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Healthy clinical trials

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NCT ID: NCT03629223 Not yet recruiting - Healthy Clinical Trials

Bioequivalence of Tablet Formulation 3 (TF3) and Tablet Formulation 2 (TF2) and Effect of Food on the Pharmacokinetics (PK) of Tepotinib

Start date: August 28, 2018
Phase: Phase 1
Study type: Interventional

The study will demonstrate bioequivalence between the new tablet formulation (TF3, test treatment) and the tablet formulation used in clinical studies (TF2, reference treatment) and will investigate effect of food on PK of tepotinib.

NCT ID: NCT03629054 Not yet recruiting - Healthy Clinical Trials

This Study in Healthy People Tests Whether Taking a Low Strength of Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate Pills

Start date: August 27, 2018
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to establish the bioequivalence of two empagliflozin/linagliptin/metformin extended release (XR) fixed dose combination (FDC) tablets (Test, T) compared with the same doses of the individual components given in separate tablets (Reference, R) when administered together after a high-fat, high-calorie meal.

NCT ID: NCT03628339 Not yet recruiting - Healthy Clinical Trials

Effect of Tepotinib on Pharmacokinetics (PK) of Cytochrome P450 (CYP) 3A Substrate Midazolam

Start date: August 20, 2018
Phase: Phase 1
Study type: Interventional

The study will investigate the effect of tepotinib on the PK of the CYP3A substrate midazolam determined from concentrations of midazolam and its main metabolite 1-hydroxymidazolam in healthy participants.

NCT ID: NCT03627871 Recruiting - Healthy Clinical Trials

Enduring Exercise Habits: Trending Norms

Start date: January 31, 2018
Phase: N/A
Study type: Interventional

Learning that most people engage in an activity can be a powerful motivator to adoption. But are there instances in which people can similarly find motivation from learning that only a minority of others engage in a behavior? Evidence suggests this may be possible when the message is that the size of the minority has been growing in recent years. In this study, we first examine how gym members' exercise patterns shift when they are informed that the minority versus the majority of (a subpopulation of) other Americans exercise frequently. We also test how gym members are affected by learning that the number of frequent exercisers has increased in recent years.

NCT ID: NCT03627520 Completed - Healthy Clinical Trials

A Mass Balance Study to Investigate the Absorption, Metabolism, and Excretion of [14C]Sulfatinib

Start date: April 2, 2018
Phase: Early Phase 1
Study type: Interventional

This is a single-center, open label and single-dose clinical trail, to explore the body mass balance and identify the major metabolites in Chinese adult male healthy volunteers after a single oral dose of [14C]Sulfatinib, to obtain the pharmacokinetic parameters of plasma and observe the safety of healthy volunteers after a single oral dose of [14C]Sulfatinib.

NCT ID: NCT03627351 Not yet recruiting - Healthy Clinical Trials

Sensory Evaluation of the Taste of Pediatric Medicines

Start date: September 1, 2018
Study type: Observational

The investigators will conduct a systematic study of the sensory perception of a diverse set of commonly used pediatric liquid medications and excipients in tandem with an equally complete genetic analysis of the adult sensory panelists to investigate the relationship between genetic variation and individual differences in the perceived flavor (taste, smell, irritation) of pediatric medicines. The flavor of each medicine and excipient will be measured individually using both cognitively demanding methods unsuitable for young children and simpler measures validated for use by children. Salivary DNA samples will be collected to carry out genome wide association study (GWAS).

NCT ID: NCT03627273 Completed - Healthy Clinical Trials

6MWT With and Without Walker

Start date: July 2014
Phase: N/A
Study type: Interventional

Elderly subjects repeated 6MWT with or without walker

NCT ID: NCT03627117 Recruiting - Healthy Clinical Trials

Influence of CBD on Episodic Memory in Healthy Subjects

Start date: August 13, 2018
Phase: N/A
Study type: Interventional

Placebo controlled, randomized, double blind, cross-over design. Single vape of 0.25ml 5% CBD e-liquid (12.5mg CBD) and single vape of 0.25ml e-liquid, tastes like lemon and madeleine. 15min vape time each. A total of 34 participants, equal number of male and female. There will be replacement of Drop-Outs until data from 34 participants are completed. The primary endpoint will be performance in a verbal memory task. The secondary endpoint will be performance in a working memory test.

NCT ID: NCT03623308 Recruiting - Healthy Clinical Trials

Whole Grain and Fiber Addition Study

Start date: May 4, 2018
Phase: N/A
Study type: Interventional

The human gut microbiota is the complex community of bacteria that reside within the human gastrointestinal tract. This community plays an important role in supporting normal immune function and digestion. Disruption of the microbial communities within the gastrointestinal tract, sometimes termed "dysbiosis" is linked to a wide range of human diseases, including obesity, metabolic syndrome, malnutrition, and cancer. Stability of the microbiome is thought to be important for human health, however the factors that drive microbiome community stability are poorly understood. Within the gastrointestinal tract, the microbiota is constantly exposed to complex mixtures of foods and the products of digestion. Importantly, changes in diet have been shown to rapidly induce shifts in microbial community composition. These compositional shifts can also affect microbial production of bioactive metabolites, which may be one mechanism to explain how the microbiome impacts host physiology and disease. Fiber is often considered to be one of the largest contributors to microbial compositional shifts that follow dietary interventions. Fiber resists digestion and persists through the gastrointestinal tract to reach the large intestine where it can be metabolized by bacteria. The end products of this metabolism are the short chain fatty acids (SCFAs), acetate and butyrate, which are often associated with beneficial health outcomes. Fibrous foods are also a source of polyphenols and other phenolic compounds that may be used by microbes in the production of secondary metabolites or freed from the food matrix by microbial enzymes. The purpose of this study is to: 1) to investigate the impact of high fiber, whole grain and bran cereal on microbiome stability, and 2) to explore the microbial contribution to polyphenol metabolism from whole grain in healthy individuals.

NCT ID: NCT03623022 Not yet recruiting - Healthy Clinical Trials

Effects of 20,000 EU of Clinical Center Reference Endotoxin (CCRE) Versus Placebo(ENDOHEART)

Start date: September 2018
Phase: Phase 1
Study type: Interventional

To determine the systemic inflammatory effects of inhaled endotoxin and associated alterations in cardiovascular function. Subjects will undergo an exposure to inhaled endotoxin in a crossover fashion with normal saline inhalation. Blood samples and sputum samples will be taken before and after inhalation challenge to measure markers of systemic inflammation. Cardiovascular measures, including a heart rate variability monitor, flow mediated dilation of the brachial artery and left ventricular stain will also be measured.