View clinical trials related to Hypertension.
Filter by:Development of pulmonary hypertension (PH) in chronic lung diseases has both functional and prognostic implications . PH in Lung diseases is usually mild to moderate with preserved cardiac output, and evolves slowly alongside the progression of lung disease and hypoxemia . However, a minority of patients develop severe PH with elevations in pulmonary artery pressure that have been described as ''out of proportion'' to the underlying disease . The aim of this study is to compare the characteristics and outcomes of consecutive patients with PH-due to lung diseases diagnosed at our specialist referral center over a 1-year period.
The purpose of this study is to assess the validity and usefulness of omics signatures for improved identification and risk stratification of patients with endocrine hypertension and stratification of patients with primary hypertension.
A prospective Danish national registry of percutaneous transluminal renal angioplasty (PTRA) in high-risk patients with renal artery stenosis selected on the basis of common national criteria, and with a common follow-up protocol for all three Danish centres offering PTRA
- Measuring the incidence and prevalence of PAH in Egyptian patients with different types of MCD - Determination of survival & the risk factors of mortality.
To provide riociguat therapy to eligible patients with PAH originating from Bayer-sponsored trials with BAY63-2521/ Riociguat / Adempas® who are currently or recently treated in these trials until lack of patient benefit as assessed by investigator, or commercial availability and reimbursement.
Study the effects of inspiratory muscle training at Low load of 25 %Maximal inspiratory pressure with slow breathing rate at 6 breaths/min on inspiratory muscle strength, lung function, chest wall expansion, abdominal expansion, exercise capacity and blood pressure in elderly with Isolated systolic hypertension.
Background (brief): 1. Burden: Excessive salinity is common in groundwater aquifers across south-western coastal Bangladesh. Higher adult mean systolic and diastolic blood pressure and increased risk of gestational hypertension has been observed among those who drank tube-well water with high sodium content. 2. Knowledge gap: Managed Aquifer Recharge (MAR) systems, that inject freshwater into shallow aquifers, reduce drinking water salinity, have been successfully installed in the south-western area, providing year-round freshwater. However, the health benefits and risks of MAR water have not been measured. 3. Relevance: If drinking MAR water can reduce hypertension in adults and pregnant women, while showing minimal risk of microbiological and chemical contamination, scale up can be considered. Hypothesis (if any): Mean systolic and diastolic blood pressure will be lower among the adult population who drink MAR water compared to people drinking saline or brackish groundwater Objectives: To determine 1. If providing access to MAR water for drinking and food preparation reduces blood pressure among the adult population > 20 years of age. 2. If providing access to MAR water for drinking and food preparation during pregnancy can reduce blood pressure among pregnant women. 3. If MAR water is contaminated with E coli and fecal coliforms. 4. Whether the MAR water is contaminated with dissolved constituents mobilized from aquifer sediments that are known to be harmful to human health. Methods: A stepped-wedge RCT will be conducted among communities before and after the intervention roll out. Study investigators will collect baseline information from all sites in the first monthly block (step) when no one will drink MAR water. There will be promoters who will convey messages regarding exclusive use of MAR water for drinking and cooking, at home and elsewhere. Measurements will be made by trained research assistants once every month. MAR water, pond water, groundwater and household stored water samples will be collected and tested once every month.
The study evaluates the technique of non-drug treatment of residual pulmonary hypertension in patients with chronic thromboembolic pulmonary hypertension after pulmonary thromboendarterectomy.
Essential hypertension is a complex trait which results from interaction between environmental factors and genetic factors. The aim of this study is to investigate the effects of interaction between environmental factors and genetic factors on long-term blood pressure (BP) based on two established cohorts including "the cohort of Hanzhong adolescent hypertension study" and "the cohort of Mei county adult salt-sensitive hypertension study". Firstly, the Hanzhong cohort-based follow-up study is designed to observe the track of BP during the whole life time, and to explore the effects of many risk factors (such as salt-sensitivity, obesity et al) on long-term BP and the occurrence of hypertension, and also to analyze the relationship of different polymorphisms of sodium and potassium metabolism-related gene with BP changes and target organ damages. In addition, by using DNA samples collected from subjects of "Mei county adult salt-sensitive hypertension study"in which all participants had completed a chronic salt loading and potassium intervention trial, we attempt to examine the single nucleotide polymorphisms (SNPs) of sodium and potassium metabolism-related genes, as well as the relationship between these SNPs and BP responses to dietary sodium/potassium intervention, long-term BP change, the risk of hypertension and target organ damages were analyzed. This study would enable us to further explore the etiology of essential hypertension as well as to identify new genetic markers for predicting early hypertension and target organ damage.
The incidence and prevalence of hypertension is increasing while the controlled rate is extremely low in China. A substantial percentage of participants with uncontrolled hypertension are correctable if potential associated factors are identified and corrected. Therefore, it is clinically relevant to investigate and identify these potential associated factors of uncontrolled hypertension so as to increase controlled rate and reduce hypertension-associated health and economic burdens in the future. Investigators plan to conduct a prospective registry study in a single-center to initially investigate the potential associated factors of uncontrolled hypertension in cardiovascular outpatient department. Furthermore, investigators plan to evaluate the effects of potential associated factors correction on hypertension controlled rate and cardiovascular outcomes.