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NCT ID: NCT05694442 Active, not recruiting - Healthy Clinical Trials

The Effect of Lipmatte K

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the safety and the effectiveness of Lipmatte K on lip hydration and brightening. The study duration is 4 weeks and the lip assessment will be carried out at baseline, week 2 and week 4.The main questions this study aims to answer are: 1. The hydration effect of the product on lip. 2. The brightening effect of the product on lip. 3. To observe any adverse effect occurrence with the usage of the product.

NCT ID: NCT05694429 Active, not recruiting - Healthy Clinical Trials

The Effect of the Combination of Cleanser and Moisturizer Product K

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the effectiveness of product K cleanser and moisturizer when use in combination for skin rejuvenation. The study duration is 8 weeks and the skin assessment will be carried out at baseline, week 2, week 4 and week 8.The main questions this study aims to answer are: 1. The effect of cleanser and moisturizer K when use in combination on skin hydration. 2. The effect of cleanser and moisturizer K when use in combination on skin elasticity. 3. To observe any adverse effect occurrence with the usage of the products.

NCT ID: NCT05678426 Active, not recruiting - Healthy Clinical Trials

TirolGESUND: Baseline-controlled Comparison of the Effects of Fasting Dietary Intervention or Smoking Cessation Combined With Exercise in Healthy Female Tyrolean Volunteers Aged 30-60 on Epigenetic and Multi-omic Biomarkers of Health, Ageing, and Disease

TirolGESUND
Start date: April 21, 2021
Phase: N/A
Study type: Interventional

The goal of this clinical study is to learn about disease-risk and age-associated changes in DNA methylation patterns associated with disease risk or age in healthy women aged 30-60 in response to health-promoting lifestyle intervention (intermittent fasting or smoking cessation). The main questions the study aims to answer are: - Are the scores of DNA methylation in epigenetic signatures associated with age, women's cancer risk, or risk exposure reduced after 6 months of lifestyle intervention compared to baseline? - What are the dynamics of DNA methylation changes during or following intervention, and do differences in changes between different sample types exist? - Which other biomarkers of health and disease, including metabolic changes, microbiome, clinical, mental, or inflammatory parameters, are altered following intervention? The investigators also aim to explore whether DNA methylation changes are associated with changes in other biomarkers mentioned above. Participants will be allocated to intermittent fasting or smoking cessation based on inclusion criteria. Intermittent fasting encompasses a 16:8 intermittent fasting schedule. Food intake is limited to an 8 h window per day with fasting for the remaining 16 h. Within the intermittent fasting study, participants are randomised to receive a ketogenic supplement (medium-chain triglyceride fibre) or not. Participants in the smoking cessation study will be guided to stop smoking. All participants will receive 1:1 personal coaching throughout the study, and will be provided with an optional exercise programme. All participants will also receive nutritional advice from a professional dietician throughout the study. Participants are invited to donate samples every 2 months for 6 months. Researchers will compare signatures at the start and after 6 months of intervention. Within the intermittent fasting group, researchers will compare effects in individuals that received the ketogenic supplement to those that did not.

NCT ID: NCT05653479 Active, not recruiting - Healthy Clinical Trials

Safety and Blood Levels After a Single Injection of UPB-101 in Healthy Japanese and Non-Japanese Non-East Asian Adults

Start date: December 5, 2022
Phase: Phase 1
Study type: Interventional

The goals of this clinical study are to characterize and compare the safety, tolerability, blood levels of UPB-101 when given to healthy Japanese and non-Japanese non-East Asian (NJNEA) adults. Eligible participant will be assigned to one of the 4 planned dosing treatment groups. Treatment groups 1, 2 and 3 will consist of Japanese adults who will be administered a single subcutaneous (SC) dose of UPB-101 (at 3 different strengths). Treatment group 4 will consist of NJNEA participants who will receive a single SC dose of UPB-101. All treatment groups will enroll and run in parallel.

NCT ID: NCT05613660 Active, not recruiting - Healthy Clinical Trials

A Proof of Science, Dose-Response Study to Evaluate the Safety, Efficacy of Different Dosages of Test Treatments

Start date: January 11, 2023
Phase: N/A
Study type: Interventional

A proof of science clinical study with randomized, four-arm, comparative, single-blind, within the arm - Dose-Response Study to evaluate the safety and efficacy of different collagen peptide-containing test treatments in adult human subjects. The dose-response will be evaluated for the effectiveness of each test treatment in three different dosages that is 2.5 g Versus 5 g Versus 10 g. 22 subjects will be enrolled per dose per test treatment to complete 20 subjects per dose per test treatment.

NCT ID: NCT05597254 Active, not recruiting - Healthy Clinical Trials

Facial Skin Clinical and Microbial Profiling From Oral Probiotic Supplementation

Start date: September 26, 2022
Phase: N/A
Study type: Interventional

The goal of this double-blind randomized clinical trial is to investigate the effects on the skin from oral intake of probiotic supplements in healthy adult men and women. The main questions it aims to answer are: • Will probiotic supplementation result in beneficial changes to different skin parameters? • Will probiotic supplementation result in alterations in the skin microbiome? Participants will consume the study product daily for 8 weeks and come in for skin measurements at baseline and after 8 weeks.

NCT ID: NCT05591157 Active, not recruiting - Healthy Clinical Trials

Evaluation of CSF-3 in Performing ECG

ECG
Start date: November 16, 2022
Phase: N/A
Study type: Interventional

CSF-3 is a wrist-worn medical device similar to a watch. It is designed to monitor a user's heart rate based on ECG (electrocardiogram) and PPG (Photoplethysmograph) readings, using off-the-shelf ECG and unique PPG chipsets with proprietary algorithms. ECG and PPG are the two primary technologies for measuring heart rate. ECG measures the bio-potential generated by electrical signals that control the expansion and contraction of heart chambers, while PPG uses light-based technology to sense the rate of blood flow as controlled by the heart's pumping action.

NCT ID: NCT05572281 Active, not recruiting - Healthy Clinical Trials

Bioequivalence Study Between Tasimelteon Capsule Formulation and Liquid Suspension Formulation in Healthy Volunteers

Start date: May 18, 2022
Phase: Phase 1
Study type: Interventional

This is a single center, two-period, randomized study to evaluate the bioequivalence of a single dose of tasimelteon capsule formulation relative to a single dose of liquid suspension formation in healthy volunteers.

NCT ID: NCT05567159 Active, not recruiting - Healthy Clinical Trials

A Study of Donanemab (LY3002813) in Healthy Participants

Start date: October 4, 2022
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to assess how fast donanemab (LY3002813) gets into the blood stream and how long it takes the body to remove it when administered as single dose in healthy participants. The study will also evaluate the safety and tolerability of donanemab. The study will last up to approximately 22 weeks.

NCT ID: NCT05560048 Active, not recruiting - Healthy Clinical Trials

Anti-exercise-fatigue Effects of Rice Protein RP-80NY in Men

Start date: September 30, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the anti-exercise-fatigue effects of rice protein RP-80NY in men