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Healthy clinical trials

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NCT ID: NCT05487781 Enrolling by invitation - Healthy Clinical Trials

Phase 1 Clinical Study to Describe Biological Safety and Pharmacokinetics of Tyrphostin

Start date: May 24, 2022
Phase: Early Phase 1
Study type: Interventional

Evaluate the biological safety and pharmacokinetics of tyrphostin AG-17 present in the solid oral formulations of the fixed-dose combination, in three different concentrations of the compound tyrphostin AG-17 contained 10 mg, 3.3 mg and 1 mg, respectively, with 700 mg of L-Carnitine tartrate each presentation, in a single dose in healthy research subjects of Mexican nationality.

NCT ID: NCT05486208 Not yet recruiting - Healthy Clinical Trials

A Study of LY3844583 in Healthy Participants and Participants With Atopic Dermatitis

Start date: August 11, 2022
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to evaluate the safety and tolerability of LY3844583 in healthy participants and participants with atopic dermatitis. The study will also assess how fast LY3844583 gets into the blood stream and how long it takes the body to remove it. The study is open to healthy participants and participants with atopic dermatitis. The study will be conducted in three parts and each participant will enroll in one part. The study will last up to 88, 116, and 186 days with 10, 13, and 14 visits for each participant in parts A, B, and C, respectively.

NCT ID: NCT05483296 Not yet recruiting - Healthy Clinical Trials

Effects of Afternoon and Evening Light on Teenagers' Melatonin Levels, Alertness, Sleepiness and Sleep

TeenLight
Start date: August 2022
Phase: N/A
Study type: Interventional

Many teenagers are familiar with this: on school days, they have to get up early; during the day, they hardly get any light exposure; in the evening, they go to bed late - and are then tired at school the next day! Around the world, teenagers are sleep deprived, with studies suggesting that almost half (~45%) suffer from inadequate sleep. Previous investigations have shown that people's sleep-wake rhythm is related to the light conditions that they are exposed to during the day and at night. However, little is known about how different light levels in the afternoon can modulate teenagers' sleep and their bodily responses to light in the late evening. Therefore, the investigators aim to study which lighting conditions have a favourable effect on these aspects and how the potentially harmful effects of light at night can be prevented.

NCT ID: NCT05482308 Not yet recruiting - Healthy Clinical Trials

A Study to Compare Two Tablet Forms of Tafamidis in Healthy Participants

Start date: August 4, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this clinical trial is to compare the amount of tafamidis in blood after taking two different tablet forms of tafamidis This study is seeking healthy participants over the age of 18. All participants in the study will receive one tablet of study medicine on the first day, then receive one dose of the other tablet form 16 days later. We will compare the amounts in blood for 8 days after taking each dose of the study medicine. Participants will take part in this study for about 80 days. The first visit is a screening visit to ensure that participants are appropriate for the study. Up to 28 days later, they will visit the study clinic twice (and stay overnight in the clinical research center for 8 nights each time). The study team will also call participants over the phone 28 to 35 days after the last dose of medicine.

NCT ID: NCT05481333 Not yet recruiting - Healthy Clinical Trials

A Trial to Learn if REGN7999 is Safe and Well Tolerated, and How it Works in the Body of Healthy Participants

Start date: October 26, 2022
Phase: Phase 1
Study type: Interventional

The primary objective of the study is to evaluate the safety and tolerability of single ascending intravenous (IV) and subcutaneous (SC) doses of REGN7999 in healthy adult participants. The secondary objectives of the study are: - To characterize the drug concentration profile of single doses of IV or SC REGN7999 - To assess the immunogenicity of single ascending SC or IV doses of REGN7999

NCT ID: NCT05481307 Not yet recruiting - Healthy Clinical Trials

A Study to Evaluate Pharmacokinetic/Pharmacodynamic Drug-drug Interaction and Safety/Tolerability Between RLD2202 and RLD2203

Start date: August 2, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate pharmacokinetic/pharmacodynamic drug-drug interactions and safety/tolerability between RLD2202 and RLD2203 in healthy adult subjects

NCT ID: NCT05480774 Recruiting - Healthy Clinical Trials

Effect of Red Ginseng Extract on Changes in Indicators of Immune Function in Vietnamese Healthy Volunteers

Start date: August 6, 2022
Phase: Phase 1
Study type: Interventional

This is a placebo-controlled, randomized, double-blind, multiple dose study that evaluated the safety, tolerability, and changes in indicators of immune function of Korean Red Ginseng Extract in Vietnamese healthy subjects following oral administration of multiple dose of Korean Red Ginseng Extract as hard capsules or placebo to healthy adult men.

NCT ID: NCT05480579 Not yet recruiting - Healthy Clinical Trials

A Study of IBI311 in Health Subjects

Start date: July 18, 2022
Phase: Phase 1
Study type: Interventional

It is designed for Multi-center, double-masked, randomized, placebo- control study with dose escalation phase I trial to evaluate the safety, tolerability, PK and immunogenicity profiles of a single intravenous injection of IBI311 in health subjects.

NCT ID: NCT05480488 Not yet recruiting - Healthy Clinical Trials

A Study to Examine the Effect of Daridorexant on the Way the Body Absorbs, Distributes, and Gets Rid of Midazolam and Warfarin in Healthy Male Subjects

Start date: August 6, 2022
Phase: Phase 1
Study type: Interventional

A study to examine the effect of daridorexant on the way the body absorbs, distributes, and gets rid of midazolam and warfarin in healthy male subjects

NCT ID: NCT05480475 Not yet recruiting - Healthy Clinical Trials

A Study to Examine the Effect of Daridorexant on the Way the Body Absorbs, Distributes, and Gets Rid of Dabigatran and Rosuvastatin in Healthy Male Subjects

Start date: September 2, 2022
Phase: Phase 1
Study type: Interventional

A study to examine the effect of daridorexant on the way the body absorbs, distributes, and gets rid of dabigatran and rosuvastatin in healthy male subjects