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NCT ID: NCT03369925 Not yet recruiting - Healthy Clinical Trials

Cognitive Effects of Citicoline in Men and Women With Age-Associated Memory Impairment

Start date: January 2018
Phase: N/A
Study type: Interventional

The objective of this trial is to determine the effects of citicoline on cognitive performance in healthy Men and Women with Age-Associated Memory Impairment compared to a placebo.

NCT ID: NCT03369548 Recruiting - Healthy Clinical Trials

CABALA Diet & Health Study

CABALA
Start date: December 4, 2017
Phase: N/A
Study type: Interventional

During digestion of fatty foods, the liver produces a substance called bile which helps with the absorption of fat in the gut (small intestine). Some research studies have shown that friendly bacteria that live in our gut can change the makeup of bile (referred to as bile acids) leading to a lowering of blood cholesterol levels, an important risk factor for developing heart disease. This finding has been found in people who consume diets high in dietary fibers and probiotics that enhance the growth of friendly gut bacteria, and also plant rich foods high in polyphenols (such as apples). At present, very little is known about how the makeup of bile acids can regulate blood cholesterol levels and if their measurement in blood, urine or stool samples can be used as an indicator of human health. The aim of this study is to explore how consumption of foods which enhance the growth of friendly gut bacteria (such as probiotics, prebiotics, and plant rich foods high in polyphenols) can change the makeup of bile acids after 8 weeks. Changes in the bile acids measured in blood and stool samples will then be related to markers of health, such as blood cholesterol, glucose, insulin, vascular health and inflammatory markers.

NCT ID: NCT03366233 Not yet recruiting - Healthy Clinical Trials

The Role of Brain Activation and Cerebral Blood Flow in Mental Fatigue.

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

To assess the changes in brain activation and cerebral blood flow due to mental fatigue in a placebo-controlled study. More specifically we want to assess whether brain activation [measured with Blood Oxygen Level Dependent (BOLD) functional resonance imaging (fMRI)] is decreased during a Flanker task in a mentally fatigued state and whether this coincides with a decline in cognitive performance. In addition we also want to evaluate whether cerebral blood flow [measured with arterial spin labeled (ASL) fMRI] in a resting state is reduced when mentally fatigued.

NCT ID: NCT03364985 Recruiting - Healthy Clinical Trials

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DWP16001 After Oral Administration in Healthy Male Volunteers

Start date: December 2017
Phase: Phase 1
Study type: Interventional

This is a dose block-randomized, double-blind, placebo- and active-controlled, single and multiple dosing, dose-escalation clinical phase 1 trial to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of DWP16001 after oral administration in healthy male volunteers.

NCT ID: NCT03363984 Recruiting - Healthy Clinical Trials

Pharmacokinetic Interaction Between Midazolam and ID-082 in Healthy Subjects

Start date: November 27, 2017
Phase: Phase 1
Study type: Interventional

A clinical study in healthy male subjects to investigate whether the administration of ID-082 can affect the fate in the body (amount and time of presence in the blood) of midazolam.

NCT ID: NCT03363906 Not yet recruiting - Healthy Clinical Trials

A Study of Dulaglutide in Healthy Participants

Start date: December 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate a new formulation of dulaglutide (study drug) administered under the skin as one injection using a single dose pen compared to three injections using a pre filled syringe. This study will evaluate how much of the study drug enters the body and how long it takes the body to get rid of it. Information about any side effects that may occur will also be collected. The study will last about 84 days, including screening and will require overnight stays in the clinical research unit (CRU).

NCT ID: NCT03363477 Completed - Healthy Clinical Trials

Study of Pharmacodynamic Equivalence of Enoxaparin Rovi to Clexane®, in Healthy Volunteers

Start date: September 25, 2015
Phase: Phase 1
Study type: Interventional

To demonstrate the pharmacodynamic (PD) equivalence of enoxaparin Rovi (100 mg/mL) 100-mg SC injection to Clexane® (100 mg/mL) 100-mg SC injection in healthy volunteers. As secondary objective, to evaluate the safety and tolerability of enoxaparin Rovi (100 mg/mL) in healthy volunteers.

NCT ID: NCT03361605 Enrolling by invitation - Healthy Clinical Trials

Neuroimaging of Anesthetic Modulation of Human Consciousness

Start date: April 12, 2017
Phase: Phase 4
Study type: Interventional

This study's purpose is to see if mental functions take place during different levels of anesthesia, using a commonly used drug (Propofol). fMRI (functional Magnetic Resonance Imaging, or "brain imaging") shows areas in the brain involved in thinking at different depths of anesthesia.

NCT ID: NCT03361566 Recruiting - Healthy Clinical Trials

Short-term Regulation of Energy and Macronutrient Balance: Impact of Energy Flux

EF
Start date: December 1, 2016
Phase: N/A
Study type: Interventional

Aim of the study is to investigate the impact of energy flux (achieved by changes in physical activity) under the conditions of energy balance, caloric restriction and overfeeding in healthy subjects.

NCT ID: NCT03356561 Recruiting - Healthy Clinical Trials

A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Ad26.ZIKV.001 in Healthy Adult Volunteers

Start date: November 26, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety, reactogenicity, and immunogenicity of Ad26.ZIKV.001 at 2 dose levels, 5*10^10 viral particles (vp) and 1*10^11 vp, administered intramuscularly as single dose and as 2-dose schedules in healthy adults.