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NCT ID: NCT05036122 Not yet recruiting - Healthy Clinical Trials

Estimating Blood [Lactate] Non-Invasively

Start date: October 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to validate the LabClasp's ability to estimate blood [lactate].

NCT ID: NCT05034913 Recruiting - Healthy Clinical Trials

Digital Photography to Estimate Anthropometric Measurements in Children

Start date: August 31, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to see if photos taken from home can accurately let physicians know the height, abdominal circumference, and wrist circumference of children, and how these measurements relate to in-person measurements.

NCT ID: NCT05034575 Enrolling by invitation - Healthy Clinical Trials

Eye Tracking in Laryngology

Start date: June 29, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to assess whether eye-tracking technology can be used to differentiate the visual gaze patterns of experienced and novice laryngoscopists while reviewing prerecorded laryngeal videos with both normal and abnormal findings and to characterize any differences arising between level of training groups.

NCT ID: NCT05034120 Not yet recruiting - Healthy Clinical Trials

Food Effect and Mass Balance Study of XZP-3621 Tablets

Start date: September 2021
Phase: Phase 1
Study type: Interventional

This is a single-center, open-label, single-dose phase I study, the study is divided into two stages. The stage 1 is to investigate the absorption, metabolism and excretion of XZP-3621 tablets in healthy Chinese subjects. The stage 2 is to evaluate the effect of food on the Pharmacokinetics of single-dose XZP-3621 tablets in Chinese Healthy Volunteers. In addition, the safety of XZP-3621 tablets in Chinese Healthy Volunteers will also be evaluated.

NCT ID: NCT05032144 Not yet recruiting - Healthy Clinical Trials

The Safety and Tolerability of STSA-1002 Following Intravenous Infusion in Healthy Subjects

Start date: September 2021
Phase: Phase 1
Study type: Interventional

A randomized,double-blind,placebo-controlled,single-ascending dose phase Ⅰa study to evaluate the safety,tolerability,pharmacokinetics and pharmacodynamics of STSA-1002 following intravenous infusion in healthy subjects

NCT ID: NCT05030857 Not yet recruiting - Healthy Clinical Trials

Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects

Start date: September 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the effect of the administration of multiple doses of GLPG4716 on the amount of midazolam (MDZ) that gets into the blood when the two drugs are administered together compared to when midazolam is administered alone. Other objectives of this study are to evaluate the safety and tolerability of GLPG4716 when administered with midazolam and assess the amount of GLPG4716 that gets into the blood when administered with midazolam. This study will also assess the effect of food on the amount of GLPG4716 that gets into the blood.

NCT ID: NCT05028959 Not yet recruiting - Healthy Clinical Trials

Hormonal Status, Performance and Health in Elite Female Athlete

FEMMES
Start date: September 15, 2021
Phase: N/A
Study type: Interventional

The repercussions of the hormonal status of high-level sportswomen on their performance and health as well as on the Athlete's Biological Passport (ABP) have been little studied and remain poorly known. The investigators therefore propose to contribute to the improvement of current knowledge by determining, thanks to the implementation of a multidisciplinary monitoring, with the use of various tests and matrices, in female elite athletes and recreational athletes (control group): - 1) the impact of cycle phase, absence of cycle or contraceptive use on physical and psychological performance, health as well as on ABP; - 2) the potential confounding effects of the athlete's environment - 3) correlations between the different matrices analyzed

NCT ID: NCT05028673 Recruiting - Healthy Clinical Trials

A Study to Evaluate a New Tablet Formulation of Lu AG06466 in Healthy Participants

Start date: August 23, 2021
Phase: Phase 1
Study type: Interventional

The main goal of this trial is to learn how a new tablet formulation of Lu AG06466 behaves in the body. Researchers will compare the new tablet formulation to the capsule formulation that is currently being tested in other clinical trials. They will measure the levels of the drug in the bloodstream for up to 3 days after participants take either the tablet or the capsule formulation. They will also look at whether the tablet formulation behaves differently when it is taken with and without food.

NCT ID: NCT05027958 Not yet recruiting - Healthy Clinical Trials

Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens Into the Human Lung

Start date: September 17, 2021
Phase: Early Phase 1
Study type: Interventional

Background: Tuberculosis (TB) is a lung disease. It is caused by inhaling a type of airborne bacterium. Tuberculin Purified Protein Derivative (PPD) is used to test for TB exposure. It is usually injected under a person s skin. In this study, it will be applied in the lung. Objective: To learn how the cells within the lung react (immune response) when exposed to PPD. Eligibility: Adults ages 18-64 who (1) have been exposed to TB but do not have active disease or symptoms or (2) have never been exposed to TB. Design: Participants will be screened with a medical history, physical exam, and blood tests. They will have a TB skin test. They will also have an electrocardiogram to examine heart rhythm. For this, sticky patches will be placed on their chest. Some screening tests will be repeated at study visits. Participants will have 3 FDG PET-CT scans. They will lie in a machine that creates pictures of the inside of their body. They will get a radioactive substance injected into their arm called 18FDG. It helps make the pictures. Participants will have 3 bronchoscopies. Their mouth and nasal airways will be numbed. They will get drugs to relax. A tube will be inserted through their nose or mouth into a lung. Fluid will be delivered into the lung and suctioned back out to collect cells. They will get PPD during the first bronchoscopy. Participation will last for about 30 days. Participants will visit the clinic up to 8 times. They will go home after each procedure. No hospital stays are needed....

NCT ID: NCT05027568 Recruiting - Healthy Clinical Trials

A Study to Assess an ATX Inhibitor (IOA-289) in Healthy Volunteers

Start date: July 5, 2021
Phase: Phase 1
Study type: Interventional

The purpose of Part 1 of this First-in-Human trial is to evaluate the safety and tolerability after single ascending oral doses of IOA-289 given to healthy male subjects, compared to placebo. After the oral dose administrations, the amount of IOA-289 present in serum will be determined for pharmacokinetic characterisation. Also the reduction of LPA in plasma will be determined as a pharmacodynamic biomarker. Part 2 is optional and its conduct will be dependent on the pharmacokinetic data generated in Part 1. Part 2 will be a randomized, crossover, open label, single oral dose administration of IOA-289 to healthy male subjects either in a fasted state, or after a high-fat meal.