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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT05380622 Recruiting - Clinical trials for Coronary Artery Disease

CHART Study of Coronary CT Angiography in Coronary Artery Disease

CHART-VISION
Start date: January 1, 2015
Phase:
Study type: Observational

In a cohort of patients referred to coronary computed tomography angiography (CCTA), the investigators aim: 1. To describe the natural history of the coronary atherosclerotic plaque development and progression or regression, as well as the plaque characterization and phenotypes over time by CCTA among deferred coronary lesions 2. To explore the precursors of plaques leading to acute coronary syndrome (ACS) or chronic coronary syndrome (CCS) in deferred coronary lesions 3. To investigate prognostic implication of qualitative and quantitative plaque analysis of stenosis and plaque features, disease patterns, hemodynamic parameters, and fat metrics on CCTA along with physiologic assessment 4. To investigate the effects of different treatment strategies according to stenosis and plaque features, fat metrics on CCTA along with physiologic assessments.

NCT ID: NCT05374733 Recruiting - Clinical trials for Coronary Artery Disease

Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions

POTUS
Start date: March 22, 2021
Phase: N/A
Study type: Interventional

Prospective, single-arm, observational study with invasive coronary physiology measurements before and after transcatheter left-sided valvular intervention.

NCT ID: NCT05368545 Recruiting - Clinical trials for Coronary Artery Disease

Influence of Lipid Lowering on Impaired Coronary Flow

Start date: May 15, 2020
Phase: N/A
Study type: Interventional

This study assess in patients with stable chest pain and coronary artery disease (CAD) determined by coronary CTA whether cholesterol lowering with regression of coronary adverse plaque characteristics is associated with recovery of impaired flow

NCT ID: NCT05353946 Recruiting - Clinical trials for Coronary Artery Disease

Coronary Rotational Atherectomy Elective vs. Bailout in Severely Calcified Lesions and Chronic Renal Failure

CRATER
Start date: February 2, 2019
Phase: N/A
Study type: Interventional

The current role of the rotational atherectomy is for non-dilatable coronary lesions and for severely calcified lesions that may interfere with optimal stent expansion. Severely calcified coronary lesions are associated with worse outcomes. In this regard, chronic kidney disease is associated with severely calcified coronary arteries. Some evidence suggests that elective rotational atherectomy used by experienced operators can be safe and effective, minimizing time and complications for patients with heavily calcified lesions. However, there is no direct randomized comparison between rotational atherectomy and angioplasty alone in the setting of chronic renal failure and with intravascular ultrasound assessment for detecting severely calcified coronary arteries.

NCT ID: NCT05349084 Recruiting - Clinical trials for Coronary Artery Disease

PET MYOCARDIAL Blood Flow Comparison to Coronary CTA and CT-FFR

Start date: June 6, 2019
Phase: N/A
Study type: Interventional

The broad, long-term objective of this pilot study is to develop an optimal, clinically usable, non-invasive evaluation of Coronary Artery Disease (CAD) in the setting of stable angina which provides both anatomic and functional information. Patients already scheduled to undergo Invasive coronary catheterization (ICA) for the clinical indication of angina will be recruited to under go stress-rest Positron Emission Tomography-Coronary CT Angiography-Fractional Flow Reserve (PET-cCTA-cFFR)

NCT ID: NCT05347316 Recruiting - Atherosclerosis Clinical Trials

Colchicine Effect on Perivascular Inflammation Index on Coronary CTA

COPIX
Start date: March 7, 2022
Phase: Phase 1
Study type: Interventional

Inflammation is an important pillar of atherogenesis in coronary disease. Studies have documented the prognostic power of measuring coronary perivascular adipose tissue attenuation (PVAT) and its good correlation as an early inflammatory biomarker in the atherogenesis process, in addition to being a predictor for cardiovascular events in the future. Colchicine, a medication with well-documented anti-inflammatory action and with an impact on reducing cardiovascular outcomes, may have an action in reducing FAI (fat attenuation index). This study aims to evaluate the effect of colchicine in reducing coronary perivascular inflammation.

NCT ID: NCT05344053 Recruiting - Clinical trials for Coronary Artery Disease

Community-based Precise Management for Patients With Coronary Artery Disease

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

The community-based precise management for patients with coronary artery disease study is a prospective, cluster-randomized, open-labeled trial. The purpose of this trial is to test whether a community-based precise management and rehabilitation model under the hierarchical medical system could help improve the cardiovascular risk factors control in patients with coronary artery disease. Additionally, the trial will also evaluate the impact of the model on major cardiovascular adverse events in patients with coronary artery disease.

NCT ID: NCT05343884 Recruiting - Clinical trials for Coronary Artery Disease

Evaluating DyNamic Myocardial Blood Flow QUantitation As a Cost Effective Care ModeL for DiabEtic Patients With Coronary Artery DiSease

NUCLEuS
Start date: March 15, 2022
Phase: N/A
Study type: Interventional

This will be a prospective randomized clinical trial comprising of n=300 diabetic patients, randomized to either dynamic (n=150) or conventional MPI (n=150) strategy. Healthcare resources utilization of each patient will be tracked. Patients will be followed up for short term outcomes and for long term outcomes.

NCT ID: NCT05340361 Recruiting - Clinical trials for Coronary Artery Disease

Efficacy and Safety of Zotarolimus-eluting Stent Overexpansion With OCT

ONYSOVER
Start date: March 23, 2022
Phase:
Study type: Observational [Patient Registry]

Investigators aimed to evaluate efficacy and safety of expansion capacity of zotarolimus-eluting durable-polymer stent assessed by optical coherence tomography (OCT) in vitro and vivo study.

NCT ID: NCT05337319 Recruiting - Clinical trials for Coronary Artery Disease

Prospective Registry of the Current Status of Care for Patients With Coronary Artery Disease

Start date: January 17, 2022
Phase:
Study type: Observational

The study will estimate the current status of care for participants with coronary artery disease