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Obesity clinical trials

View clinical trials related to Obesity.

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NCT ID: NCT05080205 Active, not recruiting - Insulin Resistance Clinical Trials

Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, Insulin Resistance and Central Reward System

Start date: February 11, 2019
Phase: N/A
Study type: Interventional

Background: Morbid obesity is associated with decreased brain µ-opioid receptor availability, possibly resulting in higher food intake needed to gain pleasure from eating. This decrease seems to normalize already 6 months after bariatric surgery, but the longer-term effects have not been studied. Obesity and insulin resistance result in significantly increased brain insulin-stimulated glucose uptake, whereas in every other tissue glucose uptake is lower. One possible explanation to this could be central inflammation and activation of brain glial cells, which has been shown to occur in animal models of obesity. Obesity has also been shown to associate with increased risk of Alzheimer's disease and cognitive decline in several studies. Aims: The first objective of this study is to both study the effects of bariatric surgery as well as compare the effects of gastric bypass and sleeve gastrectomy on food-associated pleasure, extending the follow-up period to 2 years postoperatively. The second aim is to investigate the effect of morbid obesity and weight loss on brain inflammation and gliosis and its association with increased brain insulin-stimulated glucose uptake. Furthermore, association of obesity, insulin resistance, central inflammation and neurocognitive dysfunction are evaluated.

NCT ID: NCT05027750 Active, not recruiting - Obesity Clinical Trials

Theory-Based Obesity Intervention Program for Women

Start date: April 5, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to examine the effect of education and counseling given to women according to the Theory of Planned Behavior on weight management. This study will be conducted as a single-blind randomized controlled study consisting of intervention and control groups. A total of 78 overweight and obese women included in the study. The participants assigned to either of the groups by the block randomization method. A training program consisting of a total of five sessions applied to the intervention group, and counseling will be provided for 6 months. The data will be analyzed with Statistical Package for Social Sciences (SPSS) 22.0 package program.

NCT ID: NCT04980599 Active, not recruiting - Obesity Clinical Trials

Effect of a Probiotic Strain Lactobacillus Paracasei K56 on Metabolic Symptom - a Pilot Study

Start date: January 10, 2021
Phase: N/A
Study type: Interventional

Recent data suggest that gut microbiota can function as an environmental factor that modulates the amount of body fat and obese individuals have an altered gut microbiota.The results of previous animal studies have suggest that a probiotic strain Lactobacillus paracasei K56 have reduced high-fat diet induced obesity. In this before-after pilot study, the participants were randomly assigned to 8 groups to compare the fat-reducing effect of the Lactobacillus paracasei K56 by continuously supplementing different product prototypes , and screen the best probiotic K56 prototype with the effect of fat reduction.

NCT ID: NCT04933305 Active, not recruiting - Obesity Clinical Trials

Microstructure of Ingestive Behavior and Body Weight Loss After Roux-en-Y Gastric Bypass

Drinkometer 3
Start date: April 1, 2019
Study type: Observational

Studies of appetitive behavior in humans after RYGB have produced ambiguous results. It therefore remains unclear whether there are fundamental shifts in the palatability of high-fat and sugary foods after RYGB or simply a decrease in the appetitive drive to ingest them. Moreover, learning processes may play a role as changes in diet selection progress with time in rats after RYGB. However, direct measures of an altered food selection in humans after RYGB are rare and both the durability of the phenomenon as well as the role of experience for changes in food selection remain elusive.

NCT ID: NCT04922294 Active, not recruiting - Obesity Clinical Trials

Implementation of a Cardiometabolic Disease Staging System in Primary Care

Start date: July 20, 2020
Study type: Observational

The aim of this study is to develop a clinical decision support system (CDSS) that incorporates obesity management guidelines and treatment options for use by physicians and, potentially, patients based on a cardiometabolic disease staging system. This CDSS will be designed using primary care provider input through a qualitative approach to explore physician preferences for the appearance, electronic location, treatment options, referrals, accessibility and other user requirements of the CDSS.

NCT ID: NCT04916912 Active, not recruiting - Obesity Clinical Trials

Results of Coronary Artery Bypass Grafting in Obese Patients

Start date: May 1, 2020
Study type: Observational

This study is planned to assess the effect of obesity (BMI over 30 kg / m2) on hospital outcomes of isolated coronary artery bypass grafting in patients with chronic ischemic heart disease.

NCT ID: NCT04916379 Active, not recruiting - Obesity Clinical Trials

Effect of Momordica Charantia Administration on Anthropometric Indicators in Patients With Obesity

Start date: January 21, 2020
Phase: N/A
Study type: Interventional

Momordica charantia has shown to exert anti-obesity effects through numerous mechanisms of action described in preclinical studies. Important reductions in body weight and other anthropometric indicators have been reported in clinical trials. However, these beneficial effects of Momordica charantia on obesity have been observed mainly in type 2 diabetes mellitus patients. The purpose of this study is to evaluate the effect of Momordica charantia administration on anthropometric indicators in patients with obesity.

NCT ID: NCT04907565 Active, not recruiting - Obesity Clinical Trials

Impact of Obesity on Post-operative Cognitive Dysfunction: Role of Adipose Tissue

Start date: May 21, 2021
Study type: Observational

This research aims at describing the relationship between white adipose tissue inflammation and post-operative cognitive dysfunctions.The possible link between inflammatory cytokines secretions of the white adipose tissue of a surgical wound and the arising of patient's cognitive dysfunction in the post-operative course will be investigated. The hypothesis is that obese patient's inflammation of the white adipose tissue leads to cognitive dysfunction.

NCT ID: NCT04871295 Active, not recruiting - Obesity Clinical Trials

Improving Quality of Life in Men and Women With Overweight or Obesity

Start date: April 15, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effect of the Noom Healthy Weight Program, a digital behavior change weight loss intervention, on quality of life as measured both by self-report and objective measures, compared to a waitlist control condition.

NCT ID: NCT04863040 Active, not recruiting - Obesity Clinical Trials

The Impact of Activity Breaks on Cognitive Function, Adiposity and Fitness in Preschoolers

Start date: June 1, 2020
Phase: N/A
Study type: Interventional

Project which objective is a) to test the effectiveness, in preschool children, of an integrated physical activity intervention in the classroom based on intervallic training (MOVI-HIIT) on improving executive function, body composition, cardiorespiratory fitness and b) to evaluate teachers' perceptions of barriers and facilitating elements for the implementation and monitoring of MOVI-HIIT interventions in the classroom.