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Stroke, Ischemic clinical trials

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NCT ID: NCT03944668 Enrolling by invitation - Stroke, Ischemic Clinical Trials

Comprehensive Cardiac Rehabilitation Feasibility After Stroke

CCRFast
Start date: April 29, 2019
Phase: N/A
Study type: Interventional

Comprehensive Cardiovascular Rehabilitation Feasibility After Stroke (CCR FAST) will evaluate the feasibility of enrolling Regions Hospital stroke patients in a Comprehensive Cardiovascular Rehabilitation (CCR) program. CCR will include aerobic exercise and patient education (regarding risk factors and medication compliance), similar to the rehabilitation program for cardiac disease patients. The overall goal of CCR FAST is to demonstrate the feasibility and safety of including stroke patients in a CCR program, while examining the clinical value in reducing stroke recurrence, myocardial infarction, readmission, and mortality in stroke patients.

NCT ID: NCT03942588 Completed - Stroke, Ischemic Clinical Trials

High-intensity Interval Training After Stroke

Start date: September 24, 2014
Phase: N/A
Study type: Interventional

Aerobic conditioning is very important after stroke as it may reduce the risk of subsequent stroke and overall mortality. High-intensity interval training (HIIT), in which aerobic training workload is varied between lower and higher intensity bouts within a training session, is known to be effective for maximizing aerobic capacity in healthy individuals and those with cardiac disease. HIIT has not been studied extensively in adults with stroke, but it could be an efficient way to maximize aerobic capacity in this population. Furthermore, using heart rate response to establish training intensity may lead to underestimation of target intensity after stroke because blood pressure medications may blunt the heart rate response. Ventilatory threshold is an alternate method of establishing training intensity and is derived independently of heart rate response. The investigators hypothesized that a 10-week program of treadmill HIIT with intensity based on ventilatory threshold would be feasible in adults at least 6 months post-stroke, and would increase aerobic capacity.

NCT ID: NCT03934021 Recruiting - Stroke Clinical Trials

Gut Microbiota in Acute Stroke Patients

Start date: July 1, 2018
Phase:
Study type: Observational

This study is to find out the significance of gut-microbiota in acute stroke patients, including their neurological, radiological outcomes as well as their stroke mechanisms.

NCT ID: NCT03915782 Not yet recruiting - Stroke, Ischemic Clinical Trials

Neuroprotective Effect of Remote Ischemic Conditioning in Ischemic Stroke Treated With Mechanical Thrombectomy

PROTECT I
Start date: July 1, 2019
Phase: N/A
Study type: Interventional

The benefit of mechanical thrombectomy in the treatment of ischemic stroke has been demonstrated in several multicenter randomized trials. However, it leads to a sudden reperfusion of the brain parenchyma associated to an extension of the infarct volume. Evidence has indicated that remote ischemic conditioning (RIC) reduces final infarct size in animal stroke models. The main objective of the present study is to determine whether remote ischemic conditioning can limit the final infarct volume after recanalization of the occluded cerebral artery.

NCT ID: NCT03897478 Not yet recruiting - Stroke Clinical Trials

Biomarkers of Acute Stroke in Clinic

BASIC
Start date: April 1, 2019
Phase:
Study type: Observational

The proposed study will investigate the clinical use of the ISCDX test that may differentiate between diverse stroke etiologies as listed below: Aim 1: Differentiate between cardioembolic and large artery atherosclerotic ischemic strokes, when hemorrhagic stroke is ruled out, as defined by TOAST classification of subtypes of acute ischemic stroke. Aim 2: In cases of ischemic strokes of unknown or "cryptogenic" etiology, determine the ability of biomarker blood tests to predict etiology between cardioembolic and large artery atherosclerotic.

NCT ID: NCT03892226 Recruiting - Stroke, Ischemic Clinical Trials

Cardiomyocyte Injury Following Acute Ischemic Stroke

CORONA-IS
Start date: April 1, 2019
Phase:
Study type: Observational

The primary goal of the CORONA-IS study is to characterize stroke-associated acute myocardial injury (elevated hs-cardiac troponin) using different diagnostic examinations in order get a better understanding of it's underlying pathomechanisms.

NCT ID: NCT03884166 Not yet recruiting - Stroke, Ischemic Clinical Trials

MUcociliary Clearance IN Stroke

MUCINS
Start date: May 1, 2019
Phase:
Study type: Observational

Stroke patients frequently suffer from stroke associated pneumonia. Pathophysiologically speaking, dysphagia and central nervous system (CNS)-injury induced immunosuppression largely contribute to the risk for pneumonia. In mouse models for stroke, the self-cleaning mechanisms of the lung are also affected by stroke, possibly further contributing to this risk. The investigators designed a pilot-study to examine the structural and functional integrity of the self-cleaning mechanisms of the lung in stroke patients.

NCT ID: NCT03884153 Not yet recruiting - Stroke, Ischemic Clinical Trials

CASTRO-B - Study on CRP Apheresis in STROke Patients in Berlin

CASTRO-B
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

This study explores the use of CRP level reduction in patients after suffering from acute ischemic stroke. Using selective CRP-apheresis, the investigators aim to reduce the secondary inflammatory tissue damage in the course of infarction maturation using infarction growth in MRI as the primary outcome as a surrogate.

NCT ID: NCT03839810 Recruiting - Healthy Clinical Trials

Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.

NCT ID: NCT03826030 Recruiting - Motor Activity Clinical Trials

Transcranial Direct Current Stimulation for Post-stroke Motor Recovery

TRANSPORT 2
Start date: June 1, 2019
Phase: Phase 2
Study type: Interventional

This research study is to find out if brain stimulation at different dosage level combined with an efficacy-proven rehabilitation therapy can improve arm function. The stimulation technique is called transcranial direct current stimulation (tDCS). The treatment uses direct currents to stimulate specific parts of the brain affected by stroke. The adjunctive rehabilitation therapy is called "modified Constraint-Induced Movement Therapy" (mCIMT). During this therapy the subject will wear a mitt on the hand of the arm that was not affected by a stroke and force to use the weak arm. The study will test 3 different doses of brain stimulation in combination with mCIMT to find out the most promising one.