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Healthy clinical trials

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NCT ID: NCT05432180 Recruiting - Healthy Clinical Trials

Human Milk Nutrients and Infants' Health Outcomes in South China

Start date: June 6, 2022
Phase:
Study type: Observational

The purpose of this study is to investigate the associations between human milk nutrients and infants' health outcomes in China.

NCT ID: NCT05431153 Recruiting - Healthy Clinical Trials

A Study to Investigate the Effect of Tablet Formulation and Food on PF-07104091 in Healthy Participants

Start date: June 10, 2022
Phase: Phase 1
Study type: Interventional

This is a single dose crossover pharmacokinetic (pharmacokinetics helps in understanding how the drug is changed and eliminated from the body after a participant takes it) study in healthy participants. The study consists of 5 treatments, and each participant will be randomized to receive 4 of the treatments in separate periods in a specific sequence. Each treatment consists of a single dose of PF-07104091 and the treatments differ by tablet formulation and/or whether the dose is to be given under fasted or fed conditions. Plasma pharmacokinetics of PF-07104091 will be assessed following each dose to determine the effect of tablet formulation and fed condition on the relative bioavailability of PF-07104091.

NCT ID: NCT05428917 Recruiting - Healthy Clinical Trials

Evaluation of the Impact of Laterality on Cerebral Activation During a Motor Task of the Upper Limb in Healthy Subjects.

Lateralinirs
Start date: April 8, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the differences in brain activation in healthy subjects during motor tasks, depending on the laterality of the subject, the laterality of the task and the complexity of the task. It seems that the laterality of activation is less marked in left-handed people, when using the non-dominant hand and when performing a complex task. The objective of this study is to highlight profiles of subject and modality of use of the hand with a specific lateralization of cerebral activation.

NCT ID: NCT05428696 Not yet recruiting - Healthy Clinical Trials

Safety and Tolerability, PK, and PD Study of Single and Multiple ALXN2080 Doses in Healthy Participants

Start date: September 5, 2022
Phase: Phase 1
Study type: Interventional

This study is designed to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of ALXN2080 in healthy adult participants.

NCT ID: NCT05428436 Not yet recruiting - Healthy Clinical Trials

A Study in Healthy People to Compare 2 Different Formulations of BI 1015550 Taken With or Without Food

Start date: August 15, 2022
Phase: Phase 1
Study type: Interventional

The main objective of this trial is to investigate the relative bioavailability of BI 1015550 intended Commercial Formulation (iCF) compared with Trial Formulation 2 (TF2) and the effect of food on the pharmacokinetics of BI 1015550 iCF following oral administration.

NCT ID: NCT05428306 Completed - Healthy Clinical Trials

Pharmacokinetic Interaction Between Ibuprofen and Acetaminophen, Tablets Administered Individually or in Combination

Start date: October 23, 2018
Phase: Phase 1
Study type: Interventional

This study was carried out in the Clinical and Analytical Unit of the Pharmacology and Toxicology Department of the Faculty of Medicine of the Autonomous University of Nuevo León, with the aim of comparing the bioavailability (Cmax, AUC) of an oral formulation containing ibuprofen 400 mg/ Acetaminophen 1000 mg in combination with the two oral formulations ibuprofen 400 mg or Acetaminophen 1000 mg administered as a single dose, in healthy subjects under fasting conditions

NCT ID: NCT05428293 Completed - Healthy Clinical Trials

Pharmacokinetic Interaction Between Ibuprofen and Acetaminophen Oral Suspension

Start date: February 22, 2019
Phase: Phase 1
Study type: Interventional

This study was carried out in the Clinical and Analytical Unit of the Pharmacology and Toxicology Department of the Faculty of Medicine of the Autonomous University of Nuevo León, in order to compare the bioavailability (Cmax, AUC) of an oral formulation containing Ibuprofen 100 mg/Acetaminophen 125 mg in combination with the two oral formulations Ibuprofen 100 mg or Acetaminophen 125 mg administered as a single dose, in healthy subjects under fasting conditions.

NCT ID: NCT05427604 Completed - Healthy Clinical Trials

To Evaluate the Effects of Omega 3 Fatty Acids in the Context of Cancer Prevention

Start date: February 23, 2021
Phase: N/A
Study type: Interventional

Previous studies have demonstrated, in an in vitro micro-tumour model (the spheroid) and in a mouse model, that long-chain omega-3 fatty acids, in particular docosahexaenoic acid (DHA), can inhibit tumour development. Therefore, the aim of this study was to collect DHA-enriched human serum, following ingestion of a DHA-enriched oil, in order to assess its effect on tumour development in vitro. Blood enriched in fatty acids not containing DHA will be used as a control condition, obtained after ingestion of olive oil. This study is an important step to determine the interest of DHA supplementation as a new approach to prevent tumour development, and/or as an adjuvant to cancer treatments.

NCT ID: NCT05427565 Not yet recruiting - Healthy Clinical Trials

Exploring the Cortical Hemodynamic Variability of Four Weeks iTBS on a Healthy Participant: a Case Study

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

This study will investigate the effect of caffeine and time of day on brain excitability using excitatory brain stimulation. We will recruit a healthy participant and conduct a concurrent iTBS/fNIRS protocol for 20 consecutive sessions over four weeks with or without caffeine consumption before the stimulation. Moreover, the experiment will be conducted at different times of the day (morning or afternoon)

NCT ID: NCT05427552 Recruiting - Healthy Clinical Trials

Exploring the Cortical Hemodynamic Response of Excitatory Brain Stimulation: a Pilot Study

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

Intermittent theta-burst stimulation (iTBS) is a promising treatment for major depressive disorder. However, fewer than 50% of patients show sufficient response. Therefore, the optimal treatment protocol is worth investigating. Recent studies show that the relationship between stimulation intensity and prefrontal hemodynamic response is not linear but in an inverse U-shape by exploring the hemodynamic changes before and after iTBS. Concurrent transcranial magnetic stimulation (TMS)/functional near-infrared spectroscopy (fNIRS) setup allows us to observe the prefrontal hemodynamic response during stimulation. The aim of this study is to investigate the effects of different intensities on brain activity during and after the stimulation using fNIRS.