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Stroke clinical trials

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NCT ID: NCT03202147 Suspended - Ischemic Stroke Clinical Trials

Safety and Efficacy of ALZT-OP1a as Adjuvant Treatment in Subjects With Post-Ischemic Stroke Cognitive Impairment (PSCI)

Start date: July 2016
Phase: Phase 2
Study type: Interventional

This is a Phase II, randomized, double-blinded, placebo-controlled study for subjects with evidence of PSCI.

NCT ID: NCT02773888 Suspended - Stroke Clinical Trials

An Evaluation of Non-Invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an Intraparenchymal Pressure Monitoring Device

Start date: December 2015
Phase: N/A
Study type: Interventional

Invasive intracranial pressure (ICP) monitoring is highly effective, but involves risks. HS-1000 measures ICP non-invasively by assessing the acoustic properties of the patient's head. HS-1000 device, a proprietary non-invasive ICP monitor, is expected to safely and accurately monitor ICP with minimal discomfort to patients, and provide information about normal or elevated ICP levels to the physicians.

NCT ID: NCT02533778 Suspended - Ischemic Stroke Clinical Trials

ARISE: After 8 Hours Reperfusion in Ischemic Stroke Embolization

Start date: July 2015
Phase: N/A
Study type: Interventional

A prospective pilot study to evaluate the recanalization and safety of mechanical thrombectomy through a cerebral angiogram in patients with stroke symptoms last seen normal between 8 - 24 hours.

NCT ID: NCT02460484 Suspended - Clinical trials for Perinatal Arterial Ischemic Stroke

Safety of Autologous Human Umbilical Cord Blood Treatment for Perinatal Arterial Ischemic Stroke

Start date: April 2015
Phase: Phase 1/Phase 2
Study type: Interventional

Autologous human umbilical cord blood (hUCB) stored at Cord Blood Registry will be given to children who have suffered from a Perinatal Arterial Ischemic Stroke. The aim is to determine if hUCB infusion is safe, if late functional outcome is improved, if hUCB treatment improves physiologic response in the child's SSEP & EEG, and the effect of hUCB infusion in altering anatomic findings on MRI.

NCT ID: NCT02401698 Suspended - Stroke Clinical Trials

Exploring Cerebellar Inhibition of the Motor Cortex in Stroke Patients

Start date: December 2014
Phase: N/A
Study type: Observational

The past 10 years of research in post stroke patients have shown certain types of rehabilitation can help neuronal plasticity of the brain. Transcranial magnetic stimulation (TMS) can be used to monitor this plasticity by mapping the brain's function (measuring brain activity). Recent research suggests that TMS can be used for both prognosis (determining future function) and to determine what type of rehabilitation therapy will work best after stroke. The purposes of this research study are to: 1) determine changes in cerebellar activity after motor cortical stroke 2) compare changes in recovery of motor function with changes in cerebellar - motor cortex connections; 3) determine the ability of TMS to "predict" functional outcome after stroke. The primary hypotheses are: 1) functional recovery will be correlated with TMS changes (as measure of motor threshold (MT), intracortical inhibition, cerebellar cerebral inhibition (CBI), motor evoked potentials (MEPs) and recruitment curves; 2) baseline TMS will predict future functional outcomes.

NCT ID: NCT02325427 Suspended - Stroke Clinical Trials

Changes in Brain Activity Associated With Upper Limb Motor Recovery

Start date: November 2014
Phase: N/A
Study type: Interventional

This study is to investigate changes in brain activities in acute stroke patients , and to correlate findings with clinical outcome measures. Another aim of the study is to investigate whether transcranial direct current stimulation (tDCS) could improve motor function in subjects with poor brain activity after stroke. The brain activity will be measured by single and paired pulse TMS (transcranial magnetic stimulation). The study hypothesizes that: 1. The neural mechanisms employed in patients who have different response to TMS stimulation are different. It is hypothesized that patients with no response upon TMS stimulation might have poorer motor function outcome, compared with patients with response upon TMS stimulation. 2. The result of clinical outcome measures is related with TMS measurement. 3. tDCS intervention is beneficial to subjects with poor brain activity. Clinical outcome measures will include a battery of upper limb motor tests such as upper extremity component of the Fugl-Meyer Assessment, Modified Ashworth scale for spasticity, box and block test, and manual muscle testing. Clinical outcome and TMS measurement will be assessed at within 2 weeks, 4-6 weeks and at 6 months post-stroke.

NCT ID: NCT02066116 Suspended - Stroke Clinical Trials

Kinect-based Upper Limb Rehabilitation System in Stroke Patients

Start date: November 2014
Phase: N/A
Study type: Interventional

The investigators have developed the kinect-based upper extremity rehabilitation program and designed this protocol to prove the efficacy of this program. In brief, subacute stroke patients allocated to intervention group will receive the kinect based-rehabilitation program plus conventional occupational therapy and patients allocated to control group will receive the sham virtual rehabilitation plus conventional occupational therapy, for 10 days. 20 patients with subacute stroke will be allocated into each group and after completing the 10 days intervention, they will be assessed by using objective assessment tools for upper extremity function.

NCT ID: NCT02059785 Suspended - Ischemic Stroke Clinical Trials

Phase ⅡStudy of Pinocembrin Injection to Treat Ischemic Stroke

Start date: June 2013
Phase: Phase 2
Study type: Interventional

This research is a Randomized, double-blind, placebo-controlled, multicenter clinical study. Chinese subjects with Ischemic Stroke.

NCT ID: NCT01437774 Suspended - Ischemic Stroke Clinical Trials

ReStore Thrombectomy Trial for Flow Restoration in Acute Ischemic Stroke Patients

Start date: October 2011
Phase: N/A
Study type: Interventional

The ReStore™ Thrombectomy device restores blood flow in the neurovascular by removing thrombus in patients experiencing ischemic stroke. Patients enrolled in the ReStore Trial will be randomized to treatment with the ReStore™ Thrombectomy Device (investigational treatment) or to treatment with a commercially available thrombectomy device It is expected that the investigational treatment safety profile in terms of clinically significant procedural adverse events will be comparable to the control group.

NCT ID: NCT00529945 Suspended - Stroke Clinical Trials

PFx Closure System in Subjects With Cryptogenic Stroke, TIA, Migraine or Decompression Illness

Paradigm IV
Start date: August 2007
Phase: N/A
Study type: Interventional

The primary object of this study is to demonstrate the continued safety and performance of the PFx Closure System when utilized for patients with PFOs suffering from cryptogenic stroke, transient ischemic attack, migraine or decompression illness.