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Healthy clinical trials

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NCT ID: NCT03504475 Recruiting - Healthy Clinical Trials

Bioequivalence Study of Paroxetine and Paxil® Under Fasting and Fed Conditions in Chinese Healthy Volunteers

Start date: March 29, 2018
Phase: Phase 1
Study type: Interventional

The objective of this study is to compare the rate and extent of absorption of paroxetine hydrochloride 20 mg tablets (test) and Paxil® (reference) administered as 20 mg tablet under fed conditions.

NCT ID: NCT03504306 Not yet recruiting - Healthy Clinical Trials

Validation of Ventriject Determined Maximal Oxygen Uptake

Start date: April 23, 2018
Phase:
Study type: Observational

This study aims to validate the use of the Ventriject product to estimate VO2 max, through a non-physically active test using ECG, echoseismography and echosonography.

NCT ID: NCT03503903 Active, not recruiting - Healthy Clinical Trials

Efficacy of Wet Cupping on Reactive Oxygen Species and Antioxidants

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the efficacy of Wet cupping Therapy on oxidative stress and antioxidant capacity of the body.The healthy volunteers will receive wet cupping application and their initial venous blood samples and samples after the treatment will be evaluated for oxidative stress.

NCT ID: NCT03503825 Not yet recruiting - Healthy Clinical Trials

[Tc-99m]-RPI-087 as an Imaging Marker in Osteoarthritis of the Knee Compared to Healthy Volunteers

Start date: May 7, 2018
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to test the safety and tolerability of T-087. The study will enroll 6 healthy volunteers (HVs) and 6-18 subjects with KOA. All eligible subjects will receive an intravenous injection of the radioactive investigational product (T-087), followed by SPECT/CT imaging of the knees and blood tests and clinical assessments for safety monitoring. Healthy volunteers will also have their whole body imaged and have extra blood drawn to determine where T-087 goes in the body. These additional procedures will be done on the same day as the ip administration, and repeated the following day. All subjects will have a final follow-up phone call within 2- 3 business days following the ip administration.

NCT ID: NCT03502707 Not yet recruiting - Healthy Clinical Trials

A Study to Evaluate the Safety and Immunogenicity for Regimen Selection of Ad26.RSV.preF and/or RSV preF Protein Combinations Followed by Expanded Safety and Concomitant Influenza Vaccine Administration in Adults Aged 60 Years and Older

Start date: May 11, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study for: Cohort 1 and Cohort 2: to assess the safety and reactogenicity of the intramuscular one- and two-dose regimens, with a booster at Month 12 and to select a regimen for Cohort 3. Cohort 2 and part of Cohort 1: to assess respiratory syncytial virus (RSV) neutralizing antibody levels of all regimens containing RSV pre-fusion (preF) protein compared to the one-dose adenovirus serotype 26 respiratory syncytial virus pre-fusion (Ad26.RSV.preF) regimen. Cohort 3: to demonstrate the non-inferiority of the concomitant administration of the selected regimen and seasonal influenza vaccine versus the administration of seasonal influenza vaccine alone in terms of humoral immune response expressed by the geometric mean titers (GMTs) of hemagglutination inhibition (HI) antibody titers against the influenza vaccine strains 28 days after the administration of influenza vaccine, using a non-inferiority margin of 2 for the GMT ratio (control group/co-administration group) and to assess the safety and reactogenicity of the selected regimen administered separately or concomitantly with seasonal influenza vaccine, and a booster at Month 12, and to compare the safety and reactogenicity of the co-administration group with that of the seasonal influenza vaccine + placebo group.

NCT ID: NCT03500900 Completed - Healthy Clinical Trials

Vildagliptin on Gastric Accommodation

Start date: March 1, 2016
Phase: N/A
Study type: Interventional

Dipeptidyl peptidase-4 (DPP-4) inactivates glucagon-like peptide-1 (GLP-1). Whether DPP-4 inhibition affects GLP-1 metabolism in vivo and/or food intake remains unknown. The aim of this study is to evaluate the effect of vildagliptin (DPP-4 inhibitor) on gastric accommodation and ad libitum food intake in healthy volunteers (HVs).These effects will be evaluated in two randomized, placebo-controlled, single-blinded trials. Each protocol will include ten volunteers. Protocol 1: Sixty minutes after treatment a nutrient drink (270 kcal) will be intragastrically infused and intragastric pressure (IGP) will be measured for one hour. Protocol 2: 60 min after treatment the participants consume one nutrient drink (300 kcal). Thirty minutes hereafter, the participant will eat ad libitum from a free-choice buffet for 30 minutes. Blood will be collected at several time points to measure active GLP-1 plasma levels.

NCT ID: NCT03500679 Not yet recruiting - Healthy Clinical Trials

A Study to Evaluate Safety and Immunogenicity of the ExPEC4V Clinical Trial Material After a Single Intramuscular Dose and a Second Dose 6 Months Later in Healthy Participants Aged 18 Years and Older

Start date: May 3, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety/reactogenicity of the ExPEC4V clinical trial material (CTM) after the first vaccination and to evaluate the immunogenicity of the ExPEC4V CTM, as measured by the enzyme-linked immunosorbent assay (ELISA), 14 days after the first vaccination (on Day 15).

NCT ID: NCT03500627 Recruiting - Healthy Clinical Trials

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of OP-101 After Intravenous Administration in Healthy Volunteers

Start date: March 30, 2018
Phase: Phase 1
Study type: Interventional

A clinical study to measure the effect of OP-101 after being administered intravenously in healthy volunteers.

NCT ID: NCT03499587 Recruiting - Healthy Clinical Trials

Effects of Maternal Obesity on Offspring Brain Development

Start date: March 21, 2018
Phase:
Study type: Observational

The goal of this study is to see if there are negative effects of maternal obesity during pregnancy on offspring's brain development.

NCT ID: NCT03499106 Not yet recruiting - Healthy Clinical Trials

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Inhibitor Praliciguat (IW-1973) in Healthy Volunteers

Start date: April 12, 2018
Phase: Phase 1
Study type: Interventional

The primary objective of the study is to evaluate the effect of itraconazole (a potent cytochrome P450 isoenzyme [CYP]3A inhibitor) on the pharmacokinetics of IW-1973.