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Stroke clinical trials

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NCT ID: NCT03731351 Recruiting - Clinical trials for Acute Ischemic Stroke

Mild Acute Ischemic Stroke With Large Vessel Occlusion (MISTWAVE)

Start date: August 3, 2016
Study type: Observational

Stroke remains the leading cause of disability in the United States. An estimated 40-50% of all ischemic strokes are caused by large-vessel occlusion of a major cerebral artery (LVO). However, in some cases, the occlusion results in mild symptoms, at least initially, and these patients frequently do not receive any treatment. These strokes, however, may result in unfavorable long-term outcomes despite relatively benign initial course. Recent large randomized studies in patients with severe stroke symptoms and associated LVO showed efficacy and safety of endovascular mechanical thrombectomy, but patients with mild symptoms were not specifically addressed. Based on the investigators' own data and limited evidence in the literature, the investigators propose that early mechanical thrombectomy in patients with LVO associated with mild stroke symptoms (defined as NIHSS ≤ 5) is safe, and results in favorable long-term patient outcomes. The objective of this prospective pilot study is to assess the safety and outcomes of mechanical thrombectomy in patients presenting with acute ischemic stroke due to a large vessel occlusion in the anterior or posterior circulation under 24 hours with mild symptoms (NIHSS ≤ 5).

NCT ID: NCT03731299 Completed - Stroke Clinical Trials

Muscle Synergies After Stroke

Start date: April 1, 2015
Study type: Observational

The aim of this systematic review was to determine the number of muscle synergies and the distribution of muscle weightings in stroke patients during gait.

NCT ID: NCT03730701 Not yet recruiting - Stroke Clinical Trials

Make my Day - Primary Prevention of Stroke

Start date: March 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the feasibility and effect of an ongoing digital, person-centered prevention program with a focus on primary prevention. The program is aiming to enable lifestyle change and to promote healthy activity patterns to prevent stroke.

NCT ID: NCT03729817 Not yet recruiting - Stroke Clinical Trials

Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke II

Start date: May 2019
Phase: N/A
Study type: Interventional

Recent prospective observational data has established that distal blood flow compromise measured using noninvasive quantitative magnetic resonance angiography (QMRA) identifies a high risk subgroup of patients with symptomatic atherosclerotic vertebrobasilar (VB) steno-occlusive disease, serving as an imaging biomarker for future stroke risk. The currently proposed study aims to determine if an endovascular intervention, submaximal balloon angioplasty, can be performed with adequate safety in this high risk subgroup of flow-compromised patients with VB stenosis. The study will also examine as secondary aims, the effect of the intervention on distal flow augmentation and on subsequent posterior circulation ischemic events.

NCT ID: NCT03729648 Recruiting - Stroke Clinical Trials

Expressive Arts-based Intervention for Young and Pre-elderly Stroke Survivors

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

Stroke is a devastating illness that induces numerous impairments of body function and structure, and limitations to activities in all aspects of life, thus imposing multi-faceted restrictions on one's participation in daily living. It also has detrimental impacts on one's mental health, social relationship, and quality of life. Existing research focuses primarily on older adults stroke survivors; this study is set out to contribute to current knowledge of the effectiveness of arts-based rehabilitation on younger stroke survivors. Both psychological and physiological outcomes will be examined for a comprehensive understanding on the biological, psychological, social, and spiritual changes after participating in a non-pharmacological, engaging, safe and enjoyable multi-modal expressive arts-based intervention approach of rehabilitation.This current study will adopt a 2-arm randomized controlled design with treatment-as-usual control. Upon screening for inclusion exclusion criteria, baseline data will be collected; and eligible participants will be randomized into either an 8-week Expressive Arts-based intervention group or Treatment-As-Usual control group.

NCT ID: NCT03728738 Recruiting - Ischemic Stroke Clinical Trials

Zero Degree Head Positioning in Hyperacute Large Artery Ischemic Stroke

Start date: September 25, 2018
Phase: Phase 3
Study type: Interventional

Placing the head of bed (HOB) at 0-degrees has been shown in small studies to improve blood flow to the brain in patients with ischemic stroke caused by large artery occlusions, thereby reducing stroke symptom worsening. This simple yet potentially impactful intervention has yet to be tested in a large clinical trial in hyperacute large artery ischemic stroke patients, but may provide nurses with a powerful contribution to acute stroke care that is capable of preventing worsening of stroke symptoms and promoting stabilization. Because stroke is the leading cause of preventable long-term disability in adults, this study may show that simple methods such as 0-degree HOB positioning should be considered one of the very first actions taken in the emergent management of acute ischemic stroke patients.

NCT ID: NCT03728400 Recruiting - Stroke Clinical Trials

Follow-up of Malnutrition Screening in USINV

Start date: May 29, 2018
Study type: Observational

This aim of the study is to set up a procedure for screening for undernutrition in the neurovascular intensive care unit. This screening procedure follows a specific work concerning undernutrition in thrombolyzed patients (NCT03303820). This work was motivated by the fact that, despite a high frequency of undernutrition in the hospital (at least 30% of patients), undernutrition in neurovascular unit is studied very little. A cohort of thrombolysed patients in 2014 was studied retrospectively. Patients malnourished at the entrance had a non-significant, less good recovery of their stroke (+ 1 Rankin score point at 3 months in malnourished patients at the entrance).

NCT ID: NCT03728153 Not yet recruiting - Acute Stroke Clinical Trials

Measuring Ambulation, Motor, and Behavioral Outcomes With Post-Stroke Fluoxetine in Tanzania

Start date: March 1, 2019
Phase: Phase 2
Study type: Interventional

This is a phase II, randomized study of 120 adults age 18 or above who will prescribed 20mg daily Fluoxetine for 90 days following acute, ischemic stroke.

NCT ID: NCT03728036 Not yet recruiting - Stroke Clinical Trials

Identifying the Time Course of Functional Walking Recovery After Stroke: A Rehabilitation Cohort

Start date: November 1, 2018
Study type: Observational

To better understand the time course of functional walking recovery within the first 6 months post-stroke.

NCT ID: NCT03727919 Not yet recruiting - Stroke Clinical Trials

Exoskeleton-assisted Training to Accelerate Walking Recovery Early After Stroke

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

To investigate the responsiveness to rehabilitation as a function of time within the first 3 months post-stroke and effects of exoskeleton-assisted training.