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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT04528758 Suspended - Clinical trials for Coronary Artery Disease

F-18 Rhodamine 6G PET Imaging for Myocardial Blood Flow

Start date: October 16, 2018
Phase: Early Phase 1
Study type: Interventional

Use of novel radio-pharmaceutical Rhodamine 6G to determine myocardial blood flow

NCT ID: NCT04221594 Suspended - Clinical trials for Coronary Artery Disease

Quantification of Myocardial Blood Flow Using Dynamic PET/CTA Fused Imagery

Start date: November 1, 2019
Phase:
Study type: Observational

This observational prospective clinical study is to develop software tools to fuse coronary anatomy data obtained from CT coronary angiography with dynamic PET data to noninvasively measure absolute myocardial blood flow, flow reserve and relative flow reserve across specific coronary lesions. Results will be compared to those obtained invasively in the catheterization laboratory.

NCT ID: NCT04176978 Suspended - Atherosclerosis Clinical Trials

PsA T2T Statin Trial on Carotid and Coronary Atherosclerosis

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with an increased risk of myocardial infarction (MI). Using coronary computer tomography angiogram (CCTA), it is found that a significantly higher prevalence of high-risk coronary plaque (non-calcified plaque [NCP]), supporting the notion that more aggressive cardiovascular (CV) evaluation strategy should be considered in these patients. Carotid ultrasound screening in this population may be a better alternative than traditional risk score to identify patients at high CV risk as the latter underestimated CV risk. Previous study from our group have demonstrated that achieving treatment target (minimal disease activity [MDA]) can prevent progression of carotid atherosclerosis. Nevertheless, 38% of this Treat to Target (T2T) cohort still had carotid plaque progression. Project description it is hypothesized that combination of a T2T stratgy together with high-intensity rosuvastatin treatment (Group 1: T2T-statin group) is more effective in preventing progression of coronary and carotid atherosclerosis than T2T stratgy alone (Group 2: T2T-only group) in high-risk PsA patients with carotid plaque. The primary outcome is to ascertain the effect of T2T strategy with high-intensity rosuvastain (Group 1: T2T-statin group) on the change in CIMT over a period of 12 months compared with T2T strategy alone (Group 2: T2T-only group)

NCT ID: NCT03914079 Suspended - Clinical trials for Coronary Artery Disease

Evaluation of the CAD-det System, a Novel Non-Invasive Acoustic Diagnostic for the Diagnosis of Coronary Artery Disease

CAD-det
Start date: April 5, 2019
Phase:
Study type: Observational [Patient Registry]

The primary purpose of this multi-center study is to collect and study the acoustic and electrical signals created by the heart during the cardiac cycle as a result of stenosis or plaque associated with coronary artery disease (CAD).

NCT ID: NCT03729401 Suspended - Clinical trials for Coronary Artery Disease

Personalization of Long-Term Antiplatelet Therapy - RAPID EXTEND

RAPID EXTEND
Start date: August 22, 2019
Phase: Phase 4
Study type: Interventional

In patients after myocardial infarction (MI) (heart attacks) and treated with percutaneous coronary intervention (PCI), the current standard is dual antiplatelet therapy (DAPT), with aspirin and a P2Y12 receptor inhibitor, for 1 year of treatment. At 1 year, there are several options including: i) Ongoing DAPT (with aspirin and ticagrelor), ii) Selective treatment use of a P2Y12 inhibitor based on risk profiles. This study is a pilot vanguard study to evaluate several strategies for choosing anti-platelet regimen among patients post MI and PCI at 1 year.

NCT ID: NCT03667781 Suspended - Hypertension Clinical Trials

Therapeutic Drug Monitoring of Cardiac Medications

Start date: October 1, 2018
Phase:
Study type: Observational

The investigators will interview patients and providers of patients who have hypertension and are seen in cardiology clinic about ways to discuss therapeutic drug monitoring with patients. The investigators will use these interviews to crease discussion tools to discuss therapeutic drug monitoring. The investigators will then draw one venous blood sample in a different group of patients who are seen in interventional clinic for 1 month followup after PCI. The investigators will assay this blood for therapeutic drug monitoring and will provide the results to their providers for discussion at their regularly scheduled followup cardiology visit. The investigators will have the patients and providers fill out a survey afterwards to determine how they viewed therapeutic drug monitoring.

NCT ID: NCT03660657 Suspended - Clinical trials for Ischemic Heart Disease

Ozone Therapy in Refractory Ischemic Heart Disease.

O3Cardio
Start date: February 26, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

The main objective of this clinical trial is to evaluate the effectiveness and cost-effectiveness of adding ozone therapy to standard management of patients with advanced ischemic heart disease refractory to medical and surgical treatment.

NCT ID: NCT03529916 Suspended - Clinical trials for Coronary Heart Disease

Endothelial Cell Gene Networks of CVD

Start date: May 21, 2018
Phase:
Study type: Observational

The objective of this study is to identify relevant signature gene networks of cardiovascular disease in endothelial cells derived from circulating endothelial progenitor cells of individuals with established cardiovascular disease (CVD).

NCT ID: NCT03078465 Suspended - Clinical trials for Coronary Artery Disease

Ticagrelor Versus High-dose Clopidogrel in Patients With High Platelet Reactivity on Clopidogrel After PCI

PL-PLATELET
Start date: June 20, 2017
Phase: Phase 3
Study type: Interventional

To determine the safety and efficacy of Ticagrelor versus Clopidogrel for the reduction of adverse cardiovascular outcomes in patients with high platelet reactivity on clopidogrel after successful implantation of coronary drug-eluting stents.

NCT ID: NCT03050346 Suspended - Clinical trials for Coronary Artery Disease

Breathing-Induced Myocardial Oxygenation Reserve

B-MORE-Pilot
Start date: January 2016
Phase:
Study type: Observational

This is a clinical trial to test the clinical feasibility and safety of a novel CMR protocol, combined with a specific breathing maneuver to identify myocardial regions exposed to severe coronary artery stenosis.