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NCT ID: NCT05206604 Not yet recruiting - Healthy Clinical Trials

A First-in-human Study of Multiple Doses of Topically Administered PF-07295324 and PF-07259955

Start date: January 25, 2022
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate the safety, (local and systemic) tolerability, and pharmacokinetics following multiple doses of topically applied, maximum feasible formulations of PF-07295324 (0.12% w/w) or PF-07259955 (2% w/w), on approximately 20% body surface area (BSA), in healthy adult participants.

NCT ID: NCT05205733 Not yet recruiting - Healthy Clinical Trials

Expanding Fertility Care to Poor and Low Resourced Settings Study

EXPLORE
Start date: January 2022
Phase: N/A
Study type: Interventional

We currently lack an understanding of barriers to completing the male factor infertility evaluation. Furthermore, as we continue to expand access to fertility treatment particularly within low-resourced settings, it is important that all aspects of infertility within a couple are equally explored. The COVID-19 pandemic has disproportionately affected low-income communities and communities of color at greater rates in terms of not only disease morbidity/mortality but how medical systems are accessed and care is delivered.

NCT ID: NCT05203822 Not yet recruiting - Healthy Clinical Trials

Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy Participants

Start date: January 11, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the effect of multiple doses of itraconazole on singledose tepotinib pharmacokinetics in healthy participants. Study details include: Study Duration: up to 48 days Treatment Duration: single dose of tepotinib on Days 1 and 12, 11 days of treatment with itraconazole (Days 8 to 18) Visit Frequency: residence in the Clinical Research Unit from Days -1 to 4 and Days 11 to 15, ambulatory daily visits from Days 5 to 10 and 16 to 20

NCT ID: NCT05203393 Not yet recruiting - Healthy Clinical Trials

500 "Normal" Adult Subjects Who Have Experienced no Known Brain Injury Will Participate in Collecting Data That Will Assist With the Optimization of the Diagnostic Capabilities of the Harmony in Detecting Neurologic Abnormalities.

REFRESH
Start date: January 15, 2022
Phase:
Study type: Observational

The REFRESH study is designed to collect data related to a signal in the brain that MindRhythm has named the Headpulse. The Headpulse occurs as a natural movement of the brain in conjunction with the beating of the heart. 500 "normal" subjects who are considered healthy as they do not have any current known neurological injury will collect the brain signal data from the non-invasive headband style headset for a duration of 3 minutes either once or multiple times. Upon consenting to participate to the study by way of the accompanying MindRhythm app, participants will be sent a Harmony headset kit which will include ECG leads to collect cardiac data in conjunction with the brain signal. The participant will receive training materials and instructions on how to collect and transmit data to investigators by way of the MindRhythm app. The data collected by these "normal" patients will be used as a comparator to individuals who are suspected of neurological injury. This data will assist in training the data analysis algorithm to optimize its diagnostic abilities in detecting neurological injury or abnormalities including but not limited to stroke, stroke type, and concussion. The data set will also be analyzed to determine how the signal varies within an individual and amongst other "normals." An additional benefit of collecting this data will be to gain knowledge related to the ergonomic factors of the app and the headset and its "user friendliness."

NCT ID: NCT05203289 Not yet recruiting - Healthy Clinical Trials

A Study in Healthy People to Test How 2 Different Formulations of BI 695501 Are Taken up by the Body When Given as an Injection

Start date: February 1, 2022
Phase: Phase 1
Study type: Interventional

The main objective of this trial is to compare the pharmacokinetics (PK) of 40 mg BI 695501 100 mg/mL with 40 mg BI 695501 50 mg/mL following single subcutaneous administration.

NCT ID: NCT05202145 Not yet recruiting - Healthy Clinical Trials

Drug-Drug Interaction (DDI) Study of ALXN2050 in Healthy Adult Participants

Start date: January 2022
Phase: Phase 1
Study type: Interventional

This study will evaluate the potential drug interactions between ALXN2050 and cyclosporine (Part 1), between ALXN2050 and tacrolimus (Part 2), and between ALXN2050 and mycophenolate mofetil (MMF) (Part 3).

NCT ID: NCT05201937 Not yet recruiting - Healthy Clinical Trials

A Study of JNJ-64281802 in Healthy Adult Participants

Start date: February 16, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the pharmacokinetics (PK) of JNJ-64281802 in healthy participants when administered in different multiple dose regimens and as different dose strengths.

NCT ID: NCT05199896 Not yet recruiting - Healthy Clinical Trials

Touching the World With a Cane: Cognitive and Neural Processes

TOOL_TOUCH
Start date: February 2022
Phase: N/A
Study type: Interventional

The use of tools is ubiquitous in our lives and allows us to expand the sensorimotor capacities of our body. Much research has been done on the subject in sighted people over the past decades. This work has mainly focused on the motor aspect of using the tool, neglecting the sensory aspect. However, any action involving a tool carries sensory information, for example in the use of the white cane by blind people. 26% (> 200,000) of blind people in France use a white cane to get around. By sweeping the cane on the ground, they use it as a sensorimotor extension of their body to extract information from the environment in order to locate a pedestrian crossing or possible obstacles. While it is well established that the tools increase the user's motor skills, we have only just begun to clarify how they also function as sensory extensions of the user's body and how this phenomenon is potentially dependent on constant use of the tool to compensate for a missing sense, as is the case with blind people using a cane. The aim of this study is to fill this important gap in our knowledge.

NCT ID: NCT05198440 Not yet recruiting - Healthy Clinical Trials

Neuromodulation of Motion Illusions (Vection)

NEUROVEC
Start date: January 30, 2022
Phase: N/A
Study type: Interventional

Virtual reality systems or simulators are more and more frequently used in the field of learning but also in motor rehabilitation. One of the key points of the success of these systems is the experience of "presence" which is associated with the capacity of these technologies to develop in the observer, who is static, the sensation of moving in the virtual environment (vection). However, the simulation generates a sensory conflict (an optical flow specifying self-motion and vestibular stimuli specifying body immobility). This conflict influences the temporal characteristics of the vection and consequently modifies the way users act in their virtual environment. Thus, contrary to a real situation, vection does not occur instantaneously with the appearance of a visual movement. Moreover, the visual stimulus often generates alternating periods of perception of movement of the environment and of oneself (bistable perception) which can lead to "simulator sickness", a disabling situation for the user. Thus, as vection is an essential element to allow an "optimal transfer of learning" from the simulator to reality, it may be important to promote its emergence while limiting its bistability. The aim of this project is to study the inhibitory or facilitative modulation of the emergence of the vection phenomenon by the use of non-invasive cortical stimulation techniques (transcranial electrical stimulation (tES), transcranial alternative current stimulation (tACS), and repeated transcranial magnetic stimulation (rTMS)).

NCT ID: NCT05193305 Not yet recruiting - Healthy Clinical Trials

Study of Healthy Cohort for Early Detection of Cancer

Start date: July 1, 2022
Phase:
Study type: Observational

Cancer produces a significant burden on society with a majority diagnosed at late stages when the chance of cure is low. Early diagnosis improves patient outcomes. Data consisting of lifestyle factors, medications, physical activity, years before conventional cancer diagnosis is also worthwhile for to determine early detection. This is only achievable with longitudinal tracking of a large number of healthy individuals and identifying those who do develop cancer over time.