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Kinesio taping (KT) is an elastic adhesive tape with physiological effects, often used in rehabilitation and sports medicine. KT, which can stay in the body for 3 to 5 days, exerts a pulling force on the skin thanks to its wave-like structure and elasticity, and increases the gap between the subcutaneous soft tissue and fascia with its lifting effect. In this way, it reduces the superficial pressure and causes an increase in lymph circulation. In addition, with the effect it creates on the muscles, it allows maximum contraction and relaxation of the muscle and creates positive effects on the deep lymphatics. Another effective approach to increase blood circulation is exercise. Exercise, which is known to have many benefits, has been shown to increase both systemic circulation and muscle blood flow. There are findings in the literature that KT can increase the effectiveness of exercise, but it has been stated that this issue is not clear and more studies are needed. In order to evaluate the effects of KT on increasing the effectiveness of exercise and on circulation, the oxygen saturation of the muscle in the application area can be measured. As a matter of fact, "Moxy muscle oxygen monitor" has been used in the literature, which measures regional oxygen saturation (SmO2) and total hemoglobin (THb) in capillaries under the muscle. The Moxy muscle oxygen monitor is a lightweight (42 g) and small (dimensions: 61 × 44 × 21 mm) device that measures regional blood flow and oxygenation by placing it on the skin non-invasively with near-infrared spectroscopy (NIRS). Its validity in measuring muscle oxygenation was vigorous or fairly good, and its reliability was found to be moderate to high in low-intensity exercises (SROC: r = 0.842-0.993, ICC: r = 0.773-0.992, p < .01). It is thought that the application of KT, which is known to increase lymphatic and venous circulation, together with exercise will increase the amount of oxygen in the muscles. To the best of our knowledge in the literature, no study has been found in which this effect of KT is presented objectively. For this reason, it is aimed to examine muscle oxygenation with the Moxy muscle oxygen monitor, which provides objective data on KT applied with exercise.
The purpose of this dietary intervention is to study the effects of several dietary fibers on the gut microbiota at the personal level. Hypothesis 1: Intake of specific dietary fibers improves the blood lipid profile depending on the personal microbiota of the participants. Hypothesis 2: detailed food intake analysis and continuous monitoring of gut microbiota enables to draw causative interrelationships between food components, bacteria of gut microbiome and health characteristics.
The overall aim of this project is to evaluate the quantity of dietary protein that affects gut protein metabolization and if the baseline measurements are stable.
Evaluation of safety and PK interaction between D-0120 and Alopurinol in healthy adult subjects
This is an open-label, single-dose, randomized, three-period, two-treatment, threesequence, crossover, PK, partial replicate, and comparative bioavailability study. This study may be conducted in groups. The same protocol requirements and procedures will be followed for each group.
This is a randomized double-blind, placebo-controlled, single-dose study to evaluate the safety, tolerability, and pharmacokinetics of PRA023 in healthy Caucasian and Japanese adult volunteers
This is an exploratory study designed to optimize, standardize, and validate novel breath biomarkers; there are no objective endpoints. The goal of this study is to generate pilot data to be used to generate hypothesis-driven studies.
This study is intended to quantify the effect of food on the pharmacokinetics of BPI-16350. Subjects will be randomized to a crossover sequence at a 1:1 ratio and administered the dose of BPI-16350 on Day 1 in Period 1 and on Day 15 in Period 2 under fasting conditions(Treatment A) or with a high-fat meal(Treatment B).
The aim of this study is to investigate the instantaneous effects of self-stretching, plantar self-massage and manual stimulation on balance and reaction time in healthy individuals. 102 individuals meeting the inclusion criteria will be included in the study. Individuals will be randomly divided into 3 groups: static stretching group (n=34), self-massage group (n=34) and manual stimulation group (n=34). Static stretching will be applied to all individuals (n=102). In addition to static stretching, self-massage will be applied to individuals in the self-massage group (n=34). Individuals in the manual stimulation group (n=34) will receive manual stimulation in addition to static stretching. Individuals will be evaluated in terms of static balance, dynamic balance, reaction time and foot functionality before and immediately after the applications.
The objective of this study is to evaluate the bioequivalence between two formulations of MDI, eq. to albuterol 90mcg/puff in healthy volunteers under fasting conditions.