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NCT ID: NCT06452745 Recruiting - Healthy Clinical Trials

Early Diagnosis of Colorectal Cancer Based on a Non-invasive Metabolomics Profile

EarlyCRC
Start date: July 20, 2019
Phase:
Study type: Observational

Colorectal cancer is the most frequent tumor in our environment if both sexes are considered together. Every year almost 800 cases are diagnosed in the districts of Tarragona. A little more than half of colorectal cancers are cured with surgery, with or without the addition of complementary treatments with chemotherapy and/or radiation therapy. Those who are not cured is because at the time of diagnosis the disease has already spread or they spread after having been treated surgically with curative intent. The purpose of the EarlyCRC project is to determine whether metabolites (substances of low molecular weight) can be found in the urine and stool of patients with colorectal cancer or polyps that can be easily and cheaply differentiated (urine or stool analysis) between the patients affected by colorectal cancer or polyps, from healthy individuals. For the identification of these possible metabolites, the urine analysis will be performed using the usual techniques in metabolomics, which studies the existing metabolites in biological processes.

NCT ID: NCT06449703 Recruiting - Healthy Clinical Trials

A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide in Healthy Chinese Subjects

Start date: May 6, 2024
Phase: Phase 1
Study type: Interventional

The main purpose of the trial is to compare the pharmacokinetics of insulin degludec and liraglutide as part of a combination product insulin degludec/liraglutide compared with Xultophy®. During the trial period, serials of blood samples will be collected from the participants at two dosing periods, in order to determine the concentration of insulin degludec and liraglutide. The total volume of blood taken throughout the whole trial period will be less than 400 mL. Participants will be asked to stay on daytime and overnight in the trial sites on some predefined days. For other outpatient days, participants need to attend the trial site as required for drug administration or required assessments.

NCT ID: NCT06448247 Recruiting - Healthy Clinical Trials

A Study of SPY001-001 in Healthy Volunteers

Start date: June 6, 2024
Phase: Phase 1
Study type: Interventional

This is a Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose, first in human safety, tolerability, and pharmacokinetic study of SPY001-001 in healthy participants.

NCT ID: NCT06445556 Recruiting - Healthy Clinical Trials

Uplifting Equitable Park Use &Amp; Promoting Physical Activity Among African American Families in Minnesota: A Culturally-Responsive, Community-Engaged Approach

Start date: June 14, 2024
Phase: N/A
Study type: Interventional

Social injustices, such as the absence of racial representation and culturally tailored programs in parks, may further discourage African American families from accessing and using these spaces. 10 Studies are needed to investigate how exposure to more equitable greenspace environments may support physical activity (PA) among African American families. Justice-focused, park-based PA interventions hold high promise for reducing health disparities and future cardiovascular diseases (CVD) and related chronic conditions (RCC) risk, thus carrying significant implications for the fields of public health, family medicine, and urban planning. This pilot study is a two-arm, parallel randomized controlled trial that will be conducted in partnership with community stakeholders from the Three River Park District (TRPD); TRPD parks are located in the Twin Cities region of Minnesota. This trial aims to evaluate the changes in PA, psychological health, sleep, and blood pressure among a cohort of African American parent-child dyads who will be randomized to two intervention conditions. The intervention conditions are: (1) a culturally tailored, nature-based program offered at the TRPD (hereafter, "NatureUplift"), and (2) NatureUplift plus a supplementary walking/hiking educational component (hereafter, "NatureUplift+Active"). Participant dyads will be randomized to NatureUplift or NatureUplift+Active.

NCT ID: NCT06435806 Recruiting - Healthy Clinical Trials

Medical Illustration Design Characteristic Evaluation

Start date: March 25, 2024
Phase: N/A
Study type: Interventional

The goal of this study is to understand what people understand from medical illustrations, and what meaning and emotions (such as anxiety) they derive from different design elements.

NCT ID: NCT06432504 Recruiting - Healthy Clinical Trials

Variation in the Impact of Coffee on the Metabolic Rate

Start date: March 6, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to explore variation in the impact of coffee on metabolic rate. The investigators plan to recruit healthy participants, half male and half female.

NCT ID: NCT06431399 Recruiting - Healthy Clinical Trials

To Evaluate the Safety, Pharmacokinetic Characteristics and the Effect of Food After Administration of JLP-2004

Start date: April 23, 2024
Phase: Phase 1
Study type: Interventional

To evaluate the safety, pharmacokinetic characteristics and the effect of food after administration of JLP-2004

NCT ID: NCT06426498 Recruiting - Healthy Clinical Trials

tFUS Induced Transient Scotoma for Individual Dosing

Start date: June 20, 2024
Phase: N/A
Study type: Interventional

The purposes of this research study is to: 1. Develop a technique of transcranial Focused Ultrasound Stimulation (tFUS) where meaningful effects on the brain can be easily measured. 2. Use this technique to measure threshold for effective tFUS in individuals. 3. Determine whether disruption of conscious visual detection, versus non-conscious visually-guided behavior have different thresholds for disruption with tFUS.

NCT ID: NCT06425861 Recruiting - Healthy Clinical Trials

A First in Human Trial Evaluating THB335 in Healthy Participants

Start date: May 2, 2024
Phase: Phase 1
Study type: Interventional

This study is a double blind, randomized, placebo-controlled, Phase 1 study in two parts: single ascending doses and food effect (Part 1) and multiple ascending doses (Part 2).

NCT ID: NCT06419660 Recruiting - Healthy Clinical Trials

A Study in Healthy Men to Test Whether Esomeprazole Influences the Amount of BI 3000202 in the Blood

Start date: May 21, 2024
Phase: Phase 1
Study type: Interventional

The main objective of this trial is to investigate the effect of the proton pump inhibitor esomeprazole on the pharmacokinetics of BI 3000202 in plasma.