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Obesity clinical trials

View clinical trials related to Obesity.

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NCT ID: NCT05371496 Not yet recruiting - Obesity Clinical Trials

Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction

Start date: July 2022
Phase: Phase 2
Study type: Interventional

The purpose of this research is to find out if an aggressive intervention to lose weight, will improve symptoms in patients with obesity-related cardiomyopathy, which is also known as the obese phenotype of heart failure with preserved ejection fraction (HFpEF).

NCT ID: NCT05369390 Not yet recruiting - Obesity Clinical Trials

A Research Study on How NNC0487-0111 Works in People With Overweight or Obesity

Start date: May 5, 2022
Phase: Phase 1
Study type: Interventional

NNC0487-0111 is a new medicine similar to 2 hormones that are produced in human body: amylin and glucagon-like peptide-1 (GLP-1). Both hormones work like body's own hormones and help the body to feel full. This study tests if the study medicine is safe and to find out how the medicine works in humans. This study also look at how the study medicine affects body weight and how to improve the treatment of people with overweight, obesity or related diseases. This study will have 4 parts: Part A, B, C and D. Part A: This is planned to consist of five groups, one additional group may be added. Each group will include 8 participants, with 6 participants being randomised to receive a single dose of NNC0487-0111 A and 2 participants randomised to receive placebo. The dosing within each group will be sequential, i.e., 2 sentinel participants (1 on active and 1 on placebo). Part B: This is planned to consist of three groups, one additional group may be added. Each group will include 12 participants, with 9 participants being randomised to receive NNC0487-0111 A and 3 participants randomised to receive placebo once daily for 10 days. The dosing within each group will be sequential. For the first group, 4 sentinel participants (3 on active and 1 on placebo) will be dosed followed by a safety observation period of 7 days (168 hours), before dosing of the remaining participants in the group will be initiated. For the remaining groups, 4 sentinel participants (3 on active and 1 on placebo) will be dosed followed by a safety observation period of at least 36 hours before dosing of the remaining participants in the group will be initiated. Part C and D are matching regarding planned visits and procedures, but the study interventions in Part D (NNC0487-0111 B) differ from Part A, B and C (NNC0487-0111 A). Each part is planned to consist of one group, although one additional group may be added. Each group will include 20 participants, with 16 participants being randomised to receive active treatment and 4 participants randomised to receive placebo once-daily for 12 weeks. The dosing will be sequential, i.e., 4 sentinel participants (3 on active and 1 on placebo) will be dosed followed by a safety observation period of at least 36 hours before dosing of the remaining participants in the cohort will be initiated. The remaining participants will be dosed in smaller groups of 8 participants separated by a safety observation period of at least 36 hours. A safety evaluation will be made between dosing of participants within a group and before moving on to a higher dose.

NCT ID: NCT05368311 Active, not recruiting - Obesity Clinical Trials

Effect of a Protein Intake on Weight Loss of Overweight/Obese Adults

COLABOCO
Start date: February 11, 2022
Phase: N/A
Study type: Interventional

Obesity is considered the epidemic of the 21st century. Obesity is a multifactorial disease and the most important risk factors are poor diet and sedentary lifestyle. An excessive body weight contributes to increase the risk of suffering from other diseases and mortality rates. Therefore, the prevention and control of excessive body weight as well as its comorbidities are essential. In this sense, the principal strategy to treat obesity is to improve dietary habits and increase physical activity. However, the rate of obesity continues rising. In order to deal with this problem, new strategies to combat obesity are being investigated, such as the investigation of new bioactive compounds with satiating capacity that can be included in healthy dietary patterns to improve adherence to dietary treatments. Considering this background, the main objective of this research is to assess the effect of daily consumption of protein rich bars accompanied by healthy dietary recommendations on weight loss of overweight/obese adult men and women.

NCT ID: NCT05368259 Recruiting - Obesity Clinical Trials

The AUDACITY Study (AllUrion Device in Adults With Clinical ObesITY)

AUDACITY
Start date: May 12, 2022
Phase: N/A
Study type: Interventional

The objective for this clinical study is to provide FDA with clinical evidence regarding the effectiveness and safety of the AGBS + moderate intensity lifestyle modification therapy program, indwell time of the AGBS inside the stomach, and outcomes at 48 weeks.

NCT ID: NCT05367674 Completed - Childhood Obesity Clinical Trials

Summer Harvest Adventure: A Garden-based Obesity Prevention Program for Children Residing in Low-resource Communities

SHA
Start date: March 1, 2017
Phase: N/A
Study type: Interventional

The objective of this study is to implement and test the efficacy of the "Summer Harvest Adventure," a comprehensive garden-based behavioral, social, and environmental intervention for children (ages 8-11 years) residing in low-resource communities.

NCT ID: NCT05367596 Not yet recruiting - Obesity Clinical Trials

OPTIMIzing muScle Preservation in paTients wIth Cirrhosis

OPTIMISTIC
Start date: May 2, 2022
Phase: N/A
Study type: Interventional

Patients with obesity and cirrhosis benefit from weight loss but are prone to sarcopenia (loss of muscle mass, strength, and function). This study proposes to test a specialized weight loss program Alternative-day Modified Fasting (ADMF) designed to promote weight loss and preserve skeletal muscle mass, strength, and function in patients with both Child-Pugh (CP) class A cirrhosis and obesity. This study will compare the effectiveness of the ADMF to Continuous Energy Restriction (CER) for 24-weeks. Both arms will receive a high-protein, high-BCAA diet, a late-night snack, supervised aerobic and resistance exercise, increased physical activity through self-monitoring, and group behavioral counseling. The primary aim of this trial is to evaluate the feasibility and acceptability of ADMF and CER for 6 months in patients with cirrhosis and obesity. The secondary aim is to compare changes in body composition in both diets.

NCT ID: NCT05365685 Not yet recruiting - Obesity Clinical Trials

Energy Turnover and Appetite

NEXT
Start date: September 1, 2022
Phase: N/A
Study type: Interventional

The aim of the study is to compare the effect of a low versus moderate versus high energy turnover on energy intake, appetite and food reward, in adolescents with obesity. 18 adolescents with obesity will then complete three experimental sessions in a randomized order: low, high and moderate Energy turnover.

NCT ID: NCT05364957 Not yet recruiting - Obesity Clinical Trials

Intragastric Balloon in Obese Patients With Uncontrolled Asthma

BOA
Start date: June 2022
Phase: N/A
Study type: Interventional

The main reason of this project is to study the effect of an intagastric balloon (IGB) on obese patients with asthma, so this project aims to evaluate if an IGB associated with dietary and exercise intervention improves asthma control at 1 year in obese patients with uncotrolled asthma compared to patients with only dietary and exercise intervention.

NCT ID: NCT05364814 Completed - Obesity Clinical Trials

Use of Probiotic Yogurt in Obese Women

Start date: February 2, 2022
Phase:
Study type: Observational

This study aimed to examine the effects of using probiotic yogurt on body components (body weight, height, etc.) and digestive system (distention, gas, etc.) in obesity (obese women), which is an important public health problem all over the world.

NCT ID: NCT05362747 Recruiting - Obesity Clinical Trials

ProduceRx: Improving Weight and Cardiovascular Risk in Adults With Food Insecurity and Obesity

Start date: April 26, 2022
Phase: N/A
Study type: Interventional

This is a pilot randomized controlled trial to assess the effects of providing produce vouchers during behavioral weight loss treatment in 40 adults with obesity and food insecurity. Participants will be randomized to ProduceRx (12 weekly sessions of group-based, in-person, behavioral weight loss counseling (BWL) + produce prescriptions) or a waitlist control (WLC).