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Stroke clinical trials

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NCT ID: NCT03290053 Terminated - Ischemic Stroke Clinical Trials

Contrast Enhanced Sonothrombolysis and Sonolysis in Stroke - a Swedish Study (CE-5S)

CE-5S
Start date: November 28, 2017
Phase: Phase 3
Study type: Interventional

Patients with acute ischemic stroke in anterior circulation within 4,5 hours of symptom onset, has a bone window and Trombolysis In Brain Ischemia (TIBI) <=4 in a relevant artery eligible. Both patients receiving thrombolysis and those who do not due to contraindications such as anticoagulation or recent surgery are enrolled, but into different study arms (CE-5S A for thrombolysis and B for non-thrombolysis); the decision to treat with thrombolysis or not is done according to clinical routine. All included patients are randomized to receive transcranial ultrasound and SonoVue-infusion or sham-ultrasound and placebo; i.e. in CE-5S A, contrast enhanced sonothrombolysis is compared to thrombolysis and in CE-5S B, contrast enhanced sonolysis is compared with conservative management. Main outcome is improvement in National Institute of Health Stroke Scale (NIHSS) at 24 hours compared to baseline. Main safety outcome is symptomatic intracerebral haemorrhage.

NCT ID: NCT03254160 Terminated - Ischemic Stroke Clinical Trials

DNS-3379 vs. Placebo in Stroke Rehabilitation

SPIRIT
Start date: November 13, 2017
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled parallel group outpatient 42-day treatment study that will utilize standard stroke rehabilitation outcome measures to evaluate the effect of DNS-3379 on upper extremity motor recovery in subjects following ischemic stroke.

NCT ID: NCT03034109 Terminated - Stroke Clinical Trials

Transcranial Direct Current Stimulation (tDCS) in Post-Stroke Working Memory Deficits

TDCS-PSMWD
Start date: January 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to test the effects of tDCS (Transcranial Direct Current Stimulation) on stroke patients with working memory problems.

NCT ID: NCT02928393 Terminated - Stroke Clinical Trials

A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke

Start date: February 20, 2017
Phase: Phase 2
Study type: Interventional

This Phase IIa, randomized, double-blind, placebo-controlled, parallel group study will evaluate the safety, efficacy and pharmacodynamics of basmisanil in adult participants with severe motor impairment following an ischemic stroke.

NCT ID: NCT02915484 Terminated - Stroke Clinical Trials

Transcranial Direct Current Stimulation (tDCS) in Chronic Post-Stroke Apathy

TDCS-PSA
Start date: June 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to test the efficacy and safety of tDCS (Transcranial Direct Current Stimulation) on apathy in stroke patients.

NCT ID: NCT02778087 Terminated - Stroke Clinical Trials

Mirror Therapy After Stroke: A Dosing Study

Start date: January 2017
Phase: N/A
Study type: Interventional

It has been suggested that augmenting repetitive task practice with the use of box (mirror) therapy (BT) can enhance the benefits of task practice and may provide stroke survivors an opportunity to engage in self-directed practice outside of normally scheduled therapy sessions. However, the dosage of BT to be used in clinical practice is unclear. In order for practitioners to begin integrating BT into clinical practice situations more information is needed to determine what defines a therapeutic dose. The aim of this study is to differentiate between two dosages of self-directed BT added to treatment as usual for decreasing arm and hand motor impairments, improving activity level, and increasing self-directed participation after stroke. Forty-five subjects from the Stroke Rehabilitation Unit at Helen Hayes Hospital (HHH) will be randomly assigned into three groups: treatment as usual plus 30 minute dosage of self-directed BT 5x/week; treatment as usual plus 60 minute dosage of self-directed BT 5x/week; treatment as usual plus 30 minutes of self-directed sham BT 5x/week.

NCT ID: NCT02688413 Terminated - Stroke Clinical Trials

Study Evaluating the MindMotionPRO for Early Post-stroke Upper-limb Rehabilitation

MOVE-Rehab
Start date: August 2016
Phase: N/A
Study type: Interventional

Randomised controlled multi-centered study using MindMotionPRO, an immersive virtual reality based system for upper limb motor rehabilitation in early post-stroke patients. The study aims to evaluate the ability of MindMotionPRO technology to increase the rehabilitation dose. Effectiveness will be evaluated by validated rehabilitation performance scales. Cost-effectiveness will be assessed by the resource utilization.

NCT ID: NCT02680496 Terminated - Stroke Clinical Trials

Energy Consumption and Cardiorespiratory Load During Walking With and Without Robot-Assistance

Start date: February 2016
Phase: N/A
Study type: Interventional

The primary objective of the study is to investigate the energy consumption, cardiorespiratory load and perceived exertion, and how these parameters change, during walking with robot-assistance compared to walking on a treadmill and walking overground in stroke patients. A secondary objective is to investigate whether these changes or differences in energy consumption, cardiorespiratory load and perceived exertion during walking with and without robot-assistance in stroke patients are related to changes or differences spatiotemporal gait characteristics.

NCT ID: NCT02628847 Terminated - Stroke Clinical Trials

Sildenafil and Stroke Recovery

Start date: March 2012
Phase: Phase 1
Study type: Interventional

This is a small, pilot randomized clinical trial of administering sildenafil citrate to individuals within 10 days of ischemic stroke who have motor impairment and who are undergoing inpatient rehabilitation compared to placebo. The primary outcome is motor recovery at one and three months.

NCT ID: NCT02586415 Terminated - Stroke, Acute Clinical Trials

Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3

DEFUSE 3
Start date: April 2016
Phase: N/A
Study type: Interventional

This is a study to evaluate the hypothesis that FDA cleared thrombectomy devices plus medical management leads to superior clinical outcomes in acute ischemic stroke patients at 90 days when compared to medical management alone in appropriately selected subjects with the Target mismatch profile and an MCA (M1 segment) or ICA occlusion who can be randomized and have endovascular treatment initiated between 6-16 hours after last seen well.