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Parkinson Disease clinical trials

View clinical trials related to Parkinson Disease.

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NCT ID: NCT05388526 Not yet recruiting - Parkinson Disease Clinical Trials

Frailty and Cognitive Function in Parkinson's Disease.

Start date: June 1, 2022
Phase:
Study type: Observational

Introduction: Parkinson's disease (PD) is the association of tremor, rigidity, akinesia-bradykinesia and loss of postural reflexes. Non-motor symptoms such as cognitive impairment may also develop. Cognitive impairment can be highly variable in its progression, symptoms and severity and can begin from the onset of the disease to the most advanced stages. Frailty is a syndrome characterized by a decrease in physiological reserve that results in an individual's increased vulnerability, which can lead to a variety of adverse factors when exposed to stressors. PD and frailty are highly prevalent in older people and are associated with increased morbidity and mortality. The presence of frailty in patients with PD is poorly studied, as is the association between cognitive impairment and frailty in this patient profile. Objective: Evaluate the relationship between frailty and cognitive impairment in patients with PD or secondary parkinsonism. Study design: observational, descriptive, correlative and cross-sectional. Study population: The subjects that will be part of this study will be men and women with a diagnosis of PD or secondary parkinsonism belonging to the Health Area V of the Health Service of the Principality of Asturias, Spain.

NCT ID: NCT05385497 Not yet recruiting - Parkinson's Disease Clinical Trials

Combining Aerobic Exercise and Virtual Reality for Cognitive-motor Rehabilitation in PD

Start date: September 2022
Phase: N/A
Study type: Interventional

This project will provide preliminary data on the feasibility and effects of exercise and VR on motor behavior and neuroplasticity in PD. Results from this work will provide insight into whether combination interventions utilizing AE and VR have parallel effects on cognition, gait, and neuroplasticity in PD.

NCT ID: NCT05385315 Not yet recruiting - Parkinson Disease Clinical Trials

Towards the Validation of a New Blood Biomarker for the Early Diagnosis of Parkinson's Disease

BIOPARK
Start date: May 31, 2022
Phase:
Study type: Observational

We have recently discovered a metabolic biomarker which predicts Parkinson's disease (PD) at the early stages in patients and in animal models (Mallet et al., 2022). The aim of BIOPARK is to investigate how the biomarker evolves in advanced PD stage, when diagnosis confirmation is higher, an in de novo PD patients who come from a different geographical area than those in our publication (since it is known that the metabolome is largely influenced by lifestyle). We will also evaluate if our biomarker is able to distinguish patients with a parkinsonian syndrome often confused with parkinson's disease, i.e. Multiple System Atrophy (MSA).

NCT ID: NCT05384522 Not yet recruiting - Parkinson Disease Clinical Trials

Analysis of the Prognostic Role of Epigenetic Biomarkers in Relation to the Motor Decline in Parkinson's Disease

BioGenPark
Start date: May 30, 2022
Phase:
Study type: Observational

BioGenParkinson is an observational, prospective cohort study evaluating biomarkers of Parkinson's Disease (PD) progression in community-dwelling subjects aged 65 years or more, consecutively referring to INRCA outpatient clinic of the Neurology Unit. Selected patients will undergo clinical and laboratory evaluations at the baseline, and will be followed up after 6 and 12 months. The biological evaluation will include the determination of i) routine biological parameters ii) advanced biomarkers such as epigenetic analysis of DNA methylation, genetic analysis on multiple loci associated with PD progression and specific proteins associated with motor and non-motor decline. After obtaining all data, multiple statistical analysis will be performed to evaluate the most accurate prognostic biomarkers of PD progression at this stage of disease.

NCT ID: NCT05382858 Recruiting - Parkinson Disease Clinical Trials

PSA Versus STN DBS for Dopamine-resistant TD-PD

PSA-STN
Start date: May 1, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to compare the effectiveness of the deep brain stimulation in the posterior subthalamic area (PSA) versus the subthalamic nucleus (STN) for the treatment of dopamine-resistant tremor-dominant Parkinson's disease (PD) in a randomized, double-blinded, cross-over manner.

NCT ID: NCT05379062 Not yet recruiting - Parkinson Clinical Trials

Choral Singing for Patients With Parkinson's

CHORMORPARK
Start date: May 2022
Phase: N/A
Study type: Interventional

Study Design: Multi-centered, open, prospective, three-arm, randomized, controlled parallel-group study; Study Participants: Adult patients with Parkinson's disease in Salzburg (and surroundings) and Vienna (and surroundings); Planned Sample Size: Experimental Group 1 (singing in a group/active): 30 persons; Experimental group 2 (receptive music/auditive): 30 persons; Control group (treatment as usual condition): 30 persons; Planned Duration of Study: Recruitment: spring 2022, study duration: spring 2022 to autumn 2022, evaluation phase and publication: autumn-summer 2022/2023; Primary Objectives: Reduction of depression, anxiety and physiological stress; Measurement of the Endpoints: Hospital Anxiety and Depression Scale - German Version (HADS-D), Biochemical determination: cortisol and alpha-amylase (concentration measurement in saliva).

NCT ID: NCT05377281 Not yet recruiting - Parkinson's Disease Clinical Trials

Feasibility and Safety of autoloGous UncondItioneD pEripheral Nerve Tissue Delivery to the Substantia Nigra (GUIDE)

GUIDE
Start date: May 2022
Phase: Phase 1
Study type: Interventional

This is an open-label, non-randomized, single-arm trial design to actively follow participants for 12 months. Ten participants will be enrolled to receive bilateral delivery of Peripheral Nerve Tissue (PNT) to the Substantia Nigra at the time of Deep Brain Stimulation (DBS) surgery. After 12 months, participants will be followed long term through annual visits for the rest of their lives. Participants will serve as their own donor for the tissue.

NCT ID: NCT05377073 Completed - Parkinson Disease Clinical Trials

Effects of Complementary Therapies in People With Mild to Moderate Parkinson's Disease

Start date: September 14, 2021
Phase: N/A
Study type: Interventional

The aim of this study was to compare the effects of Hatha Yoga versus Stretching on physical outcomes, quality of life, physical activity and motor examination in persons with Parkinson Disease. The hypothesis of this study is that Hatha Yoga will improve more than Stretching on physical outcomes, quality of life, physical activity and on motor examinations in persons with parkinson Diseases

NCT ID: NCT05376761 Not yet recruiting - Clinical trials for PD - Parkinson's Disease

EC50 of Dexmedetomidine in Deep Brain Stimulation Implantation of Patients With Parkinson's Disease

Start date: May 10, 2022
Phase: Phase 4
Study type: Interventional

Dexmedetomidine (DEX) sedation is widely used in deep brain stimulation implantation (DBSI) of patients With Parkinson's disease. However, intraoperative application of DEX may affect the discharge activity of deep brain nuclei and reduce the discharge frequency of Subthalamic nucleus (STN) neurons. At present, there is still a lack of prospective intervention research to explore the optimal dose that does not affect MER mapping in patients with Parkinson's disease. The present study uses the Dixon and Massey up-and-down method to analyze the EC50 of DEX in patients with PD undergoing STN-DBS sedation, to clarify the balance meets the sufficient comfort of patients without affecting the accurate target of MER and the optimal dosage of DEX for boundary recognition.

NCT ID: NCT05375032 Recruiting - Parkinson Disease Clinical Trials

Acute Effects of Cycling Dual-task in Parkinson´s Disease.

Start date: May 13, 2022
Phase: N/A
Study type: Interventional

Taking into account the process of functional and cognitive evolution that patients with Parkinson's disease experience throughout the pathology, the objective of this study is to evaluate the acute effects of aerobic exercise in forced cycling performed with lower limbs and freecycling of upper limbs combined with cognitive stimuli on attention, exploration skills, and short-term motor skills in people with Parkinson's disease.