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NCT ID: NCT05699200 Not yet recruiting - Healthy Clinical Trials

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Start date: February 2023
Phase: N/A
Study type: Interventional

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

NCT ID: NCT05698862 Recruiting - Healthy Clinical Trials

Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA

GutBrainGABA
Start date: May 21, 2022
Phase: N/A
Study type: Interventional

Gut microbiota produce different metabolites within the human body, which include neurotransmitters. Animal studies have demonstrated a critical role for the gut microbiota in various aspects of brain and behavioural function, and a smaller number of studies in humans have shown differences of gut microbiota composition in psychiatric conditions. However, almost nothing is known about the impact of neurotransmitters produced by the gut microbiota on human brain and behaviour. The way in which differences in brain, behaviour and personality traits are associated with the gut microbiota, and how they are influenced by a probiotic will be explored, with a special focus on GABA (Gamma Amino Butyric Acid). Abnormalities of microbiota composition have been identified in metabolic disorders, such as inflammatory bowel disease and obesity, and psychiatric conditions, such as depression and anxiety. The aim of this intervention trial will be to answer the following fundamental questions: 1. Does the population of gut bacteria capable of producing GABA modulate brain-based measures of GABA? 2. Does the population of gut bacteria capable of producing GABA influence performance in behavioural tasks known to depend on GABA-ergic function? The impact of a GABA producing probiotic on the measures of GABA in the brain and serum, relevant metabolites in blood, faecal and urine samples and performance in GABA dependent behavioural tasks will be investigated in this trial.

NCT ID: NCT05698771 Recruiting - Healthy Clinical Trials

NAD-brain: a Pharmacokinetic Study of NAD Replenishment Therapy

NAD-brain
Start date: January 29, 2023
Phase: N/A
Study type: Interventional

The objective of the NAD-brain study is to determine the blood and brain pharmacokinetics of NAD replenishment therapy (NRT) using Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN).

NCT ID: NCT05695495 Not yet recruiting - Healthy Clinical Trials

Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study)

DMT BDR
Start date: March 15, 2023
Phase: Phase 1
Study type: Interventional

N,N-dimethyltryptamine (DMT) is a psychoactive substance with similar effects such as LSD or psilocybin. However, DMT is less well characterized than the latter substances. The present study is a modern randomized cross-over trial, investigating different intravenous DMT boluses over a broad dose range. Thus, different doses will be tested and related to subjective and autonomic effects.

NCT ID: NCT05694533 Not yet recruiting - Healthy Clinical Trials

Study of Potential CYP3A4 Induction by INDV-2000 in Healthy Adults

Start date: March 15, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the potential for cytochrome P450 (CYP) 3A4 induction after dosing with INDV-2000 via use of midazolam as a probe.

NCT ID: NCT05694442 Active, not recruiting - Healthy Clinical Trials

The Effect of Lipmatte K

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the safety and the effectiveness of Lipmatte K on lip hydration and brightening. The study duration is 4 weeks and the lip assessment will be carried out at baseline, week 2 and week 4.The main questions this study aims to answer are: 1. The hydration effect of the product on lip. 2. The brightening effect of the product on lip. 3. To observe any adverse effect occurrence with the usage of the product.

NCT ID: NCT05694429 Active, not recruiting - Healthy Clinical Trials

The Effect of the Combination of Cleanser and Moisturizer Product K

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the effectiveness of product K cleanser and moisturizer when use in combination for skin rejuvenation. The study duration is 8 weeks and the skin assessment will be carried out at baseline, week 2, week 4 and week 8.The main questions this study aims to answer are: 1. The effect of cleanser and moisturizer K when use in combination on skin hydration. 2. The effect of cleanser and moisturizer K when use in combination on skin elasticity. 3. To observe any adverse effect occurrence with the usage of the products.

NCT ID: NCT05694182 Recruiting - Healthy Clinical Trials

The Safety and Efficacy of an Oral Superfruits Supplement

Start date: December 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the safety and effectiveness of an oral superfruits supplement for skin brightening and wrinkle reduction. Superfruits are reported to have high bioactive compounds with beneficial effects on human health. The study duration is 12 weeks and the skin assessment will be carried out at baseline, week 2, week 6 and week 12. The participants will consume the supplement for 6 weeks and at week 12, final skin assessment will be conducted. The main questions this study aims to answer are: 1. The skin brightening effect of the oral superfruits supplement. 2. The effect of the oral superfruits supplement on wrinkle reduction. 3. To observe any adverse effect occurrence with the consumption of the oral superfruits supplement.

NCT ID: NCT05693961 Completed - Healthy Clinical Trials

An Invasive Controlled Desaturation Study to Determine the Accuracy of the CART-I Pulse Oximeter

Start date: June 12, 2021
Phase: N/A
Study type: Interventional

A pulse oximeter is used for continuous monitoring of peripheral oxygen saturation (SpO2) and plays an important role in the early detection of hypoxia, guiding the titration of supplemental oxygen, and reducing the need for blood gas analysis. Therefore, the SpO2 accuracy of a pulse oximeter should be validated for patient safety. The objective of this study is to evaluate whether the CART-I pulse oximeter with a ring-type wearable PPG sensor (Sky Labs Inc., Seoul, Korea) provides clinically reliable SpO2 readings over the range of 70-100% SaO2, during steady-state, non-motion conditions.

NCT ID: NCT05693948 Recruiting - Healthy Clinical Trials

The Efficacy of Topical Serum X for Skin Brightening

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the effectiveness of topical serum X containing arbutin and glutathione for skin brightening. The study duration is 12 weeks and the skin assessment will be carried out at baseline, week 4, 8 and week 12.The main questions this study aims to answer are: 1. The skin brightening effect of the product on facial skin. 2. To observe any adverse effect occurrence with the usage of the product.