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NCT ID: NCT06329245 Not yet recruiting - Healthy Clinical Trials

Development of Prosocial Behaviors and Related Brain Network in Infants of High and Low Risk of ASD

Start date: April 1, 2024
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to compare the developmental trajectories of prosocial behaviors and functional network connections in infants and toddlers at high and low risk of autism spectrum disorder (ASD). The main questions it aims to answer are what the differences in prosocial behaviors and related brain network connections between infants/toddlers at high and low risk of ASD are. Participants will receive developmental and social communicational assessments (Griffiths Mental Developmental Scales, Peabody Developmental Motor Scales, The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist), resting-state EEG and MRI in a natural sleeping state.

NCT ID: NCT06327880 Not yet recruiting - Healthy Clinical Trials

A Study to Learn About the Study Medicine Called PF-07054894 in People of Japanese Origin

Start date: April 24, 2024
Phase: Phase 1
Study type: Interventional

The purpose of this clinical study is to learn about the safety and effects of the study medicine (PF-07054894) in healthy Japanese participants. The study is seeking the following participants: - Male or female Japanese participants aged 18 years or older. The participants should be healthy after going through some medical tests. - Have a Body Mass Index (BMI) of 16 to 32 kilogram per meter squared; and a total body weight of more than 45 kilograms (100 pounds). - Are willing and able to follow all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures. In research, the participants in clinical studies are assigned by chance to separate groups that are given different treatments. Hence participants will be by chance assigned to receive either PF-07054894 or a harmless treatment that has no medical effect (placebo). Both these will be taken by mouth for 14 days. The total duration of the study is about 11 weeks, with a follow-up via telephone about 6 weeks after first treatment.

NCT ID: NCT06327256 Not yet recruiting - Healthy Clinical Trials

A Study in Healthy People to Test How Well Different Doses of BI 3000202 Are Tolerated and How They Affect the Way the Body Handles Midazolam

Start date: April 5, 2024
Phase: Phase 1
Study type: Interventional

The aim of this trial is to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) following multiple rising doses of BI 3000202 and to investigate the effect of BI 3000202 on the metabolism of midazolam.

NCT ID: NCT06325930 Not yet recruiting - Healthy Clinical Trials

An Open-Label Phase 1 Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-HU6

Start date: March 26, 2024
Phase: Phase 1
Study type: Interventional

This is a single-center, non-randomized, open-label Phase 1 study to characterize the absorption, metabolism, excretion, mass balance, pharmacokinetics (PK), safety and tolerability of HU6 following administration of a single dose of [14C]-HU6 in a fed state with a standard meal administered approximately 15 minutes prior to dosing.

NCT ID: NCT06325150 Not yet recruiting - Healthy Clinical Trials

The Impact of Light Exposure on Cognitive Function in Classrooms

Start date: May 1, 2024
Phase: Phase 1
Study type: Interventional

Humans are constantly exposed to a variety of light types, created naturally or through artificial means. Light exposure captured by the eyes impacts many physiological functions in humans, including but not limited to cognitive output, fatigue levels, and mood regulation. The level of impact on cognitive learning from different types of light on undergraduate adult students remains unclear.

NCT ID: NCT06314347 Not yet recruiting - Healthy Clinical Trials

Reference Value of Figure of 8 Walk Test

Start date: May 1, 2024
Phase:
Study type: Observational

The aim of the study is to determine the reference values of the Figure 8 Walking Test in healthy adults.

NCT ID: NCT06311656 Not yet recruiting - Healthy Clinical Trials

A Study to Evaluate Safety, Tolerability of LY4100511 (DC-853) in Healthy Asian and Non-Asian Participants

Start date: March 12, 2024
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to assess the safety and tolerability of LY4100511 (DC-853) after single and multiple dose administrations in healthy asian participants and non-Asian participants.

NCT ID: NCT06311487 Not yet recruiting - Healthy Clinical Trials

Time and Nutrient-Dependent Effects of Aerobic Exercise on Metabolism in Adults (TANDEM Study)

TANDEM
Start date: March 2024
Phase: N/A
Study type: Interventional

This study plans to learn more about metabolic responses to aerobic exercise at different times of the day (morning or evening) under fasting versus fed conditions.

NCT ID: NCT06311097 Not yet recruiting - Healthy Clinical Trials

Dairy Products to Your Gut and Brain

YourGutBrain
Start date: March 2024
Phase: N/A
Study type: Interventional

The goal of this intervention study is to compare the effects of fermented dairy and non-fermented dairy on bowel habits and cognitive performance in healthy women with defecations every other day or less. Furthermore, the study aims to explore underlying mechanisms linking the gut and the brain. In addition, a sub-study will be conducted to explore differences in gut and brain measures between women with daily (reference group) and few (intervention group) weekly bowel movements, respectively, and to explore associations between measures of gut- and brain function.

NCT ID: NCT06310876 Not yet recruiting - Healthy Clinical Trials

A Thorough QT Study of ABBV-CLS-7262 in Healthy Subjects

Start date: March 2024
Phase: Phase 1
Study type: Interventional

This is a randomized, blinded, placebo and active-controlled, 4-period, crossover design thorough QT/QTc (TQT) study to evaluate the effect of ABBV-CLS-7262 on cardiac repolarization in healthy adult subjects.