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Depression clinical trials

View clinical trials related to Depression.

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NCT ID: NCT05482646 Recruiting - Depressive Symptoms Clinical Trials

Tai Chi Versus Conventional Exercise to Alleviate Depression in Insomniacs

Start date: August 2, 2022
Phase: N/A
Study type: Interventional

This study aims to examine the effectiveness of Tai Chi and conventional exercise in alleviating depressive symptoms in older insomniacs.

NCT ID: NCT05482217 Completed - HIV Infections Clinical Trials

The Effectiveness of CBI on Depression and Adherence in HIV Infected Adolescents

Start date: July 26, 2021
Phase: N/A
Study type: Interventional

Aim: To explore the effectiveness of psychoeducation and problem-solving (Life-steps) on depression and adherence in HIV-infected adolescents. Methods: Forty-two adolescents were randomized into 21 controls and 21 intervention groups. The intervention group was exposed to 5-week sessions of life steps applied by a lay counselor. The PHQ-9 and visual analog scale (VAS) were used to measure the outcomes: depression and adherence. They were applied at baseline, 5-weeks, and 24 weeks post-intervention.

NCT ID: NCT05481957 Active, not recruiting - Bipolar Depression Clinical Trials

Vortioxetine Adjunctive Treatment in Bipolar Depression

Vortioxetine
Start date: March 1, 2022
Phase: Phase 4
Study type: Interventional

Depressive episode of bipolar disorder is often the first symptom of patients with bipolar disorder, which is characterized by frequent recurrence, relatively long duration, high comorbidity rate and high fatality rate. People with bipolar disorder spend a third of their lives depressed, and it is these depressive symptoms that lead to long-term disability and early death. The treatment of bipolar depression is controversial. The latest Mood Disorders CPG guidelines recommend first-line therapy: quetiapine, lurasidone, lithium, valproate, lamotrigine monotherapy or combination of quetiapine, lurasidone plus Mood stabilizer, olanzapine plus fluoxetine therapy. In addition, the use of antidepressants is still controversial, and their efficacy, prognosis and risk of mania remain to be evaluated. Vortioxetine is a novel antidepressant with unique characteristics, and its multi-mode mechanism of action can be used to treat a wide spectrum of symptoms of depression. Current clinical experience suggests that the clinical conversion rate of vortioxetine is low, and the depressive symptoms and cognitive symptoms of people with depressive episodes are significantly improved. As of September 2019, a total of 4.87 million patient years (nearly 3 months of treatment with 20 million patients) were treated with vortioxetine in PSUR (Periodic Safety Update), with 51 reported cases of hypomania and 322 reported cases of mania. Based on the above data, the post-marketing conversion rate of vortioxetine is approximately 1 in 10,000 patient-years or 1 in 40,000 patients. Therefore, the efficacy and risk of transferring to mania of vortioxetine in bipolar II depressive episode deserve further investigation.

NCT ID: NCT05480150 Recruiting - Clinical trials for Major Depressive Disorder

Chinese Longitudinal and Systematic Study of Bioplar Disorder

CLASS-BD
Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Affective disorders (mainly including major depressive disorder and bipolar disorder) are common, chronic and highly disabling mental disorders, which lack of objective biological markers. It is believed that genetic and environmental factors are involved in the development of affective disorders. Gut microbes can affect the function of brain neural circuits by mediating metabolic, immune, endocrine and autonomic changes along the brain-gut axis. The brain can also regulate intestinal microbes through endocrine, neural structure, neurogenic exosomes and other pathways. Based on the brain-gut axis, this study intends to establish a large cohort of affective disorders, and screen out efficient and convenient biomarkers for clinical diagnosis and efficacy prediction by studying key indicators such as intestinal microbes, serum metabolites and immune indexes, brain-derived exosomes, and brain functional imaging.

NCT ID: NCT05478941 Recruiting - Depression Clinical Trials

Can Virtual Reality Improve the Progressive Muscular Relaxation Technique Efficacy?

VRelax
Start date: February 8, 2022
Phase: N/A
Study type: Interventional

The purposes of the current research project are as follows: 1. investigate if the PMRT associated with a personalized-relaxing scenario in VR can facilitate the recalling of the relaxing image in the real world than the standard procedure (consisting of PMRT associated with the in-imagination exposure to a comfortable subjective context). The investigators assume that VR would be more efficient than in-imagination since it would make easy the visualization process favor people cope with more realistic sensory experiences than in-imagination exposure. Accordingly, the VR exposure would elicit the strongest association between the relaxation procedure (neutral stimulus, NS) and the relaxing context in VR (conditioning stimulus, CS); 2. whether exposure to a personalized VREs has a more significant impact on anxiety, depression, stress, sense of presence, and quality of psychological well-being; these constructs are investigated by comparing the participants' performance on self-report questionnaires (described in the next section), before the start of the training (T0; baseline), at the end of all the four relaxing sessions, one week after the end of relaxation sessions (T1; day 7), and during follow up (T2; day 14); 3. if the relaxing sessions administered via Zoom are more proper for managing anxiety and stress than a procedure learned via an audio registration. Considering the ability to generate vivid visual images is positively associated with the capacity to feel present in a virtual world, all the participants are asked to fulfill two questionnaires before the VR or the Guided Imagery exposure to investigate the vividness and the capacity to control mental images respectively, and to control the impact of these two dependent variables on the sense of presence self-reported after the in imagination or VR exposure.

NCT ID: NCT05477758 Not yet recruiting - Depression Clinical Trials

The Impact of Pain on Depression Outcomes

Start date: July 2022
Phase:
Study type: Observational

This study is a secondary data analysis of three of largest Randomised Controlled Trials (RCTs) of behavioural activation (BA) for older people with depression in the United Kingdom (UK) primary care. The analysis will aim to explore the impact of pain on depression outcomes of older people receiving BA and potentially identify sub-groups of people who may not respond as well to treatment.

NCT ID: NCT05477706 Active, not recruiting - Depression Clinical Trials

Peer Intervention to Improve Access Among Rural Women Veterans With Psychological Distress and Unmet Social Needs

EMBER
Start date: October 1, 2021
Phase: N/A
Study type: Interventional

This research project will refine and evaluate delivery of a peer-delivered evidence-based intervention to improve perceived access and actual engagement with mental health treatment and social resource service use among rural women Veterans, especially Veterans of color, with psychological distress and unmet social needs.

NCT ID: NCT05477472 Completed - Major Depression Clinical Trials

Low Dose St John's Wort for Depression

Start date: August 2005
Phase:
Study type: Observational

This observational study observes the routine use of low-dose St John's Wort herbal mother tincture in patients with major depression. It measures intensity of depression at the beginning of St Johns Wort and after 6 weeks and evaluates tolerability and compliance.

NCT ID: NCT05477420 Recruiting - Depression Clinical Trials

Readiness for E-mental Health- Awareness, Acceptance, and Preference Towards Technology-Mediated Mental Health Treatment Among Individuals With Elevated Depressive Symptoms in Hongkong

Start date: March 20, 2022
Phase: N/A
Study type: Interventional

The goals of this study is as follow: 1. to understand the acceptability/perception of seeking E-mental health service versus other options for depression in Hong Kong, 2. to investigate the extent to which people preferring E-mental health service systemically differ from people preferring traditional face-to-face service, and the extent to which digital health interventions increase reach and access to groups who may less well served by traditional mental health services (e.g. people with financial difficulties, men with depression, people with high level of stigma. etc), and 3. to examine whether treatment preferences shift after receiving a clients' decision aids about psychotherapy in digital and in in-person format.

NCT ID: NCT05476237 Not yet recruiting - Depression Clinical Trials

Adolescent Depression Screening and Treatment in Mozambican Primary Care

Start date: November 2022
Phase: N/A
Study type: Interventional

This is a cluster-randomized pilot trial of depression screening and treatment implementation at four Youth-friendly Health Services (YFHS) in primary care clinics, two in Maputo City and two in Maputo Province. YFHS will be stratified by urbanicity, such that one YFHS in Maputo City and one YFHS in Maputo Province will be randomized to interpersonal psychotherapy (IPT)-A and the other YFHS in each location with be randomized to treatment as usual (TAU).