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Obesity clinical trials

View clinical trials related to Obesity.

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NCT ID: NCT03124134 Active, not recruiting - Obesity Clinical Trials

Gelesis Glycemic Index Study

GLIDE
Start date: April 18, 2017
Phase: N/A
Study type: Interventional

A study to determine glucose and insulin responses to 50g and 100 g of carbohydrate with and without Gelesis200.

NCT ID: NCT03123510 Recruiting - Obesity Clinical Trials

Effect of a Synbiotic Supplement on a High-protein Diet

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

The objective of the trial is to study how a synbiotic treatment will affect weight loss and management in individuals enrolled in weight loss diet Profile®. The investigators propose to follow up 2 cohorts of Profile® subjects during 6 months. One group will receive a synbiotic treatment supplement (Bifidobacterium spp plus bimuno- galacto-oligosaccharides (B-GOS)) while the other group will receive placebo capsules. Anthropomorphic and metabolic analysis will be performed by-monthly. Fecal samples will be obtained before and after the dietary intervention and samples will be sequenced trough next generation DNA sequencing to analyze the gut microbiota. Because dietary interventions with high protein and low glycemic index have been shown to be effective in reducing weight, but has also been linked to potential colon harm due to increased fermentation of undigested protein on the colon, the investigators expect supplementation of Profile® with a synbiotic product will lead to an increased overall wellbeing without compromising weight management.

NCT ID: NCT03122977 Recruiting - Obesity Clinical Trials

Acute-phase Response & Periodontal Treatment in Obese Patients

PERIO-OBESE
Start date: June 1, 2016
Phase: N/A
Study type: Interventional

The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in terms of acute-phase responses following no surgical periodontal treatment in obese patients affected by periodontitis.

NCT ID: NCT03121755 Completed - Obesity Clinical Trials

CCK1R Function in Patient Leukocytes

Start date: January 21, 2015
Phase: N/A
Study type: Observational

The type 1 cholecystokinin receptor (CCK1R) is a potential target for the treatment of obesity, due to the ability of this GI hormone to elicit satiety. However, this receptor has been shown to be sensitive to the cholesterol content of the membrane in which it is expressed. Because some patients who might be candidates for the use of CCK agonists to treat their obesity and co-morbidities, the goal of this study is to determine how metabolic abnormalities might affect the responsiveness of this receptor to CCK. Because the normal site mediating CCK-stimulated satiety is on vagal afferent neurons that cannot easily be studied, we will collect buffy coat cells from a peripheral blood sample from patients involved in the Sangre Por Salud Biobank at Mountain Park Medical Center. Ex vivo, the CCK1R will be expressed on these cells and will be functionally characterized, and the cholesterol content of the cells will be assayed. These data will be correlated with the clinical, biochemical, and metabolic phenotypic data collected as part of the parent study.

NCT ID: NCT03120871 Not yet recruiting - Obesity Clinical Trials

Microbiome Insulin Sensitivity Study

MISS
Start date: April 24, 2017
Phase: N/A
Study type: Observational

The Microbiome Insulin Sensitivity Study "MISS" is a pilot study designed to study microbiome composition across puberty and how it relates to insulin sensitivity and secretion in obese girls, who are at increased risk for developing type 2 diabetes in puberty. The investigators will evaluate the gut microbiome composition in fecal samples of 57 obese girls in three groups: prepubertal (Tanner 1), early pubertal (Tanner 2-3), and late pubertal (Tanner 4-5). Insulin sensitivity will also be measured via an intravenous glucose tolerance test (IVGTT) in 18 prepubertal and late pubertal participants.

NCT ID: NCT03120455 Recruiting - Obesity Clinical Trials

Effects of Almond Versus Pistachio on Weight Loss

Start date: April 2017
Phase: N/A
Study type: Interventional

The purpose of the current study is comparing the effect of almond and pistachio, as the two common types of nuts, consumption on healthy obese and overweight female who following a hypocaloric diet for 12 weeks. The secondary aim of the current study is to evaluate of these two type of nuts on other cardiometabolic risk factors.

NCT ID: NCT03120429 Recruiting - Obesity Clinical Trials

Effects of Moderate Consumption of Lean Fish on Weight Loss

Start date: April 2017
Phase: N/A
Study type: Interventional

the aim of present study is to compare the specific effects moderate consumption of lean fish on weight loss of healthy obese and overweight female adults, while participants follow energy-restricted diets also to investigate the effects of this intervention on carbohydrate and lipid profiles, as cardiometabolic risk factors.

NCT ID: NCT03120286 Completed - Clinical trials for Polycystic Ovary Syndrome IVF

OVERWEIGHT AND OBESITY ADVERSELY AFFECT IVF OUTCOMES IN WOMEN WITH PCOS

Start date: December 2014
Phase: N/A
Study type: Observational

The effect of overweight and obesity on IVF outcomes is still questionable. The purpose of this study was to determine if overweight/obesity in women with PCOS were associated with an adverse IVF outcome compared to those with normal weight. Design: Retrospective cohort study.

NCT ID: NCT03120260 Recruiting - Obesity Clinical Trials

Comparing Effect of Short Sleep Duration on Weight Loss of Overweight and Obese Women Attending a Weight Loss Program

Start date: April 17, 2017
Phase: N/A
Study type: Interventional

The purpose of the present study is to evaluate the effect of sleep duration on weight loss of obese and overweight adult when they are in a weight loss plan (NovinDiet Protocol). The investigators aim is to compare the effects of short term sleep duration with normal sleep duration with respect to body weight (and abdominal adiposity).

NCT ID: NCT03119610 Not yet recruiting - Obesity Clinical Trials

The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity

INOSO
Start date: June 2017
Phase: Phase 1/Phase 2
Study type: Interventional

Obesity is highly prevalent in older adults and is a major cause of sarcopenia and disability in older adults. Although exercise can counteract the effects of obesity and sarcopenia, many have difficulty adhering to an exercise program and the benefits of exercise are variable. Therefore, there is an urgent need to test novel pharmacologic interventions to prevent disability and loss of independence. Oxytocin is a pituitary hormone released during parturition and lactation that is also known to suppress appetite in rodents and humans; and, recent small studies have found that intranasal oxytocin reduces body weight in adults. We propose a pilot study of intranasal oxytocin as a novel approach to promote weight loss and increase muscle mass in older subjects with sarcopenic obesity.