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Stroke clinical trials

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NCT ID: NCT03661073 Not yet recruiting - Stroke Clinical Trials

Motor Imagery Ability After Stroke

Start date: September 2018
Phase: N/A
Study type: Interventional

Individuals with stroke may experience sensory-motor deficit and/or neglect, with possible reduction in motor imagery ability (MI). To our knowledge, no study completely investigated MI ability in one individual whereas MI practice can be performed using visual or kinesthetic modalities (respectively visualizing with mind's eyes or imagining movement using sensation) and internal or external perspectives (performing action as spectator or as actor). This study aims to investigate MI ability in patients with stroke as compared to aged-matched healthy individuals. The investigators will assess explicit MI ability using 3 questionnaires (Movement Imagery Questionnaire-RS - MIQ-RS, Kinesthetic and Visual Imagery Questionnaire-20 - KVIQ-20, Vividness of Movement Imagery Questionnaire-2 - VMIQ-2) and 2 tests (imagined Time Up and Go - iTUG, imagined Box and Block test - iBBT). Outcome parameters will be i) the composite score of vividness measured for all tests using Likert scales, ii) the temporal equivalence between MI and Physical practice (PP - where MI/PP ratio equal to 1 indicate good MI ability and respect of temporal equivalence between MI and PP) and iii) the amplitude of electrodermal activity. The investigators will also study implicit MI ability using a hand laterality judgment task. Outcomes parameters will be response time (i.e. the duration to identify the hand laterality) and the percentage of correct responses.

NCT ID: NCT03660852 Not yet recruiting - Stroke Clinical Trials

Impact of a Magnetic Resonance Imaging (MRI) Scanner Exclusively Dedicated to Emergency in the Clinical Management of Patients Presenting With Diplopia or Dizziness

Start date: September 2018
Study type: Observational

IRM-DU is a prospective observational single center study conducted in an emergency department to evaluate the impact of a MRI scanner exclusively dedicated to emergency in the clinical management of patients presenting with dizziness or diplopia. The study will compare 2 strategies : after and before availability of a MRI scanner dedicated to emergency. The primary endpoint is the proportion of patients with a diagnosis of stroke confirmed by imaging (MRI or Computed tomography (CT)) in the group "before implementation of the emergency MRI scanner" and the group "after implementation of the emergency MRI scanner". The hypothesis is that the availability of a MRI scanner dedicated to emergency will improve the diagnosis of stroke in patients presenting with dizziness or diplopia, and will reduce Emergency Department stay, hospital stay and hospitalisation costs.

NCT ID: NCT03660618 Completed - Hypertension Clinical Trials

LSFG-SKIN, Laser Speckle Flowgraphy

Start date: May 23, 2017
Phase: N/A
Study type: Interventional

The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or environmental changes, such as temperature, light and pressure.

NCT ID: NCT03659409 Recruiting - Depression Clinical Trials

Stroke Of Mindfulness: Investigating Physiological and Psychological Well-being

Start date: May 12, 2016
Phase: N/A
Study type: Interventional

This study evaluates the impact of mindfulness-based interventions on psycho-social and physiological well-being among stroke survivors and their family caregivers. This study will employ a treatment wait-list cross-over design, with half the participants randomized to receive the intervention first (treatment group), while the other half receives the interventions 2 months following the end of the treatment phase (wait-list group).

NCT ID: NCT03659266 Not yet recruiting - Stroke Clinical Trials

Effects of Combined Treatment by Botulinum Toxin and Lokomat® on Walking Ability in Chronic Stroke

Start date: November 2018
Phase: N/A
Study type: Interventional

75% patients in the chronic phase of a stroke keep walking disabilities. Focal spasticity in the paretic lower limb frequently causes these walking disabilities, and the gold standard treatment is intramuscular injection of Botulinum toxin A in the spastic muscles. To potentiate the effects of toxin, walking rehabilitation is usually prescribed in the weeks following injection, but the protocols vary and few have been evaluated in the medical literature. In particular, the effect on walking ability of combined treatment by botulinum toxin A and robot-assisted gait training has never been evaluated. Tested hypothesis: Robot-assisted gait training by Lokomat® motorized exoskeleton potentiates botulinum toxin's effects better than conventional walking therapy. The aim of this study was to evaluate the effects on walking ability of the association of focal spasticity treatment by Botulinum toxin and Lokomat-assisted walking rehabilitation in patients suffering from spastic hemiparesia after stroke in the chronic phase. Outcome: -Primary: distance walked (meters) in the six-minute walk test (SMWT) Prospective, randomized, controlled, opened, monocentric study with a crossover design. Recruitment of patients over 18 years of age, in the chronic phase of stroke, who have already been treated by Botulinum toxin injection for focal spasticity in our PMR ward. Assessment at Day one (D0), Week four (W4) and Week eight (W8). Following a preliminary study which had the six-minute walk test as a secondary outcome, the expected results are a significant improvement of the distance walked in the SMWT after robotic rehabilitation, and a lack of significant improvement following conventional therapy. The study should serve to further harmonize and optimize rehabilitation protocols after toxin injections, and to justify the use of robotic rehabilitation for patients in the chronic phase of stroke.

NCT ID: NCT03658798 Recruiting - Stroke Clinical Trials

Grasping Rehabilitation With Functional Electrical Stimulation Garment

Start date: October 2, 2017
Phase: N/A
Study type: Interventional

This study tests the feasibility, safety and efficacy of garments embedding conductive electrodes (FES-shirt) for the independent delivery of functional electrical stimulation (FES). 12 people with SCI and 12 people with stroke who have some degree of arm paralysis will receive 40 hours of FES with these FES-shirt. The ability to use the FES-shirts and the improvement in function while receiving FES will indicate the immediate benefits. Their functional capabilities will be measured before and after 40 FES sessions to evaluate the carry-over effects.

NCT ID: NCT03655964 Recruiting - Stroke, Ischemic Clinical Trials

Effect of Olmesartan and Nebivolol on Ambulatory Blood Pressure and Arterial Stiffness in Acute Stage of Ischemic Stroke

Start date: August 20, 2018
Phase: Phase 2
Study type: Interventional

Single-blind, randomized, active-treatment controlled clinical study evaluating the effect of omesartan and nebivolol versus no treatment on 24-hour brachial and central aortic blood pressure in hypertensive patients with acute ischemic stroke

NCT ID: NCT03653780 Recruiting - Stroke Clinical Trials

Physiological Responses During Overground Gait Training With a Wearable Exoskeleton After Stroke

Start date: August 27, 2018
Phase: N/A
Study type: Interventional

To investigate the acute physiological responses during 20-minute overground gait training with a wearable exoskeleton in persons after stroke

NCT ID: NCT03653312 Recruiting - Ischemic Stroke Clinical Trials

Neuromuscular Electrical Stimulation in Acute Ischemic Stroke

Start date: August 27, 2018
Phase: N/A
Study type: Interventional

The purpose of the study is to examine the added effect of NeuroMuscular Electric Stimulation (NMES) as an exercise therapy tool in the acute phase of ischemic stroke in order to increase the patient's functionality. Further, to induce and measure neuroplasticity in the central nervous system during rehabilitation training. This randomized controlled trial includes 50 patients allocated to either control or intervention. The inclusion, test, training and re-test will be provided during the first 14 days after ictus, starting day 1 after ictus and a follow-up at day 90. The exercise training with external NMES is done with the patient every weekday for 27 minutes. The neural plasticity test will be performed using Transcranial Magnetic Stimulation (TMS).

NCT ID: NCT03653299 Completed - Clinical trials for Post-stroke in Association to Phototherapy

Effects of Phototherapy on Gait and Balance of Post-stroke Individuals

Start date: June 13, 2016
Phase: N/A
Study type: Interventional

Hemiparesis and/or hemiplegia is one of the most common clinical signs of stroke, characterized by partial or complete loss of motor function, resulting in varying degrees of impairment and disability. The aim of this study is evaluate the acute effects of application of phototherapy to detect if this therapeutic approach may be beneficial in gait and balance post-stroke individuals. For such, 10 volunteers, with a history of injury (stroke) between 6 months to 5 years, with deficit in functional capacity in the gait due spasticity of extensor muscles of the affected limb, specifically the Triceps Sural. The evaluation will consist of three-dimensional gait analysis, muscle activity during gait, mobility, static and functional balance, and mobility of volunteers.