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Heart Failure clinical trials

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NCT ID: NCT04978987 Recruiting - Heart Failure Clinical Trials

Identification of Disease Specific Pathways and Modifiers in Phospholamban R14del Cardiomyopathy

DECIPHER-PLN
Start date: November 1, 2020
Phase:
Study type: Observational

Background A specific mutation in phospholamban (the PLN R14del mutation), has its origin in the northern parts of the Netherlands (Figure) and causes a severe lethal dilated and/or an arrhythmogenic cardiomyopathy. A large proportion of the population of Groningen (1:1000) carries this mutation. Until now, there is no specific treatment available for patients with PLN cardiomyopathy. Patients are treated like any other type of heart failure patients, although PLN cardiomyopathy has a different etiology from "usual" heart failure. Treatment is therefore insufficient; malignant ventricular arrhythmias and end-stage heart failure at a young age are very prevalent. To develop treatment options, the investigators aim to study the following knowledge gaps: - Pathophysiology. The clinical phenotype of PLN R14del cardiomyopathy bears characteristics of both arrhythmogenic and dilated cardiomyopathy (ACM and DCM). Using an "omics" approach of plasma, cardiac and skeletal muscle of patients and controls, the investigators aim to reveal distinct pathways affected by the mutant PLN, unique to the PLN R14del cardiomyopathy. This will be related to clinical data and mutant PLN expression levels in both cardiac and skeletal muscle biopsies. Using this extensive profiling, the investigators aim to identify disease mechanisms and provide the context for future risk stratification and disease progression monitoring. - Penetrance. Subjects with a heterozygous PLN R14del mutation show a wide variety in phenotype. Within the same family, patients can present either with over heart failure in their 20's or completely asymptomatic until at least their 70's. So far, no modifiers have been identified. The investigators will study cardiomyocytes derived from induced pluripotent stem cells from patients who are severely affected versus family members who are unaffected but carry the mutation. - Treatment response. The investigators have identified potential treatments, and confirmed their efficacy in in vivo models of PLN cardiomyopathy. To establish their efficacy in a human setting, the investigators will generate 3D cardiac tissues of cardiomyocytes gathered from induced pluripotent stem cells of patients affected in varying degrees and subject these tissues to the treatment. Methods: For the above purposes, the investigators will collect and analyze the following data/materials: - Serum and plasma of 90 PLN R14del carriers: 30 unaffected, 30 early affected and 30 end stage. - Skin biopsy of 20 PLN R14del carriers: 10 unaffected, 10 end stage. - Cardiac muscle biopsy (obtained during left ventricular assist device [LVAD]/ heart transplant [HTx] surgery) of 30 patients: 10 R14del, 10 arrhythmogenic cardiomyopathy, 10 dilating cardiomyopathy. - Skeletal muscle biopsy of 10 patients: 5 R14del, 5 non R14del family members

NCT ID: NCT04977310 Not yet recruiting - Heart Failure Clinical Trials

TARGET-LOAD Pilot Study Comparing Hemodynamics-guided LVAD Unloading vs. Standard of Care

Start date: December 1, 2021
Phase: N/A
Study type: Interventional

This study is a prospective, randomized-controlled, non-blinded, multi-center, pilot trial to compare standard-of-care left ventricular assist device (LVAD) unloading plus heart failure (HF) medications reverse-remodeling management versus hemodynamics-guided LVAD unloading with use of the wireless monitoring system CardioMEMS plus HF medications reverse-remodeling management.

NCT ID: NCT04977011 Completed - Stroke Clinical Trials

Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient

Start date: January 2, 2019
Phase: N/A
Study type: Interventional

Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning. The effectiveness of music intervention in reducing anxiety of patients in Intensive Care Unit (ICU) is still unknown. The purpose of this study was to examine the effectiveness of music intervention on anxiety, agitation, sleep quality and physiological parameters on patients in ICU. This study was conducted from January to June 2019. A total of 196 hospitalized ICU patients were divided into two groups. Subjects in experimental group received 30 minutes music intervention for 3 days on bedside whereas subjects in control group received routine care only. The primary outcome was anxiety. Agitation Sedation Scale, sleep quality and physical parameters were selected to collect as secondary outcomes.There was no significant difference between the groups at baseline. The results of this study support that music can reduce anxiety and agitation levels in ICU's patient. Nurses can incorporate this intervention into the daily care in order to reduce the discomfort of patients.

NCT ID: NCT04976348 Not yet recruiting - Heart Failure Clinical Trials

The Maastricht Cardiomyopathy Registry

mCMP-registry
Start date: August 2021
Phase:
Study type: Observational [Patient Registry]

The Maastricht cardiomyopathy registry (mCMP-registry) is an prospective observational registry including multi-omics (diagnostic) measurements performed as part of routine clinical care, bio-banking (optional), and yearly questionnaires (optional). It's objective is to optimize (early) diagnosis and risk-stratification of (early) cardiomyopathy phenotypes and to create a better understanding of underlying pathophysiological processes

NCT ID: NCT04975633 Recruiting - Heart Failure Clinical Trials

USC and Bodyport Remote Heart Failure Management Study

Start date: May 10, 2021
Phase: N/A
Study type: Interventional

A feasibility study investigating the Bodyport virtual cardiac clinic vs usual care for outpatient heart failure management at Keck Medical Center of USC

NCT ID: NCT04974021 Active, not recruiting - Clinical trials for Arrhythmias, Cardiac

Iron Intravenous Therapy in Reducing the Burden of Severe Arrhythmias in Heart Failure With Reduced Ejection Fraction

RESAFE
Start date: June 20, 2019
Phase:
Study type: Observational

An open label,single-center, non-interventional prospective study with the aim on investigating the effect of intravenous ferric carboxymaltose in restoring iron status and reducing the risk of severe arrhythmic events in participants with iron deficiency and a reduced ejection fraction (HFrEF).

NCT ID: NCT04973579 Recruiting - Clinical trials for Coronary Artery Disease

Simultaneous Cardiac Surgery and Micronet-covered Stent Carotid Revascularization in High Perioperative Stroke Risk Patients

SIM-GUARD
Start date: May 1, 2021
Phase:
Study type: Observational

Prospective, single-center, clinical registry of patients with symptomatic/critical carotid artery stenosis at risk of stroke coexisting with unstable or multivessel severe coronary artery disease and/or severe valvular heart disease undergoing endovascular treatment of carotid atherosclerosis using a mesh stent in combination with cardiac surgery (coronary artery bypass grafting (CABG) and/or valve surgery). A study involving clinical data evaluation of truly simultaneous treatment outcomes in patients deemed to require carotid revascularization at the time of surgical cardiac intervention (single-stage, simultaneous treatment). An open-label study, without randomization - a single arm study. Academic Registry - scientific activity of the Faculty of Medicine, Collegium Medicum, Jagiellonian University and John Paul II Hospital.

NCT ID: NCT04971993 Not yet recruiting - Clinical trials for Heart Failure NYHA Class III

Step and Walking Pattern From Cardiac Monitor Study

SWAN
Start date: September 2021
Phase:
Study type: Observational

To understand the feasibility of characterizing walking patterns in heart failure subjects and subjects at risk for arrhythmias using an investigational wearable monitor called the SWAN study system.

NCT ID: NCT04970953 Not yet recruiting - Clinical trials for Heart Failure With Preserved Ejection Fraction

Diastolic Exercise Stress Testing in Heart Failure

DEST-HF
Start date: July 2021
Phase:
Study type: Observational

Patients with an intermediate risk (HFA-PEFF score 2-4 points) for heart failure with preserved ejection fraction (HFpEF) will be further investigated with invasive right heart catheterization. All patients with a resting pulmonary artery wedge pressure (PAWP) <15mmHg will undergo the following stress test modalities in a randomized order: (1) bicycle ergometry, (2) dynamic handgrip exercise, (3) 500ml fluid challenge over 5 minutes, (4) leg raise testing. Exercise induced HFpEF will be diagnosed if PAWP rises to >25mmHg.

NCT ID: NCT04970888 Not yet recruiting - Aging Clinical Trials

Comparing the Effects of Cognitive Training and Physical Exercise on Cognition, Cerebral Autoregulation and Cerebral Vasoreactivity in Men and Women With Heart Failure

ReCARDIO
Start date: September 1, 2021
Phase: N/A
Study type: Interventional

The objective of this project is to assess the effects of combined physical exercise and cognitive training interventions on cognitive and brain health in patients with heart failure (HF). Also, the role of sex on the effects of the interventions will be assessed.