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Stroke clinical trials

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NCT ID: NCT03844594 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

Eptifibatide in Endovascular Treatment of Acute Ischemic Stroke (EPOCH)

Start date: March 1, 2019
Phase: Phase 3
Study type: Interventional

The study is a single-arm, open-label, multicenter clinical trial.The primary purpose of this trial is to evaluate the incidence of symptomatic intracranial hemorrhage in patients with acute ischemic stroke within 48 hours after the use of Eptifibatide injection. Patients with acute ischemic stroke treated with intravascular thrombolytic therapy, mechanical thrombolysis, angioplasty and so on were treated with Eptifibatide injection on the first day, followed by the second day, the third day, the discharge day and the 90 days.

NCT ID: NCT03843463 Not yet recruiting - Stroke Clinical Trials

Escitalopram and Language Intervention for Subacute Aphasia

ELISA
Start date: February 2019
Phase: Phase 2
Study type: Interventional

In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).

NCT ID: NCT03843008 Not yet recruiting - Ischemic Stroke Clinical Trials

Melatonin in Acute Stroke

Start date: April 2019
Phase: N/A
Study type: Interventional

This study will measure Interleukin 6 (IL-6), a well-documented inflammatory biomarker that is increased in the acute phase of stroke, and to compare its levels after the administration of melatonin - a well-documented anti-inflammatory and anti-oxidant - that regulates circadian rhythm, which helps promote sleep.

NCT ID: NCT03840954 Not yet recruiting - Stroke, Acute Clinical Trials

Effects of Neuromuscular Electrical Stimulation in Muscle Architecture and Functionality of Patients After Acute Stroke

Start date: March 30, 2019
Phase: N/A
Study type: Interventional

Introduction: Stroke is a sudden illness, responsible for important neurological and cognitive sequelae that can result in functional limitations and dependence. It is the leading cause of neurological impairment in young adults and resting-related muscle loss is one of the major factors involved. Early rehabilitation is essential for these patients and neuromuscular electrical stimulation (NMES) has been identified as an intervention alternative due to its known effects on the prevention of muscle loss in patients with various pathologies. Objective: To evaluate the effects of NMES associated with conventional physiotherapy compared to conventional physiotherapy on muscle thickness and functionality of patients with acute stroke. Methodology: This is a randomized clinical trial, which will be performed at the Emergency and Unit Unit of the Stroke of the Hospital de Clínicas of Porto Alegre (HCPA). Patients with acute stroke, with up to 72 hours of hospital admission, who present with lower limb force deficit due to the current stroke will be included. Patients will be randomized into two groups: intervention group, who will receive the application of NMES associated with conventional physiotherapy and control group, who will receive the conventional physiotherapy of the HCPA. EEMS training will be applied once a day (30 minutes of application per session with an increase of five minutes each week and gradual reduction in OFF time), five days a week until hospital discharge or up to a maximum of three weeks. The following outcomes will be assessed before and after the intervention: quadriceps and tibial thickness and quality of the quadriceps and tibialis anterior, muscle strength, stroke severity, gait, functionality and disability.

NCT ID: NCT03833544 Not yet recruiting - Stroke Clinical Trials

Lower Limb Flexor Synergy Training in Chronic Stroke

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

This study evaluates whether a 4-week exercise training program focusing on lower limb flexors can improve lower limb motor function late after stroke. It is hypothesized that there would be significant improvements in gait and strength of the flexor muscles as a result of the training. It is also hypothesized that the training effects, if any, would be retained at 4 weeks after ending the training.

NCT ID: NCT03833518 Not yet recruiting - Stroke Clinical Trials

Cortical Biomarkers of Hand Function and Recovery After Injury

Start date: March 2019
Phase: N/A
Study type: Interventional

This is a pilot study to collect data to support a VA grant submission to study fMRI and neurophysiological predictors of hand function and recovery during a robotic intervention in people with hand impairments due to stroke or spinal cord injury.

NCT ID: NCT03831451 Not yet recruiting - Stroke Clinical Trials

Stroke Ready: A Stroke Preparedness Brief Intervention

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

This is a randomized controlled behavioral intervention trial to assess the efficacy of a brief intervention to increase stroke preparedness.

NCT ID: NCT03830983 Not yet recruiting - Stroke Clinical Trials

Atrial Cardiomyopathy in Patients With Stroke of Undetected Mechanism

Start date: February 1, 2019
Phase:
Study type: Observational

The goal of this study is to evaluate left atrial structural and functional abnormalities in stroke of likely cardio-embolic origin and atherosclerotic stroke with cardiac MRI.

NCT ID: NCT03830372 Not yet recruiting - Depression Clinical Trials

"VRTierOne" as a Method Supporting the Post-stroke Rehabilitation

VRTierOne
Start date: February 11, 2019
Phase: N/A
Study type: Interventional

Thanks to using VR googles and the phenomenon of total immersion "VR Tier One" allows to completely separate the patient from the hospital environment, provides an intense visual, auditory and kinesthetic stimulation. Depending on the stage of therapy it can have a calming and mood-improving effect or, in another part of the game, it can motivate and cognitively activate the patient. The additional aim of the game is to help the patients regain their emotional balance, let them recognize their resources in order to bring them to power in the rehabilitation process and trigger the natural recovery mechanisms.

NCT ID: NCT03829397 Not yet recruiting - Clinical trials for Post-stroke Depression

To Investigate the Correlation of Stroke Patients and Demoralized

Start date: February 11, 2019
Phase:
Study type: Observational

This study aim to clarify the participants's mental state with Demoralization Scale- Mandarin Version(DS-MV). Based on clinical observations and literature review, investigators assume participants's DS-MV score high correlation with PHQ-9 score.