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NCT ID: NCT05093400 Recruiting - Healthy Clinical Trials

Oropharynx (OPX) Salivary Biomarker Study

Start date: September 17, 2021
Phase: N/A
Study type: Interventional

The goal of this study is to analyze certain biomarkers to look at the relationship between HPV in the saliva, stage at presentation, and a potential self-test compared to saliva of non-cancerous participants.

NCT ID: NCT05092932 Recruiting - Healthy Clinical Trials

Walking Aid Assessment, Arm Strength and Force Under the Foot in Normal Subjects

Start date: January 1, 2020
Study type: Observational

This study will collect biomedical performance data on walking characteristics in normal, healthy people when walking with walking aids and when walking unaided. Data will be used for independent reporting and for comparison to matched people with pathological conditions. Data collected will including walking ability, balance, force under the feet when walking and muscle strength.

NCT ID: NCT05091502 Recruiting - Healthy Clinical Trials

Personalised Modeling and Simulation Procedures for the Differential Diagnosis of Dynapenia: a Study on Healthy Volunteers

Start date: October 2021
Phase: N/A
Study type: Interventional

The ForceLoss study aims to develop personalised modeling and simulation procedures to enable the differential diagnosis for the loss of muscle force, namely dynapenia. Dynapenia can be caused by diffuse or selective sarcopenia, lack of activation, or improper motor control. Each of these causes requires different interventions, but a reliable differential diagnosis is currently impossible. While instrumental methods can provide information on each of these possible causes, it is left to the experience of the single clinician to integrate such information into a complete diagnostic picture. But an accurate diagnosis for dynapenia is important in a number of pathologies, including neurological diseases, age-related frailty, diabetes, and orthopaedic conditions. The hypothesis is that the use of a mechanistic, subject-specific model of maximum isometric knee extension, informed by a number of instrumental information can provide a robust differential diagnosis of dynapenia. In this preliminary study, on healthy volunteers, the investigators will develop and optimize (i) the experimental protocol and (ii) the modeling and simulation framework, assessing both feasibility and reliability of the proposed procedures. Medical imaging, electromyography (EMG) and dynamometry data will be collected and combined to inform a personalised musculoskeletal model of each participant. Biomechanical computer simulations of a Maximal Voluntary Isometric Contraction (MVIC) task will then be performed. To validate the proposed approach, the models' estimates will be compared to in vivo dynamometry measurements and experimental EMG data.

NCT ID: NCT05085106 Recruiting - Healthy Clinical Trials

Safety, Tolerability and Pharmacokinetics of Felbinac Trometamol Eye Drops

Start date: October 21, 2020
Phase: Phase 1
Study type: Interventional

To evaluate the safety and tolerability of felbinac trometamol eye drops of single-dose, multiple-dose, dose escalation in healthy subjects, for providing the basis for the dose setting in the later clinical study.

NCT ID: NCT05080036 Recruiting - Healthy Clinical Trials

Muscle Activation of the Lower Limb in Response to a Medio-lateral Imbalance in Monopodal Stance

Start date: August 1, 2021
Phase: N/A
Study type: Interventional

The "static" single-leg stance has been extensively studied in the literature for its relevance in functional evaluation, therapeutic exercise, sports training and research for fall prevention (particularly for the elderly and patients with neurological diseases). However, the motor strategies of the supporting limb have been investigated only at the ankle level. In particular it is not known, at the hip, how the muscular system reacts to medial and lateral imbalances. Colonna (2012) has hypothesized, basing on a myofascial chains approach, that the balance is managed by the front and back spiral chains. The aim of the present study is to perform a preliminary experimental analysis to verify Colonna's hypothesis, testing a method for the investigation of motor strategies underlying equilibrium. Five healthy subjects will be examined by means of electromyographic analysis of the gluteus maximus, gluteus medius, adductor longus, tibialis anterior and peroneus longus. Subjects will undergo perturbations of their monopodal balance.

NCT ID: NCT05079425 Recruiting - Healthy Clinical Trials

A First-in-Human Study to Assess Single and Multiple Doses of NXC736 in Healthy Participants

Start date: September 10, 2021
Phase: Phase 1
Study type: Interventional

This is a randomized, double-blind, placebo- controlled, single and multiple dosing, dose-escalation clinical phase 1 trial to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of NXC736 after oral administration in healthy male volunteers.

NCT ID: NCT05076877 Recruiting - Healthy Clinical Trials

A Study of Lazertinib (JNJ-73841937) in Healthy Participants

Start date: September 17, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the effect of steady-state concentrations of lazertinib on the single-dose pharmacokinetics (PK) of probe substrates (midazolam, rosuvastatin, and metformin) in healthy adult participants.

NCT ID: NCT05076422 Recruiting - Healthy Clinical Trials

A Study to Test How Well Overweight Men Tolerate Different Doses of BI 3006337

Start date: October 18, 2021
Phase: Phase 1
Study type: Interventional

The main objectives of this trial are to investigate safety, tolerability and pharmacokinetics of BI 3006337 in overweight, healthy male subjects following subcutaneous administration of single-rising doses.

NCT ID: NCT05073939 Recruiting - Healthy Clinical Trials

Effect of Oral Oxytocin on Women's Response to Emotional Stimuli

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

The main aim of the study is to investigate whether orally administered oxytocin (24IU) could modulate females' neural and behavioral responses to affective stimuli including emotional faces and affective scenes.

NCT ID: NCT05073523 Recruiting - Healthy Clinical Trials

Dietary Biomarkers 2.0: From Potential Towards Implementation.

Start date: September 27, 2021
Phase: N/A
Study type: Interventional

The aim of this project is to fill a gap in the translation of dietary biomarkers as unbiased measures of food intake from high-end academic research into a methodology that ca be easily applied across academic, public and private health sector to objectively assess specific dietary intakes at group and individuals' level to a) improve understanding of diet and health relationships b) address compliance in dietary intervention studies and c) assess individuals' dietary intakes to guide their eating towards improved health. The study will be carried out as a three-way cross-over design with three different meal compositions (A, B, C) where each meal is provided 3 times per day during four days per meal. A wash-out period of 7 days where participants consume their habitual diet is implemented and a 3-day run-in before the study meal intervention. The first day of study meal intervention includes postprandial measurements during 8 hours.