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NCT ID: NCT06119412 Enrolling by invitation - Healthy Clinical Trials

An Alternative Technique for Measuring Blood Pressure

Start date: October 20, 2023
Phase: N/A
Study type: Interventional

This cross design study will be conducted to evaluate the combination of palpation and auscultation techniques as an alternative technique for the measurement of blood pressure. The main questions it aims to answer are: - Is there a statistical difference between the results of systolic blood pressure measured with the old and new technique? - Is there a statistical difference between the results of systolic blood pressure measured with the old and new technique? Participants' blood pressure will be measured twice.

NCT ID: NCT06060925 Enrolling by invitation - Healthy Clinical Trials

Imaging Biomarkers for Myofascial Pain

Start date: January 1, 2023
Phase:
Study type: Observational

Myofascial pain syndrome (MPS) is highly prevalent in the community. It is primarily diagnosed using patient self reports and physical examination, which lack reliability, sensitivity and specificity and does not provide insights into the abnormal biological and physiological processes in soft tissues. While a number of treatment methods are available to patients, there are currently no criteria to determine which treatments might be best for each patient's unique myofascial pain phenotype. To improve evidence-based management of myofascial pain, there is a critical need to develop quantitative measures that advance the understanding of the physiological processes in the underlying the soft tissues across the clinical continuum of MPS. The objective of this project is to develop a quantitative biomarker informed by the current understanding of underlying tissue-level mechanisms at the level of the "myofascial unit" (muscle, nerve, fascia, vasculature, lymphatics) that are likely to be involved in MPS.

NCT ID: NCT06029114 Enrolling by invitation - Healthy Clinical Trials

MR Elastography of Cognitive Impairment

Start date: October 11, 2023
Phase:
Study type: Observational

The purpose of this research is to further investigate the potential of brain stiffness as a novel biomarker for Alzheimer's disease.

NCT ID: NCT05962645 Enrolling by invitation - Healthy Clinical Trials

Phase 1 Study Into Pharmacokinetics and Food Effect of Vapendavir in Healthy Participants and Participants With COPD

Start date: May 19, 2023
Phase: Phase 1
Study type: Interventional

Vapendavir (VPV) is potent virostatic antiviral agent active against all known enterovirus species. VPV binds to the viral capsid, thereby inhibiting viral attachment to the target cell and, independently, preventing release of viral RNA (ribonucleic acid) into the cell. Alt VPV-101 is meant to investigate vapendavir in patients with chronic obstructive pulmonary disease (COPD) who develop a rhinoviral infection. This is a Phase 1, open-label, unblinded study. The primary objective of this study is to characterize single and multiple dose (plus a loading dose) plasma PK profiles of VPV in healthy participants (Group A) and participants with COPD (Group B). Group A is an open-label, 2-sequence, and up to a 3-period, cross-over study to assess the single-dose PK parameters and safety of VPV. Healthy participants may opt to participate in only the first 2 periods, all 3 periods or BID dosing, but it is preferred that participants complete all 3 periods. Group B is an open-label, multi-dose investigation of VPV PK parameters and safety in participants with COPD. Post-dose, follow up will continue for a minimum of 14 days and a maximum of 30 days, depending on which Group the participant is in and which periods said participant completes. There is a target for up to 24 adult participants comprised of healthy participants and participants with COPD.

NCT ID: NCT05959031 Enrolling by invitation - Healthy Clinical Trials

Parameter Space of kTMP

SBIR_2022
Start date: August 16, 2022
Phase: N/A
Study type: Interventional

The investigators have recently developed a new non-invasive brain stimulation (NIBS) system, kilohertz transcranial magnetic perturbation (kTMP) that opens up a new experimental space for safely modulating neural excitability in targeted areas of the human brain. This project will characterize the broad parameter space of kTMP in terms of tolerability and efficacy in healthy individuals. Following earlier feasibility studies, we are now increasing our number of subjects in order to capture preliminary safety and effectiveness information on a near-final device.

NCT ID: NCT05957497 Enrolling by invitation - Healthy Clinical Trials

Drone Biological Samples Transport vs Walking (DBT - Drone Biology Transport)

DBT
Start date: April 27, 2023
Phase:
Study type: Observational

The transport of biological samples is a key step in the pre-analysis process in health facilities and must meet quality requirements (NF:EN:ISO 151989) to ensure that samples are transported in are transported in good conditions. Still in the experimental stage, drone-based air transport is participating in the aeronautical revolution of the development of unmanned aircraft on board in all areas of society, including health. This first project, led by the Biology Centre and the INNOVABIO Biological Resources Centre of the CHU de CAEN in collaboration with the company Delivrone, will allow to evaluate the feasibility in real condition of the mode of transport by drone versus transport of reference on the quality of a varied panel of medical biology examinations (biochemistry, hematology and haemostasis), on the safety of people (potentially infectious samples), on the control of the delivery time, on the control of the transport temperature (15-25°C ). The samples will be taken on 30 healthy volunteers with a total panel of 23 blood tests performed.

NCT ID: NCT05948774 Enrolling by invitation - Healthy Clinical Trials

A SAD/MAD Study to Evaluate the Safety, Tolerability, PK of MT200605 in Healthy Subjects

Start date: July 11, 2023
Phase: Phase 1
Study type: Interventional

The goal of this randomized, double-blind, placebo control, Phase I clinical trial is to evaluate the Safety, Tolerability, and Pharmacokinetics after Single Ascending Dose (SAD) and multiple Ascending Dose (MAD) of MT200605 for Injection in Healthy Subjects. The main questions it aims to answer are: 1. The safety and tolerability of MT200605 injection in health subjects 2. The Pharmacokinetic characteristic of MT200605 injction in health subjects The study aims to recruit 60 health subjects and participants will be randomly allocate to two stages (SAD and MAD) with 36 subjects in SAD and 24 subjects in MAD stages. The placebo will be used in this study, and the researchers will compare the placebo and test article to see if the MT200605 will be safe or well tolerated.

NCT ID: NCT05857488 Enrolling by invitation - Healthy Clinical Trials

Feasibility, Safety and Utility of Endomicroscopy to Study the Intestines of Unsedated Infants at University of Virginia (UVa)

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to demonstrate the feasibility of using the transnasal endomicroscopy (TNE) platform, using intestinal potential difference (IPD) and microbiome brush to evaluate the intestine of unsedated infants.

NCT ID: NCT05784233 Enrolling by invitation - Healthy Clinical Trials

Relevance and Salience During Attention Task

Start date: September 15, 2022
Phase: N/A
Study type: Interventional

In this line of research, we are examining the influence of relevance of a salient item on task performance, depending on overall task set.

NCT ID: NCT05764642 Enrolling by invitation - Healthy Clinical Trials

A Study of Renal Microvessel Imaging for Chronic Kidney Disease

Start date: August 9, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this research is to study the efficacy of ultrasound microvessel imaging for evaluation of Chronic Kidney Disease. Definity is an ultrasound contrast agent currently approved by the FDA for use on the heart, liver, and urinary tract. This study will look at its effectiveness on the kidney.