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Stroke clinical trials

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NCT ID: NCT03917511 Recruiting - Chronic Stroke Clinical Trials

Effects of Combined Robot-assisted Therapy With Mirror Priming in Stroke Patients

Start date: December 17, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the effects of combining robotic-assisted training and mirror therapy on upper extremity motor and physiological function, daily functions, quality of life and self-efficacy in stroke patients.

NCT ID: NCT03916562 Recruiting - Stroke Clinical Trials

Optimization Principles in Hemiparetic Gait

Start date: November 13, 2018
Phase: N/A
Study type: Interventional

This project seeks to identify the how walking impairments in stroke survivors contribute to mobility deficits through the use of behavioral observations and computational models. The chosen approach integrates biomechanical analyses, physiological assessments and machine learning algorithms to explain how asymmetries during walking influence balance and the effort required to walk. Ultimately, the results of this work may lead to more personalized rehabilitation strategies to improve walking capacity and efficiency, and ultimately reduce fall risk in stroke survivors.

NCT ID: NCT03913286 Recruiting - Stroke Clinical Trials

Neuromotor Prosthetic to Treat Stroke-Related Paresis

Cortimo
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

The purpose of the research is to develop a new medical device prototype to restore functional movement of an arm made weak due to a chronic stroke

NCT ID: NCT03910855 Recruiting - Depression Clinical Trials

Impact of Mindfulness on Psychological Well-being of Stroke Survivors and Their Caregivers

SOMII
Start date: September 1, 2018
Phase: N/A
Study type: Interventional

This study will employ a randomized control design. Stroke survivors and family caregivers will be recruited for the study, and randomized either to receive mindfulness-based intervention or health education. Both programs consist of 4 2-hour sessions. Participants of the mindfulness-based intervention (MBI) will be taught and guided in practice of psychosocial interventions that are focused on (1) stress management and coping skills, (2), body awareness and movement, (3) feelings of empathy and compassion and (4) motivation for rehabilitation. Participants of the health education program (HEP) will learn and discuss topics related to self-care and post-stroke management. Measures will be administered prior to and on completion of the intervention, and at 3-month follow-up. They will be used to assess symptoms associated with depression, anxiety, stress, perceived quality of life and participant characteristics such as personality variables.

NCT ID: NCT03909438 Recruiting - Stroke Clinical Trials

Investigation and Study on the Status of Endovascular Therapy in Acute Ischemic Stroke Ischemic Stroke

IS-EVT
Start date: September 1, 2018
Phase:
Study type: Observational

This study aims to build a database for patients with acute ischemic stroke who receive endovascular therapy and analyze the current situation, effectiveness, safety and cost-effectiveness of endovascular therapy for acute ischemic stroke in China.

NCT ID: NCT03903770 Recruiting - Stroke Clinical Trials

Personalized Upper Extremity Rehabilitation for Persons With Stroke

SUPER
Start date: September 1, 2018
Phase: N/A
Study type: Interventional

Approximately 80% of individuals with chronic stroke present with long lasting upper extremity (UE) impairments. Advances in rehabilitation technology, such as robotics, virtual reality (VR) and neuromuscular electrical stimulation (NMES), have separately demonstrated their effectiveness in improving UE function of individuals with stroke. The potential to influence recovery may be further enhanced by combining these modalities in order to target motor deficits of the individual. Research has shown that not all persons with stroke may be able to recover hand function. In particular, such recovery depends on the integrity of the corticospinal tract (CST), which links the motor areas of the brain to the UE (and hand) musculature. Instead of using a 'one-size-fits-all' approach to UE rehabilitation, CST integrity will be assessed through transcranial magnetic stimulation (TMS), a non-invasive approach, and match the intervention to the individual's specific impairments. The perSonalized UPper Extremity Rehabilitation (SUPER) intervention is proposed, which combines robotics, VR activities, and NMES. The objectives of this study are to determine the feasibility of the SUPER intervention in individuals with moderate/severe stroke. Stroke participants will receive a 5-week intervention (3x per week) combining robotic therapy and VR activities, based on their functional level. Those with low potential for hand recovery will receive an intervention focussing on elbow and shoulder movements. For those with a good potential for hand recovery, the last 30 minutes of the robotic or VR session will be complemented by muscle-triggered NMES. Feasibility indicators associated with process, resources, management and treatment will be measured. Outcomes of UE and hand function will include the Fugl-Meyer upper extremity assessment, the Box and Block test and the ABILHAND. It is expected that feasibility criteria will be met and that the SUPER intervention will lead to significant improvements in UE impairment compared to a waitlist group.

NCT ID: NCT03899298 Recruiting - Stroke Clinical Trials

Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions

Start date: March 20, 2019
Phase: Phase 1
Study type: Interventional

To determine the safety and efficacy of Amniotic and Umbilical Cord Tissue for the treatment of the following condition categories: Orthopedic, Neurologic, Urologic, Autoimmune, Renal, Cardiac and Pulmonary Conditions. The hypotheses are that the treatments are not only extremely safe, but also statistically beneficial for all conditions. Outcomes will be determined by numerous valid outcome instruments that compile general quality of life information along with condition-specific information as well.

NCT ID: NCT03897153 Recruiting - Stroke, Acute Clinical Trials

Evaluation of the SONAS® Ultrasound Device for the Assessment of Bilateral Cerebral Perfusion in Subjects With Acute Stroke

Start date: February 12, 2019
Phase: N/A
Study type: Interventional

The purpose of this clinical investigation is to determine the safety and feasibility of detecting acoustic signals related to blood supply in subjects with acute large vessel occlusion (LVO) stroke by using the SONAS® device.

NCT ID: NCT03892265 Recruiting - Obesity Clinical Trials

A Longitudinal Cohort Study to Evaluate Cardiovascular Risk Factors and Disease in Haiti

Start date: March 27, 2019
Phase:
Study type: Observational

Investigators will establish a longitudinal cohort of 3,000 adults >18 years in Port-au-Prince using multistage random sampling, and follow them for 2 to 3.5 years depending on the timing of study enrollment to evaluate the prevalence and incidence of cardiovascular disease risk factors and diseases. Cardiovascular risk factors include hypertension, diabetes, obesity, dyslipidemia, kidney disease, poor diet, cigarette smoking, physical inactivity, and inflammation. Cardiovascular disease include myocardial infarction, heart failure, stroke, and CVD mortality. It is anticipated that hypertension prevalence will be ≥10% in 18-30 year olds, that hypertension incidence will be >10 events/1000 person years. Association of determinants and risk factors with CVD will also be examined. Whole blood, serum, plasma, stool, and urine samples will be biobanked for future studies.

NCT ID: NCT03892226 Recruiting - Stroke, Ischemic Clinical Trials

Cardiomyocyte Injury Following Acute Ischemic Stroke

CORONA-IS
Start date: April 1, 2019
Phase:
Study type: Observational

The primary goal of the CORONA-IS study is to characterize stroke-associated acute myocardial injury (elevated hs-cardiac troponin) using different diagnostic examinations in order get a better understanding of it's underlying pathomechanisms.