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NCT ID: NCT06331546 Recruiting - Healthy Clinical Trials

Gut Oxalate Absorption in Calcium Oxalate Stone Disease

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will - ingest fixed diets containing low and moderately high amounts of oxalate for 5 days at a time - ingest a soluble form of oxalate and sugar preparations to test gut permeability - collect urine, blood, stool and breath sample during the fixed diets and the soluble oxalate test

NCT ID: NCT06331221 Recruiting - Healthy Clinical Trials

Effects of Different Concentric and Eccentric Muscle Fatigue Protocols on the Knee Joint Position Sense

Start date: November 2, 2023
Phase: N/A
Study type: Interventional

The aim of this study was to investigate the effects of different concentric and eccentric muscle fatigue protocols on the knee joint position sense of healthy individuals.

NCT ID: NCT06330402 Recruiting - Healthy Clinical Trials

Exploration of Gait Biomechanics and Pain

Start date: September 26, 2023
Phase: N/A
Study type: Interventional

This interventional study aims to test gait biomechanics in healthy individuals with and without experimental knee pain. The main questions it aims to answer are: - How do gait patterns change during painful walking? - Can pain sensitivity testing and gait biomechanics predict experimental knee pain intensity? Participants will receive two knee injections: a) Hypertonic saline (painful condition) and b) Isotonic saline (control condition).

NCT ID: NCT06329245 Not yet recruiting - Healthy Clinical Trials

Development of Prosocial Behaviors and Related Brain Network in Infants of High and Low Risk of ASD

Start date: April 1, 2024
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to compare the developmental trajectories of prosocial behaviors and functional network connections in infants and toddlers at high and low risk of autism spectrum disorder (ASD). The main questions it aims to answer are what the differences in prosocial behaviors and related brain network connections between infants/toddlers at high and low risk of ASD are. Participants will receive developmental and social communicational assessments (Griffiths Mental Developmental Scales, Peabody Developmental Motor Scales, The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist), resting-state EEG and MRI in a natural sleeping state.

NCT ID: NCT06329076 Recruiting - Healthy Clinical Trials

Losartan Modulates Neural Responses to Looming Visual Stimuli: An Eye-tracking Study

Start date: March 5, 2024
Phase: N/A
Study type: Interventional

The main aim of the present study is to investigate the effects of orally administered losartan on the perception of time-to-collision of threatening and non-threatening stimuli by combining a validated looming fear eye-tracking paradigm with a randomized between-subject placebo-controlled pharmacological trial design.

NCT ID: NCT06329063 Recruiting - Healthy Clinical Trials

Oral Vasopressin Modulates Neural Responses to Looming Visual Stimuli: An Eye-tracking Study

Start date: March 5, 2024
Phase: N/A
Study type: Interventional

The main aim of the present study is to investigate the effects of orally administered vasopressin (AVP) on the perception of time-to-collision of threatening and non-threatening stimuli by combining a validated looming fear eye-tracking paradigm with a randomized between-subject placebo-controlled pharmacological trial design.

NCT ID: NCT06329050 Recruiting - Healthy Clinical Trials

The Effects of Losartan on Attention Control: An Eye-tracking Study

Start date: March 5, 2024
Phase: N/A
Study type: Interventional

The main aim of the present study is to investigate the effects of orally administered Losartan on bottom-up and top-down attentional control to socio-emotional stimuli by combining a validated saccade/antisaccade eye-tracking paradigm with a randomized between-subject placebo-controlled pharmacological trial design.

NCT ID: NCT06329037 Recruiting - Healthy Clinical Trials

The Effects of Oral Vasopressin on Attention Control: An Eye-tracking Study

Start date: March 5, 2024
Phase: N/A
Study type: Interventional

The main aim of the present study is to investigate the effects of orally administered vasopressin (AVP) on bottom-up and top-down attentional control to socio-emotional stimuli by combining a validated saccade/antisaccade eye-tracking paradigm with a randomized between-subject placebo-controlled pharmacological trial design.

NCT ID: NCT06327880 Not yet recruiting - Healthy Clinical Trials

A Study to Learn About the Study Medicine Called PF-07054894 in People of Japanese Origin

Start date: April 24, 2024
Phase: Phase 1
Study type: Interventional

The purpose of this clinical study is to learn about the safety and effects of the study medicine (PF-07054894) in healthy Japanese participants. The study is seeking the following participants: - Male or female Japanese participants aged 18 years or older. The participants should be healthy after going through some medical tests. - Have a Body Mass Index (BMI) of 16 to 32 kilogram per meter squared; and a total body weight of more than 45 kilograms (100 pounds). - Are willing and able to follow all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures. In research, the participants in clinical studies are assigned by chance to separate groups that are given different treatments. Hence participants will be by chance assigned to receive either PF-07054894 or a harmless treatment that has no medical effect (placebo). Both these will be taken by mouth for 14 days. The total duration of the study is about 11 weeks, with a follow-up via telephone about 6 weeks after first treatment.

NCT ID: NCT06327256 Not yet recruiting - Healthy Clinical Trials

A Study in Healthy People to Test How Well Different Doses of BI 3000202 Are Tolerated and How They Affect the Way the Body Handles Midazolam

Start date: April 5, 2024
Phase: Phase 1
Study type: Interventional

The aim of this trial is to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) following multiple rising doses of BI 3000202 and to investigate the effect of BI 3000202 on the metabolism of midazolam.