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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT03679091 Recruiting - Platelet Reactivity Clinical Trials

Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable CAD.

Start date: August 29, 2018
Phase: Phase 4
Study type: Interventional

Ticagrelor has been demonstrated to provide a more rapid and more powerful inhibition of platelet aggregation compared with clopidogrel in coronary artery disease (CAD) patients. However, current guidelines recommend ticagrelor 90 mg twice daily might not be suitable for patients of Chinese. Therefore, the investigators performed this study to observe the efficacy of 60-mg ticagrelor in comparison to 75-mg clopidogrel in Chinese patients with stable CAD.

NCT ID: NCT03677791 Not yet recruiting - Clinical trials for Coronary Artery Disease

Effects of Ubiquitous 360° Patient Counselling Environment

Start date: November 2018
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the effectiveness of the ubiquitous 360° counselling environment in the anxiety and adherence to treatment of the patients coming to CCTA (coronary computed tomography angiography). In this study, ubiquitous environment is 360° panoramic photo-based network environment, incorporating digital materials that enable versatile authentic counselling.

NCT ID: NCT03675347 Recruiting - Clinical trials for Coronary Artery Disease

Recurrent Events After Percutaneous Coronary INterventio for ACS

AGAIN
Start date: October 1, 2018
Phase:
Study type: Observational

Patients undergoing PCI for ACS are exposed to a significant ischemic and bleeding risk. The aim of our study is instead to analyze in detail the rates of recurrent events, but also their predictors and impact on outcomes, in a population of unselected real life patients treated with PCI for ACS discharged on either Clopidogrel, Prasugrel or Ticagrelor who already experienced an adverse event during the first year of follow up.

NCT ID: NCT03674307 Not yet recruiting - Clinical trials for Cardiovascular Diseases

Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates

CARSK
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The Canadian Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK) will test the hypothesis that eliminating the regular use of non-invasive screening tests for CAD AFTER waitlist activation is not inferior to regular (i.e., annual) screening for CAD during wait-listing for the prevention of Major Adverse Cardiac Events. Secondary analyses will assess the impact of screening on the rate of transplantation, and the relative cost-effectiveness of screening.

NCT ID: NCT03674255 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Extracellular Vesicles At REst and STress

EVAREST
Start date: March 2015
Phase:
Study type: Observational

EVAREST will identify and validate novel blood and imaging biomarkers of potential value for consistent and accurate interpretation of stress echocardiography. During phase one, blood samples will be collected to assess the impact of cardiac stress on levels of circulating biomarkers and examine whether the measurement of these biomarkers can provide additional prognostic information. Phases one, two and three will also determine whether novel imaging biomarkers can be identified in the echocardiograms that can be used for objective interpretation of the stress echocardiograms. EVAREST will recruit up to 5000 patients (First 500 during phase one, an additional 500 during phase two and an additional 4000 during phase three) from multiple hospitals across United Kingdom, who have been referred for a stress echocardiogram as part of their investigations into ischaemic heart disease.

NCT ID: NCT03671603 Not yet recruiting - Clinical trials for Coronary Artery Disease

Post-Marketing Safety Study in ST-Segment Elevation Myocardial Infarction (STEMI) Participants Undergoing Primary Percutaneous Coronary Intervention (PCI) Procedure With VISIPAQUE® as the Contrast Medium

Start date: September 2018
Phase:
Study type: Observational

The purpose of this study is to prospectively observe the incidence rate of acute kidney injury (AKI), major adverse renal and cardiovascular events (MARCE) in participants who were diagnosed with ST-segment elevation myocardial infarction (STEMI) and have completed primary percutaneous coronary intervention (PCI) procedure following an injection of iso-osmolar contrast medium iodixanol (Visipaque) during the in-hospital period and up to 30 days post-PCI follow-up period. The study will provide a better safety profile of Visipaque as the contrast medium in PCI procedure.

NCT ID: NCT03667781 Not yet recruiting - Hypertension Clinical Trials

Therapeutic Drug Monitoring of Cardiac Medications

Start date: September 2018
Phase:
Study type: Observational

The investigators will interview patients and providers of patients who have hypertension and are seen in cardiology clinic about ways to discuss therapeutic drug monitoring with patients. The investigators will use these interviews to crease discussion tools to discuss therapeutic drug monitoring. The investigators will then draw one venous blood sample in a different group of patients who are seen in interventional clinic for 1 month followup after PCI. The investigators will assay this blood for therapeutic drug monitoring and will provide the results to their providers for discussion at their regularly scheduled followup cardiology visit. The investigators will have the patients and providers fill out a survey afterwards to determine how they viewed therapeutic drug monitoring.

NCT ID: NCT03665389 Not yet recruiting - Clinical trials for Coronary Artery Disease

Evaluation of Fractional Flow Reserve Calculated by Computed Tomography Coronary Angiography in Patients Undergoing TAVR

FORTUNA
Start date: September 13, 2018
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate the relationship between fractional flow reserve (FFR) derived from coronary computed tomography angiography (FFRct) before transcatheter aortic valve replacement (TAVR) and FFR after TAVR so as to investigate whether FFRct is useful for evaluating myocardial ischemia of severe AS. Furthermore, by measuring the instantaneous wave-free ratio (iFR) which is a physiological diagnostic method of coronary artery stenosis before and after TAVR and comparing iFR (iFR before and after TAVR) and FFR (FFR after TAVR) with FFRct (FFRct before and after TAVR), It also aims to deepen understanding of resting coronary artery physiology in aortic valve stenosis.

NCT ID: NCT03661827 Not yet recruiting - Clinical trials for Coronary Artery Disease

Dobutamine vs Adenosine CMR Study

DISCORDANCE
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

This is a single centre, prospective diagnostic accuracy study to assess the comparative sensitivity of dobutamine versus adenosine for detection of severe non-infarct epicardial coronary artery stenosis in subjects with reduced LV EF ( EFed referred for clinical coronary angiography for investigation of symptoms or to establish the cause heart failure. Study participants will be identified from hospital angiography referral waiting lists, or already known with CAD and from heart failure outpatient clinics at Glenfield General Hospital. Clinical and CMR data will be collated on-site (at Glenfield General Hospital) from medical records stored and stress cardiac MRI scans at Glenfield General Hospital. The analysis will occur over a 12-month period following study commencement.

NCT ID: NCT03660657 Not yet recruiting - Clinical trials for Ischemic Heart Disease

Ozone Therapy in Refractory Ischemic Heart Disease.

O3Cardio
Start date: October 2018
Phase: Phase 2/Phase 3
Study type: Interventional

The main objective of this clinical trial is to evaluate the effectiveness and cost-effectiveness of adding ozone therapy to standard management of patients with advanced ischemic heart disease refractory to medical and surgical treatment.