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Stroke clinical trials

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NCT ID: NCT03402594 Completed - Stroke Clinical Trials

High Flow Oxygen Therapy and Acute Ischemic Stroke

Start date: July 1, 2016
Phase: N/A
Study type: Interventional

Hypoxemia is common in acute ischemic stroke and associated with neurological deterioration and mortality. However, the benefit of oxygen therapy is controversial. Severity of stroke may affect the benefit of oxygen supplementation. Abnormal breathing patterns are commonly found among stroke patients and may increase the risk of hypoxemia. High flow nasal cannula (HFNC) has several advantages from controllable fraction of inspired oxygen (FiO2), reduction of nasopharyngeal resistance and positive end expiratory pressure effect. In this study, we aimed to assess the therapeutic effect of HFNC on oxygen desaturation index (ODI) and neurological outcomes in stroke patients with moderate and severe severities, compared with no and low flow oxygen supplementation.

NCT ID: NCT03402204 Completed - Ischemic Stroke Clinical Trials

Efficacy of High and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcome in Patients With AIS

Start date: April 25, 2016
Phase: Phase 3
Study type: Interventional

Patients with acute ischemic stroke will be divided into 2 groups by double-blind, randomized, and controlled trial. Personality and past history of the patients will be recorded after the patients signed inform consent. The patient will be collected blood among 10 cc. for measurement biomarker in serum that related plaque stability for baseline and obtained neurological examination for baseline. The patients must be take pills for 180 days by randomized code number on pill box, and patients must be turn into the site for follow up visit at Day 90 and Day 180. All visits of the patients will be collected blood among 10 cc. for measurement biomarker in serum that related plaque stability and obtained neurological examination. Next, the data will be separated with code number for divided group into 2 groups. Group 1 is simvastatin 10 mg per day treatment (n=36) and Group 2 is simvastatin 40 mg per day treatment. Finally, all data of each group will be calculated mean ± standard deviation, and compared by statistical analysis.

NCT ID: NCT03385538 Completed - Ischemic Stroke Clinical Trials

Clopidogrel Response and CYP2C19 Genotype in Ischemic Stroke Patients

CLOGIS
Start date: November 1, 2015
Phase: Phase 4
Study type: Interventional

Personalized therapy as prophylaxis in ischemic stroke patients is not yet an option. From patients with ischemic heart disease, we know that patients with in vitro high on treatment platelet reactivity (HTPR) have an increased risk of stent thrombosis following per-cutaneous coronary intervention. Other studies have shown association of CYP2C19 genotypes with different responses to the anti platelet drug Clopidogrel. We measure HTPR in ischemic stroke patients on increasing doses of clopidogrel and investigate the CYP2C19 genotype for each patient.

NCT ID: NCT03377465 Completed - Clinical trials for Myocardial Infarction

Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis

Start date: November 15, 2016
Phase: N/A
Study type: Interventional

A stroke is the second cause of deaths after heart attack, one of the most important causes of malfunction as far as adults are concerned and the second as for the frequency cause of dementia. In spite of a possibility of the therapy of stroke ( tissue plasminogen activator) and recognized most of risk factors there is expected that incidence rate on stroke connected with ageing of the society will be growing. It will cause medical and social consequences. There are many of potential causes of cardiac strokes, which are not entirely examined. More over many cryptogenic strokes are presumed to have an embolic etiology, and the frequent cause of these kind of strokes at young age is probably the mechanism of paradoxical embolism through patent foramen ovale. As far as the investigators are concerned, at present there is lack of any recommendations for these scientific hypothesis.

NCT ID: NCT03375346 Completed - Stroke Clinical Trials

Effects of Whole-body Vibration Exercise on Stroke Patients

Start date: August 4, 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the effect of the whole body vibration exercise on cortical activity and gait function in patients with chronic stroke.

NCT ID: NCT03366532 Completed - Clinical trials for Coronary Artery Disease

Dietary Analyses in the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-Up Study

Diet
Start date: August 1980
Phase: N/A
Study type: Observational

To determine the relationships of a variety of nutrients, foods, and dietary patterns with the subsequent risk of developing type 2 diabetes, cardiovascular disease, and mortality in US men and women.

NCT ID: NCT03364374 Completed - Stroke Clinical Trials

Postural Control and Fine Motor Skills in People With Stroke

Start date: February 4, 2015
Phase: N/A
Study type: Observational

This study evaluates the relationship between seated posture and fine motor performance in a drawing task in people with stroke and in healthy control subjects.

NCT ID: NCT03349138 Completed - Stroke Clinical Trials

Integrated Cognitive, Sensory, and Motor Rehabilitation of Hand Functions

INCOGNITO
Start date: January 1, 2015
Phase: N/A
Study type: Interventional

This study evaulates the addition to the standard theraphy of enriched sensorimotor training by means of robotic glove therapy, or functional electrical stimulation in the treatment of chronic stroke patients with upper limb motor impairments. All the patients receive the conventional physiotherapic treatment. Supplemental to the conventional treatment, patients are evenly split in four groups to provide different treatments for an equivalent amount of time. Patient in the first group receive supplemental conventional therapy; patients in the second group receive robotic glove therapy; patients in the third group receive functional electrical stimulation; patients in the fourth group receive robotic glove treatment and functional electrical stimulation in different sessions.

NCT ID: NCT03335787 Completed - Stroke Clinical Trials

Effectiveness of Kinesio Taping On Balance In Patients With Stroke

Start date: September 20, 2017
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the long term effects of Kinesio taping applied on ankle and peroneal muscle in patients with stroke.

NCT ID: NCT03334968 Completed - Stroke, Ischemic Clinical Trials

Prolidase Enzyme Activity in Stroke Patients

Start date: May 1, 2016
Phase: N/A
Study type: Observational

Stroke is a major cerebrovascular disease that causes significant burdens for human health and life, including high morbidity, mortality, and disability. Prolidase enzyme activity was found in various organs, such as the heart, brain, thymus, kidney, lung, pancreas, and spleen, and in plasma, leukocytes, erythrocytes, and dermal fibroblasts. An increase in collagen turnover is known to be correlated with increased prolidase enzyme activity. The aim of this study was to investigate whether SPA levels in AIS patients can be used as a potential diagnostic and prognostic marker. SPA levels were prospectively evaluated in 37 patients aged between 20 and 85 years who were admitted within 24 hours of the onset of AIS. The control group included 37 healthy volunteers of similar age without any disease.