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Obesity clinical trials

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NCT ID: NCT05088317 Enrolling by invitation - Obesity Clinical Trials

Relationship of Exercise Capacity With Physical Activity Level, Sleep Apnea Risk and Quality of Life in Obese Adults

Start date: September 4, 2021
Study type: Observational

Volunteer female and male individuals aged 20-65 years, followed in the Tuzla State Hospital Internal Diseases Unit, diagnosed with obesity (BMI> 30 kg/m^2), and meeting the inclusion criteria will be included in the study. The control group will consist of healthy male and female individuals between the ages of 20-65 who have not been diagnosed with obesity. The demographic and clinical characteristics of the participants who voluntarily accepted to participate in the study will be questioned with the "Evaluation Form" prepared by the researchers, and the body compositions of the participants will be evaluated. The "Charlson Comorbidity Index" will be used to determine the existing chronic diseases of the participants and to evaluate participants' comorbidities. Next; the "Incremental Shuttle Walk Test" will be applied to determine exercise capacity. In addition, in order to determine the level of physical activity, a "pedometer" device will be given to the participants, participants will be asked to carry the device on them for 7 days, and at the end of the period, the pedometer data will be recorded. At the same time, participants will be required to fill in the "International Physical Activity Questionnaire-Short Form". Participants will be asked to fill in the "STOP-Bang Test" to assess the risk of sleep apnea, the "Obesity-Specific Quality of Life Scale" to assess the health-related quality of life, and the "Hospital Anxiety and Depression Scale" to determine the anxiety and depression level of the participants. Handgrip strength will be evaluated with a hydraulic hand dynamometer. Assessments take an average of 45 minutes is planned.

NCT ID: NCT05080699 Enrolling by invitation - Obesity Clinical Trials

Evaluating Benefit of Peptide Based Diet in Obese HEN Patients

Start date: October 11, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the effects of a low energy, high protein tube feeding formula on body weight in tube fed patients who are obese. It will also assess study formula tolerance as well as impact of the study formula on lean body mass, blood pressure, blood sugar and lipids.

NCT ID: NCT05013359 Enrolling by invitation - Obesity Clinical Trials

Awareness, Care & Treatment In Obesity Management - An International Observation Among Teens (ACTION Teens)

Start date: August 21, 2021
Study type: Observational

ACTION Teens is a multinational cross-sectional survey-based study. The study consists of a quantitative online survey to be conducted among three groups of respondents in ten countries worldwide. The respondent population will include Adolescents Living with Obesity (ALwO), Caregivers of ALwO, and HCPs treating adolescents who have obesity. The goal of this study is to provide insights to drive awareness around the needs of adolescents living with obesity and their caregivers, as well as to identify key areas of misalignment between adolescents, their caregivers and the HCPs involved in obesity treatment and management. ACTION Teens is designed to generate evidence to identify and address these challenges on both a global and local level, extending the insights from the previously conducted ACTION-IO study.

NCT ID: NCT04907214 Enrolling by invitation - Obesity Clinical Trials

SGLT2 Inhibitor Effects on Inflammation and Heart Disease in Obesity Pilot

Start date: July 29, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

Obesity is associated with increased cardiometabolic disease risk due, in part, to heightened chronic inflammation arising from adipose tissue. There are no current targeted therapies to prevent or reverse the chronic inflammation of obesity, and a better understanding of these inflammatory pathways in humans is key to future therapeutic interventions. This project will determine both the anti-inflammatory potential of the SGLT2 inhibitor empagliflozin, and the contribution of adipose inflammation to surrogate measures of cardiovascular disease in a randomized controlled trial of obese patients.

NCT ID: NCT04899791 Enrolling by invitation - Obesity Clinical Trials

Positive Effects of Daily Consumption of Bread Enriched With Hydroxytyrosol on the Results of a 12-week Dietary Intervention on Subjects With Type 2 Diabetes Mellitus and Overweight/ Obesity

Start date: May 24, 2021
Phase: N/A
Study type: Interventional

Hydroxytyrosol is a phenolic compound drawn from the olive tree and its leaves as a by-product obtained from the manufacturing of olive oil and has antioxidant and antidiabetic effects. The use of HT extract in food products is a good strategy to improve their nutritional quality. However, this extract has a strong odour and flavour, so it is important to be encapsulated for the odour and flavour to be covered up. The purpose of the study is to investigate the effects of regular consumption of bread enriched with HT on biochemical parameters (blood glucose and cholesterol levels).

NCT ID: NCT04898400 Enrolling by invitation - Obesity Clinical Trials

Eosinophils in Human Adipose Tissue

Start date: June 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to better understand the interactions between the innate immune system, in particular eosinophils (EOS), and adipose tissue (AT) in human health and in disease states such as obesity and insulin resistance.

NCT ID: NCT04878289 Enrolling by invitation - Clinical trials for Overweight and Obesity

Teaching Obesity Treatment Options to Adult Learners Intervention Via VA Video Connect

Start date: April 15, 2021
Phase: N/A
Study type: Interventional

The goal of this study is to assess the feasibility and acceptability of Teaching Obesity Treatment Options to Adult Learners (TOTAL intervention), which includes an educational video about obesity treatment options within VA in conjunction with three telemedicine motivational sessions to increase obesity treatment initiation. 10 participants will be recruited from the Madison VA Medical Center. Participation involves 3.5 hours of total time with study follow up to 18 months.

NCT ID: NCT04836312 Enrolling by invitation - Obesity Clinical Trials

Intermittent Fasting Adherence and Self Tracking

Start date: July 12, 2021
Phase: N/A
Study type: Interventional

This pilot study will randomize 34 patients with hypertension and obesity to either time-restricted feeding alone or a commitment device to encourage time-restricted feeding, including a commitment pledge, involvement of a supportive partner, setting of implementation intentions, and multiple daily reminder text messages. The intervention will last 12 weeks, followed by a 6-week follow-up period. The primary outcome is adherence to the IF regimen, captured via daily text message, over 18 weeks

NCT ID: NCT04799327 Enrolling by invitation - Obesity Clinical Trials

The Effect of SHR20004´╝łNoiiglutide ´╝ë on Body Weight in Obese Subjects Without Diabetes

Start date: March 29, 2021
Phase: Phase 2
Study type: Interventional

The study is being conducted to assess the efficacy and safety of SHR20004 on body weight in obese subjects without diabetes.

NCT ID: NCT04793334 Enrolling by invitation - Obesity Clinical Trials

Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea

Start date: March 20, 2021
Study type: Observational

Obesity is a common risk factor for the development of obstructive sleep apnea. However, not all subjects with obesity develop obstructive sleep apnea. This study will attempt to determine the mechanistic drivers between obesity and obstructive sleep apnea.