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Stroke clinical trials

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NCT ID: NCT03562663 Completed - Chronic Stroke Clinical Trials

Brain Stimulation and Robotics in Chronic Stroke Motor Recovery

Start date: January 2012
Phase: Phase 3
Study type: Interventional

Motor skill training and transcranial direct current stimulation (tDCS) have separately been shown to alter cortical excitability and enhance motor function in humans. Their combination is appealing for augmenting motor recovery in stroke patients, and this is an area presently under heavy investigation globally. The investigators have previously shown that the timing of tDCS application has functional significance, that tDCS applied prior to training can be beneficial for voluntary behavior, and that tDCS effects may not simply be additive to training effects, but may change the nature of the training effect. The investigators have separately reported in a randomized-controlled clinical trial, that upper limb robotic training alone over 12 weeks can improve clinical function of chronic stroke patients. Based on our results with tDCS and robotic training, the investigators hypothesize that the same repeated sessions of robotic training, but preceded by tDCS, would lead to a sustained and functional change greater than robotic training alone. The investigators will determine if clinical function can be improved and sustained with tDCS-robotic training and cortical physiology changes that underlie functional improvements.

NCT ID: NCT03559829 Completed - Stroke Clinical Trials

Feasibility of Home-based Virtual Reality Rehabilitation for the Upper Extremity in Subacute and Chronic Stroke

Start date: September 23, 2016
Phase: N/A
Study type: Interventional

Regaining upper extremity function is very important for stroke survivors to increase their independence and ability to perform activities of daily living (ADLs). Outpatient stroke rehabilitation currently takes place in a therapy clinic, however access can be limited by financial resources and transportation difficulties. The Feasibility of Home-Based Virtual Reality Rehabilitation for the Upper Extremity in Subacute and Chronic Stroke Study seeks to explore the safety, usability, and efficacy of a home based virtual reality biofeedback system to promote distal upper extremity (wrist and hand) recovery after stroke. The purpose of the study is to assess the feasibility of using a home-based virtual reality system to increase the dose of upper extremity rehabilitation in subacute and chronic stroke patients.

NCT ID: NCT03555474 Completed - Strokes Thrombotic Clinical Trials

Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation in Stroke Rehabilitation

Start date: October 5, 2009
Phase: N/A
Study type: Interventional

Approximately 50% of patients have persistent motor disability following stroke. Current treatment approaches with conventional physiotherapy have limited efficacy. Repetitive transcranial magnetic stimulation (rTMS) and Functional electrical stimulation (FES) have been shown to improve the neuronal plasticity and motor control in few preliminary studies. Their efficacy in human stroke subjects is unproven. We planned to study their efficacy in improving the motor functions of stroke patients in a randomized trial. Sixty consecutive haemodynamically stable adult patients with first ischemic stroke within last 7-30 days were randomized into three treatment groups to receive either physiotherapy alone, or physiotherapy combined with either FES or rTMS. Outcome was assessed using Fugl Meyer assessment for physical performance of upper limb. Three groups were compared for the outcome measures using intention to treat analysis.

NCT ID: NCT03549975 Completed - Stroke Clinical Trials

Hand Rehabilitation Using Botulinum Toxin and Functional Electrical Stimulation-pilot Study

Start date: May 18, 2016
Phase: Phase 4
Study type: Interventional

The investigator tried to find out possibility of functional improvement using botulinum toxin injection targeting finger flexor spasticity with functional electrical stimulation among chronic stroke patients who did not show any improvement in hand function.

NCT ID: NCT03534856 Completed - Stroke Clinical Trials

Sensorimotor Changes in Stroke Following Mindfulness

Start date: July 13, 2016
Phase: N/A
Study type: Interventional

Roughly 30% of stroke survivors experience spasticity, a velocity-dependent increase in stretch reflexes. In this pilot study, the investigators aimed to examine the effects of mindfulness meditation on spasticity and quality of life in individuals after stroke.

NCT ID: NCT03528018 Completed - Stroke Clinical Trials

Efficacy of a Combined Transcranial Direct Current Stimulation and Virtual Reality Intervention

REACT01
Start date: June 1, 2015
Phase: N/A
Study type: Interventional

Rehabilitation options for stroke survivors who present severe hemiparesis in chronic stages are limited and may end in compensation techniques that involve the use of the less affected arm to achieve some degree of functional independence. Transcranial direct current stimulation (tDCS) is a non-invasive technique that has been used after stroke to promote excitability of the surviving neural architecture in order to support functional recovery. Interestingly, cortical excitability has been reported to increase when tDCS is combined with virtual reality. This synergetic effect could explain the promising results achieved by preliminary experimental interventions that combined both approaches on upper limb rehabilitation after stroke. The objective of this study is to explore the use of these interventions in subjects with severe hemiparesis and to determine its efficacy in comparison to conventional physical therapy

NCT ID: NCT03502122 Completed - Stroke Clinical Trials

Design and Verification of Individualized Smart Assistive Devices for Stroke Rehabilitation

Start date: April 24, 2012
Phase: N/A
Study type: Interventional

This study aims to design and verify a multi-mode smart assistive device system for Stroke Rehabilitation by using EEG, fMRI, IMU and questioners

NCT ID: NCT03500705 Completed - Stroke Clinical Trials

Upper Limb Unilateral Strength Training and Mirror Therapy for Chronic Stroke Patients

Start date: October 22, 2014
Phase: N/A
Study type: Interventional

This is a pilot randomised controlled trial investigating a combination of unilateral strength training (cross-education) and mirror therapy for the rehabilitation of upper limb impairment following a stroke. This study has been conducted as part of a PhD qualification at the Institute of Technology Sligo in Ireland with all assessments being conducted at the institute and all therapy sessions taking place at the participant's home. The study was conducted in conjunction with Sligo University Hospital and it attained ethical approval through the relevant University Hospital Ethics Committee.

NCT ID: NCT03500250 Completed - Depression Clinical Trials

Feasibility of the Post-Stroke Depression-toolkit

Start date: April 1, 2012
Phase:
Study type: Observational [Patient Registry]

Rationale: Depression is a frequent complication after a stroke. In stroke guidelines several recommendations focus on early screening, and treatment off depression after stroke. Introducing clinical practice guidelines into routine daily practice however, is a difficult process. In order to make the recommendations applicable to clinical practice a toolkit was developed (the Post Stroke Depression-toolkit), which provides assessment tools for the early detection of depression after stroke, and a set of interventions in case of a positive screening for (risk on) depressive symptoms. Objective: to investigate the feasibility of the Post Stroke Depression-toolkit in daily practice. Study design: An explanatory mixed-methods, before-and-after study design. Study population: Nurses working on the neurological wards of one university hospital and two general hospitals in the Netherlands were included in the study. Additionally, data were obtained from patient charts.

NCT ID: NCT03497650 Completed - Stroke Clinical Trials

Unilateral Strength Training and Mirror Therapy for Chronic Stroke Patients

Start date: October 22, 2014
Phase: N/A
Study type: Interventional

This is a pilot randomised controlled trial investigating a combination of unilateral strength training (cross-education) and mirror therapy for the rehabilitation of lower limb impairment following a stroke. This study has been conducted as part of a PhD qualification at the Institute of Technology Sligo in Ireland with all assessments being conducted at the institute and all therapy sessions taking place at the participant's home. The study was conducted in conjunction with Sligo University Hospital and it attained ethical approval through the relevant University Hospital Ethics Committee.