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Stroke clinical trials

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NCT ID: NCT03915782 Not yet recruiting - Stroke, Ischemic Clinical Trials

Neuroprotective Effect of Remote Ischemic Conditioning in Ischemic Stroke Treated With Mechanical Thrombectomy

PROTECT I
Start date: July 1, 2019
Phase: N/A
Study type: Interventional

The benefit of mechanical thrombectomy in the treatment of ischemic stroke has been demonstrated in several multicenter randomized trials. However, it leads to a sudden reperfusion of the brain parenchyma associated to an extension of the infarct volume. Evidence has indicated that remote ischemic conditioning (RIC) reduces final infarct size in animal stroke models. The main objective of the present study is to determine whether remote ischemic conditioning can limit the final infarct volume after recanalization of the occluded cerebral artery.

NCT ID: NCT03915431 Not yet recruiting - Ischemic Stroke Clinical Trials

A Study of NCS-01 in Patients With Acute Ischemic Stroke

Start date: August 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This is an initial Phase1/2 dose-finding, double-blind, placebo-controlled, multi-center study to evaluate the safety and tolerability of NCS-01 in patients with acute ischemic stroke. All patients will be randomized within 24 hours of stroke onset. This study will be conducted in 2 stages.

NCT ID: NCT03910101 Not yet recruiting - Stroke Clinical Trials

The Effect of Spasticity-correcting Hand Surgery for Spasticity Related Symptoms

Start date: April 28, 2019
Phase: N/A
Study type: Interventional

Spasticity - a variety of motor over-activity and part of the upper motor neuron syndrome - is a common cause of impaired motor function after brain injuries of different etiologies. In addition, it may cause pain and impaired hygiene, contractures, deformities etc. Spasticity has been reported in 30 to 90% of patients with stroke, traumatic brain injury (TBI), incomplete spinal cord injury (SCI) and cerebral palsy (CP). Spasticity therapy has emerged as an important approach to alleviate related symptoms. Positive effects on spasticity are well recognized following systemic and intra-thecal pharmacological treatment, as well as after intra-muscularly injected substances; the effect of the latter is, however, of limited duration. While pharmacological spasticity therapy has been applied for decades, surgical procedures remain fairly uncommon in adults with spasticity, but not in pediatric patients with CP, and outcomes after surgical treatment are scarcely described in the literature. The study center is a specialized unit initially focused on reconstructive as well as spasticity reducing surgery in the upper extremities for SCI patients. Subsequently, patients with spasticity also due to various other Central nervous system diseases have been referred to the center for surgical treatment. Studies describing the effect of spasticity-reducing surgery in the upper extremities are rare and the group is heterogeneous. The aim of the study is therefore to evaluate the results and compare against todays golden standard treatment (boutuliniumtoxin injections).

NCT ID: NCT03910075 Not yet recruiting - Hemiparesis Clinical Trials

Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)

I-ACQUIRE
Start date: August 1, 2019
Phase: Phase 3
Study type: Interventional

This is a Phase III clinical trial to compare the efficacy of two dosages of a new infant rehabilitation protocol - I-ACQUIRE - to usual and customary forms of infant rehabilitation in infants who experienced Perinatal Arterial Stroke (PAS).

NCT ID: NCT03904017 Not yet recruiting - Stroke, Acute Clinical Trials

The Role of Hyperoxia in Acute Ischemic Stroke

Start date: June 1, 2019
Phase: N/A
Study type: Interventional

This study is being conducted to evaluate the potential therapeutic role of hyperoxia when applied in the immediate ischemic period following a stroke in the controlled Emergency Department setting. The study will evaluate the effects of hyperoxia in stroke patients on the production of markers of free radical damage and inflammatory markers associated with hyperoxic lung injury.

NCT ID: NCT03903068 Not yet recruiting - Clinical trials for Post-stroke Depression

The Pilot Study of TACs Therapy for PSD

TRACUD
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Post-stroke depression (PSD) is one of the most common post-stroke dysfunction, with a high incidence. PSD affects prognosis and disease rehabilitation, increases disease mortality and suicide risk, and aggravates the economic burden on individuals and society. Studies have shown that transcranial alternating current (TAC) can also be used to treat depression, insomnia and anxiety. So far, this stimulator has been approved by FDA and is widely used in clinical practice in North America. However, there have not been any reports on the use of this technology in the treatment of depression and post-stroke depression in China. In this study, the latest TACs technology was used to treat PSD, and the therapeutic effects and adverse reactions could be preliminarily observed.

NCT ID: NCT03898960 Not yet recruiting - Cerebral Stroke Clinical Trials

Post Marketing Study to Evaluate the GCE Device

SPERO
Start date: March 31, 2019
Phase:
Study type: Observational

A post-market study evaluating the Geometric Clot Extractor (GCE) Device in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.

NCT ID: NCT03898375 Not yet recruiting - Stroke Clinical Trials

The Effect of Optic Flow During Treadmill Walking on the Gait Pattern in People Post-stroke

Start date: May 2019
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the onset, magnitude and duration of the effect of manipulating the optic flow on the gait pattern during Virtual Reality (VR)-enhanced treadmill walking compared to treadmill walking without VR in people post-stroke.

NCT ID: NCT03897478 Not yet recruiting - Stroke Clinical Trials

Biomarkers of Acute Stroke in Clinic

BASIC
Start date: April 1, 2019
Phase:
Study type: Observational

The proposed study will investigate the clinical use of the ISCDX test that may differentiate between diverse stroke etiologies as listed below: Aim 1: Differentiate between cardioembolic and large artery atherosclerotic ischemic strokes, when hemorrhagic stroke is ruled out, as defined by TOAST classification of subtypes of acute ischemic stroke. Aim 2: In cases of ischemic strokes of unknown or "cryptogenic" etiology, determine the ability of biomarker blood tests to predict etiology between cardioembolic and large artery atherosclerotic.

NCT ID: NCT03892824 Not yet recruiting - Stroke Clinical Trials

Carotid Artery Implant for Preventing Stroke in Atrial Fibrillation Patients Taking Oral Anticoagulants

CAPTURE2
Start date: April 2019
Phase: N/A
Study type: Interventional

This study will assess the safety of the Vineā„¢ Embolic Protection System (embolic filtering device) in atrial fibrillation (AF) patients on top of oral anticoagulants (OAC), and remain at high risk for stroke recurrence. All patients will receive bilateral implants in the common carotid arteries