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Coronary Artery Disease clinical trials

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NCT ID: NCT05087797 Completed - Clinical trials for Coronary Artery Disease

The Effect of Nicorandil on Left Ventricular Myocardial Strain in Patients With Coronary Chronic Total Occlusion

Start date: April 8, 2019
Phase: Phase 4
Study type: Interventional

Background Nicorandil is recommended as a second-line treatment for stable angina, but randomized-controlled trials (RCTs) to evaluate the benefit of nicorandil for patients with chronic total occlusion (CTO) are still lack. Objective To determine whether nicorandil can improve left ventricular myocardial strain in patients with CTO. Methods Patients with CTO were included and were randomized to the nicorandil group and the control group. Nicorandil was given orally 15 mg/day for 3 months in the nicorandil group. 3-dimentional-speckle tracking echocardiography (3D-STE) and the Seattle angina questionnaire (SAQ) survey were performed at baseline and at 3 months. Participants were randomized according to an IBM SPSS23.0-generated randomization schedule, with a 1:1 allocation to the nicorandil group or the control group.

NCT ID: NCT05050877 Completed - Clinical trials for Coronary Artery Disease

Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention II

Start date: June 1, 2000
Phase:
Study type: Observational

As a multi-center, retrospective observation study in southern China, this study included the main study population of patients who underwent coronary angiography at 5 hospitals from Guangzhou, Shenzhen, Yangjiang, Maoming and Longyan from January 2000 to Decemeber 2020. The hospitalization information was collected in the form of direct derivation of the case, and cardiac and renal adverse events were collected through outpatient system. Data on all-cause death were obtained from the Guangdong Provincial Public Security and matched to the electronic Clinical Management System of the Guangdong Provincial People's Hospital records.

NCT ID: NCT05007054 Completed - Clinical trials for Three Vessel Coronary Disease

Long-Term Outcomes in Patients With Three-Vessel Disease

Start date: May 1, 2021
Phase:
Study type: Observational

The long-term outcome of coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), and medical therapy (MT) alone for triple-vessel disease (TVD) patients is controversial. The aim of this study is to evaluate the long-term outcome of TVD patients among these three treatment strategies, to find out the most appropriate treatment methods for these patients.

NCT ID: NCT04986410 Completed - Clinical trials for Coronary Artery Disease

Quantitative Analysis of Functional CT Imaging of Coronary Atherosclerosis

Start date: July 1, 2017
Phase:
Study type: Observational

The purpose of this prospective observational study is to evaluate the diagnostic and prognostic performance of a "one-stop" comprehensive coronary artery anatomy and function assessment for CAD.

NCT ID: NCT04968977 Completed - Clinical trials for Left Main Coronary Artery Disease

PCI vs. CABG in UPLM-ISR

LM-DRAGON
Start date: January 1, 2001
Phase:
Study type: Observational [Patient Registry]

Left main (LM) coronary artery disease is associated with high morbidity and mortality owing to the large myocardial territory at risk for ischemia. Evidence from randomized controlled trials supports that percutaneous coronary intervention (PCI) with drug-eluting stents (DES) for LM disease is an acceptable treatment strategy compared with coronary artery bypass graft surgery in patients with low or intermediate anatomic complexity. However in-stent restenosis (ISR) after DES in LM disease is still occurring with an incidence of 9,7%. Studies comparing the percutaneous coronary intervention with coronary artery bypass grafting (CABG) in the treatment of in-stent restenosis in unprotected left main have been scarce. While surgical revascularization is considered to be the standard treatment for this kind of stent failure, owing to a high risk of perioperative morbidity and mortality, the restoration of flow with PCI may be a reliable alternative. Additionally, it is not clear whether re-PCI is safe in these patients. Therefore, the purpose of the present study was to compare long-term outcomes following PCI or CABG for UPLM-ISR disease.

NCT ID: NCT04961606 Completed - Clinical trials for Coronary Artery Disease

Exercise Adherence of Home-based Cardiac Rehabilitation

Start date: November 3, 2020
Phase:
Study type: Observational

The study explored the influencing factors of exercise adherence of home-based cardiac rehabilitation in patients with coronary artery disease.

NCT ID: NCT04959357 Completed - Clinical trials for Coronary Microvascular Dysfunction

The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease

Start date: March 15, 2018
Phase:
Study type: Observational

The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to investigate the effect of different types of ischemic heart disease on the LV systolic function, and to explore the value of LS on the diagnosis of coronary microvascular dysfunction.

NCT ID: NCT04950699 Completed - Clinical trials for Coronary Heart Disease

Peking University & University of Michigan Study of MI and Atherosclerosis

PUUMA
Start date: January 1, 2012
Phase:
Study type: Observational

Coronary heart disease and myocardial infarction have become a major threat to the health of our people. Their incidence rate and mortality rate are still rising. Dyslipidemia is one of the important risk factors. However, little is known about the genetic information of myocardial infarction and dyslipidemia, especially in Chinese population. This project aims to identify new loci related to myocardial infarction and blood lipid level in Chinese population, compare these gene variations with 94 gene variations related to myocardial infarction and blood lipid level in European population, and extract gene variations related to myocardial infarction and blood lipid level in Chinese population. In this case-control study, 3998 blood samples and 702 new blood samples were collected from the sample bank of Peking University Third Hospital and first hospital, respectively. The blood samples were collected from Asian heart disease hospital, Taiyuan cardiovascular disease hospital, Beijing Third Hospital and Shijingshan community follow-up population According to the results of carotid ultrasound or treadmill exercise test, the samples were divided into myocardial infarction group and control group, and the corresponding blood lipid levels were collected. The samples were genotyped by the metabochip gene chip of Illumina company. The data were processed by the calling algorithm of BeadStudio Gentrain 1.0 and the GenoSNP software. The related genes of myocardial infarction were analyzed by logistic regression, and the related genes of blood lipid level were analyzed by linear regression.

NCT ID: NCT04934241 Completed - Clinical trials for Coronary Artery Disease

The Effect of Self-Acupressure on Pain and Sleep in Coronary Artery Patients

Start date: June 28, 2021
Phase: N/A
Study type: Interventional

This study will be conducted to evaluate the effect of acupressure applied to patients with coronary artery disease (CAD) on pain and sleep quality.

NCT ID: NCT04930939 Completed - Clinical trials for Coronary Artery Disease

Heart Rate Variability-guided Training in Cardiac Rehabilitation

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Background: Previous studies have reported that heart rate variability (HRV)-guided training is a better option for improving autonomic function and aerobic capacity (i.e., oxygen uptake and power output at second ventilatory threshold and maximal exercise) during a cardiopulmonary exercise test compared to predefined training in sedentary and physically active healthy people. Nevertheless, none of these previous studies have been carried out with coronary artery disease (CAD) patients. Methods: A total of 23 patients with CAD were divided into HRV-guided training group (HRV-G; n = 11) and predefined training group (PRE-G; n = 12). All patients trained three days a week for eight weeks (18 sessions). Patients allocated in the PRED-G carried out a previously established cardiac rehabilitation programme, combining sessions of moderate and high intensity, while patients allocated in the HRV-G carried out sessions of moderate or high intensity on the basis of their daily HRV assessments. The weekly averaged and isolated parasympathetic-related HRV indices, heart rate recovery, resting heart rate, and aerobic capacity were assessed before and after of the training programme.