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Obesity clinical trials

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NCT ID: NCT03887078 Recruiting - Obesity Clinical Trials

Noom Coach for Bariatric Health

Start date: September 14, 2018
Phase: N/A
Study type: Interventional

Mobile technologies/smartphone applications offer a means to effect behavior change without significant obstacles that typically limit implementation of empirically supported therapies (e.g., in-person sessions); however, rigorous research on apps is limited, and high-quality, adequately powered, randomized controlled trials with large samples are required. As more Americans consider bariatric surgery for the treatment of severe obesity, it is imperative to improve factors influencing suboptimal surgical outcomes (e.g., failure to adhere to diet and exercise recommendations and psychosocial impairment). This study will evaluate the effect of the Noom Coach for Bariatric Health platform in improving standard interventions utilized in bariatric surgery programs.

NCT ID: NCT03886870 Completed - Obesity Clinical Trials

Obesity, Lifestyle and Work Intervention

Start date: September 3, 2014
Phase: N/A
Study type: Interventional

The main aim of this study was to examine whether introducing a work intervention into a traditional lifestyle rehabilitation program for persons with BMI above 30, would affect the participants' ability to work and their lifestyle change. The investigators wanted to find out how the participants experienced their health, workability and work capacity, quality of life, diet and self-efficacy before and during the intervention

NCT ID: NCT03885700 Completed - Obesity Clinical Trials

School Intervention Program to Promote Healthy Lifestyle Among Male Adolescent Students in King Faisal Residential City, Jeddah, Western Region, 2014-15

Start date: January 1, 2015
Phase: N/A
Study type: Interventional

Through a cluster randomized control trial, 148 male adolescents' students were randomly assigned into either intervention group who received an educational program for two months (n=79), or control groups (n=69) who didn't attend the program. The principle outcomes were the changes in physical activities, consumption of healthy diet, sedentary life habits and anthropometric measurements. The outcomes of the intervention group were compared with their own baseline readings, as well as with the readings of the control group. Rationale: - Saudi adolescents are in need for more exploration of their health problems and related health behaviors and application of intervention preventive services. - As a National Guard community medicine resident : I have a major interest in the health of adolescent and in fulfilling the aim of the school health programs of application of interventional preventive service that will target this vulnerable risky group. Aim: - Promote healthy life style among National Guard adolescents age group by application of interventional preventive program. Objectives: I. To measure physical activity patterns , sedentary behaviors and dietary habit among randomly selected adolescent in intervention and control group at National Guard Schools in Jeddah city 2014-2015. II. To implement an interventional school promotional program among the school children from the addressed age group in 2014-2015. III. To measure the effect of the interventional school promotional program among the two groups in relation to demographic, socioeconomic and other factors related to health in 2014-2015 .

NCT ID: NCT03885297 Recruiting - Obesity Clinical Trials

3mg Liraglutide for Overweight or Obesity

Start date: January 18, 2019
Phase:
Study type: Observational

In this study investigators will investigate the beneficial metabolic sequelae of Liraglutide in patients with obesity or overweight; including changes in vital signs, anthropometric characteristics (weight, body mass index and body composition), biochemical parameters, metabolomics and micro-ribonucleotide acid (miRNA) molecules from blood tests. Liraglutide is a commercially available analogue of a gut hormone physiologically produced in our bowel in response to food, licenced for the treatment of overweight or obesity. Liraglutide will be offered to patients attending National Health System (NHS) or private clinics within indication and according to their agreed clinical management. Investigators aim to collect real-life information for this study along with planned clinical management from patients who agree to their treatment and to take part in our study. Patients will be able to withdraw from treatment and study at any time without giving any explanation. If successful, this study will help us combine clinical, biochemical and molecular information which will allow us to gain deeper understanding on the mechanisms behind the beneficial metabolic effects of Liraglutide in overweight and obesity. Data generated from this study will hopefully help us acquire funding for a larger multicentre study; the results of which can have substantial impact on millions of people with overweight or obesity around the world.

NCT ID: NCT03885245 Not yet recruiting - Obesity Clinical Trials

Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes

SANDIA
Start date: August 1, 2019
Phase: Phase 2
Study type: Interventional

Patients with obese late onset (after childhood) asthma can have lower FeNO levels, yet be highly symptomatic and poorly responsive to inhaled steroids. This is a common asthma phenotype, particularly among females. This reduction of NO occurs through increased arginase activity and uncoupling of NO synthase (NOS), by accumulation of asymmetric di-methyl arginine (ADMA), which further lowers the L-arginine/ADMA ratio, preferentially promoting reactive oxygen species (ROS) formation and inflammation at the expense of NO. Indeed, in patients with obese late onset asthma, lower L-arginine/ADMA plasma ratios are associated with reduced FeNO, increased bronchial hyperreactivity, and greater asthma morbidity. In our pilot studies, the administration of L-citrulline, as an L-arginine donor, to patients with obese late onset asthma increased the L-arginine/ADMA ratio, FeNO levels, and improved asthma control and lung function. Therefore, the objectives of the protocol are to: a) determine the efficacy of L-citrulline, as an add-on treatment to improve the asthma control and lung function in obese late onset asthmatics; b) leverage the use of asthmatic and control cells to further understand obesity-related changes in epithelial airway NO metabolism, and how these changes relate to bronchoconstriction and lung function, c) determine airway epithelial changes in mitochondrial function and bioenergetics in obese late onset asthmatics and how these are modified by L-citrulline. To do this, 54 obese late onset asthmatics with suboptimal control will be blindly randomized, in a cross over study, comparing 15g/day of L-citrulline vs. placebo, in two 8-week treatment periods with a 6-week washout in between. The co-primary study outcomes are asthma control (ACQ, ACT) and FeNO, and secondary endpoints plasma L-arginine/ADMA, FEV1 and PC20 methacholine. Parallel to this study, a small study of 10 healthy obese controls will receive open label L-citrulline for 8 weeks to establish comparative reference values for the study aims. During the initial treatment phase, 50% of study participants will be randomly allocated to undergo pre and post L-citrulline treatment bronchoscopy to obtain BAL and airway epithelial cells. The research group proposing this study is highly experience in asthma clinical trials, implementation of cross over design studies, and in the use of research bronchoscopies.

NCT ID: NCT03885115 Enrolling by invitation - Obesity Clinical Trials

Lace Up and Move: Structured After School Intervention for Hispanic and African American Youth

LUAM
Start date: November 28, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to test the efficacy of Lace Up and Move (LUAM), a structured after-school exercise intervention, designed to increase moderate-to-vigorous physical activity (MVPA) and enhance sleep quality among Hispanic and African American (AA) boys and girls.

NCT ID: NCT03881657 Completed - Obesity Clinical Trials

Reverse Colocated Integrated Care Intervention Among Persons With Severe Persistent Mental Illness at US-Mexico Border

Start date: November 24, 2015
Phase: N/A
Study type: Interventional

This study evaluated whether patients with severe and persistent mental illness (SPMI) who received coordinated co-located behavioral health and primary care services were more likely to improve health outcomes after 12 months compared to SPMI patients who receive only behavioral health services from the local mental health authority (LMHA) Tropical Texas Behavioral Health (TTBH).The study employed a randomized control trial (RCT) design where intervention participants receiving integrated behavioral health were compared to control participants receiving the usual care provided within an LMHA for SPMI patients. Patients were placed in each group using a randomized number process. Demographic and health outcome data were collected from intervention and control participants at baseline. Health outcome data was subsequently collected at 6-month and 12-month follow-up points.

NCT ID: NCT03881540 Completed - Obesity Clinical Trials

Efficacy of tDNA Care on Weight Loss and Metabolic Outcomes in Patients With Overweight, Obesity and Type 2 Diabetes

Start date: June 2014
Phase: N/A
Study type: Interventional

The aim of this study was to investigate the effectiveness of structured lifestyle intervention following a transcultural diabetes nutrition algorithm (tDNA) care compared to usual diabetes care in patients with overweight, obesity and type 2 diabetes (T2D), receiving either the motivational interviewing counseling or conventional counselling technique in an outpatient clinic setting. The hypothesis is weight loss and glycated haemoglobin (A1C) level will be improved in patients following the tDNA care compared to usual diabetes care and the improvements will be greater in those receiving motivational interviewing counseling than conventional counselling.

NCT ID: NCT03881280 Enrolling by invitation - Clinical trials for Overweight and Obesity

The System Fammeal With Tailored Recommendations and Gamification for Parents to Counteract Childhood Obesity

Fammeal
Start date: February 6, 2019
Phase: N/A
Study type: Interventional

The investigators aim to test an evidence-based intervention, allocated to a mobile app designed to parents and their children with 3 to 6 years old, identified by family doctors or nurses at well-child care visits as overweight or obese for age. This intervention aims to improve parent's perceptions and attitudes regarding children's weight status and food intake, leading to better dietary intake and children's' eating behaviors through positive parental child-feeding practices. In this study, the investigators aim to assess the feasibility of the intervention and explore its impact on the beliefs and attitudes of parents.

NCT ID: NCT03880838 Not yet recruiting - Obesity Clinical Trials

Evaluation of a Letter Intervention Promoting a Plant-based Diet

Start date: March 29, 2019
Phase: N/A
Study type: Interventional

The researchers' mission is to promote healthier eating behavior and to reduce costs associated with healthcare. The purpose of this study is to evaluate the effects of mailing randomly selected participants a letter promoting a plant-based diet. Depending on the experimental condition, participants may additionally receive a free documentary, Forks Over Knives, and they may also get letters which use commitment- or prevention-focused messages to encourage watching the documentary and changing their eating behavior. The researchers hypothesize that receiving the documentary will be associated with lower insurance claims and improved health outcomes one and two years later. The researchers also hypothesize that using either commitment- or prevention-focused messages will also contribute to lower insurance claims and improved health outcomes compared to experimental conditions where materials did not include these messages. This study will help the researchers design evidence-supported programs that can improve people's health.