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Stroke clinical trials

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NCT ID: NCT03857243 Terminated - Hemiparesis Clinical Trials

Dual Transcranial Direct Current Stimulation (dTDCS)-Enhanced Therapy After Hemorrhagic Strokes and VEGF

Start date: January 2014
Phase: N/A
Study type: Interventional

This study will evaluate the feasibility of dual tDCS to improve arm motor function in chronic stroke patients. In addition it will collect pilot data on the blood biomarkers associated with treatment effect.

NCT ID: NCT03767192 Terminated - Clinical trials for Acute Ischemic Stroke

Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window (ImpACT-24A)

Start date: January 2009
Phase: N/A
Study type: Interventional

The primary objective of the study is to assess the safety and effectiveness of SPG stimulation with the ISS in patients with an acute ischemic stroke in the anterior circulation initiated within 24 hours from stroke onset.

NCT ID: NCT03387267 Terminated - Stroke Clinical Trials

Videofluoroscopic Swallowing Study (VFSS)

Start date: October 24, 2017
Phase: N/A
Study type: Interventional

The study procedure of simultaneous VFSS and DDS measurement will be completed in one day and the subject will be followed within 2 business days after the study procedure to monitor for adverse events.

NCT ID: NCT03367091 Terminated - Stroke Clinical Trials

Energy Consumption and Cardiorespiratory Load During Overground Gait Training With a Wearable Exoskeleton After Stroke

Start date: July 9, 2018
Phase: N/A
Study type: Interventional

To investigate acute metabolic and cardiorespiratory responses during overground gait training with a wearable exoskeleton in persons after stroke

NCT ID: NCT03346538 Terminated - Clinical trials for Acute Ischemic Stroke

Dose Finding Study of MCI-186 in Acute Ischemic Stroke

Start date: November 17, 2017
Phase: Phase 2
Study type: Interventional

To investigate the efficacy and safety of MCI-186 (bolus followed by continuous infusion) in acute ischemic stroke patients through a double-blind, parallel-group comparison with the existing MCI-186 dosing regimen (administration twice daily for 14 days) as the control.

NCT ID: NCT03290053 Terminated - Ischemic Stroke Clinical Trials

Contrast Enhanced Sonothrombolysis and Sonolysis in Stroke - a Swedish Study (CE-5S)

Start date: November 28, 2017
Phase: Phase 3
Study type: Interventional

Patients with acute ischemic stroke in anterior circulation within 4,5 hours of symptom onset, has a bone window and Trombolysis In Brain Ischemia (TIBI) <=4 in a relevant artery eligible. Both patients receiving thrombolysis and those who do not due to contraindications such as anticoagulation or recent surgery are enrolled, but into different study arms (CE-5S A for thrombolysis and B for non-thrombolysis); the decision to treat with thrombolysis or not is done according to clinical routine. All included patients are randomized to receive transcranial ultrasound and SonoVue-infusion or sham-ultrasound and placebo; i.e. in CE-5S A, contrast enhanced sonothrombolysis is compared to thrombolysis and in CE-5S B, contrast enhanced sonolysis is compared with conservative management. Main outcome is improvement in National Institute of Health Stroke Scale (NIHSS) at 24 hours compared to baseline. Main safety outcome is symptomatic intracerebral haemorrhage.

NCT ID: NCT03264742 Terminated - Stroke, Acute Clinical Trials

Ghrelintrial With Patients With Stroke

Start date: April 1, 2017
Study type: Observational

Patients are assigned to KSW's Stroke Unit as part of the emergency treatment. There the patients are included in the study and treated according to the concept on the Stroke Unit within the complex treatment. The patients are included after clarification and with the consent of the patients. On the morning after the day of intake, the first determination of the ghrelin takes place in the routine blood sampling. Similarly, 48 hours later and 3 months after the stroke, a blood sampling is performed to determine ghrelin. The De Morton Mobility Index (DEMMI), the 9-hole-peg assay and the modified Rankin Scale (mRS) are determined on the day of admission, on the 3rd day, and three months after stroke. This is done within the framework of the routine clarification and treatment on the Stroke Unit.

NCT ID: NCT03254160 Terminated - Ischemic Stroke Clinical Trials

DNS-3379 vs. Placebo in Stroke Rehabilitation

Start date: November 13, 2017
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled parallel group outpatient 42-day treatment study that will utilize standard stroke rehabilitation outcome measures to evaluate the effect of DNS-3379 on upper extremity motor recovery in subjects following ischemic stroke.

NCT ID: NCT03034109 Terminated - Stroke Clinical Trials

Transcranial Direct Current Stimulation (tDCS) in Post-Stroke Working Memory Deficits

Start date: January 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to test the effects of tDCS (Transcranial Direct Current Stimulation) on stroke patients with working memory problems.

NCT ID: NCT02928393 Terminated - Stroke Clinical Trials

A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke

Start date: February 20, 2017
Phase: Phase 2
Study type: Interventional

This Phase IIa, randomized, double-blind, placebo-controlled, parallel group study will evaluate the safety, efficacy and pharmacodynamics of basmisanil in adult participants with severe motor impairment following an ischemic stroke.