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NCT ID: NCT05252520 Withdrawn - Healthy Clinical Trials

A Study of JNJ-77474462 (Bermekimab) in Healthy Chinese Participants

Start date: May 1, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the pharmacokinetics (PK) of JNJ-77474462 following single ascending dose subcutaneous (SC) administration to healthy Chinese participants.

NCT ID: NCT05182047 Withdrawn - Healthy Clinical Trials

A Study of Butamirate Citrate Syrup Versus (vs) Sinecod Syrup (Vanilla) in Adult Healthy Study Volunteers

Start date: March 18, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate bioequivalence with respect to rate and extent of absorption of 2-phenylbuturic acid of the novel medication butamirate citrate syrup 1.5 milligrams per milliliter (mg/mL), and the medication sinecod syrup (vanilla) 1.5 mg/mL after single-dose administration in fasting condition by healthy volunteers.

NCT ID: NCT05159128 Withdrawn - Healthy Clinical Trials

A Study of JNJ-75105186 in Healthy Japanese and Chinese Participants

Start date: November 15, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of JNJ-75105186 after single ascending oral dose administration in healthy Japanese participants and after single oral dose administration in healthy Chinese participants.

NCT ID: NCT05061277 Withdrawn - Healthy Clinical Trials

Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Recifercept in Healthy Chinese Participants

Start date: October 25, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the pharmacokinetic (PK), safety, tolerability and immunogenicity of a single subcutaneous (SC) dose of the lyophilized formulation of recifercept in healthy Chinese participants.

NCT ID: NCT04997616 Withdrawn - Healthy Clinical Trials

Determination of Cannabinoid and Cannabinoid Metabolite Levels in Healthy Volunteers

Start date: January 3, 2023
Phase: Early Phase 1
Study type: Interventional

Levels of major cannabinoid and cannabinoid metabolites (i.e., CBD, CBD-OH) will be determined in the plasma of healthy volunteers following 10 days of Happy Lane Hemp Extract/CBD soft gels (25 mg per capsule) supplementation using liquid chromatography-mass spectrometry (LCMS).

NCT ID: NCT04941365 Withdrawn - Healthy Clinical Trials

Quantifying Systemic Immunosuppression to Personalize Cancer Therapy

SERPENTINE
Start date: July 7, 2022
Phase: N/A
Study type: Interventional

It is nowadays well established that the immune system can profoundly influence disease outcome in cancer patients. Increasing evidence is indeed showing that patients displaying spontaneous T cell-mediated immune response against their tumor (defined as immune surveillance) have higher chance to respond to therapies and display globally better prognosis. Conversely, patients whose tumor is characterized by immunosuppression, usually involving myeloid cells and chronic inflammation pathways, often undergo rapid progression and rarely benefit from therapy. Hence, capturing the immune features of individual tumors can help to predict disease course and tailor the therapeutic workup in clinical setting.

NCT ID: NCT04894656 Withdrawn - Healthy Clinical Trials

Intestinal Permeability and Gastroparesis

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate potential mechanisms that could lead to the development of a condition known as gastroparesis.

NCT ID: NCT04853524 Withdrawn - Healthy Clinical Trials

A Study of JNJ-56136379 in Healthy Participants

Start date: May 6, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the effect of multiple-dose JNJ-56136379 on the single-dose pharmacokinetics (PK) of the combination of bictegravir (BIC), emtricitabine (FTC), tenofovir alafenamide (TAF) in healthy adult participants.

NCT ID: NCT04782661 Withdrawn - Healthy Clinical Trials

A Study of JNJ-70075200 in Healthy Participants

Start date: March 1, 2022
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate safety and tolerability of JNJ-70075200 compared with placebo after administration of single ascending doses of JNJ-70075200 as oral solution (Part 1); multiple ascending doses of JNJ-70075200, administered as oral solution over 14 consecutive days (Part 2); and the option of a single dose of JNJ-70075200 administered as an oral solid formulation (Part 3).

NCT ID: NCT04738617 Withdrawn - Healthy Clinical Trials

Inter- and Intra-individual Variation in Acute Responses to Two Different Warm-up Types.

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

The goal is to assess inter- and intraindividual variation in response to different warm-up protocols in a randomized, cross-over study with U16 and U17 Portuguese soccer players.