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Hypertension clinical trials

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NCT ID: NCT03713515 Not yet recruiting - Hypertension Clinical Trials

Bridging the Evidence-to-practice Gap: Evaluating Practice Facilitation as a Strategy to Accelerate Translation of a Systems-level Adherence Intervention Into Safety Net Practices

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

The proposed project will address this evidence-to-practice gap by evaluating, in a cluster-randomized controlled trial, the effect of practice facilitation (PF) of the ALMA intervention versus a self-directed control on implementation fidelity (primary outcome) and clinical measures at 12 months (secondary outcomes).

NCT ID: NCT03713333 Not yet recruiting - Hypertension Clinical Trials

Implementing Digital Health in a Learning Health System

Start date: October 20, 2018
Phase: N/A
Study type: Interventional

The need for new models of integrated care that can improve the efficiency of healthcare and reduce the costs are key priorities for health systems across the United States. Treatment costs for patients with at least one chronic medical or cardiovascular condition make up over 4-trillion dollars in spending on healthcare, with estimations of a population prevalence of 100-million affected individuals within the next decade. Therefore, the management of chronic conditions requires innovative and new implementation methods that improve outcomes, reduce costs, and increase healthcare efficiencies. Digital health, the use of mobile computing and communication technologies as an integral new models of care is seen as one potential solution. Despite the potential applications, there is limited data to support that new technologies improve healthcare outcomes. To do so requires; 1) robust methods to determine the impact of new technologies on healthcare outcomes and costs; and 2) evaluative mechanisms for how new devices are integrated into patient care. In this regard, the proposed clinical trial aims to advance the investigator's knowledge and to demonstrate the pragmatic utilization of new technologies within a learning healthcare system providing services to high-risk patient populations.

NCT ID: NCT03712033 Recruiting - Hypertension Clinical Trials

TEC4Home Stroke - Feasibility of Home Telemonitoring Technology in Managing Hypertension Among Stroke/TIA Patients

Start date: March 1, 2018
Study type: Observational

This study will test the feasibility of a home blood pressure telemonitoring (HBPTM) system in patients with minor stroke or TIA in the past year. The telemonitoring system will consist of a blood pressure machine and an online survey to submit blood pressure measurements. The investigators want to test whether patients can persistently use the telemonitoring system with ease and whether telephone instructions for blood pressure medications from the research nurse can be correctly understood. A secondary purpose of this study is to look at the effects of telemonitoring in blood pressure and stroke recurrence.

NCT ID: NCT03711201 Not yet recruiting - Hypertension Clinical Trials

Effects of Preoperative Operating Room Environment Presentation in Hypertensive Patients

Start date: October 30, 2018
Phase: N/A
Study type: Interventional

The aim of this study was to investigate the effects of preoperative operating room environment introduction on preoperative hypertension and blood pressure in hypertensive patients.

NCT ID: NCT03710902 Recruiting - Hypertension Clinical Trials

Empowerment and Mobile Technology in the Control of Cardiovascular Risk Factors in Patients With Ischemic Stroke

Start date: October 17, 2018
Phase: N/A
Study type: Interventional

The CARDIOSTROKE is a randomized trial comparing mobile-device assisted control of hypertension together with screening of occult atrial fibrillation to standard care in patients with recent ischemic stroke or transient ischemic attack.

NCT ID: NCT03710473 Not yet recruiting - Clinical trials for Systemic Hypertension

Non-Invasive Blood Pressure Measurement in Critically Ill PAtients Post Cardiosurgical Therapy

Start date: November 1, 2018
Study type: Observational

The aim of the present study is to evaluate the accuracy of measuring beat-by-beat diastolic blood pressure from a non-invasive, cuffless and non-obtrusive watch-like optical device worn at the wrist.

NCT ID: NCT03709771 Not yet recruiting - Hypertension Clinical Trials

Novel Mechanisms and Predictors of VEGF Receptor Inhibitor-Associated Hypertension

Start date: October 2018
Study type: Observational

The purpose of this study is to understand the effect of VEGF inhibitor treatment on blood pressure and blood vessel function.

NCT ID: NCT03708601 Not yet recruiting - Clinical trials for Essential Hypertension

A Registry Study on Biomarkers in Essential Hypertension

Start date: August 20, 2019
Study type: Observational

This is a national registry study to determine serial biomarkers of Essential Hypertension

NCT ID: NCT03708146 Recruiting - Clinical trials for Pulmonary Arterial Hypertension

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BIA 5-1058

Start date: June 24, 2018
Phase: Phase 1
Study type: Interventional

This is a single centre, double-blind, randomised, placebo-controlled, parallel staggered group study of BIA 5-1058 in 10 different cohorts of 15 healthy subjects. Subjects will be randomly assigned to receive once-daily oral doses of BIA 5-1058 or matching placebo for 10 days. The primary objectives of the study are to assess the safety and tolerability of BIA 5-1058 after repeated ascending doses under fed and fasted conditions and to assess the pharmacokinetics (PK) of BIA 5-1058 after repeated ascending doses under fed conditions having matching fasting cohorts for comparison of bioavailability. It is planned that comparison cohorts will be dosed in parallel, i.e. Cohorts 1 and 2, 3 and 4, 5 and 6, 7 and 8 and 9 and 10. Cohorts may be split or dosed sequentially for logistical purposes; however, data from both comparison cohorts (e.g. Cohorts 1 and 2) must be available before dose escalation to the next dose levels.

NCT ID: NCT03707561 Enrolling by invitation - Clinical trials for Pulmonary Hypertension

Russian National Registry of Newly Diagnosed Patients With PAH and CTEPH (RUS-registry of PH)

Start date: January 2016
Study type: Observational [Patient Registry]

RUS-registry of PH is a multicenter, observational study of the clinical course and disease management of PAH and CTEPH patients. designed to gather demographic, clinical and prognostic data of routine medical care in prospective manner for newly initiated treatment since Jan 2016. The internet-based registry ( fulfills high quality standards through several measures (planned minimum centre contribution of at least 10 patients per year, automated plausibility checks of data at entry, queries, monitoring with source data verification in >50% of participating centers). All consecutive patients diagnosed with WHO Group I PAH according to specific hemodynamic criteria will be enrolled in participating centers after signing the informed consents. Participating patients will be followed for a minimum of five years from the time of enrollment. It can be applied, among further purposes, for quality assurance: individual centers can confidentially compare their results with the combined outcome of the other centers. It is expected that the registry contributes to optimization of specific drug therapy for PAH and PH.