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Coronary Artery Disease clinical trials

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NCT ID: NCT05206084 Not yet recruiting - Clinical trials for Coronary Artery Disease

A Clinical Investigation to Evaluate the Safety and Efficacy of IBS in Patients With Coronary Artery Disease

IRONMAN-II
Start date: January 2022
Phase: N/A
Study type: Interventional

A prospective, multi-center, single-blinded, randomized trial to assess the safety and efficacy of the Sirolimus-Eluting Iron Bioresorbable Coronary Scaffold System (IBS) in treating patients with coronary artery disease compared to the Abbott Vascular XIENCE Everolimus Eluting Coronary Stent System (XIENCE).

NCT ID: NCT05205499 Not yet recruiting - Clinical trials for Coronary Artery Disease

A Clinical Trial to Evaluate the Safety and Efficacy of IBS in Patients With Coronary Artery Disease

IRONMAN-III
Start date: January 2022
Phase: N/A
Study type: Interventional

A prospective, multi-center, single-arm trial to assess the safety and efficacy of the Sirolimus-Eluting Iron Bioresorbable Coronary Scaffold System (IBS) in treating patients with coronary artery disease.

NCT ID: NCT05203484 Not yet recruiting - Clinical trials for Ventricular Tachycardia

Effect of Multielectrode Versus Point-by-Point Mapping on Recurrence of Ventricular Tachycardia in Ischemic Heart Disease

EMPIRE-VT
Start date: February 1, 2022
Phase: N/A
Study type: Interventional

VT ablation is a frequently performed intervention in patients with symptomatic ventricular tachycardia, electrical storm due to monomorphic VT and appropriate ICD shocks, primarily aiming at reducing the burden of complaints, and ICD shocks. The recommendations for its use were described in the ESC guideline for ventricular arrhythmias and the prevention of sudden cardiac death. To visualize the arrhythmogenic substrate leading to ventricular tachycardia complex mapping techniques are currently used in clinical routine, including conventional Point-by-Point mapping or Multielectrode Mapping. The latter is associated with shorter Mapping and overall procedure times, while maintaining the same primary endpoint of the procedure itself. The aim of this trial is to validate, whether the reduction of mapping and procedure time is associated with a comparable long-term outcome compared with conventional Point-by-Point mapping.

NCT ID: NCT05202041 Not yet recruiting - Clinical trials for Coronary Artery Disease

Non-IRA Functional Evaluation With AccuFFRangio in NSTE-ACS

Start date: January 15, 2022
Phase: N/A
Study type: Interventional

This is a prospective, single-center clinical trial. AccuFFRangio (ArteryFlow Technology Co., Ltd., Hangzhou, China) is a novel method for evaluating the functional significance of coronary stenosis by computing the pressure in the vessel based on angiographic images. The purpose of this study is to investigate the diagnostic performance and prognostic ability of AccuFFRangio for non-IRA in NSTE-ACS patients.

NCT ID: NCT05200637 Not yet recruiting - Clinical trials for Coronary Artery Disease

Vascular Response of Orsiro vs. Xience Drug-Eluting Stents for Treating Coronary Bifurcation Lesions

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

This study aims to compare vessel response and clinical outcomes of a biodegradable-polymer, ultra-thin strut, drug-eluting stent (Orsiro, Biotronik) and a durable-polymer, thin-strut, drug-eluting stent (Xience, Abbott) for the treatment of coronary bifurcation lesions with two-stent double-kissing crush technique. How the differences in stent platforms affect vessel healing process will be examined by optical coherence tomography.

NCT ID: NCT05199428 Not yet recruiting - Clinical trials for Coronary Artery Disease

Optina Eye to Heart Connection

Start date: February 15, 2022
Phase:
Study type: Observational

This is a prospective cross-sectional, single-center retinal imaging study expecting to enroll approximately 400 male and female subjects ≥ 18 years of age. Subjects having undergone clinically-indicated coronary angiography or coronary computed tomography angiography (CCTA) within one month of consent at the Montreal Heart Institute (MHI) will be screened for inclusion in the study.

NCT ID: NCT05196659 Not yet recruiting - Heart Failure Clinical Trials

Collaborative Quality Improvement (C-QIP) Study

C-QIP
Start date: March 2022
Phase: N/A
Study type: Interventional

The overarching goal of this study is to develop, implement, and evaluate the effect of a collaborative quality improvement (C-QIP) intervention (consisting of non-physician health workers, text messages for a healthy lifestyle, and a clinical decision support system) on processes of care and clinical outcomes among individuals with previous cardiovascular disease in India.

NCT ID: NCT05193019 Not yet recruiting - Clinical trials for Acute Coronary Syndrome

Parenteral Antiplatelet Agents in Real-world Spanish PCI Patients

PATREAL
Start date: March 1, 2022
Phase:
Study type: Observational

This registry will provide exploratory and descriptive information regarding contemporary practice patterns of parenteral antiplatelet therapy in the PCI (Percutaneous Coronary Intervention) setting and will investigate as well the short-term effectiveness and safety of the currently available parenteral antiplatelet agents in a cohort of "real-world" patients undergoing PCI in Spain.

NCT ID: NCT05184075 Not yet recruiting - Clinical trials for Coronary Artery Disease

The Ideal Sequence of Hybrid Coronary Revascularization With Endoscopic Coronary Revascularization

HYBRID
Start date: January 12, 2022
Phase: N/A
Study type: Interventional

Hybrid coronary revascularization (HCR), a combination of coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI), has emerged as an alternative treatment for multivessel coronary artery disease patients. However, the ideal sequence (PCI or CABG) is unclear. Therefore, the aim of this non-inferiority randomized controlled trial is to investigate the ideal sequence of hybrid coronary revascularization with endoscopic coronary revascularization.

NCT ID: NCT05180942 Not yet recruiting - Melanoma Clinical Trials

Statins and prOgression of Coronary atheRosclerosis in melanomA Patients Treated With chEckpoint inhibitorS

SOCRATES
Start date: February 2022
Phase: Phase 2
Study type: Interventional

This study will incorporate a prospective randomised open blinded end-point trial in participants with stage 2, 3 or 4 melanoma treated with ICI to evaluate the impact of statin therapy on changes in coronary plaque burden and composition.