus. The purpose of this study is to assess how this crepitus may be used as an indicator for joint degeneration in healthy human subjects and those with low back pain, and if chiropractic adjusting causes change in this crepitus. We hypothesis that change in crepitus after adjustment may be a useful indication of changes in joint mobility and joint stiffness.

NCT ID: NCT05414591 Completed - Healthy Clinical Trials

Pharmacokinetics and Safety Following Administration of DWP16001

Start date: May 1, 2021
Phase: Phase 1
Study type: Interventional

To compare and evaluate the safety and pharmacokinetic characteristics after administration of DWP16001 Drug A and DWP16001 Drug B in healthy adult volunteers

NCT ID: NCT05406050 Completed - Healthy Clinical Trials

Bioequivalence Study of Eldecalcitol Soft Capsule in Healthy Chinese Subjects

Start date: October 20, 2020
Phase: Phase 1
Study type: Interventional

A single-center, open-label, randomized, two-period, crossover study design of pharmacokinetics and bioavailability in healthy Chinese subjects under fasting conditions.

NCT ID: NCT05398146 Completed - Healthy Clinical Trials

The Effect of Three Methods Used in Reducing Pain During Dressing Change

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

This randomized controlled study aims to determine the effect of listening to music (LM), ball squeezing (BS), and performing mathematical operations (MO) in reducing the pain experienced during the first dressing in children aged 8-18 with appendectomy.

NCT ID: NCT05396742 Completed - Healthy Clinical Trials

Pharmacokinetic Study of Ravulizumab Administered Subcutaneously With Recombinant Human Hyaluronidase PH20 (rHuPH20) in Healthy Adult Volunteers

Start date: August 9, 2018
Phase: Phase 1
Study type: Interventional

The main objectives of this study were to estimate the absolute bioavailability of ravulizumab/rHuPH20 subcutaneous (SC) and to assess the safety and tolerability of ravulizumab/rHuPH20 SC.

NCT ID: NCT05393856 Completed - Healthy Clinical Trials

CG-549 Tablet Pharmacokinetics Study

Start date: September 23, 2019
Phase: Phase 1
Study type: Interventional

This will be an open label, crossover, single dose study consisting of 2 parts (Part A and Part B) in a total of 24 healthy male and female subjects.