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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT05066074 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Safety and Efficacy Between the Distal and Proximal Radial Vascular Access Technique

Start date: August 16, 2021
Phase: N/A
Study type: Interventional

The investigators are conducting a randomized clinical trial, having as a primary objective, to compare vascular access time between distal and proximal radial approach. Secondary objectives include comparing incidence of distal and proximal radial artery occlusion, at 24 hrs and 30 days. As a tertiary objective investigators will compare the preference of the patients for each access in subsecuent interventional procedures.

NCT ID: NCT04974541 Enrolling by invitation - Clinical trials for Ischemic Heart Disease

Improving Wellbeing in Ischemic Heart Disease

Start date: August 30, 2021
Phase: N/A
Study type: Interventional

The purpose of this research is to see if Heart Health Yoga (HHY) Program when added on to standard cardiac rehabilitation (CR) will improve overall wellbeing and quality of life for patients experiencing ischemic heart disease, heart problems caused by narrowed heart arteries.

NCT ID: NCT04810364 Enrolling by invitation - HIV Infections Clinical Trials

HIV Infection And Evolvement of Atherosclerotic Plaque

HIVE
Start date: January 5, 2020
Phase:
Study type: Observational [Patient Registry]

In a prospective multi-center observational study, 200 HIV-infected patients treated with antiretroviral treatment (ART) and who suffered from coronary artery disease (CAD) will be enrolled. Blood samples for biological parameters will be collected with all participants: lipid profile and markers of systemic inflammation specific for HIV-infection (lipopolysaccharide-binding protein; cytokines: IL-1β, IL-6, IL-8, IL-10, TNF -α, INF-γ, INF-α; procalcitonin; inflammatory hsCRP). All of them will undergo functional testing (Echo, CMR both at rest and stress if necessary) and invasive imaging with QCA, FFR, QFR, OCT, IVUS, VH-IVUS, NIRS. Patients will be treated according to the current and previous recommendations. Both medical treatment and percutaneous transluminal coronary angioplasty (PTCA) with or without stenting will be done. Collected data will be analyzed: correlation between ART, blood test results, coronary angiography results, including performed PTCA, history of myocardial infarctions, and other cardiovascular events. The follow-up period will achieve 12 months prospectively with collected clinical events and imaging outcomes which will be determined at the baseline and 12-month follow-up. The independent ethics expertise will be provided by the Central Clinical Hospital of the Russian Academy of Sciences (Moscow, Russia). The monitoring of the clinical data with imaging will be provided by The Ethics Board of Central Clinical Hospital of the Russian Academy of Sciences.

NCT ID: NCT04789278 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Incidental Coronary Calcification Quality Improvement Project

ICC QI
Start date: March 30, 2021
Phase: N/A
Study type: Interventional

This is a multi-center, randomized quality improvement project. At least 200 statin-naïve patients without a history of atherosclerotic cardiovascular disease with incidental coronary artery calcium (CAC) on a prior non-gated chest CT will be enrolled across the Stanford Healthcare System and the Palo Alto Veteran's Affairs Healthcare System. Patients will be randomized in a 1:1 fashion to notification or usual care arms. The primary aim of this project is to estimate the increase in 6-month statin prescription among statin-naïve patients without a history of atherosclerotic cardiovascular disease with incidental CAC on a non-gated chest CT who are randomized to receive notification of their findings vs. usual care.

NCT ID: NCT04744571 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions

Start date: February 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the safety and efficacy of drug-coated balloon angioplasty for the treatment of chronic total occlusions patients with chronic total occlusion (CTO) lesion.

NCT ID: NCT04680338 Enrolling by invitation - Clinical trials for Cardiovascular Diseases

Early Detection of Silent Myocardial Ischemia

EarlySynergy
Start date: May 27, 2019
Phase: N/A
Study type: Interventional

Early-Synergy investigates a diagnostic imaging approach in asymptomatic individuals from the general population for early detection of silent myocardial ischemia and cardiac dysfunction. The diagnostic imaging approach consists of cardiac computed tomography for coronary artery calcium scoring (CT-CAC) and cardiac magnetic resonance (CMR) stress perfusion imaging. Early-Synergy investigates the effect of early detection of silent myocardial ischemia and cardiac dysfunction by CMR in asymptomatic individuals with increased CAC. In addition, the diagnostic yield of CMR for early detection of silent myocardial ischemia and cardiac dysfunction is investigated. Asymptomatic individuals at increased risk (CAC ≥ 300) are therefore randomized 1:1 to either CMR stress perfusion imaging or a control group.

NCT ID: NCT04676100 Enrolling by invitation - Clinical trials for Coronary Artery Disease

International CR Registry

ICRR
Start date: September 27, 2021
Phase:
Study type: Observational

The ICRR is a health services registry to establish the quality of CR delivery, and the effectiveness in terms of patient outcomes, in low-resource settings. The purposes of the registry are care optimization, evidentiary support for CR advocacy / policy, and research. All programs in low-resource settings will be welcome to participate at no cost. Programs will follow procedures approved by their local ethics board for collection of program and patient-reported variables. Assessments occur pre-cardiac rehabilitation (CR), post-CR and annually thereafter.

NCT ID: NCT04636892 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Evaluating Infrasonic Hemodynography

Start date: January 4, 2021
Phase: N/A
Study type: Interventional

This comparative diagnostic accuracy study will determine the accuracy of a noninvasive wearable infrasonic sensor to detect the mechanical, electrical, and hemodynamic function of the cardiovascular system.

NCT ID: NCT04545112 Enrolling by invitation - Clinical trials for Multi Vessel Coronary Artery Disease

Xeltis Coronary Artery Bypass Graft (XABG) First in Human (FIH)

XABG-FIH
Start date: October 22, 2020
Phase: N/A
Study type: Interventional

A FIH study to collect preliminary device safety, feasibility and performance data of the XABG in patients with symptomatic coronary artery disease (SCAD), with suitable multi vessel disease (MVD) and selected by the local Heart Team for elective coronary artery bypass grafts surgery of at least 3 bypass grafts (minimally 1 artery and 2 veins or 2 arteries and 1 vein).

NCT ID: NCT04451044 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

DEFINE GPS
Start date: June 17, 2021
Phase: N/A
Study type: Interventional

Multi-center, prospective, randomized controlled study comparing PCI guided by angiography versus iFR Co-Registration using commercially available Philips pressure guidewires and the SyncVision co-registration system, employing an adaptive design study for interim sample size re-estimation.