View clinical trials related to Healthy.
Filter by:The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B. infantis), given to healthy newborns can affect various health outcomes and to explore impacts of the infant gastrointestinal microbiome. The main questions it aims to answer are: - Does B. infantis probiotics impact immune function and does it lower the number of bacterial infections and use of antibiotics? - Does B. infantis probiotics impact overall health, development, growth and wellbeing? - Does B. infantis probiotics impact inflammatory diseases, allergies and autoimmune diseases Researchers will compare B. infantis probiotics to a placebo (a look-alike substance that contains no probiotic) to see if B. infantis colonization impact the human immunesystem and various clinical and biochemical health markers. Participants (parents) will - Orally administrate the B. infantis probiotic to their newborn child daily in three weeks from 7 days of age. - Answer baseline and follow up questionnaires in a study app - Take five stool samples from the child and one stool sample from the mother - Collect a 4 week of passive dust sample at home (Electrostatic Dust fall Collector) - Donate one dried bloodspot and one blood sample from their child
Few data are so far available regarding the adult normal values of circulating NKT-like cell concentration, and none for the pediatric population. The primary objective of this study is to determine the reference values for NKT-like cells in pediatric and adult patients (derivation cohort). The secondary objective is to validate the results obtained from the adult derivation cohort with those obtained from an adult validation cohort, consisting of a group of healthy adult volunteers.
The main purpose of the trial is to compare the pharmacokinetics of insulin degludec and liraglutide as part of a combination product insulin degludec/liraglutide compared with Xultophy®. During the trial period, serials of blood samples will be collected from the participants at two dosing periods, in order to determine the concentration of insulin degludec and liraglutide. The total volume of blood taken throughout the whole trial period will be less than 400 mL. Participants will be asked to stay on daytime and overnight in the trial sites on some predefined days. For other outpatient days, participants need to attend the trial site as required for drug administration or required assessments.
This study explores the effects of varying volumes of resistance training on body composition, strength, peak power, and muscle thickness in untrained women over eight weeks. A randomized controlled trial involving 45 female college students assessed the outcomes across three groups: low-volume training (LVT) with three weekly sessions, moderate-volume training (MVT) with four weekly sessions, and high-volume training (HVT) with five weekly sessions. Participants were untrained, aged 18-65, and free from cardiovascular diseases or performance-enhancing drugs. The hypothesis suggested that moderate volume training would yield optimal muscle development, considering the potential non-linear dose-response relationship where excessive training might be detrimental. Measurements included body composition, muscle thickness, and peak power through a force platform during vertical jumps. Data analysis focused on changes in muscle thickness, strength, and body composition, with statistical significance set at p < 0.05. The study aimed to provide insights into how different training volumes affect physiological adaptations in untrained women, potentially guiding fitness regimen optimizations for similar populations.
This is a Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose, first in human safety, tolerability, and pharmacokinetic study of SPY001-001 in healthy participants.
Sperm cryopreservation is an essential tool for men fertility preservation in the context of gonadotoxic treatments or/and pathologies such as cancers, gamete donation and ART. Nevertheless, it is validated that the freezing and thawing procedures affect sperm parameters and in particular motility. It is therefore essential to determine the impact of storage time on motility and particularly the number of progressive motile spermatozoa which will determine the choice of ART technique. However, few studies have analyzed the impact of storage time in liquid nitrogen and no study over a long period on human spermatozoa and their use in ART. The aim of this study is to assess the impact of long-time storage, from 2 to 12 years, in liquid nitrogen on standard semen parameters, notably motility.
This study evaluates the FIFA 11+ Kids Training Protocol, specifically its application to young female volleyball players. It compares it against standard warm-up routines in terms of enhancing motor skills and physical performance. The research anticipates that the FIFA 11+ principles will yield positive outcomes when integrated with existing knowledge of volleyball performance metrics. The study involved 34 young female volleyball players divided into an exercise group (15 players) and a control group (19 players). Initial assessments included anthropometric measurements and motor competence tests such as balancing backward, jumping sideways, moving sideways, and eye-hand coordination (KTK3+ tests). Subsequent sessions focused on physical and functional tests, including balance performance, agility (pro-agility test), vertical jump (countermovement jump test), and the functional movement screen (FMS) test. A two-way analysis of variance was used to compare the effects of the exercise versus the control group over time, revealing that the exercise group showed significant improvements in dynamic balance, KTK balancing backward, and KTK moving sideways. This study aims to provide innovative insights into the effectiveness of the FIFA 11+ Kids Training Protocol, highlighting its potential benefits in improving physical and motor competencies in young female volleyball players.
Social injustices, such as the absence of racial representation and culturally tailored programs in parks, may further discourage African American families from accessing and using these spaces. 10 Studies are needed to investigate how exposure to more equitable greenspace environments may support physical activity (PA) among African American families. Justice-focused, park-based PA interventions hold high promise for reducing health disparities and future cardiovascular diseases (CVD) and related chronic conditions (RCC) risk, thus carrying significant implications for the fields of public health, family medicine, and urban planning. This pilot study is a two-arm, parallel randomized controlled trial that will be conducted in partnership with community stakeholders from the Three River Park District (TRPD); TRPD parks are located in the Twin Cities region of Minnesota. This trial aims to evaluate the changes in PA, psychological health, sleep, and blood pressure among a cohort of African American parent-child dyads who will be randomized to two intervention conditions. The intervention conditions are: (1) a culturally tailored, nature-based program offered at the TRPD (hereafter, "NatureUplift"), and (2) NatureUplift plus a supplementary walking/hiking educational component (hereafter, "NatureUplift+Active"). Participant dyads will be randomized to NatureUplift or NatureUplift+Active.
Current first-line treatments for major depression (antidepressants and psychotherapy) show a long latency to response, and less than half of all patients experience full remission with optimized treatment, indicating the need for new developments. The aim of this study is to extend and further develop a longstanding line of research of using sleep neurophysiology as a 'window to the brain' and treatment development in major depression. Particularly, this project is designed to test the feasibility, efficacy and mechanisms of action of a new sleep-based treatment technology.
The upper limbs play an essential role for safe and efficient walking in healthy persons and persons post-stroke. Nevertheless, in current post-stroke gait rehabilitation (research) the upper limbs are barely targeted. To address this gap, my project aims to investigate the selective motor control of the upper limbs during walking and the contribution of the cortical activity to the arm swing in independent walkers after stroke. To gain insight in the direct effects of stroke on the arm swing, the primary motor control of the arm swing will be evaluated by determining muscle synergies (i.e group of muscles working together as a task-specific functional unit). Additionally, the cortical activity (EEG-analysis) during walking of persons post-stroke will be compared to healthy controls and the relationship between stroke-induced changes in cortical activity and arm swing deviations will be assessed. Furthermore, I will evaluate whether improvements in cortical activity relate to improvements in primary motor control of the arm swing. This innovative project will be the first to investigate the direct coupling between the cortex and the muscle synergies in persons post-stroke during independent walking to investigate the arm swing. These fundamental insights in the primary motor control of the arm swing and the contribution of the cortical activity will allow to develop targeted interventions aiming to improve arm swing and as such optimize post-stroke gait rehabilitation. Research questions: 1. How can muscle synergies explain arm swing alterations in independent walkers after stroke? 2. How do stroke-induced changes in cortical activity relate to arm swing deviations in persons after stroke? 3. Are changes in primary motor control of the upper limb during walking related to normalization of brain activity in independent walkers after stroke?