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Stroke clinical trials

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NCT ID: NCT03845855 Recruiting - Stroke Clinical Trials

Effects of Virtual Reality on Dual Task Performance

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the effects of virtual reality treatment in addition to robotic gait therapy on dual task performance, balance and gait in chronic stroke patients. Half of participants will attend virtual reality treatment in addition to robotic gait therapy for 12 sessions, while the other half will attend only robotic gait therapy for 12 sessions.

NCT ID: NCT03845686 Recruiting - Clinical trials for Left Hemispheric Stroke, Subacute Phase

Brain Markers Predicting Reading Recovery After Stroke

Start date: April 4, 2018
Phase:
Study type: Observational

For millions of stroke survivors acquired reading deficits represent a significant handicap preventing them from returning to work or continuing their education. The goal of the proposed research is to investigate what brain mechanisms enable recovery of impaired reading. To achieve this goal, we will directly measure changes in brain perfusion (blood flow) and activation among recovering stroke survivors using a neuroimaging technique called perfusion fMRI (functional Magnetic Resonance Imaging). We will test if re-perfusion (return of circulation) and re-appearance of reading-related brain activity in the left-brain network for reading is associated with recovery. The ability to predict recovery from neuroimaging has tremendous value in rehabilitation for generating prognoses. It may also dramatically improve the quality of research evaluation for novel, targeted interventions such as noninvasive brain stimulation or pharmacologic therapies.

NCT ID: NCT03841695 Recruiting - Stroke Clinical Trials

The Therapeutic Effect of the Hand Robot on Stroke Patients Upper-lime Rehabilitation of Stroke Patients

Start date: December 21, 2018
Phase: N/A
Study type: Interventional

In the present study, the RMTC finger-hand robot and combined with the mechanism of neuroplasticity will be used on the upper-limb rehabilitation of stroke patients. The participants will be randomized assigned to treatment group (TG, robot assisted treatment) and control group (CG, conventional treatment). In the experimental group, task oriented bi-manual training will be applied using the unaffected hand to guide the affected hand by RMTC robot system. The investigators will estimate the motor function of distal part of upper-limb before and after treatments. The results will be compared with the convention rehabilitation treatment. The primary outcomes are Fugl-Meyer assessment (FMA); and the secondary outcome measurements are modified Ashworth scale (MAS),Action Reach Arm Test (ARAT), Box & block test、Brunnstrom recovery Stage, and motor activity log (MAL).

NCT ID: NCT03839810 Recruiting - Healthy Clinical Trials

Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.

NCT ID: NCT03839316 Recruiting - Stroke Clinical Trials

Effects of Bihemispheric Transcranial Direct Current Stimulation on Motor Function in Stroke Patients

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

Motor impairment (impairment of movement) due to stroke is one of the leading disabilities in adults. In addition to established means of facilitating motor recovery after stroke such as physical and occupational therapy, a variety of experimental rehabilitation approaches have been tested. Although there have been significant advances in stroke rehabilitation with these techniques and treatments, research on this subject is continuing. Recent studies have focused on non-invasive brain stimulation techniques. Transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) therapies, which are methods of non-invasive brain stimulation that may be effective on cerebral remodelling, aim to reestablish the disturbed balance between the anatomic areas of the brain seen in stroke patients. The primary aim of this study is to evaluate the effectiveness of bihemispheric transcranial direct current stimulation (tDCS) applications on the upper extremity motor functions of patients with stroke.

NCT ID: NCT03838289 Recruiting - Stroke Clinical Trials

Study of Cerebral Venous System in Acute Ischemic Stroke Patients Receiving Reperfusion Therapy

VAST
Start date: February 2019
Phase:
Study type: Observational

The VAST study is a single-center prospective observational study that enrolled individuals with acute ischemic stroke (AIS) within 24 hours onset. The patients will receive neurological examination, multimodal computed tomographic perfusion (CTP) or multimodal magnetic resonance perfusion (MRP) before reperfusion therapy. The hypoperfusion volume, ischemic core volume, brain edema, cerebral arterial collaterals will be evaluated on baseline brain image. The status of cerebral venous system (CVs) including superficial middle cerebral vein, vein of Labbe, vein of Trolard, Sphenoid sinus, thalamostriate vein, Internal cerebral vein, Rosenthal's vein will be evaluated in phases of reconstructed imaging from CTP/MRP. The investigators will explore the venous markers for prognosis of AIS patients who received reperfusion therapy, and find the role of venous system in reperfusion injury.

NCT ID: NCT03835455 Recruiting - Stroke, Acute Clinical Trials

Acceptability and Feasibility of Finger Foods

Start date: January 21, 2019
Phase:
Study type: Observational

This study will investigate the feasibility of using a finger food menu on an acute stroke rehabilitation ward. This study has a mixed methods design, with quantitative, qualitative and economic components which will be used to inform a future randomised control trial.

NCT ID: NCT03832413 Recruiting - Healthy Clinical Trials

Characterization of the DELPhI System in Assessing Brain's Functionality in Different Neurological Disorders

Start date: April 23, 2018
Phase:
Study type: Observational

We use Transcranial magnetic stimulation (TMS), combined with simultaneous registration of electroencephalograph (EEG),for examining human cortical functionality. TMS-EEG is a noninvasive brain stimulation method that allows to study human cortical function in vivo. EEG provides an opportunity to directly measure the cerebral response to TMS, measuring the cortical TMS Evoked potential (TEP). In this study we measure TEPs, in a wide variety of neurological conditions and healthy as a measure of cerebral reactivity across wide areas of neocortex.

NCT ID: NCT03828851 Recruiting - Stroke Clinical Trials

Development of Domiciliary Program on Improving Activities of Daily Living Program for Patients With Stroke

Start date: February 15, 2018
Phase: N/A
Study type: Interventional

Background and Purposes: Administering activities of daily living (ADL) and recovery of ADL functions are the primary efficacy indicators in long-term care and the main treatment goals in rehabilitation for patients with stroke. Residential rehabilitation is a direct way to observe patients' living environment and provides feasible ADL treatment plans for patients with stroke living at home or in the community. However, there are three limitations in previous studies on ADL training in residential rehabilitation. First, few studies provide clear programs or principles on ADL training in home environment. Second, the domains of ADL that are assessed are too limited. Previous studies only assess patients' ADL actual performance, not assess ADL capability and ADL perceived difficulty. Three, effects of ADL training on other function (e.g., motor, cognition, perception) are not investigated. These limitations reduce clinicians and researchers to provide effective ADL training in home environment. Therefore, to overcome these limitations, the investigators will develop a program of Domiciliary care- Activities of Daily Living (DO-ADL) and evaluate the effects of the DO-ADL program on ADL and other functions (i.e., motor, cognition, perception, sensory, quality of life, and depression). Methods: The 3-year research project consists of 2 stages. In the first stage, the investigators will conduct a pilot study. A six-week home program on basic ADL (BADL) will be designed. Thirty patients with stroke will be recruited and assigned into two groups (i.e., BADL home program and control group who receives traditional rehabilitation in hospital) for evaluating the feasibility of the BADL home program. In the second stage, the investigators will hold expert meetings to establish the principles of administrating the DO-ADL program and design the 12-week DO-ADL program according to the results from the first stage. The DO-ADL program contains the training on BADL and instrumental ADL (IADL). The investigators will recruit 60 patients with stroke and divide them into two groups (i.e., DO-ADL group and traditional rehabilitation group). The primary outcome measures are the Canadian Occupational Performance Measure, the Barthel Index-based Supplementary Scales, the Frenchay Activities Index, and ADL domain of the Stroke Impact Scale. The secondary outcome measures are the Fugl-Meyer Assessment, the Mini Mental State Examination, the Test of Visual Perceptual Skills-Third Edition, and the Center of Epidemiological Study-Depression

NCT ID: NCT03828435 Recruiting - Stroke Clinical Trials

Individualized rTMS Protocol for Stroke Recovery

Start date: April 2016
Phase: N/A
Study type: Interventional

This study aims to develop individualized therapeutic protocol to improve stroke recovery and fits the scheme of Mechanisms, biomarkers, and treatment strategies for stroke, aging, and Parkinson's disease by advanced EEG analysis and transcranial magnetic stimulation technique.