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NCT ID: NCT05707403 Not yet recruiting - Healthy Clinical Trials

A Study in Healthy Men to Test How BI 1015550 is Taken up and Handled by the Body

Start date: February 15, 2023
Phase: Phase 1
Study type: Interventional

This trial is intended to examine the absolute oral bioavailability of BI 1015550 as tablet formulation for oral administration, using an intravenous microtracer approach with [14C]-labelled BI 1015550. These data are considered necessary to further support the understanding of the pharmacokinetics of BI 1015550.

NCT ID: NCT05706948 Not yet recruiting - Healthy Clinical Trials

High Intensity Interval Training on Cardiopulmonary Parameters With or Without Facemask in Healthy Participants

Start date: January 2023
Phase: N/A
Study type: Interventional

To determine the effects of high intensity interval training on cardiovascular function, cardio metabolic markers and cardiorespiratory fitness in healthy individuals with or without facemask

NCT ID: NCT05706532 Not yet recruiting - Healthy Clinical Trials

Cardiovascular and Cerebrovascular Control in Healthy Subjects

CardioSan
Start date: February 2023
Phase:
Study type: Observational

The aim of the study is to evaluate autonomic function and cerebrovascular control in 30 healthy subjects by means of noninvasive analysis of time series variability. To this extent, heart period, systolic and mean arterial blood pressure, cerebral blood velocity, peripheral resistances, respiration will be recorded from subjects during an orthostatic challenge. The interactions between autonomic cardiovascular function, cerebrovascular and peripheral control will be evaluated explioiting the most advanced signal processing techniques.

NCT ID: NCT05703841 Not yet recruiting - Healthy Clinical Trials

A Study of JNJ-77242113 Following Oral Administration in Healthy Chinese Adult Participants

Start date: February 20, 2023
Phase: Phase 1
Study type: Interventional

The purpose of the study is to assess what drug does to body when healthy Chinese participants receive single oral dose of JNJ-77242113.

NCT ID: NCT05702450 Not yet recruiting - Healthy Clinical Trials

Study to Evaluate Pharmacokinetics, Safety and Efficacy of CM310

Start date: March 30, 2023
Phase: Phase 1
Study type: Interventional

This is a single-center, randomized, open study to evaluate the pharmacokinetics, safety and immunogenicity CM310 in healthy subjects.

NCT ID: NCT05699200 Not yet recruiting - Healthy Clinical Trials

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Start date: February 2023
Phase: N/A
Study type: Interventional

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

NCT ID: NCT05695495 Not yet recruiting - Healthy Clinical Trials

Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study)

DMT BDR
Start date: March 15, 2023
Phase: Phase 1
Study type: Interventional

N,N-dimethyltryptamine (DMT) is a psychoactive substance with similar effects such as LSD or psilocybin. However, DMT is less well characterized than the latter substances. The present study is a modern randomized cross-over trial, investigating different intravenous DMT boluses over a broad dose range. Thus, different doses will be tested and related to subjective and autonomic effects.

NCT ID: NCT05694533 Not yet recruiting - Healthy Clinical Trials

Study of Potential CYP3A4 Induction by INDV-2000 in Healthy Adults

Start date: March 15, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the potential for cytochrome P450 (CYP) 3A4 induction after dosing with INDV-2000 via use of midazolam as a probe.

NCT ID: NCT05692869 Not yet recruiting - Healthy Clinical Trials

A Study of Continuous Blood Pressure Monitoring in Healthy Participants

Start date: January 31, 2023
Phase: N/A
Study type: Interventional

The main purpose of this study in healthy participants is to find out whether the traditional ambulatory blood pressure monitor (ABPM) and newer wearable devices (EmbracePlus smartwatch device, Biobeat chest patch device, and Aktiia wrist device) will accurately pick up changes in blood pressure caused by 2 different medications (propranolol and pseudoephedrine). The study will last about 29 days excluding the screening period of 28 days.

NCT ID: NCT05688397 Not yet recruiting - Healthy Clinical Trials

Evaluation of the Vaginal Colonization of Two New Lactobacillus Strains After Oral Administration in Healthy Volunteers

Start date: January 15, 2023
Phase: N/A
Study type: Interventional

Randomized study to determine whether the vaginally isolated strains of Lactobacillus gasseri and/or Lactobacillus crispatus can colonize the vagina when taken orally for 18 days. Secondary outcomes comprise evaluation of safety, tolerability, impact on vaginal microbiota and vaginal pH