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Obesity clinical trials

View clinical trials related to Obesity.

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NCT ID: NCT04841551 Recruiting - Adiposity Clinical Trials

Kybella for the Treatment of Flank Fat (FF)

Start date: May 2021
Phase: Phase 4
Study type: Interventional

To Determine the safety and Effectiveness of Kybella for the treatment of Flank Fat (FF)

NCT ID: NCT04839419 Recruiting - Metabolic Syndrome Clinical Trials

Obesity-hypoventilation in Metabolic Syndrom Patients

Start date: August 1, 2020
Study type: Observational

The purpose of the study is to determined the prevalence of obesity-hypoventilation syndrome in patients with metabolic syndrom.

NCT ID: NCT04828733 Recruiting - Obesity Clinical Trials

Laparoscopic Gastric Bypass With the Total Wrapping of the Fundus of Gastric Excluded Part for Treating Obesity and GERD

Start date: March 29, 2021
Phase: N/A
Study type: Interventional

Background and study aims: Currently, one anastomosis Gastric Bypass/Mini Gastric Bypass (OAGB/MGB) is a common bariatric procedure. Obesity and gastroesophageal reflux disease are steadily increasing world weight and antireflux surgery must be performed simultaneously with bariatric surgery in obese patients. In these cases, most often, hiatus cruroraphy is performed, and less often fundoplication using the fundus of the excluded part of the stomach. We hypothesize that total fundoplication can not only treat GERD but also prevent the return of weight like a banded gastric bypass. The aim study is to compare bariatric and antireflux results after OAGB/MGB plus suture cruroplasty (SCP) with and without total fundoplication. Methods: Adult participants (n=100) are randomly allocated to one of two groups: Experimental surgical bariatric procedure in the first (A) group: patients (n=50) undergo the laparoscopic one anastomosis gastric bypass with the total wrapping of the fundus of gastric excluded part and suture cruroplasty (OAGB + SCP + TF group); Active comparator surgical bariatric procedure in the second (B) group: patients (n=50) undergo the laparoscopic one anastomosis gastric bypass with only suture cruroplasty (OAGB + SCP group). All patients are then followed up 12, 24, 36 months after surgery where record the changing body mass index and change of GERD symptoms (GERD-HRQL).

NCT ID: NCT04819308 Recruiting - Obesity Clinical Trials

Differences in Nutrient Use During Exercise Between Children of Varying Body Mass Indices and Fitness Levels

SUPER kids
Start date: March 18, 2021
Study type: Observational

Children who have previously participated in the study MI Energy will be invited to participate in SUPER kids. Investigators want to better understand differences in nutrient use (e.g., fatty acid and carbohydrate) during rest and exercise in children of varying body types and activity levels.

NCT ID: NCT04818177 Recruiting - Obesity Clinical Trials

Immunoglobulin G Therapy

Start date: April 2, 2021
Study type: Observational [Patient Registry]

The overall goal of this proposal is to investigate effects of obesity on pharmacokinetics of immunoglobulin G (IgG) and to develop strategies for optimization of dosing of IgG in obese patients. There is an ongoing debate regarding the most appropriate dosing of IgG formulations in obese patients. Obesity poses significant health risks; and evidence supporting dosing strategies of IgG in obese patients is inadequate. Some of the adverse reactions have been attributed to a relative overdosing in these patients, due to a limited distribution of IgG into fat tissue.

NCT ID: NCT04815122 Recruiting - Obesity Clinical Trials

Correlation Between COMT Val158Met Polymorphism and Dopaminergic Transporter Density (DAT) in Obese Women

Start date: April 2021
Study type: Observational

The present study aims to evaluate the correlation between the presence of COMT Val158Met polymorphism and the density of dopaminergic transporters (DAT) in young obese women.

NCT ID: NCT04814147 Recruiting - Clinical trials for Obesity-Associated Insulin Resistance

Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients

Start date: March 16, 2021
Study type: Observational

Epidemiological studies show a very rapid increase in the epidemic of obesity in the Caribbean population. 6 out of 10 adults are overweight and 1 out of 4 is obese. Most are women. Consequences : harm to health and possible reduction in life expectancy due to the association with many cardiovascular comorbidities. Adverse effects of obesity on the cardiovascular and endocrine systems are attributed a chronic low-grade inflammatory state in obese patients. Visceral adipose tissue is largely responsible for the inflammatory syndrome. Obesity can also induce the formation of multi-protein platforms called inflammasomes also activated by mitochondrial production. Morbid obesity treatment with sleeve gastrectomy is an effective long term therapeutic for weight loss but also beneficial in terms of insulin resistance and cardiovascular complications. Some patients nevertheless remain resistant to the beneficial cardio-metabolic effects of bariatric surgery. However, the mechanisms that regulate the extent of weight loss and its stabilization after bariatric surgery are still poorly understood. Our study aims to describe the evolution of postoperative weight loss and the place of preoperative inflammation in its amplitude. The hypothesis is that the level of inflammation in visceral fat before surgery determines the extent of postoperative weight loss in obese women who have undergone sleeve gastrectomy.

NCT ID: NCT04812964 Recruiting - Obesity Clinical Trials

Modulation of the Intestinal Microbiome by a High Protein Diet

Start date: April 3, 2018
Phase: N/A
Study type: Interventional

The objective of this study is to test and determine whether a high protein diet induces weight loss by modulating the composition and function of the intestinal microbiome in obesity. This will be investigated in a randomized clinical study comparing the effect of isocaloric high and normal protein diets on the intestinal microbiome composition, gene content, and metabolome of obese subjects.

NCT ID: NCT04812314 Recruiting - Obesity Clinical Trials

Exercise Effects on Adipose Tissue Structure and Function

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.

NCT ID: NCT04812132 Recruiting - Obesity Clinical Trials

RCT Comparing OAGB and Long Limb Roux Gastric Bypass

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

A prospective multicenter randomized controlled trial to compare the outcomes of one-anastomosis gastric bypass to long biliary limb Roux gastric bypass. We plan to enroll up to 500 patients from three different clinics in Estonia. Outcomes are excess weight loss %, impact on type 2 diabetes, hypertension, hyperlipidemia and obstructive sleep apnea. Other outcomes are nutritional deficiencies, occurrence of reflux disease and impact on quality of life. There are planned outpatient visits 1, 5 and 10 years after the surgery to measure the impacts. There are a lot of studies comparing OAGB to standard Roux gastric bypass but non comparing it to long biliary limb gastric bypass.