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Stroke clinical trials

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NCT ID: NCT03387267 Terminated - Stroke Clinical Trials

Videofluoroscopic Swallowing Study (VFSS)

PORSCHE
Start date: October 24, 2017
Phase: N/A
Study type: Interventional

The study procedure of simultaneous VFSS and DDS measurement will be completed in one day and the subject will be followed within 2 business days after the study procedure to monitor for adverse events.

NCT ID: NCT03346538 Terminated - Clinical trials for Acute Ischemic Stroke

Dose Finding Study of MCI-186 in Acute Ischemic Stroke

Start date: November 17, 2017
Phase: Phase 2
Study type: Interventional

To investigate the efficacy and safety of MCI-186 (bolus followed by continuous infusion) in acute ischemic stroke patients through a double-blind, parallel-group comparison with the existing MCI-186 dosing regimen (administration twice daily for 14 days) as the control.

NCT ID: NCT03290053 Terminated - Ischemic Stroke Clinical Trials

Contrast Enhanced Sonothrombolysis and Sonolysis in Stroke - a Swedish Study (CE-5S)

CE-5S
Start date: November 28, 2017
Phase: Phase 3
Study type: Interventional

Patients with acute ischemic stroke in anterior circulation within 4,5 hours of symptom onset, has a bone window and Trombolysis In Brain Ischemia (TIBI) <=4 in a relevant artery eligible. Both patients receiving thrombolysis and those who do not due to contraindications such as anticoagulation or recent surgery are enrolled, but into different study arms (CE-5S A for thrombolysis and B for non-thrombolysis); the decision to treat with thrombolysis or not is done according to clinical routine. All included patients are randomized to receive transcranial ultrasound and SonoVue-infusion or sham-ultrasound and placebo; i.e. in CE-5S A, contrast enhanced sonothrombolysis is compared to thrombolysis and in CE-5S B, contrast enhanced sonolysis is compared with conservative management. Main outcome is improvement in National Institute of Health Stroke Scale (NIHSS) at 24 hours compared to baseline. Main safety outcome is symptomatic intracerebral haemorrhage.

NCT ID: NCT03254160 Terminated - Ischemic Stroke Clinical Trials

DNS-3379 vs. Placebo in Stroke Rehabilitation

SPIRIT
Start date: November 13, 2017
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled parallel group outpatient 42-day treatment study that will utilize standard stroke rehabilitation outcome measures to evaluate the effect of DNS-3379 on upper extremity motor recovery in subjects following ischemic stroke.

NCT ID: NCT03034109 Terminated - Stroke Clinical Trials

Transcranial Direct Current Stimulation (tDCS) in Post-Stroke Working Memory Deficits

TDCS-PSMWD
Start date: January 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to test the effects of tDCS (Transcranial Direct Current Stimulation) on stroke patients with working memory problems.

NCT ID: NCT02928393 Terminated - Stroke Clinical Trials

A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke

Start date: February 20, 2017
Phase: Phase 2
Study type: Interventional

This Phase IIa, randomized, double-blind, placebo-controlled, parallel group study will evaluate the safety, efficacy and pharmacodynamics of basmisanil in adult participants with severe motor impairment following an ischemic stroke.

NCT ID: NCT02915484 Terminated - Stroke Clinical Trials

Transcranial Direct Current Stimulation (tDCS) in Chronic Post-Stroke Apathy

TDCS-PSA
Start date: June 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to test the efficacy and safety of tDCS (Transcranial Direct Current Stimulation) on apathy in stroke patients.

NCT ID: NCT02895776 Terminated - Acute Stroke Clinical Trials

Risk Factors of Conversion From Local to General Sedation in Endovascular Stroke Therapy

AMAS
Start date: December 22, 2015
Phase:
Study type: Observational

Thrombectomy is now the standard of care of revascularization in acute ischaemic stroke. Data tend to show that final neurologic outcome is superior if the thrombectomy procedure was performed under conscious sedation. The Rothschild Foundation is a high output centre with more than 400 thrombectomy procedures every year. We report a rate of 5% of these procedures requiring general anesthesia despite conscious sedation being the standard of care. This study aims to identify clinical factors associated with a risk of conversion of a conscious sedation to a general anesthesia.

NCT ID: NCT02778087 Terminated - Stroke Clinical Trials

Mirror Therapy After Stroke: A Dosing Study

Start date: January 2017
Phase: N/A
Study type: Interventional

It has been suggested that augmenting repetitive task practice with the use of box (mirror) therapy (BT) can enhance the benefits of task practice and may provide stroke survivors an opportunity to engage in self-directed practice outside of normally scheduled therapy sessions. However, the dosage of BT to be used in clinical practice is unclear. In order for practitioners to begin integrating BT into clinical practice situations more information is needed to determine what defines a therapeutic dose. The aim of this study is to differentiate between two dosages of self-directed BT added to treatment as usual for decreasing arm and hand motor impairments, improving activity level, and increasing self-directed participation after stroke. Forty-five subjects from the Stroke Rehabilitation Unit at Helen Hayes Hospital (HHH) will be randomly assigned into three groups: treatment as usual plus 30 minute dosage of self-directed BT 5x/week; treatment as usual plus 60 minute dosage of self-directed BT 5x/week; treatment as usual plus 30 minutes of self-directed sham BT 5x/week.

NCT ID: NCT02748252 Terminated - HIV Clinical Trials

Prognosis of a First-Ever Stroke in Persons Living With HIV

PROFES
Start date: December 2015
Phase:
Study type: Observational

With aging of the persons living with HIV, cardiovascular diseases now account for substantial mortality and morbidity. Stroke frequency grows exponentially with aging and its incidence doubles every decade over 55 years of age. The prognosis of ischemic stroke depends mainly on the care in Stroke Units in the acute phase of the disease (thrombolysis/thrombectomy). It is important that HIV patients are referred to these units in the first hours of a stroke and not to their infectious disease units which is a loss of chance. It would also be important to know whether HIV patients need specific protocols for stroke emergency management. The study aims to compare the functional prognosis after the first occurrence of an ischemic stroke, in patients admitted to a Stroke Unit, whether they are infected or not infected by HIV.