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Stroke, Ischemic clinical trials

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NCT ID: NCT03839810 Recruiting - Healthy Clinical Trials

Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.

NCT ID: NCT03826030 Not yet recruiting - Motor Activity Clinical Trials

Transcranial Direct Current Stimulation for Post-stroke Motor Recovery

TRANSPORT 2
Start date: February 2019
Phase: Phase 2
Study type: Interventional

This research study is to find out if brain stimulation at different dosage level combined with an efficacy-proven rehabilitation therapy can improve arm function. The stimulation technique is called transcranial direct current stimulation (tDCS). The treatment uses direct currents to stimulate specific parts of the brain affected by stroke. The adjunctive rehabilitation therapy is called "modified Constraint-Induced Movement Therapy" (mCIMT). During this therapy the subject will wear a mitt on the hand of the arm that was not affected by a stroke and force to use the weak arm. The study will test 3 different doses of brain stimulation in combination with mCIMT to find out the most promising one.

NCT ID: NCT03814889 Not yet recruiting - Stroke Clinical Trials

Passive Tactile Stimulation for Stroke Rehabilitation

PTS
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Stroke can lead to weakness and spasticity in the arm or hand. The purpose of this study is to optimize the design of gentle vibratory stimulation delivered to the hands of individuals with chronic stroke, and explore the effect on range of movement and spasticity.

NCT ID: NCT03804476 Recruiting - Stroke Clinical Trials

Phase 1 Study to Assess AER-271

Start date: June 26, 2018
Phase: Phase 1
Study type: Interventional

The objective of this Phase 1 trial is to assess the safety, tolerability and pharmacokinetics of AER-271 in health subjects.

NCT ID: NCT03794947 Not yet recruiting - Fatigue Clinical Trials

Remote Ischaemic Conditioning for Fatigue After Stroke

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

This is a pilot randomised control trial to assess the safety, compliance, and acceptability of delivering a 6-week programme of remote ischaemic conditioning (RIC) to stroke patients suffering with fatigue, and study feasibility. A minimum of 34 patients who have suffered an ischeamic or haemorrhagic stroke and who suffer from fatigue, will be recruited and randomised to receive a 6-week programme of either RIC or a sham intervention.

NCT ID: NCT03764306 Terminated - Stroke, Ischemic Clinical Trials

New Ischemic Cerebral Lesions After Endarterectomy vs. Stenting for the Treatment of Symptomatic Carotid Stenosis

CARECarotid
Start date: May 1, 2015
Phase: N/A
Study type: Interventional

Background and purpose. Even if periprocedural cerebral microembolism associated with carotid endarterectomy or stenting usually does not manifest as clinically overt stroke, neuropsychological disturbances resulting from these events represent an important clinical and socioeconomic problem. Still, it remains unclear whether the use proximal protection can lower the incidence of cerebral embolism associated with the treatment of carotid stenosis. Materials and methods. This was a prospective randomised single-centre study, which was aimed at comparison of surgical eversion endarterectomy with stenting under proximal protection in symptomatic patients. The investigators evaluated the incidence of new ischaemic lesions revealed by the diffusion-weighted magnetic resonance imaging 2-4 days after the treatment and neurologic events.

NCT ID: NCT03753555 Recruiting - Stroke, Ischemic Clinical Trials

The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques

INSIST-HRMRI
Start date: December 1, 2018
Phase: Phase 4
Study type: Interventional

Intracranial atherosclerotic disease is the most common cause of ischemic stroke that is directly attributed to the progression or rupture of intracranial high-risk plaque in Asia. Many studies mainly from Euro-American population with a focus on extracranial carotid plaque have fully demonstrated the advantages of intensive statin therapy on stabilizing or reversing plaque burden, reversing plaque composition presenting that lipid-rich necrotic core (LRNC) is gradually replaced by fibrous tissue, and even reversing pattern of arterial remodeling to reduce the occurrence of cerebrovascular events. Yet, direct evidence of the effect of intensive statin therapy on intracranial atherosclerotic plaques is lacking and the effect of statin intensity and duration on intracranial plaque burden and composition is still unclear. High resolution magnetic resonance imaging (HRMRI) is a new and non-invasive technique that enable to assess the morphologic characteristics of vascular wall and plaque composition of intracranial artery. Based on above discussion, the investigators conduct this study to further determine the effect of intensive statin in ischemic stroke with intracranial atherosclerotic plaques.

NCT ID: NCT03733431 Not yet recruiting - Stroke Clinical Trials

Non-invasive TRanscutaneous Cervical Vagus Nerve Stimulation as a Treatment for Acute Stroke; Safety and Feasibility Study

TR-VENUS
Start date: March 2019
Phase: N/A
Study type: Interventional

This study aims to determine safety and feasibility of non-invasive transcutaneous cervical Vagus nerve stimulation (nVNS) when delivered promptly after clinical diagnosis of acute stroke. Vagus nerve stimulation will be performed via GammaCore® device. A total of 60 patients will be randomized to each of 3 different groups; 'standard dose' vagal stimulation, 'high dose' vagal stimulation, and 'sham stimulation' (1:1:1 ratio). Adverse device events, serious adverse device events, and feasibility of vagal nerve stimulation at the setting of acute stroke will be evaluated. The study will be performed in a multi-center fashion among stroke centers within TurkStrokeNet Network.

NCT ID: NCT03728153 Not yet recruiting - Acute Stroke Clinical Trials

Measuring Ambulation, Motor, and Behavioral Outcomes With Post-Stroke Fluoxetine in Tanzania

MAMBO
Start date: March 1, 2019
Phase: Phase 2
Study type: Interventional

This is a phase II, randomized study of 120 adults age 18 or above who will prescribed 20mg daily Fluoxetine for 90 days following acute, ischemic stroke.

NCT ID: NCT03726814 Not yet recruiting - Stroke, Ischemic Clinical Trials

A Clinical Study of iEPC Intervent Subjects With Cerebral Hemorrhagic Stroke

Start date: December 2018
Phase: Early Phase 1
Study type: Interventional

This is a single centre、single arm、open-label,to investigate the safety and efficacy of EPC transplantation in the brain