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Coronary Artery Disease clinical trials

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NCT ID: NCT04844944 Not yet recruiting - Clinical trials for Coronary Artery Disease

The Helios Heart Registry: A Standardized Registry for Patients With Specific Cardiac Diseases

H²-Registry
Start date: June 1, 2021
Phase:
Study type: Observational [Patient Registry]

Investigator-initiated, prospective, non-randomized, open label, non-interventional multicenter registry to evaluate current treatment of three major cardiovascular disease entities in clinical practice using a standardized variable-set of relevant covariates and outcome measures.

NCT ID: NCT04842838 Not yet recruiting - Clinical trials for Coronary Artery Disease

Comparative Clinical Study of Drug-coating Balloon Strategy and Drug-eluting Stent Strategy

Kissing-DCB
Start date: June 30, 2021
Phase: N/A
Study type: Interventional

The trial aims to evaluate the long-term clinical outcome of the DCB-only technique is non-inferior to the provisional T stenting with DES in the patients who have 'true' bifurcation lesions.

NCT ID: NCT04835467 Not yet recruiting - Atherosclerosis Clinical Trials

First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI

Start date: June 1, 2021
Phase: N/A
Study type: Interventional

Patients will undergo intracoronary imaging using combined optical coherence tomography-fluorescence lifetime imaging (OCT-FLIm) during percutaneous coronary intervention, and the obtained imaging data will be used to assess the efficacy of this dual-modal catheter imaging strategy in characterizing high-risk plaque.

NCT ID: NCT04826497 Not yet recruiting - Clinical trials for Coronary Heart Disease

Effect of Nicorandil on Cardiac Sympathetic Nerve for the Patients of Acute ST Segment Elevation Myocardial Infarction

Start date: April 2021
Phase: Phase 4
Study type: Interventional

The investigators evaluate the effects of intracoronary and intravenous administration of nicorandil on cardiac sympathetic nerve activity and distribution in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

NCT ID: NCT04826354 Not yet recruiting - Clinical trials for Atheroscleroses, Coronary

Effects of Statin for Elderly Patients With Atherosclerotic Cardiovascular Disease

Start date: April 2021
Phase: Phase 4
Study type: Interventional

High-dose statins can reduce mortality and cardiovascular events in patients with established atherosclerotic cardiovascular disease (ASCVD). Therefore, US and European recommendations recommend that established ASCVD patients (coronary artery disease, cerebrovascular disease, peripheral vascular disease) use high-dose statins to lower LDL cholesterol levels by at least 50%. However, in actual practice, high-dose statins are relatively less used, and the reason is unclear, but it is believed to be due to concerns about the side effects of high-dose statins. Most of the side effects of statins are statin-associated muscle symptoms (SAMS), which are more common than the incidence in clinical studies, especially in frontline care. These muscle side effects are dose-dependent and are common at high doses, and the incidence is known to increase in the elderly over 70 years of age. However, the US recommendation recommends using high-dose statins to lower LDL cholesterol by 50% or more to prevent cardiovascular events even in ASCVD patients over 70 years of age. Most early studies on lowering LDL cholesterol in ASCVD patients used high doses of statins. However, after introducing cholesterol absorption inhibitors ezetimibe and PCSK9 inhibitor, large-scale clinical studies have been conducted to lower LDL cholesterol using these drugs. In this study, as in the statin study, cardiovascular events were significantly reduced, and together with statins, it became a standard treatment for ASCVD patients. On the other hand, the clinical benefit shown in clinical studies using cholesterol-lowering agents so far depends entirely on how much LDL cholesterol is lowered and how long it is maintained in a low state, indicating that LDL cholesterol management is the core of arteriosclerosis treatment. In addition to high-dose statins, a combination of low-dose statins and ezetimibe can be cited as a method for lowering LDL cholesterol to more than 50%. In the latter case, it is expected that there will be an advantage of reducing muscle side effects by reaching the target LDL cholesterol level by using a low-dose statin. However, no studies compare the difference in muscle side effects between low-dose statins and ezetimibe combination drugs, which reduce LDL cholesterol to the same extent compared to high-dose statins, in elderly patients over 70 years of age with ASCVD. In this study, the association of low-dose rosuvastatin 5mg and ezetimibe combination (rosuvastatin 10/5mg) compared to high-dose rosuvastatin 20mg in elderly patients 70 years of age or older with established ASCVD. This study aims to compare and analyze the incidence of muscle symptoms (SAMS) and their effect on LDL cholesterol.

NCT ID: NCT04826172 Not yet recruiting - Clinical trials for Coronary Artery Disease

Exploratory Study on the Safety, Tolerability, and Pharmacodynamics of IMB-1018972 in Subjects With Angina Due to Obstructive Coronary Artery Disease (IMPROVE-Ischemia)

Start date: March 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of IMB-1018972 in subjects with obstructive CAD and inducible ischemia.

NCT ID: NCT04822675 Not yet recruiting - Clinical trials for Coronary Artery Disease

REvascularization and Valve Intervention for Ischemic Valve diseasE: REVIVE Trial

REVIVE
Start date: June 2021
Phase: N/A
Study type: Interventional

Ischemic mitral regurgitation (MR) and coronary artery disease is common and associated with significant morbidity and mortality. Ischemic MR has been traditionally treated surgically through either valve repair or replacement at the time of concomitant bypass grafting. Although patients with ischemic MR represent a heterogeneous group, outcomes for these patients over the intermediate term is poor owing to left ventricle (LV) dysfunction causing MR and the presence of coronary disease, which portends poor survival. There is an emergence of percutaneous therapies to treat MR which have been shown to be a less invasive, safe, and viable approach to treat comorbid patients. The decision to treat ischemic MR either surgically or percutaneously is influenced by the presence of coronary disease and the ability to provide adequate revascularization. Mitral valve surgery concomitant to surgical revascularization, however, is associated with a several fold increase in mortality. In fact, the incremental risk increase is further magnified in high-risk patients. We therefore propose a novel prospective study to guide intervention for ischemic MR. Patients will be randomized to undergo surgical therapy with either mitral repair/replacement and/or concomitant coronary artery bypass grafting OR percutaneous mitral repair, followed by the ideal Heart Team determined mode of revascularization with either percutaneous coronary intervention or coronary artery bypass grafting.

NCT ID: NCT04814212 Not yet recruiting - Clinical trials for Coronary Artery Disease

Drug-Coated Balloon in Anticoagulated and Bleeding Risk Patients Undergoing PCI

DEBATE
Start date: May 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to compare DCB with DES in stable CAD or ACS patients who are at high risk of bleeding. Our hypothesis is that the strategy of using DCB and therefore shorter DAPT regimen is superior to the treatment using DES and longer DAPT in patients at high risk of bleeding.

NCT ID: NCT04810845 Not yet recruiting - Myocardial Ischemia Clinical Trials

SmartCardia for the Detection of Myocardial Ischemia in Coronary Artery Disease

Smartschemia
Start date: April 2021
Phase: N/A
Study type: Interventional

Coronary artery disease and myocardial ischemia are among the leading causes of death and disability in the Westerns countries. Timely and accurate diagnosis of myocardial ischemia at the moment of symptom onset is crucial and often delayed. Portable smart medical devices nowadays offers the possibility of ubiquitous self multi-parametric monitoring. Application of such technologies to timely and autonomous detection of myocardial ischemia could be an effective strategy to an earlier and better treatment of symptomatic coronary artery disease. The primary objective is to assess the changes in recorded by the SmartCardia patch (respiratory rate, pulse transit time, heart rate and single ECG trace) during induced ischemia during elective coronary angioplasty procedures. The secondary objective is to asses whether myocardial ischemia can be predicted and quantified by changes in the parameters recorded by SmartCardia patch (respiratory rate, pulse transit time, heart rate and single ECG trace).

NCT ID: NCT04808401 Not yet recruiting - Clinical trials for Coronary Artery Disease

Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery

Promise-O2
Start date: March 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients undergoing non-cardiac vascular surgery.