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NCT ID: NCT03843151 Not yet recruiting - Healthy Clinical Trials

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1358894 in the Blood

Start date: March 5, 2019
Phase: Phase 1
Study type: Interventional

The main objective of this trial is to investigate the relative bioavailability of BI 1358894 in plasma when given as oral single dose together with multiple oral doses of itraconazole (Test, T) as compared to when given alone as oral single dose (Reference, R).

NCT ID: NCT03842761 Not yet recruiting - Healthy Clinical Trials

A Study to Test How Different Doses of BI 685509 Are Tolerated in Patients With Liver Problems

Start date: February 27, 2019
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is the evaluation of safety and tolerability in patients with mild to moderate hepatic impairment [Child-Turcotte-Pugh (CTP) classification A and B] over different dose regimes of BI 685509 compared to placebo. A secondary objective is to investigate pharmacokinetics of different doses of BI 685509 in patients with mild to moderate hepatic impairment (CTP A and CTP B). In addition, another secondary objective is to compare safety, tolerability, and pharmacokinetics in patients with mild to moderate hepatic impairment (CTP A and CTP B) of single BI 685509 dose to individually matched healthy volunteers

NCT ID: NCT03842345 Not yet recruiting - Healthy Clinical Trials

DELPhI Evaluation of Psychiatric Conditions

Start date: February 2019
Study type: Observational

DELPhI acquisition and analysis software, a QuantalX Neuroscience development, which is designed to measure, analyze, and display brain electrical activity of human electroencephalogram (EEG), to transcranial magnetic stimulation (TMS), will be used to evaluate different psychiatric conditions.

NCT ID: NCT03841721 Active, not recruiting - Healthy Clinical Trials

Linezolid in Healthy Volunteers

Start date: May 1, 2018
Phase: Phase 1
Study type: Interventional

Linezolid is the first synthetic antibiotic of oxazolidinone group that can inhibit bacterial protein synthesis. Previous studies have found that linezolid was an effective treatment for multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). In addition, the current dosage recommendation (1,200 mg/day) occasionally resulted in serious adverse events including bone marrow suppression and peripheral neuropathy. The objective study were determine the pharmacokinetics of oral linezolid 300 mg /day in healthy volunteers. This study conducted in six healthy volunteers. All subject received an oral linezolid 300 mg/day by directly observed treatment (DOT) at the same time each day for 5 days. Blood samples were collected on day 5 at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 12 and 24 h post dosing. The separated plasma samples were evaluated by ultra-performance liquid chromatography (UPLC). All pharmacokinetic parameters were calculated.

NCT ID: NCT03841630 Not yet recruiting - Healthy Clinical Trials

A Safety Study of LY3437943 Given as a Single Injection in Healthy Participants

Start date: March 13, 2019
Phase: Phase 1
Study type: Interventional

This study is being conducted to determine the side effects related to LY3437943 given as a single injection under the skin to healthy participants. Blood tests will be performed to check how much LY3437943 gets into the bloodstream and how long the body takes to get rid of it. Each enrolled participant will receive a single dose of LY3437943 or placebo. The study will last up to approximately 71 days for each participant, including screening.

NCT ID: NCT03840746 Recruiting - Healthy Clinical Trials

Interactions Between Fibre and Polyphenols on Colonic Phenolic Acid Production and Biomarkers of Health ( 6 Weeks)

Start date: July 11, 2018
Phase: N/A
Study type: Interventional

The investigators have studied the acute interactions of polyphenols and NDC in a single meal in a human study containing tomatoes, lovage & onions, with and without inulin. The investigators now wish to study the longer-term interactions of these foods over 6 weeks as well as their impact on biomarkers of human health, the gut microbiome, human proteome and markers of risk of chronic disease. This may allow better targeted evaluation of foods which influence health through the gut microbiome.

NCT ID: NCT03840330 Completed - Healthy Clinical Trials

High-intensity Training for Improving Physical Performance of Aged Women

Start date: December 20, 2015
Phase: N/A
Study type: Interventional

This study evaluates the adaptations on the functional capacity and cardiovascular in elderly after a physical activity program circuit training. The participants were divided into three groups: Circuit training based on high-intensity interval training group (HIT), Circuit training at moderate intensity group (MIT) and Control group (GC).

NCT ID: NCT03839810 Recruiting - Healthy Clinical Trials

Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.

NCT ID: NCT03838822 Completed - Healthy Clinical Trials

Kinetics of Metabolic Cofactors in NAFLD

Start date: September 1, 2018
Phase: Early Phase 1
Study type: Interventional

There is a strong correlation between major adverse health consequences of obesity and development of non-alcoholic fatty liver disease (NAFLD). NAFLD is characterized by abnormal hepatic accumulation of triglycerides and other lipids. It has become a worldwide health problem that accelerates cirrhosis, type 2 diabetes mellitus (T2DM), and especially premature cardiovascular morbidity and mortality. The plasma level of glutathione (GSH) is typically depleted in individuals with metabolism related disorders. However, cellular GSH levels cannot be increased by supplementing GSH and it must be synthesized within the liver either de novo or by salvation pathway. The level of GSH is not enough to maintain and regulate the thiol redox status of the liver in subjects with high hepatic steatosis at fasting stage due to the depletion of glycine. Glycine can be synthesized via the interconversion of serine. It has been shown that the serine synthesis is downregulated in patients with NAFLD and supplementation of serine has attenuated alcoholic fatty liver by enhancing homocysteine metabolism in mice and rats. Depleted liver glutathione is also restored by the administration of N-acetylcystein as in acetaminophen poising. L-carnitine and nicotinamide that both stimulate the transfer of fatty acids from cytosol to mitochondria have been identified as two additional cofactors that are depleted in patients with NAFLD. In this study, the kinetics in blood of pivotal metabolic cofactors, serine, L-carnitine, N-acetylcystein and nicotinamide after single and simultaneous dietary supplementation, are measured.

NCT ID: NCT03837964 Not yet recruiting - Healthy Clinical Trials

A Study to Test How Food Influences the Amount of BI 1291583 in the Blood of Healthy Men

Start date: February 28, 2019
Phase: Phase 1
Study type: Interventional

To assess the effect of food on the pharmacokinetics of an oral tablet formulation of BI 1291583, by investigating the relative bioavailability following single dose administration under fed and fasted conditions.