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Coronary Artery Disease clinical trials

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NCT ID: NCT00786175 Withdrawn - Diabetes Mellitus Clinical Trials

A Survey to Evaluate the Rate of Abnormal Glucose Tolerance Among Hong Kong Chinese Subjects With Coronary Heart Disease

Start date: October 2008
Phase: N/A
Study type: Observational

Hypothesis: there is a high prevalence rate of diabetes, including asymptomatic undiagnosed glucose intolerance, among subjects with coronary heart disease in Hong Kong. A cross-sectional survey is planned to study the rate of undiagnosed diabetes and glucose intolerance among the Chinese patients with coronary heart disease in Hong Kong. The survey results will be important for us to plan the logistics to investigate and manage the potential glucose abnormality of our heart disease patient.

NCT ID: NCT00743769 Withdrawn - Clinical trials for Myocardial Infarction

A Phase 1 Safety Study of the Intravenous Administration of Thymosin Beta in Healthy Volunteers

Start date: April 2008
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine whether the intravenous administration of single- and multiple-ascending doses of Thymosin Beta 4 is safe and tolerable in healthy volunteers.

NCT ID: NCT00738517 Withdrawn - Heart Failure Clinical Trials

Immunoadsorption and Immunoglobulin Substitution for Heart Failure After Myocardial Infarction

Start date: September 2008
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to investigate, if immunoadsorption of autoantibodies with subsequent substitution of immunoglobulins is able to improve cardiac function of patients with heart failure after myocardial infarction and presence of cardiac autoantibodies.

NCT ID: NCT00727051 Withdrawn - Clinical trials for Coronary Artery Disease

Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates

Start date: June 2007
Phase:
Study type: Observational

The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for coronary artery disease in high risk patients prior to liver and lung transplantation. The current protocol for coronary artery disease assessment at UCSF before liver and lung transplantation involves screening with stress tests and/or coronary angiograms in patients with increased risk of coronary artery disease. Coronary angiogram will be used as gold standard for assessment of coronary CTA accuracy.

NCT ID: NCT00589862 Withdrawn - Clinical trials for Coronary Artery Disease

Clinical Management of Antiplatelet Drug Resistance in Patients With Drug Eluting Coronary Stents

Start date: October 2007
Phase: Phase 4
Study type: Interventional

It is recommended that patients who have drug-eluting stents placed in their coronary arteries take aspirin and Plavix (Clopidogrel) for at least a year. Patients who stop taking these antiplatelet drugs or who have resistance to the antiplatelet effects of these drugs are at a higher risk of clots occurring inside the stents which may result in a heart attack. At the present time, it is unknown if increasing the doses of the antiplatelet agents is effective in overcoming this resistance. The purpose of this project is to identify patients with antiplatelet drug resistance and to test whether an increase in the Plavix (Clopidogrel) dose overcomes antiplatelet drug resistance.

NCT ID: NCT00584337 Withdrawn - Clinical trials for Coronary Artery Disease

Coronary CT Angiography as the Primary Initial Method of Evaluating Patients With Subacute Chest Pain (CT PRIME)

CTPRIME
Start date: January 2008
Phase: N/A
Study type: Observational

This study is designed to evaluate a new approach to the diagnosis of chronic or sub-acute chest pain patients in the out-patient setting. Patients in this study are selected to be "low-risk", meaning they are not having an acute or recent heart attack (AMI), based on screening blood tests and electrocardiograms (EKGs). In addition, these patients have a low or intermediate pre-test likelihood of the coronary artery disease (CAD), which means that probability of the CAD based on the available clinical and historical information, does not make a diagnosis of the CAD a certain clinical diagnosis in the particular patient and this, in turn, requires an additional diagnostic work up.

NCT ID: NCT00579241 Withdrawn - Clinical trials for Coronary Artery Disease

Detection of Ultrasound Contrast Signals in the Cerebral Circulation

Start date: April 27, 2006
Phase: N/A
Study type: Interventional

To Determine whether transcranial ultrasound can detect the presence of intravenously injected microbubbles used routinely for dobutamine stress echocardiography.

NCT ID: NCT00563238 Withdrawn - Myocardial Ischemia Clinical Trials

Beta-blocker Before Extubation

Start date: November 2007
Phase: N/A
Study type: Interventional

Silent myocardial ischemia is known to occur in the general medical intensive care unit population immediately following tracheal extubation. We believe these patients are at risk for primary cardiac events in the 4 hours immediately following extubation. Metoprolol is a selective beta-1 antagonist, with little to no beta-2 activity at low and moderate doses. The cardioprotective effects of beta blockade have been well documented in randomized controlled trials. In patients undergoing extubation, prophylactic use of intravenous metoprolol may reduce post-extubation ischemia events as well as precursors of cardiogenic pulmonary edema (atrial and ventricular wall tension). Our primary hypothesis is that prophylactic metoprolol (titrated to reduce resting heart rate by at least 10%) prior to tracheal extubation will reduce the rate of ischemia as judged by ST segment analysis.

NCT ID: NCT00530361 Withdrawn - Clinical trials for Coronary Heart Disease

An Efficacy and Safety Study for Nesiritide in Heart Failure Patients With Reduced Kidney Function Undergoing Coronary Artery Bypass Graft Surgery Requiring Cardiopulmonary Bypass (CPB Pump or Heart Lung Machine)

Start date: n/a
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess whether nesiritide compared to placebo when given with standard of care therapies, helps preserve kidney function in heart failure (HF) patients undergoing heart bypass graft surgery that requires the use of a cardiopulmonary bypass machine (CPB pump or heart-lung machine).

NCT ID: NCT00474565 Withdrawn - Clinical trials for Coronary Artery Disease

Coronary Artery and Coronary Artery Bypass Graft Imaging Using a Specialized Catheter and Computed Tomography

Start date: February 2007
Phase: Phase 1
Study type: Interventional

The present study relates to a new approach to coronary artery and coronary artery by-pass graft imaging, and more particularly to computed tomographic angiography following an aortic root injection of a low amount of contrast (up to 30 cc) via a percutaneously placed catheter (Vanguard DX, Medrad Inc.) positioned in the aortic root. The objective of the study is to show the feasibility of Coronary artery CTA using aortic root injection of contrast compared to the standard invasive cardiac catheterization.