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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT06434935 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Initial Evaluation of Vascudyne Coronary Artery Bypass Conduit

Start date: November 7, 2023
Phase: Early Phase 1
Study type: Interventional

The Vascudyne Coronary Artery Bypass Study (VCAB-1) is an initial safety and feasibility study of the Vascudyne, Inc. Coronary Artery Bypass Conduit (CAB A) for bypass of stenosed native coronary arteries in patients undergoing coronary artery bypass surgery.

NCT ID: NCT06376851 Enrolling by invitation - Clinical trials for Coronary Artery Disease

AI DErived Plaque Quantification: CCTA and AI-QCPA for Determining Effective CAD Management

Start date: March 27, 2024
Study type: Observational [Patient Registry]

The objective of HeartFlow's DECIDE Registry is to collect observational data about the management of patients before and after HeartFlow Artificial Intelligence-Quantitative Coronary Plaque Analysis (AI-QCPA).

NCT ID: NCT06237673 Enrolling by invitation - Clinical trials for Coronary Artery Disease

The "CAD-Man" EXTEND Study

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

CAD-Man Extend is the long-term follow-up (clinical, laboratory, and computed tomography (CT) imaging) of a single-center, randomized, controlled CAD-Man trial comparing a CT-first strategy with a direct- invasive coronary angiography (ICA) diagnostic and management strategy, in 329 patients clinically referred for ICA with atypical angina or chest pain. Overall goal: The extension of CAD-Man follow-up (clinical, laboratory, and CT imaging) to approximately 10 years will provide the opportunity to compare plaque burden with CT-guided management versus direct-ICA at long-term and other endpoints.

NCT ID: NCT06214624 Enrolling by invitation - Clinical trials for Coronary Heart Disease

Exercise and Brain in Coronary Heart Disease

Start date: April 19, 2022
Phase: N/A
Study type: Interventional

The Heart-Brain project is a randomized controlled trial designed to examine the effects of two different exercise programs of 12-week duration: 1) aerobic high intensity interval training (HIIT), and 2) aerobic HIIT plus resistance training, on brain health and other outcomes in coronary heart disease patients.

NCT ID: NCT06194526 Enrolling by invitation - Coronary Stenosis Clinical Trials

Whole Blood Transcriptomic Signal According to Coronary Atherosclerotic Plaque Burden Assessed by CT Angiography

Start date: September 19, 2023
Study type: Observational

The present clinical study aims to identify transcriptomic patterns derived from whole blood samples related to coronary atherotic burden. Additionally, as a secondary analysis, the research team will explore the algorithm's ability to detect the presence of aortic disease and pro-inflammatory cardiometabolic alterations, such as hepatic steatosis and surrogate markers of coronary inflammation.

NCT ID: NCT06154265 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Intraoperative Echocardiography in Low-Risk CABG Surgery

Start date: February 1, 2024
Phase: N/A
Study type: Interventional

This goal of this study is to better understand when and where intraoperative transesophageal echocardiography (TEE) should (or should not) be used during coronary artery bypass graft (CABG) surgeries.

NCT ID: NCT06083155 Enrolling by invitation - Clinical trials for Coronary Microvascular Dysfunction

The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)

Start date: October 15, 2020
Study type: Observational [Patient Registry]

The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational. Patients receive yearly online questionnaires on their anginal complaints for 5 years after their CFT.

NCT ID: NCT06041581 Enrolling by invitation - Stroke Clinical Trials

SHADES Mechanistic Trial

Start date: April 25, 2024
Phase: N/A
Study type: Interventional

Cardiovascular disease (CVD) is common, deadly, and costly, and adults with insomnia represent a large group of people at elevated risk of developing CVD in the future. This clinical trial will determine if our updated insomnia treatment, called the SHADES intervention, improves CVD factors thought to explain how insomnia promotes CVD and if these improvements are due to positive changes in sleep factors. A total of 200 primary care patients with insomnia and CVD risk factors will be randomized to 6 months of the SHADES intervention (internet, telephonic, and/or face-to-face cognitive-behavioral therapy for insomnia) or the active control condition (sleep education/hygiene, symptom monitoring, and primary care for insomnia). Before and after treatment, participants will complete measurements of the CVD factors (systemic inflammation, autonomic dysfunction, metabolic dysregulation, proinflammatory gene expression) and the sleep factors (insomnia symptoms, sleep onset latency, wake after sleep onset, sleep efficiency). Researchers will test whether the SHADES intervention produces greater improvements in the CVD factors than the active control condition.

NCT ID: NCT06031974 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Dietary Intervention to Stop Coronary Atherosclerosis in Computed Tomography: Long-Term Follow-Up

Start date: January 13, 2023
Study type: Observational

A long-term evaluation of the impact of intensive diet and lifestyle intervention on coronary plaque dynamics in patients with coronary atherosclerosis diagnosed in computed tomography angiography (CCTA). 92 patients who completed the Dietary Intervention to Stop COronary Atherosclerosis in Computed Tomography study (DISCO-CT, NCT02571803) will be followed-up.

NCT ID: NCT06025305 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Identifying Vulnerable CoronAry PLaqUes With Artificial IntElligence-assisted CT Angiography

Start date: July 1, 2023
Study type: Observational

The goal of this observational study is to develop an automatic whole-process AI model to detect, quantify, and characterize plaques using coronary CT angiography in coronary artery disease patients. The main questions it aims to answer are: 1. Whether the AI model enables to detect and quantify coronary plaques compared with intravascular ultrasound or expert readers; 2. Whether the AI model enables to identify vulnerable plaques using intravascular ultrasound or optical coherence tomography as the reference standard. 3. Whether the AI model enables to predict future adverse cardiac events in a large cohort of 10,000 patients with non-obstructive CAD.