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Stroke clinical trials

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NCT ID: NCT03503617 Not yet recruiting - Cerebral Stroke Clinical Trials

RehabTouch Home Therapy for Stroke Patients

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

We will investigate the efficacy of a newly developed exercise device (RehabTouch) for people in the subacute stage after a stroke compared to a traditional tabletop exercise program. RehabTouch uses embedded sensors that can track and record the patient's direction and degree of movement as they perform exercises described on a computer.

NCT ID: NCT03500939 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

Penumbral Rescue by Normobaric O2 Administration in Patients With Ischemic Stroke and Target Mismatch ProFile

PROOF
Start date: June 2018
Phase: Phase 2
Study type: Interventional

The main objective of the PROOF trial is to investigate efficacy and safety of normobaric hyperoxygenation (NBHO) as a neuroprotective treatment in patients with acute ischemic stroke due to large vessel occlusion likely to receive endovascular mechanical thrombectomy (TBY) in a randomized controlled clinical phase IIb trial.

NCT ID: NCT03496480 Not yet recruiting - Stroke Clinical Trials

Stroke complicAtions After TraUmatic expeRieNces and Stress

SATURN
Start date: April 15, 2018
Phase:
Study type: Observational

The primary aim of this retrospective cohort study is to test the hypothesis that previous traumatization (long) before an ischemic stroke increases the degree of stroke-induced PTSD symptoms at 9-13 months after the stroke event. Secondary outcome parameters include quality of life and depression.

NCT ID: NCT03495206 Not yet recruiting - Stroke, Acute Clinical Trials

Safety, Tolerability and Pharmacokinetics of Y-2 Sublingual Tablet

Start date: April 2018
Phase: Phase 1
Study type: Interventional

The primary objective is to evaluate the safety and tolerability of single ascending dose of Y-2 sublingual tablets in healthy male and female adult subjects. The secondary objective is to characterize the single-dose pharmacokinetics of Y-2 sublingual tablets in healthy male and female adult subjects.

NCT ID: NCT03494920 Not yet recruiting - Ischemic Stroke Clinical Trials

DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval

Start date: April 2018
Phase: Phase 3
Study type: Interventional

The study will be a multicentre, prospective, randomized, open label, blinded endpoint (PROBE) phase 3 trial (2 arm with 1:1 randomization) in ischemic stroke patients within 4.5 hours of stroke onset. Randomised patients will be stratified for site of baseline arterial occlusion into one of three groups: 1. internal carotid artery (ICA) 2. middle cerebral artery (MCA) 3. basilar artery (BA). Patients will be randomised to either bridging intravenous thrombolysis with endovascular clot retrieval (ECR), or direct endovascular clot retrieval.

NCT ID: NCT03494530 Not yet recruiting - Ischemic Stroke Clinical Trials

Lixiana Acute Stroke Evaluation Registry

LASER
Start date: April 15, 2018
Phase:
Study type: Observational

Edoxaban (also referred to as Lixiana) is an anti-clotting drug, approved by Health Canada for the prevention of stroke in patients with atrial fibrillation (abnormal heart rhythm). We are doing this study to try to determine the best time to start apixaban treatment after an ischemic stroke has occurred. The purpose of the LASER study is to determine the safety of early edoxaban use after TIA/ischemic stroke in patients with atrial fibrillation using advanced MR imaging. This study will also gather information about participant general well being, mental status, and the effects of the TIA/stroke on daily living, as well as CT and MRI of the brain.

NCT ID: NCT03486782 Not yet recruiting - Stroke Clinical Trials

Dual Site-dual Channel Non-invasive Brain Stimulation for Language and Cognitive Function in Stroke Patients

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on ipsilesional inferior frontal cortex, ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex. 2) IFG stimulation: anodal stimulation on ipsilesional inferior frontal cortex; 3) DLPFC stimulation: anodal stimulation on ipsilesional dorsolateral prefrontal cortex area. 4) sham stimulation

NCT ID: NCT03486769 Not yet recruiting - Stroke Clinical Trials

Dual Site-dual Channel Non-invasive Brain Stimulation for Motor Function in Stroke Patients

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of motor function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. 2) M1 stimulation: anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex; 3) PMC stimulation: anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. 4) sham stimulation

NCT ID: NCT03484182 Not yet recruiting - Stroke Clinical Trials

Efficacy of an Interactive Web-Based Home Therapy Program After Stroke

STRONG
Start date: March 2018
Phase: N/A
Study type: Interventional

Stroke is the leading cause of disability worldwide. Of the annual incidence of stroke (~750,000) in the USA about 60% fail to recover arm and hand use contributing to reduced quality of life for survivors and caregivers. How can therapists facilitate the rehabilitation of individuals with arm movement deficits and increase their quality of life over a long time period? It is known that principles of treatment including repetition, feedback, challenge and progression are important for producing recovery. The ability for patients to train at home and manage their own rehabilitation duration, intensity and progression, via effective self-management strategies, is vital. What is needed is an effective, easy to use, low cost system that self-motivates patients to intensively practice their therapy exercises at home while maintaining elements of repetition, feedback, challenge and progression. In this proposal the investigators intend to adapt just such a "web-based system" originally designed in the UK. The first version of the system has shown preliminary efficacy and feasibility in a small pilot study in UK. The investigators will adapt the system for use in the USA, with the assistance of consultants from the UK. The purpose of this study is to investigate the efficacy and feasibility of using a free, easy to use, interactive web-based upper extremity stroke rehab program on individuals with stroke who have recently been discharged from outpatient rehabilitation. The goal is to compare the home use of the web-based stroke rehab program with that of written exercises in a randomized controlled trial. The aims/objectives are to (1) adapt the existing system for use in America including adding bilateral activities and then to assess (2) motor function immediately before and after six weeks intervention and after twenty weeks follow up in order to support the efficacy of using this web-based intervention; (3) behavioral changes in motivation and self-efficacy at the same time points to understand the relationship between behavioral and motor function changes; (4) perceptions of patients and caregivers of the web-based program to understand feasibility and barriers to home use; and (5) perceptions of therapists to understand feasibility and barriers to clinic use.

NCT ID: NCT03481205 Not yet recruiting - Acute Stroke Clinical Trials

Ischemic Conditioning by Aircrews for Refractory Occlusions

ICARO
Start date: June 1, 2018
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to demonstrate the feasibility of performing remote limb ischemic conditioning (RLIC) using the Doctormate device, a special blood pressure device used to perform RLIC, on patients with acute ischemic stroke due to large vessel occlusion being transported to a thrombectomy capable center by the helicopter.