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NCT ID: NCT05536687 Terminated - Healthy Clinical Trials

VALIDITY AND RELIABILITY OF THE 6-MINUTES WALKING TEST EVALUATED BY FEETME® INSOLES

ValiFeet6
Start date: October 1, 2021
Phase: N/A
Study type: Interventional

Currently, the guidelines for performing the 6MWT established by the American Thoracic Society and the European Respiratory Society (ATS/ERS) recommend the use of an indoor or outdoor corridor with a 30 m flat surface (6MWT30) for patients with respiratory diseases, which is also a recommendation for healthy adults. However, not all hospitals, nursing homes or clinics have a corridor of sufficient length to properly perform the 6MWT. A simple way to make the test available to more health care professionals would be to reduce the length of the hallway. In times when access to the hospital is difficult, the ability to assess functional abilities at a distance becomes essential. Today, this is becoming possible with tools such as connected watches, accelerometers, connected shoes and insoles. They give access to a quantitative analysis of walking without necessarily requiring large spaces, specialized personnel or even being in a hospital environment. The FeetMe® Evaluation device consists of connected insoles as well as a mobile application allowing the evaluation of standard clinical walking tests. This device allows a better understanding of patients' walking and is transposable in real life. The objective of the present study is to demonstrate the validity and reliability of the measurement of the distance walked during a 6-minute test with connected insoles in standard conditions (6MW30), degraded conditions (6MW10) in a clinic and at home in a healthy population divided into age subgroups. In addition, this study will investigate whether there is a relationship between 6 minutes of uncontrolled walking from real-life walking data and a standard 6-minute test.

NCT ID: NCT05386823 Terminated - Healthy Clinical Trials

Evaluate the Safety, Tolerability and PK of HF1K16 in Healthy Volunteers

Start date: March 27, 2021
Phase: Phase 1
Study type: Interventional

HF1K16 is an investigational pegylated liposome formulation of tretinoin for injection for the induction of remission in patients with acute promyelocytic leukemia (APL) and for the treatment of solid tumors through targeting myeloid derived suppressor cells (MDSCs). This phase 1 Trial is a Randomized, Double-Blind, Placebo-Controlled Study in Healthy Subjects to Evaluate the Safety, Tolerability and Pharmacokinetics of HF1K16.

NCT ID: NCT05254613 Terminated - Healthy Clinical Trials

A Study of Single and Multiple SC Doses of ALXN1830 in Healthy Adult Participants

Start date: November 12, 2019
Phase: Phase 1
Study type: Interventional

This study will evaluate the effects of single ascending doses (SAD) and multiple ascending doses (MAD) of ALXN1830 administered subcutaneously (SC) to healthy adult participants.

NCT ID: NCT05205447 Terminated - Healthy Clinical Trials

Study of the Effects of Itraconazole and Carbamazepine on LY3410738 in Healthy Participants

Start date: January 5, 2022
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to learn about how itraconazole and carbamazepine affect the levels of LY3410738 in the blood stream of healthy participants. Participation could last up to 75 days.

NCT ID: NCT05083078 Terminated - Healthy Clinical Trials

A Study of Guselkumab and Risankizumab in Healthy Participants and Participants With Psoriatic Arthritis

Start date: November 4, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the tissue distribution of guselkumab and risankizumab in healthy participants (Part 1) and psoriatic arthritis (PsA) participants (Part 2 and Part 3).

NCT ID: NCT04941989 Terminated - Healthy Clinical Trials

A Study in Healthy Subjects to Assess the Safety, Tolerability and Pharmacokinetics of HTL0022562

Start date: June 22, 2021
Phase: Phase 1
Study type: Interventional

Phase 1, randomised, double-blind, first in human, two part, single centre, placebo controlled, single and multiple ascending dose trial in healthy adult subjects to evaluate the safety, tolerability and pharmacokinetics of HTL0022562.

NCT ID: NCT04940949 Terminated - Healthy Clinical Trials

A Study to Evaluate Lu AF90103 in Healthy Men

Start date: May 26, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the safety and tolerability of Lu AF90103 and what the body does to Lu AF90103 after single doses of the drug administered directly into a vein.

NCT ID: NCT04889222 Terminated - Healthy Clinical Trials

Effect of Skin Pigmentation and Race/Ethnicity Factors on the Accuracy of Masimo Pulse Oximeters

Start date: April 5, 2021
Phase:
Study type: Interventional

This study is designed to compare the accuracy of a noninvasive measurement of oxygen saturation compared to reference values obtained by a laboratory blood gas analyzer. Subgroups will be analyzed by skin pigmentation and self-identified race/ethnicity information. Study procedures follow ISO-80601-2-61:2011 standard requirements for basic safety and essential performance of pulse oximeter equipment. Arterial blood samples will be collected from subjects while undergoing a controlled desaturation procedure wherein the concentration of oxygen inhaled is slowly reduced until the subject's arterial oxygen concentration is approximately 70%.

NCT ID: NCT04811573 Terminated - Healthy Clinical Trials

A Study in Healthy People to Compare 3 Different Formulations of Apremilast Tablets Taken With or Without Food

Start date: March 31, 2021
Phase: Phase 1
Study type: Interventional

The aim of this trial is to establish bioequivalence between EU-, US- and Japan-sourced Otezla® tablet formulations to assure comparability of results from Phase III trials of BI 730357 (new oral agent for treatment of psoriasis as well as other T helper 17 cells (Th17)-mediated diseases) regardless of whether only the EU-sourced Otezla® or EU and US-sourced Otezla®/Japan-sourced Otezla® have been used as an active comparator.

NCT ID: NCT04730804 Terminated - Healthy Clinical Trials

A Study of ALXN1830 in Healthy Adult Participants

Start date: March 17, 2021
Phase: Phase 1
Study type: Interventional

This trial will study the effects of single and multiple doses of ALXN1830 in healthy adult participants.